大疱性类天疱疮并发银屑病1例

Serbian Journal of Dermatology and Venereology Pub Date : 2018-12-01 DOI:10.2478/sjdv-2018-0018

O. Suwarsa, Lengga Herlina, E. Sutedja, H. Dharmadji, R. Hindritiani, H. Gunawan

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引用次数: 4

摘要

大疱性类天疱疮(BP)和牛皮癣是慢性复发性炎症性皮肤病。BP合并银屑病的发病机制尚不清楚。39岁男性，慢性斑块型银屑病5年病史，在接受窄带紫外线B (NBUVB)治疗5个月后，躯干和上肢出现瘙痒性大疱。躯干大疱皮肤活检显示典型的BP组织学特征。直接免疫荧光染色显示免疫球蛋白G和C3在基底膜区沉积，支持BP的诊断。据推测，导致BP病变的自身免疫过程可能是由紫外光治疗和/或牛皮癣中的炎症过程诱导的。

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Concurrence of Bullous Pemphigoid and Psoriasis: A Case Report

Abstract Bullous pemphigoid (BP) and psoriasis are chronic recurrent inflammatory skin diseases. The pathogenesis of concurrence of BP with psoriasis is still unknown. A 39-year-old male with a five-year history of chronic plaque psoriasis developed itchy large tense bullae on the trunk and upper extremities after he had been receiving narrow band ultraviolet B (NBUVB) therapy over five months. Skin biopsy from bulla on the trunk showed typical histological features of BP. Direct immunofluorescent staining showed deposit of immunoglobulin G and C3 in the basement membrane zone (BMZ) which supported the diagnosis of BP. It has been postulated that the autoimmune process responsible for BP lesions might be induced by ultraviolet light therapy and/or the inflammatory processes that occur in psoriasis.

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来源期刊

Serbian Journal of Dermatology and Venereology

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期刊介绍： Serbian Journal of Dermatology and Venereology is a journal of the Serbian Association of Dermatologists and Venereologists. The journal is published in English, quarterly and intended to provide rapid publication of papers in the field of dermatology and venereology. Manuscripts are welcome from all countries in the following categories: editorials, original studies, review articles, professional articles, case reports, and history of medicine.