JRSM Cardiovascular Disease最新文献

{"title":"A high-risk population for stroke recurrence exists among home-based stroke survivors discharged from an acute care hospital: A retrospective analysis.","authors":"Kyosuke Fukuda, Hikaru Izumiya, Soichi Kondo, Kosuke Okada, Kyoko Hirata, Chisaki Onoda, Takashi Amari, Yuta Sakamoto, Takuya Miyahara, Yuki Hamano","doi":"10.1177/20480040251362577","DOIUrl":"10.1177/20480040251362577","url":null,"abstract":"<p><strong>Objectives: </strong>To examine whether the factors determining discharge destination after acute-phase treatment for stroke differ based on recurrence risk levels.</p><p><strong>Design: </strong>Retrospective study.</p><p><strong>Setting: </strong>General acute care hospital.</p><p><strong>Participants: </strong>Acute ischemic stroke survivors (<i>n</i> = 1219).</p><p><strong>Main outcome measures: </strong>Patients were stratified using the Stroke Prognosis Instrument II (SPI-II) and evaluated through forced-entry multiple logistic regression analysis. Among the independent variables, the primary outcome measure was the modified Rankin Scale (mRS) at discharge. Covariates included age, sex, and histories of diabetes, cerebral infarction, cerebral hemorrhage, coronary artery disease, hypertension, and congestive heart failure. The dependent variable grouped participants into those discharged home and those discharged to a medical facility.</p><p><strong>Results: </strong>Among the 1219 included participants, 914 were classified into the home care group and 305 into the medical facility care group. SPI-II-based stratification revealed that 78.665% of the home care group had a moderate or higher risk of stroke recurrence. Multiple logistic regression analysis demonstrated that mRS at discharge was a significant factor across all stratified models, while age was a significant factor only within the moderate-risk group.</p><p><strong>Conclusions: </strong>Discharge decisions after acute-phase treatment were primarily influenced by short-term functional independence, as reflected by mRS, rather than recurrence risk levels. Thus, a substantial proportion of stroke survivors with a high recurrence risk transitioned to home care. These findings highlight the need to revise current medical and social welfare services and to develop targeted strategies for stroke recurrence prevention, based on a more detailed understanding of the living environments of stroke survivors.</p>","PeriodicalId":30457,"journal":{"name":"JRSM Cardiovascular Disease","volume":"14 ","pages":"20480040251362577"},"PeriodicalIF":1.5,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12290355/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144733654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meta-analysis of the association between marital status and cardiovascular diseases.","authors":"Ali Moradi, Hannaneh Khadem, Mohammadreza Rahmani, Mohammad Sadra Saghafi, Helia Ghadri, Maryam Mohammadi, Mina Rabbani, Meysam Moulaee, Niloofar Deravi, Sahar Khoshravesh, Sina Seyedipour, Ehsan Emami, Mahdiyeh Naziri","doi":"10.1177/20480040251362578","DOIUrl":"10.1177/20480040251362578","url":null,"abstract":"<p><p>Significant morbidity and death are connected to cardiovascular disease (CVD), with classic risk factors such as age, sex, smoking, hypertension, hyperlipidemia, and diabetes accounting for 80% of the risk. The other 20% of risk variables are poorly understood. The influence of marital status is one more element whose function is unclear. A comprehensive literature review was conducted on PubMed, Scopus, and Web of Science databases and data from the included articles were extracted and analyzed. A meta-analysis was conducted using the findings of the 13 publications. In this study, we evaluated the incidence of CVD across different marital statuses by analyzing 13 cohort studies from 11 countries with 1,809,825 participants. Our results showed no significant differences in CVD incidence among married (HR 1.00, 95% confidence interval [CI] 0.84-1.20) and unmarried individuals (HR 1.24, 95% CI 0.95-1.62). Divorced individuals had a 28% higher incidence (HR 1.28, 95% CI 1.14-1.44), and widowed individuals showed a 28% increase (HR 1.28, 95% CI 1.11-1.48). The results show no discernible difference in the incidence of CVD between married and single people. However, divorced and widowed people have a noticeably increased risk of CVD incidence. The high heterogeneity of the research highlights the complexity of the link. These results emphasize how crucial it is to take marital status into account when evaluating CVD risk and developing preventative measures.