JRSM Cardiovascular Disease最新文献

{"title":"Changing trends in the use of novel oral anticoagulants and warfarin for treating non-valvular atrial fibrillation.","authors":"Alexander Birkinshaw,&nbsp;Christopher H Fry,&nbsp;David Fluck,&nbsp;Pankaj Sharma,&nbsp;Thang S Han","doi":"10.1177/2048004020915406","DOIUrl":"https://doi.org/10.1177/2048004020915406","url":null,"abstract":"<p><strong>Background: </strong>Prevention of thromboembolism by novel oral anticoagulants is increasing, whilst use of vitamin K antagonists is on the decline. We assessed changes in the use of these anticoagulants in treating non-valvular atrial fibrillation between 2014 and 2018.</p><p><strong>Methods: </strong>One-hundred and sixty-two consecutive patients (95 men, 67 women) with non-valvular atrial fibrillation, mean age 72.3 years (standard deviation = 11.0), underwent cardiac assessment in a single cardiac unit. Use of anticoagulants at the time of investigation was documented: overall 83 (51.2%) patients were prescribed novel oral anticoagulants and 79 (48.8%) warfarin treatment. Trends in treatment rates with either anticoagulant class over time were characterised by calculating the average annual percentage change using a Joinpoint Regression Program 4.7.0.0.</p><p><strong>Results: </strong>There were diverging trends in anticoagulant treatment from 2014 to 2018 without join points: yearly increase in novel oral anticoagulant treatment (41.9, 45.5, 53.7, 53.1 and 72.7%, average annual percentage change = 16.2%, 95% confidence interval = 5.8% to 27.5%, <i>p</i> < 0.001), and decrease in warfarin treatment (57.1, 54.5, 46.3, 46.9 and 27.3%, average annual percentage change = -14.4%, 95% confidence interval = -25.2% to -2.1%, <i>p</i> < 0.001).</p><p><strong>Conclusions: </strong>Changing trends in treatment with anticoagulants for patients with non-valvular atrial fibrillation observed within less than two years provide important information to healthcare services to estimate future pharmaco-economic costs for such treatments.</p>","PeriodicalId":30457,"journal":{"name":"JRSM Cardiovascular Disease","volume":" ","pages":"2048004020915406"},"PeriodicalIF":1.6,"publicationDate":"2020-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/2048004020915406","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37829183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex differences in the agreement between left ventricular ejection fraction measured by myocardial perfusion scintigraphy and by echocardiography.","authors":"Sams Jaker,&nbsp;Amjad Burgan,&nbsp;Vineet Prakash,&nbsp;Alexander Birkinshaw,&nbsp;Kishan Moosai,&nbsp;Adam Jacques,&nbsp;David Fluck,&nbsp;Mark MacGregor,&nbsp;Otar Lazariashvili,&nbsp;Pankaj Sharma,&nbsp;Christopher H Fry,&nbsp;Thang S Han","doi":"10.1177/2048004020915393","DOIUrl":"https://doi.org/10.1177/2048004020915393","url":null,"abstract":"Background Left ventricular ejection fraction (LVEF) is generally measured by echocardiography but is increasingly available with myocardial perfusion scintigraphy. With myocardial perfusion scintigraphy, the threshold of LVEF below which there is a risk for myocardial infarct or sudden cardiac death is higher for women (51%) than for men (43%). We tested the hypothesis that such a sex difference may also occur with echocardiography and myocardial perfusion scintigraphy. Methods Four hundred and four men, mean age = 67.7 ± SD = 12.3 yr; 339 women, 67.7 ± 11.7 yr had separate myocardial perfusion scintigraphy and echocardiography examinations within six months. A subset of 327 of these patients (181 men, 68.8 ± 12.1 yr; 146 women, 66.4 ± 12.1 yr) had examinations within one month and were additionally analysed as this sub-group. Myocardial perfusion scintigraphy and echocardiography were used to measure LVEF at rest and their agreement (neither considered as a reference method) was assessed by Bland–Altman plots: LVEF difference (myocardial perfusion scintigraphy minus echocardiography ) against average LVEF ( MPS + Echo 2 ). Results Of patients who had myocardial perfusion scintigraphy and echocardiography performed within six months, mean LVEF difference = +1.1% (95% limits of agreement: −19.3 to +21.6) in men but +10.9% (−10.7 to +32.5) in women. LVEF difference diverged from zero marginally in men (mean difference = +1.1, 95%CI  = +0.1 to +2.1, p =  0.028) but more in women (+10.9, +9.8 to +12.1, p < 0.001). The LVEF difference correlated with average LVEF itself in both men (r =  0.305, p < 0.001) and women (r =  0.361, p < 0.001), and with age in women (r = 0.117, p = 0.031). Similar results were observed for the subset. Conclusions Caution should be taken when interpreting LVEF measured by different techniques due to their wide limits of agreement and systematic bias, more markedly in women.","PeriodicalId":30457,"journal":{"name":"JRSM Cardiovascular Disease","volume":" ","pages":"2048004020915393"},"PeriodicalIF":1.6,"publicationDate":"2020-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/2048004020915393","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37816254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sulodexide improves pain-free walking distance in patients with lower extremity peripheral arterial disease: A systematic review and meta-analysis.","authors":"Antonio Vittorino Gaddi,&nbsp;Fabio Capello,&nbsp;Oana Florentina Gheorghe-Fronea,&nbsp;Simone Fadda,&nbsp;Roxana Oana Darabont","doi":"10.1177/2048004020907002","DOIUrl":"https://doi.org/10.1177/2048004020907002","url":null,"abstract":"<p><p>Peripheral arterial disease is associated with very high cardiovascular risk. The main symptom is intermittent claudication, which strongly affects the quality of life. Therefore, treatment goals in peripheral arterial disease consist of the reduction of cardiovascular events and the relief of symptoms. An increase in pain-free walking distance, evaluated based on the Initial Claudication Distance, was also a strong positive prognostic factor in patients with peripheral arterial disease. Our objective was to reassess whether sulodexide is effective in improving Initial Claudication Distance. For this, we searched the literature according to the PRISMA checklist for double blind clinical trials assessing the improvement in the Initial Claudication Distance after 90 days of standard therapeutic regimen with sulodexide in adult patients with peripheral arterial disease. We found and assessed for bias in 11 studies eligible for review and meta-analysis. Data extracted from those studies favoured the sulodexide group, showing an overall difference in Initial Claudication Distance of +68.9 (CI 95%; ± 11.9 m) at the end of treatment (p < 0.001). According to this review, sulodexide is effective in improving Initial Claudication Distance and consequently the quality of life in patients with peripheral arterial disease. Further studies are needed to assess the effects of this drug on disease progression in asymptomatic patients with peripheral arterial disease.</p>","PeriodicalId":30457,"journal":{"name":"JRSM Cardiovascular Disease","volume":" ","pages":"2048004020907002"},"PeriodicalIF":1.6,"publicationDate":"2020-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/2048004020907002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37687045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A multifaceted investigation into molecular associations of chronic thromboembolic pulmonary hypertension pathogenesis.","authors":"Stephen J Halliday,&nbsp;Daniel T Matthews,&nbsp;Megha H Talati,&nbsp;Eric D Austin,&nbsp;Yan R Su,&nbsp;Tarek S Absi,&nbsp;Niki L Fortune,&nbsp;David Gailani,&nbsp;Anton Matafonov,&nbsp;James D West,&nbsp;Anna R Hemnes","doi":"10.1177/2048004020906994","DOIUrl":"https://doi.org/10.1177/2048004020906994","url":null,"abstract":"<p><strong>Purpose: </strong>Chronic thromboembolic pulmonary hypertension is characterized by incomplete thrombus resolution following acute pulmonary embolism, leading to pulmonary hypertension and right ventricular dysfunction. Conditions such as thrombophilias, dysfibrinogenemias, and inflammatory states have been associated with chronic thromboembolic pulmonary hypertension, but molecular mechanisms underlying this disease are poorly understood. We sought to characterize the molecular and functional features associated with chronic thromboembolic pulmonary hypertension using a multifaceted approach.</p><p><strong>Methods: </strong>We utilized functional assays to compare clot lysis times between chronic thromboembolic pulmonary hypertension patients and multiple controls. We then performed immunohistochemical characterization of tissue from chronic thromboembolic pulmonary hypertension, pulmonary arterial hypertension, and healthy controls, and examined RNA expression patterns of cultured lymphocytes and pulmonary arterial specimens. We then confirmed RNA expression changes using immunohistochemistry, immunofluorescence, and Western blotting in pulmonary arterial tissue.