皮肤白血病1例报告

Serbian Journal of Dermatology and Venereology Pub Date : 2018-12-01 DOI:10.2478/sjdv-2018-0017

D. Mihajlović, M. Dinić, Z. Mijuskovic, N. Petrov, O. Tasić, Marija Elez, L. K. Sekulovic

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引用次数: 0

摘要

摘要白血病皮肤是一种特殊的皮肤病变，其特征是肿瘤细胞的弥漫性浸润，可发生在所有类型的白血病中。白血病皮肤可以有各种各样的皮肤表现，如丘疹、黄斑、结节、斑块和溃疡。我们报告一例52岁的女性，其躯干、大腿和上臂出现红斑性黄斑和丘疹。皮肤穿刺活检显示CD45、CD15、CD68和溶菌酶阳性细胞单形态、血管周围和dnexal浸润。根据随后的骨髓活检和外周血细胞免疫表型分析，诊断为急性单核细胞白血病（FAB AML-M5b）。在我们的病例中，提示白血病诊断的第一个临床体征是红斑性黄斑和丘疹的存在。因此，我们认为，在鉴别诊断躯干、上臂和腿部斑丘疹时，应考虑白血病皮肤

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Leukemia Cutis – A Case Report

Abstract Leukemia cutis is a specific skin lesion which is characterized by diffuse infiltration of neoplastic cells and can occur in all types of leukemia. Leukemia cutis can have varied cutaneous presentations such as papules, macules, nodules, plaques and ulcers. We report a case of 52-year-old woman who presented with erythematous macules and papules over her trunk, thighs and upper arms. A skin punch biopsy showed monomorphic, perivascular and periadnexal infiltration by the cells positive for CD45, CD15, CD68 and lysozyme. According to the subsequent bone marrow biopsy and immunophenotypic analysis of peripheral blood cells, the diagnosis of acute monocytic leukemia (FAB AML-M5b) was made. In our case, the first clinical sign suggestive of the diagnosis of leukemia was the presence of erythematous macules and papules. Therefore, we believe that leukemia cutis should be taken into consideration in the differential diagnosis of maculopapular rush on the trunk, upper arms and leg

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来源期刊

Serbian Journal of Dermatology and Venereology

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期刊介绍： Serbian Journal of Dermatology and Venereology is a journal of the Serbian Association of Dermatologists and Venereologists. The journal is published in English, quarterly and intended to provide rapid publication of papers in the field of dermatology and venereology. Manuscripts are welcome from all countries in the following categories: editorials, original studies, review articles, professional articles, case reports, and history of medicine.