</p>","PeriodicalId":30457,"journal":{"name":"JRSM Cardiovascular Disease","volume":"14 ","pages":"20480040251362578"},"PeriodicalIF":1.5,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12290264/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144733655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pregnancy and breastfeeding in the mother with cardiomyopathy.","authors":"Bianca Maria Coldea, Lucille Middleton, Catherine Aiken, Catriona J Bhagra","doi":"10.1177/20480040251352901","DOIUrl":"10.1177/20480040251352901","url":null,"abstract":"<p><p>Cardiomyopathies are diseases of the heart muscle, characterised by structural and functional abnormalities of the myocardium that are not caused by ischemia, valvular problems or congenital heart disease. They are responsible for one-third of pregnancy-related cardiovascular deaths. A woman may enter pregnancy with a pre-existing diagnosis, or the cardiomyopathy may emerge or develop de novo during pregnancy. The most common cardiomyopathies encountered in pregnancy are dilated cardiomyopathy, hypertrophic cardiomyopathy and peripartum cardiomyopathy. All cardiomyopathies can be complicated by clinical heart failure, arrhythmia and thromboembolic events. Pregnancy may be poorly tolerated in women with dilated cardiomyopathy. New York Heart Association Class (NYHA) III/IV symptoms, and severe left ventricular dysfunction are the main determinants of adverse maternal outcomes. Peripartum cardiomyopathy is a diagnosis of exclusion with symptom onset towards the end of pregnancy, or within a few months following delivery. The management of heart failure and arrhythmias is based upon established guidelines, tailored for the unique considerations of pregnancy. Contemporary data suggests that recovery in cardiac function by 12 months is approximately 60-70% for the peripartum group. Maternal cardiovascular risk can be determined using specific risk-predictive scores. All patients with cardiomyopathy who wish to consider pregnancy should be offered individualized pre-conception and contraceptive counselling by a multidisciplinary team. This article reviews the management of women with cardiomyopathy during pregnancy and breastfeeding, focusing on the essential role of the multidisciplinary team at every stage of pregnancy and postpartum period to improve the maternal, fetal, and neonatal outcomes.</p>","PeriodicalId":30457,"journal":{"name":"JRSM Cardiovascular Disease","volume":"14 ","pages":"20480040251352901"},"PeriodicalIF":1.4,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12264410/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144650748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of dual-task activities on spatiotemporal gait parameters in patients with cardiovascular diseases.","authors":"Verônica Filter de Andrade, Alesandra Costa, Laura Buzin Zapparoli, Natara de Boni Pioner, Fernanda Cechetti, Raquel Saccani, Diego Busin, Guilherme Auler Brodt, Leandro Viçosa Bonetti","doi":"10.1177/20480040251351403","DOIUrl":"10.1177/20480040251351403","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to evaluate the influence of dual-task (DT) on the spatiotemporal gait parameters of patients with cardiovascular diseases.</p><p><strong>Design: </strong>This was an observational, cross-sectional, and comparative study. Participants: The study included 28 males, aged between 51 and 77 years, divided into two groups: Cardiovascular Disease Group (CVDG - N = 14) and Control Group (CG - N = 14). Main outcome measures: Participants performed the simple gait task and dual-task activities (including the cognitive and gait tasks) in a motion analysis system. For statistical analysis, it was conducted a mixed analysis of variance (Mixed ANOVA) and for significant main effects (condition or group) or interactions (group × condition) it was performed post-hoc tests with Bonferroni correction. A significance level (alpha) of 0.05 was set.</p><p><strong>Results: </strong>Group comparisons revealed a significant difference solely in step width, where the CVDG showed lower mean values than the CG (p = 0.001). However, DTs similarly affected both groups, resulting in significant reductions in gait speed (p = 0.000), cadence (p = 0.002), step length (p = 0.000), and stride time (p = 0.007). Regarding the interaction effect, the CVDG exhibited a significantly longer step time during the verbal fluency and arithmetic DT conditions when compared to their own performance in the simple gait condition (p = 0.037).