</p><p><strong>Results: </strong>Clot lysis times in chronic thromboembolic pulmonary hypertension patients are similar to multiple controls. Chronic thromboembolic pulmonary hypertension endarterectomized tissue has reduced expression of both smooth muscle and endothelial cell markers. RNA expression profiles in pulmonary arteries and peripheral blood lymphocytes identified differences in RNA transcript levels related to inflammation and growth factor signaling, which we confirmed using immunohistochemistry. Gene expression data also suggested significant alterations in metabolic pathways, and immunofluorescence and Western blot experiments confirmed that unglycosylated CD36 and adiponectin expression were increased in chronic thromboembolic pulmonary hypertension versus controls.</p><p><strong>Conclusions: </strong>Our data do not support impaired clot lysis underlying chronic thromboembolic pulmonary hypertension, but did demonstrate distinct molecular patterns present both in peripheral blood and in pathologic specimens of chronic thromboembolic pulmonary hypertension patients suggesting that altered metabolism may play a role in chronic thromboembolic pulmonary hypertension pathogenesis.</p>","PeriodicalId":30457,"journal":{"name":"JRSM Cardiovascular Disease","volume":" ","pages":"2048004020906994"},"PeriodicalIF":1.6,"publicationDate":"2020-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/2048004020906994","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37687043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy of washout rate analysis for thallium-201 single-photon emission computed tomography myocardial perfusion imaging using cadmium zinc telluride detectors: A phantom study.","authors":"Masaru Ishihara,&nbsp;Masahisa Onoguchi,&nbsp;Takayuki Shibutani","doi":"10.1177/2048004019900600","DOIUrl":"https://doi.org/10.1177/2048004019900600","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to assess the accuracy of washout rate (WOR) analysis for thallium-201 chloride (²⁰¹Tl) single-photon emission computed tomography myocardial perfusion imaging data acquired using cadmium zinc telluride detectors and a myocardial phantom.</p><p><strong>Methods: </strong>A myocardial phantom was injected with 10.5 MBq ²⁰¹Tl, and 10-min acquisitions were performed at 0, 24, 46, and 62 h to accommodate natural radioactive decay over time. Global myocardial WOR (global-WOR) and regional WOR (regional-WOR, left anterior descending artery [LAD], right coronary artery [RCA], and left circumflex artery [LCX]) were analyzed between 0 and 24 h (infarction model), 0 and 46 h (ischemia model), and 0 and 62 h (normal model), respectively. We compared the calculated radioactive decay-rate as a reference standard and phantom imaging WOR (phantom-WOR).</p><p><strong>Results: </strong>Decay-rate versus phantom-WOR were 20.4% vs. 20.8% (global-WOR), 21.3% (LAD), 21.2% (RCA), and 19.7% (LCX) for the infarction model; 35.4% vs. 35.6% (global-WOR), 35.5% (LAD), 36.2% (RCA), and 35.2% (LCX) for the ischemia model; and 44.5% vs. 45.1% (global-WOR), 45.4% (LAD), 44.7% (RCA), and 43.5% (LCX) for the normal model.</p><p><strong>Conclusion: </strong>WOR analysis for ²⁰¹Tl single-photon emission computed tomography myocardial perfusion imaging using cadmium zinc telluride detectors is a reliable analysis method.</p>","PeriodicalId":30457,"journal":{"name":"JRSM Cardiovascular Disease","volume":" ","pages":"2048004019900600"},"PeriodicalIF":1.6,"publicationDate":"2020-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/2048004019900600","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37574155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thanks to Reviewers","authors":"","doi":"10.1177/2048004020904822","DOIUrl":"https://doi.org/10.1177/2048004020904822","url":null,"abstract":"","PeriodicalId":30457,"journal":{"name":"JRSM Cardiovascular Disease","volume":"9 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/2048004020904822","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45928109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Left ventricular free wall rupture in myocardial infarction: A retrospective analysis from a single tertiary center.","authors":"Swaroop Varghese,&nbsp;Marc-Alexander Ohlow","doi":"10.1177/2048004019896692","DOIUrl":"https://doi.org/10.1177/2048004019896692","url":null,"abstract":"<p><strong>Objective: </strong>Left ventricular free wall rupture (LVFWR) is a rare but severe complication of acute myocardial infarction (AMI). During the era of pre-thrombolysis, autopsies revealed an incidence of approximately 8%.