Karger Kompass Pneumologie最新文献_第4页

Lungenemphysem: Die Bedeutung der quantitativen Computertomographie-Analyse 气肿学:定量计算机断层扫描分析的重要性

Karger Kompass Pneumologie Pub Date : 2019-12-01 DOI: 10.1159/000503911

M. Wagner

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PharmaNews

Karger Kompass Pneumologie Pub Date : 2019-12-01 DOI: 10.1159/000505008

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PharmaNews

Karger Kompass Pneumologie Pub Date : 2019-12-01 DOI: 10.1159/000505007

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Kommunikation entlang der Behandlungsmeilensteine bei Patienten mit fortgeschrittenem Lungenkrebs 与早期肺癌患者的沟通

Karger Kompass Pneumologie Pub Date : 2019-12-01 DOI: 10.1159/000503947

M. Villalobos, A. Siegle, L. Hagelskamp, C. Jung, Michael Thomas

{"title":"Kommunikation entlang der Behandlungsmeilensteine bei Patienten mit fortgeschrittenem Lungenkrebs","authors":"M. Villalobos, A. Siegle, L. Hagelskamp, C. Jung, Michael Thomas","doi":"10.1159/000503947","DOIUrl":"https://doi.org/10.1159/000503947","url":null,"abstract":"Patienten mit fortgeschrittenem Lungenkrebs und ihre Betreuungspersonen sind mit einer komplexen Situation konfrontiert, da ihre krankheitsbezogene Belastung physische, psychosoziale und spirituelle Bedürfnisse umfasst. Im Verlauf ihrer Krankheit, die mit einer begrenzten Prognose verbunden ist, sind sie verschiedenen multidisziplinären Gesundheitssystemumfeldern und -anbietern ausgesetzt, was eine kontinuierliche und koordinierte Versorgung erschwert. Darüber hinaus stellt die Entscheidung zwischen aktiver Krebstherapie und End-of-Life-Care einen ständigen Balanceakt dar. Mehrere Studien haben gezeigt, dass eine frühzeitige Palliativversorgung und entsprechendes Advance Care Planning die Lebensqualität und die Zufriedenheit mit der Versorgung verbessern. Für diese Strategie müssen die Kommunikationsfähigkeiten der Gesundheitsdienstleister und die interprofessionelle Zusammenarbeit gestärkt werden. Ein longitudinal strukturierter Kommunikationsansatz entlang der wichtigen Meilensteine der Erkrankung kann die Patienten unterstützen, da er die Bewältigung erleichtert, das prognostische Bewusstsein fördert und eine frühzeitige palliative Versorgung sowie Advance Care Planning ermöglicht. Gute interprofessionelle Zusammenarbeit und Kommunikation führen zu einer besseren Koordination und Kontinuität der Versorgung.","PeriodicalId":306175,"journal":{"name":"Karger Kompass Pneumologie","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133168635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Lokal fortgeschrittenes oder metastasiertes NSCLC. Umfangreiche Real-World-Daten bestätigen Chance auf Langzeitüberleben unter Nivolumab bei guter Verträglichkeit 速效或转移的NSCLC大量内存数据支持其在尼革通信下的长期生存能力，其耐受性很高

Karger Kompass Pneumologie Pub Date : 2019-12-01 DOI: 10.1159/000505006

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Pleuraerguss: Vereinfachte Kriterien zur Unterscheidung zwischen Exsudat und Transsudat 昴衣回收:用来区分进苏和流苏的简化标准