</p><p><strong>Conclusions: </strong>No significant differences between groups were found in both single-task and DTs gait across most of the analyzed parameters. Additionally, DT activities similarly affected the gait parameters of both groups. Although cardiovascular diseases are commonly associated with motor and cognitive declines, DTs did not affect participants with cardiovascular impairment differently.</p>","PeriodicalId":30457,"journal":{"name":"JRSM Cardiovascular Disease","volume":"14 ","pages":"20480040251351403"},"PeriodicalIF":1.4,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12198543/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The pearls for optimal intrapartum care in women with cardiac disease.","authors":"Caroline Thompson, Laura Ormesher, Kailash Bhatia","doi":"10.1177/20480040251349579","DOIUrl":"10.1177/20480040251349579","url":null,"abstract":"<p><p>Cardiac disease during pregnancy is one of the leading causes of maternal mortality and morbidity in both the UK and the USA. Labour, delivery, and the initial postpartum phase are characterised by significant haemodynamic alterations that play a significant role in the clinical deterioration observed in women with heart disease. Heart failure, arrhythmia, and myocardial ischaemia can occur in women with high-risk cardiac lesions during labour. The cardio-obstetric multidisciplinary team, after risk stratification, should establish an individualised cardiac care plan that incorporates patients' preferences. This care plan should address the location, mode, timing of delivery, monitoring, analgesia, and anaesthetic options for operative intervention, uterotonics that may be administered, emergency contact numbers for relevant personnel along with appropriate postpartum care. High-risk patients need to be delivered in tertiary units. Clear haemodynamic objectives should be established along with a postpartum contraception plan with information cascaded to community midwifery teams and primary care providers to ensure surveillance and continuity of care. Co-ordinated multidisciplinary care can enhance preparedness for obstetric and cardiac emergencies, thereby decreasing morbidity and mortality associated with heart disease in pregnancy during childbirth.</p>","PeriodicalId":30457,"journal":{"name":"JRSM Cardiovascular Disease","volume":"14 ","pages":"20480040251349579"},"PeriodicalIF":1.4,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12198545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aortopathy in pregnancy: Unanswered questions.","authors":"Stephanie L Curtis","doi":"10.1177/20480040251351398","DOIUrl":"10.1177/20480040251351398","url":null,"abstract":"<p><p>Aortic dissection in pregnancy has a high mortality rate for mother and fetus. Women at risk are largely those with hereditary thoracic aortic disease, that is typically undiagnosed. Existing literature has focussed on characterising the phenotype of these women, but many questions remain about the causes of dissection in pregnancy and how to best manage women antenatally and postnatally. The widespread uptake of genetic testing has allowed us to refine the genotype and we need to use this to better individualise risk. We do not know how often to screen women during pregnancy and postpartum, nor do we know whether beta-blockers affect event rates. We have very little data on the outcomes of women who have undergone aortic surgery who embark on a pregnancy, including those who have residual dissection. Passive vaginal delivery is advised for delivery, but we do not know if this is safer than elective caesarean section and there is a paucity of evidence on the effectiveness of neuraxial anaesthesia in these women. Dissection postpartum can occur days or weeks after delivery. There is little evidence on the postnatal care or blood pressure control of women who have dissected postpartum and no guidelines on best postpartum care. Lastly, we know little of the birth experience of these women and whether birth plans were successful. This paper aims to discuss some of these unanswered questions in the hope that with further research and discussion of best practice we can collectively reduce this devastating event in young women.