</p><p><strong>Method: </strong>The objective of this retrospective study was to analyze the current incidence of LVFWR and to identify predictors by comparing the AMI-cohort with LVFWR to those without. The control group involved a random selection of one in every ten patients who presented with acute myocardial infarction between 2005 and 2014.</p><p><strong>Result: </strong>A total of 5143 patients with AMI were treated at the Central Hospital, Bad Berka (71% men, median age 68 years). Out of these, seven patients with LVFWR were identified with an overall incidence of 0.14%. Clinically, LVFWR patients presented late to admission since symptom onset (median 24 h vs. 6.1 h; p < 0.0001), were more likely in cardiogenic shock (28.6% vs. 3.2%; p = 0.02) and were usually accompanied by emergency physicians (71.4% vs. 20.7%; p = 0.006). Higher troponin T (median 8.6 vs. 0.5 ng/ml; p < 0.0002), higher CRP (median 50 vs. 0.5 mg/l; p = 0.05) as well as a lower hematocrit-values (0.33 vs. 0.42; p = 0.04) were observed. All LVFWR patients were operated (100% vs. 1.6%; p < 0.001). The patients had lower rates of beta-blocker treatment (57.1% vs. 95.8%; p = 0.003). The 30-day mortality was significantly higher (42.9% vs. 6.8%; p = 0.01).</p><p><strong>Conclusion: </strong>Compared to the thrombolytic era, the current incidence of LVFWR with AMI, who reach the hospital alive, is significantly lower. However, 30-day mortality continues to be high.</p>","PeriodicalId":30457,"journal":{"name":"JRSM Cardiovascular Disease","volume":"8 ","pages":"2048004019896692"},"PeriodicalIF":1.6,"publicationDate":"2019-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/2048004019896692","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37514138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of adherence to anti-hypertensive medications among adult hypertensive patients on follow-up in Hawassa Referral Hospital: A case-control study.","authors":"Atsede Getenet,&nbsp;Mulugeta Tesfa,&nbsp;Aster Ferede,&nbsp;Yalew Molla","doi":"10.1177/2048004019892758","DOIUrl":"https://doi.org/10.1177/2048004019892758","url":null,"abstract":"<p><strong>Introduction: </strong>Hypertension is a global challenge which accounts for high morbidity and mortality rates in the world. The availability of effective anti-hypertensive medications does not result in a good outcome in controlling blood pressure which points towards poor adherence. Thus, this study was conducted to assess the determinants of adherence to anti-hypertensive medication among hypertensive patients on follow-up in Hawassa Referral Hospital.</p><p><strong>Methods: </strong>Institution-based case-control study was conducted on a sample of 289 clients from February to May 2018. Census was conducted on 1600 clients to select cases and controls. Then, systematic random sampling was used to select study subjects, and adherence was measured by Morisky medication adherence scale. The associations of variables were analyzed using bivariable followed by multivariable logistic regression analyses.</p><p><strong>Results: </strong>The respondent's adherence to medication was found to be 67% as measured by Morisky medication adherence scale. The multivariate logistic regression analysis showed that medication adherence was found to be better in younger age (<45) (AOR = 3.8), clients living in urban areas (AOR = 6.84), those clients who had good knowledge (AOR = 3.13), those with no co-morbidities (AOR = 3.14) and patients who controlled their blood pressure (<140/90) (AOR = 2.35).</p><p><strong>Conclusions: </strong>The rate of medication adherence was found to be low, and hence educational interventions focusing on factors promoting adherence and patients' health support should be implemented.