Karger Kompass Pneumologie Pub Date : 2019-12-01 DOI: 10.1159/000504151

F. Stanzel

{"title":"Pleuraerguss: Vereinfachte Kriterien zur Unterscheidung zwischen Exsudat und Transsudat","authors":"F. Stanzel","doi":"10.1159/000504151","DOIUrl":"https://doi.org/10.1159/000504151","url":null,"abstract":"Background: An important part of the investigation of pleural effusion is the identification of markers that help separate exudate from transudate. Objectives: The purposes of this study were to compare the accuracy of published and new sets of criteria to distinguish between exudative and transudative pleural effusions, and to determine whether serum biochemical analysis is necessary. Methods: An externally validated cohort study was performed. Pleural effusions were determined to be transudative or exudative on the basis of an assessment of the medical record by two clinicians blinded to biochemical results. Sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and area under the receiver operating characteristic curve were determined for each proposed combination of criteria. Results: Pleural fluid analysis was available for 311 thoracenteses in the main cohort and for 112 thoracenteses in the validation cohort. The best sensitivity (97% [95% CI 94-99]) and negative likelihood ratio (0.04 [95% CI 0.02-0.08]) for identifying exudative effusions were observed with criteria combining pleural fluid lactate dehydrogenase greater than 0.6 the upper limit of normal serum lactate dehydrogenase and pleural fluid cholesterol greater than 1.04 mmol/L (40 mg/dL). The overall diagnostic accuracy was similar to Light's criteria. Findings were similar in the validation cohort. Conclusions: Our proposed criteria using simultaneously pleural fluid lactate dehydrogenase and pleural fluid cholesterol can identify an exudate with a sensitivity and an overall diagnostic accuracy similar to Light's criteria. It avoids simultaneous blood sampling, thus reducing patient discomfort and potential costs.","PeriodicalId":306175,"journal":{"name":"Karger Kompass Pneumologie","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125815089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Schweres Asthma im Kindesalter und Bronchiektasen 小时候气喘病和支气管病

Karger Kompass Pneumologie Pub Date : 2019-12-01 DOI: 10.1159/000504207

D. Brandt

{"title":"Schweres Asthma im Kindesalter und Bronchiektasen","authors":"D. Brandt","doi":"10.1159/000504207","DOIUrl":"https://doi.org/10.1159/000504207","url":null,"abstract":"Background: Chest computed tomography (CT) scans have a recognised role in investigating adults with severe asthma to exclude alternative diagnoses, but its role in children is less clear. The objective of this study was to review the CT findings of our local cohort of children with severe asthma and to explore whether clinical or pathobiological parameters predicted CT changes. Methods: Retrospective observational single centre study including all children attending the Leicester difficult asthma clinic (DAC) who underwent a chest CT from 2006 to 2011. Additionally, we recruited eight age-matched, non-asthmatic controls to compare differences in CT findings between asthmatic and non-asthmatic children. All CT images were independently scored by two radiologists. The DAC patients were sub-divided into binary groups for each abnormality identified so that comparisons could be made against recorded clinical variables including age, lung function, serum total IgE levels, and sputum leukocyte differential cell counts. Results: Thirty DAC patients (median 12 yrs., range 5-16) were included. The most common abnormalities were bronchial wall thickening (BWT) and air trapping (AT), observed in 80 and 60% of DAC patients. Bronchiectasis (BE) was identified in 27% of DAC patients. DAC patients with evidence of BE on CT images were older than those without BE (13.9 ± 0.67 vs 11.5 ± 0.61, p = 0.038). We also identified a positive correlation between increasing BE severity and extent with age (r = 0.400, p = 0.028). Conclusion: Abnormal CT findings were highly prevalent in our cohort of children with severe asthma, with bronchiectasis identified in approximately one third of children. We found no alternative diagnoses that resulted in a change in clinical management.","PeriodicalId":306175,"journal":{"name":"Karger Kompass Pneumologie","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125904031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Kaleidoskop

Karger Kompass Pneumologie Pub Date : 2019-08-01 DOI: 10.1159/000501416

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PharmaNews

Karger Kompass Pneumologie Pub Date : 2019-08-01 DOI: 10.1159/000502322

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Die wundersame Zeitvermehrung 有的人就是这样

Karger Kompass Pneumologie Pub Date : 2019-08-01 DOI: 10.1159/000501418

H. Walach

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