</p>","PeriodicalId":30457,"journal":{"name":"JRSM Cardiovascular Disease","volume":"14 ","pages":"20480040251351398"},"PeriodicalIF":1.4,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12174743/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144327034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of hemorrhagic pleural effusion postprimary PCI-rare event of postcardiac injury syndrome.","authors":"Prempassan Krishnamurthy, Panneer Selvam Ganesan, Manikandan Rajendran","doi":"10.1177/20480040251350187","DOIUrl":"10.1177/20480040251350187","url":null,"abstract":"<p><strong>Background: </strong>Postcardiac injury syndrome (PCIS) includes pleuropericardial inflammation and effusion syndromes after traumatic mesothelial cell injury to the pericardium or pleural cavity. Several triggers have been identified, that can cause PCIS including percutaneous coronary intervention (PCI), cardiac implantable electronic device (CIED) implantation, and cardiac surgical procedures. Though most common form occurs postcardiac surgeries, there are reports of PCIS occurring after PCI.</p><p><strong>Case summary: </strong>We present one such rare event of right-sided pleural effusion occurring after primary PCI, diagnosed based on ESC guidelines on PCIS, after exclusion of other possible causes.</p><p><strong>Discussion: </strong>PCIS is a diagnosis of exclusion, typically presenting as new onset pericardial effusion. Although rare, pleural effusion can occur as a part of PCIS with reports of both left- and right-sided pleural effusion. Management being conservative seems relatively simpler, but given the possibility of recurrence, long-term follow up becomes important, which necessitates making the diagnosis of PCIS, though rare. This case is one of the rare events occurring during a commonly performed procedure worldwide. PCIS in diagnosis of unexplained pleural/pericardial effusion occurring after PCI should always be considered. This may be an insight for taking into account, such uncommon events after a common intervention.</p>","PeriodicalId":30457,"journal":{"name":"JRSM Cardiovascular Disease","volume":"14 ","pages":"20480040251350187"},"PeriodicalIF":1.4,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12163298/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Normal and adverse pulmonary arterial flow patterns after the Fontan procedure and correlation with invasive CMR (iCMR) hemodynamics: A retrospective observational study.","authors":"Sanja Dzelebdzic, Surendrenath V Reddy, Daniel Young, Tarique Hussain","doi":"10.1177/20480040251344344","DOIUrl":"10.1177/20480040251344344","url":null,"abstract":"<p><strong>Background: </strong>Branch pulmonary artery flow patterns in the Fontan circulation manifest oscillations reflecting venous pressure changes. The clinical importance of variation in branch pulmonary artery flow patterns and the relationship with the single ventricle performance is not understood. We describe insights gained from simultaneous hemodynamic and phase contrast magnetic resonance using interventional CMR (iCMR) in these patients.</p><p><strong>Method: </strong>Twenty-seven patients with Fontan circulation referred for iCMR were studied using phase-contrast velocity mapping. The isovolumetric relaxation period (IVRT) was assessed using standard or velocity-encoded cine imaging of the atrioventricular valve (AVV) and aortic valve. We qualitatively assessed branch pulmonary artery flows considering four patterns: IVRT flow reversal, IVRT flow reaching baseline, and normal - phasic flow or continuous flow. We further collected comprehensive left and right heart iCMR hemodynamic and flow data, including pressures, aortopulmonary collateral (APC) burden, and degree of AVV regurgitation.</p><p><strong>Results: </strong>Most patients underwent extracardiac Fontan palliation and did not have significant APC burden. Cardiac cycle analysis demonstrated that flow reversal and flow reaching baseline correlated with IVRT (v-wave timing on SVC pressure). Further analysis showed statistically significant difference in pulmonary capillary wedge pressure (PCWp) v-wave (<i>P</i> = .008) among the described groups. Notably, patients with IVRT flow reversal pattern had higher PCWp v-wave and most had severe AVV regurgitation.</p><p><strong>Conclusion: </strong>Branch pulmonary artery IVRT flow reversal and IVRT baseline patterns in patients with Fontan circulation may represent indirect signs of single ventricle poor performance and severe AVV regurgitation.