</p>","PeriodicalId":30457,"journal":{"name":"JRSM Cardiovascular Disease","volume":"8 ","pages":"2048004019892758"},"PeriodicalIF":1.6,"publicationDate":"2019-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/2048004019892758","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37603462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Renal artery injury during inferior vena cava filter removal with endobronchial forceps.","authors":"Carlos A Padula,&nbsp;Andrew R Lewis,&nbsp;Gregory T Frey,&nbsp;J Mark McKinney,&nbsp;Ricardo Paz-Fumagalli,&nbsp;Charles A Ritchie,&nbsp;Zlatko Devcic,&nbsp;Beau B Toskich","doi":"10.1177/2048004019893513","DOIUrl":"https://doi.org/10.1177/2048004019893513","url":null,"abstract":"<p><p>Retrieval of tip-embedded inferior vena cava filters using endobronchial forceps is a well-described technique. The tip of dorsally tilted filters may be in proximity to the right renal artery, increasing the risk of arterial injury during retrieval. We present one case that illustrates renal artery injury requiring emergent stent graft repair. The three subsequent cases illustrate techniques that avoid renal artery injury using a femoral and jugular approach with the assistance of an arterial fiducial wire. Renal artery injury is a potential complication during retrieval of filters using endobronchial forceps that can be prevented with careful planning.</p>","PeriodicalId":30457,"journal":{"name":"JRSM Cardiovascular Disease","volume":"8 ","pages":"2048004019893513"},"PeriodicalIF":1.6,"publicationDate":"2019-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/2048004019893513","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37459961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iliac venous stenting for outflow obstruction does not significantly change the quality of life of patients with severe chronic venous insufficiency.","authors":"Alexander Shiferson,&nbsp;Edouard Aboian,&nbsp;Michael Shih,&nbsp;Qinghua Pu,&nbsp;Theresa Jacob,&nbsp;Robert Y Rhee","doi":"10.1177/2048004019890968","DOIUrl":"https://doi.org/10.1177/2048004019890968","url":null,"abstract":"<p><strong>Purpose: </strong>Percutaneous endovenous iliac stenting has emerged as a new modality in the treatment of advanced chronic venous insufficiency with outflow obstruction. However, the effect of this intervention on the quality of life remains unclear. We examined the impact of iliac venous stenting for outflow obstruction as compared to conservative medical management on the quality of life in severe chronic venous insufficiency patients.</p><p><strong>Methods: </strong>Medical records of all patients with CEAP class 5 and 6 disease (N = 172) who underwent ilio-caval venography with intravascular ultrasonography (IVUS) at a single institution over a seven-year period, were reviewed for this case-control study. Quality of life evaluation was performed utilizing the Chronic Venous Insufficiency Quality of Life Questionnaire (CIVIQ-20) one year after the index procedure.</p><p><strong>Results: </strong>Of the 172 severe chronic venous insufficiency patients, 109 were stented and 63 patients were treated medically based on their venography and IVUS results. The indication for stenting was confirmation of IVUS determined surface area or diameter outflow stenosis of greater than 50% within the common or external iliac venous systems. Eighty patients (47%) responded with completed CIVIQ-20 questionnaires for analysis. Of these, 47 were from the stented group and 33 from the non-stented group. At least moderate persistent pain or discomfort post-procedure was reported by 20 (43%) stented group patients and 19 (58%) non-stented group patients. Scores for all the other criteria in the CIVIQ-20 were similar between the groups. The mean total CIVIQ-20 score was 45.23 and 47.13, respectively, in stented group and non-stented group patients. (<i>p</i> = 0.678).</p><p><strong>Conclusion: </strong>There was no significant difference in the quality of life reported by CEAP 5 and 6 patients who underwent iliac venous stenting versus those who were treated medically for presumed iliac outflow obstruction. Prospective studies are needed to determine the true value of iliac venous stenting based on IVUS criteria in the management advanced chronic venous insufficiency.</p>","PeriodicalId":30457,"journal":{"name":"JRSM Cardiovascular Disease","volume":"8 ","pages":"2048004019890968"},"PeriodicalIF":1.6,"publicationDate":"2019-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/2048004019890968","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37459960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}