</p>","PeriodicalId":30457,"journal":{"name":"JRSM Cardiovascular Disease","volume":"14 ","pages":"20480040251344344"},"PeriodicalIF":1.4,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12125515/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Higher cortisol level and reduced circulating triiodothyronine in patients with cardiovascular diseases: A case-control study.","authors":"Muhammad Javid, Safir Ullah Khan, Maleeha Akram, Rodolfo Daniel Cervantes-Villagrana, Muhammad Rafi, Muhammad Fiaz Khan, Syed Shakeel Raza Rizvi","doi":"10.1177/20480040251340609","DOIUrl":"10.1177/20480040251340609","url":null,"abstract":"<p><strong>Background: </strong>Thyroid hormone plays a key role in cardiovascular diseases (CVDs), and stress may impact this relationship by affecting cortisol and triiodothyronine (T3) levels. This study explored the association between stress, indicated by cortisol levels, and thyroid function in cardiovascular patients, particularly those with hypertension.</p><p><strong>Methods: </strong>A cohort of 87 cardiovascular patients (37 females, 50 males) and 60 healthy controls (28 females, 32 males) was analyzed. Patients included those with coronary artery disease, acute myocardial infarction, and a high proportion with anterior wall myocardial infarction (AWMI, 52%). Anthropometric data and blood samples were collected, and cortisol and T3 levels were measured using the radioimmunoassay method. Blood pressure measurements were also recorded to assess associations with cortisol, thyroid function, and hypertension.</p><p><strong>Results: </strong>Cardiovascular patients had significantly higher cortisol levels (1065.99 ± 700.54 ng/mL vs 768.35 ± 563.10 ng/mL, <i>p</i> < .001) and lower T3 levels (1.25 ± 0.48 ng/mL vs 1.33 ± 0.46 ng/mL) compared to controls. The prevalence of AWMI was 52%. Blood pressure was significantly higher in cardiovascular patients of both sexes (<i>p</i> < .0007). Additionally, 39% of cardiovascular patients had elevated cortisol, and 38% had reduced T3. No sex-based differences in cortisol levels were observed.</p><p><strong>Conclusion: </strong>This study found significant associations between elevated cortisol and reduced T3 levels in cardiovascular patients, particularly those with hypertension. Although stress-induced thyroid dysfunction remains a hypothesis, these findings suggest a potential link between cortisol, T3, and CVD. Further longitudinal research is needed to explore causal mechanisms.</p>","PeriodicalId":30457,"journal":{"name":"JRSM Cardiovascular Disease","volume":"14 ","pages":"20480040251340609"},"PeriodicalIF":1.4,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12084702/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of prognostic value of triglyceride-glucose index and atherogenic index of plasma in patients with acute coronary syndrome: A retrospective study.","authors":"Shiru Bai, Tianlei Chen, Yanru Li, Xinning Li, Rongpin Du","doi":"10.1177/20480040251341155","DOIUrl":"https://doi.org/10.1177/20480040251341155","url":null,"abstract":"<p><strong>Objective: </strong>Few studies have compared the prognostic value of the triglyceride glucose (TyG) index and atherogenic index of plasma (AIP) in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI). We aimed to compare the prognostic value of the TyG index, AIP, and combined diagnosis in patients with ACS undergoing PCI.</p><p><strong>Methods: </strong>Patients with ACS who underwent PCI were enrolled and divided into two groups according to major adverse cardiovascular and cerebrovascular events (MACCEs). Univariate and multivariate Cox proportional hazard regressions were performed to determine independent risk factors for MACCEs. The area under the receiver operating characteristic curve (AUC) was used to evaluate the diagnostic value of the TyG index, AIP, and combined prediction.</p><p><strong>Results: </strong>The study included 114 patients. Multivariate Cox regression revealed that the TyG index and AIP were independent predictors of MACCEs. The AUC of the TyG index and AIP were 0.710 (95% confidence interval [CI]: 0.618-0.791) and 0.626 (95% CI: 0.531-0.715), respectively, and the optimal cutoff points were 8.83 and 0.30, respectively. The difference between the TyG index and AIP was not significant. The AUC of the combined diagnosis was 0.706 (95% CI: 0.614-0.788), with no significant improvement compared with the TyG index or AIP.</p><p><strong>Conclusion: </strong>Both the TyG index and AIP were independent predictors of MACCEs in ACS patients undergoing PCI. The TyG index and AIP had similar predictive values for MACCEs, but the combined prediction did not improve significantly.</p>","PeriodicalId":30457,"journal":{"name":"JRSM Cardiovascular Disease","volume":"14 ","pages":"20480040251341155"},"PeriodicalIF":1.4,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12078966/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}