Ecotoxicology and Environmental Safety最新文献

{"title":"Exogenous organic acids promoted phytoremediation by Hydrangea macrophylla in cadmium‑contaminated soil.","authors":"Yunjing Song, Qian Cheng, Bing Zhao","doi":"10.1016/j.ecoenv.2024.117551","DOIUrl":"https://doi.org/10.1016/j.ecoenv.2024.117551","url":null,"abstract":"<p><p>Cadmium (Cd) contaminants with high toxicity and mobility seriously threatens the ecological environment and human safety. Hydrangea macrophylla is a potential plant for Cd-contaminated soil remediation. Exogenous organic acids have been proven to effectively enhance the phytoremediation of soil contaminated with Cd. However, research on the effects of organic acids on Cd tolerance and accumulation of H. macrophylla remains scarce. In this study, a potted experiment was performed with H. macrophylla as the research object. The effects of acetic acid (AA), citric acid (CA), and malic acid (MA) with different concentrations (2.5, 5, and 10 mmol·kg^-1) on the growth physiology, Cd absorption and accumulation of H. macrophylla and soil microecological environment under Cd stress were systematically studied. Results indicated that organic acids increased chlorophyll content and promoted the growth of H. macrophylla, the biomass of shoots and roots increased by 165.44 % , 161.50 % under 5 mmol·kg^-1 citric acid treatment. Furthermore, organic acids reduced the level of membrane lipid peroxidation in leaves, increased plant biomass and promoted root growth of H. macrophylla. By boosting superoxide dismutase (SOD), peroxidase (POD), and catalase activities (CAT), elevating levels of proline (Pro), non-protein thiol (NPT), glutathione (GSH) and phytochelatins (PCs), exogenous organic acids promoted the Cd tolerance of H. macrophylla. In particular, 5 mmol·kg^-1 CA had the best effect on improving the Cd tolerance of H. macrophylla. The roots of H. macrophylla accumulated a large amount of Cd, ranging from 365.04 to1111.67 μg·plant^-1. Appropriate concentration of organic acids increased the total Cd accumulation by 1.12-2.07 times of H. macrophylla. The translocation factor (TF) increased by 97.91 %, 107.95 % under 5 mmol·kg^-1 CA and 10 mmol·kg^-1 MA treatments. Nevertheless, TF values were all less than 1. We posit that using H. macrophylla and organic acids could reduce the Cd bioavailability in the soil mainly through rhizosphere immobilization and plant absorption. Additionally, organic acids increased the soil pH, accompanied by changes in soil enzyme activities. 10 mmol·kg^-1AA and MA reduced the available Cd concentration by 20.42 % and 31.65 %, respectively. Overall, exogenous organic acids can assist H. macrophylla in phytoremediation. 5 mmol·kg^-1 CA treatment was considered the best choice for the remediation of heavy Cd-contaminated soil by H. macrophylla.</p>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"290 ","pages":"117551"},"PeriodicalIF":6.2,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142851837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BP-3 exposure at environmentally relevant concentrations induced male developmental reproductive toxicity via ER/CCL27/ROS pathway in mice.","authors":"Hong-Mei Li, Yan-Rong Gao, Qing Chang, Xiu-Ying Pei, Jia-He Sun, Yu-Jia Lin, Ya-Nan Tian, Qiang-Wang, Bin Zhao, Heidi Qunhui Xie, Hui-Ming Ma, Hai-Ming Xu","doi":"10.1016/j.ecoenv.2024.117556","DOIUrl":"https://doi.org/10.1016/j.ecoenv.2024.117556","url":null,"abstract":"<p><p>BP-3 is the most widely used ultraviolet absorber, but its toxic effects and mechanisms far from being elucidated. This study evaluated the male developmental reproductive toxicities and mechanism of low-doses of BP-3. The results indicated that BP-3 (2.28 and 228 μg/L) led to a decrease in sperm quantity, quality and testosterone level, impaired blood-testis barrier (BTB) integrity and cytoskeleton, accompanied by aggravated oxidative stress in testes of mice on postnatal day 56 (PND 56). Notably, chemokine CCL27, a driver of oxidative stress, was significantly upregulated induced by BP-3. Similar disrupted effects were detected in testes of mice on PND14, which could be antagonized by ICI 182780 (estrogen receptor antagonist). Mechanistically, BP-3 directly interacted with ER, which boosted CCL27 expression, reactive oxygen species (ROS) accumulation, and BTB and cytoskeleton impairment. In vitro, si-CCL27 and/or ROS scavenger treatment significantly antagonized BP-3-induced oxidative stress and the decrease of BTB and cytoskeleton related genes in TM4 cells. These findings demonstrate that prolonged exposure to low-doses of BP-3 resulted in detrimental effects on testicular development through activation of the ER/CCL27/ROS axis. This study provides a novel perspective understanding the male reproductive toxicity risk caused by BPs exposure at low-doses.</p>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"290 ","pages":"117556"},"PeriodicalIF":6.2,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142845453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of fine particulate matter and its chemical constituents on influenza-like illness in Guangzhou, China.","authors":"Keyi Wu, Weidong Fan, Jing Wei, Jianyun Lu, Xiaowei Ma, Zelin Yuan, Zhiwei Huang, Qi Zhong, Yining Huang, Fei Zou, Xianbo Wu","doi":"10.1016/j.ecoenv.2024.117540","DOIUrl":"https://doi.org/10.1016/j.ecoenv.2024.117540","url":null,"abstract":"<p><strong>Background: </strong>Although the link between fine particulate matter (PM_2.5) and influenza-like illness (ILI) is well established, the effect of the chemical constituents of PM_2.5 on ILI remains unclear. This study aims to explore this effect in Guangzhou, China.</p><p><strong>Methods: </strong>Daily data on ILI cases, PM_2.5 levels, and specific PM_2.5 constituents (black carbon [BC], chlorine [Cl^-], ammonia [NH₄⁺], nitrate [NO₃^-], and sulfate [SO₄^2-]) in Guangzhou, China, were collected for the period of 2014-2019. Additionally, data on gaseous pollutants and meteorological conditions were obtained. By using quasi-Poisson regression models, the association between exposure to PM_2.5 and its constituents and ILI risk was estimated. Stratified subgroup analyses were performed by gender, age, and season to explore in depth the effects of these factors on disease risk.</p><p><strong>Results: </strong>Single-pollutant modeling results showed that an increase of one interquartile range (IQR) in Cl^-, SO₄^2-, PM_2.5, NH₄⁺, BC, and NO₃^- corresponded to relative risks of ILI of 1.046 (95 % CI: 1.004, 1.090) (lag03), 1.098 (95 % CI: 1.058, 1.139) (lag01), 1.091 (95 % CI: 1.054, 1.130) (lag02), 1.093 (95 % CI: 1.049, 1.138) (lag02), 1.111 (95 % CI: 1.074, 1.150) (lag03), and 1.103 (95 % CI: 1.061, 1.146) (lag03), respectively. Notably, the association between ILI and BC remained significant even after adjusting for PM_2.5 mass. Subgroup analyses indicated that individuals aged 5-14 and 15-24 years may exhibit higher sensitivity to BC and Cl^- exposure than other individuals. Furthermore, stronger associations were observed during the cold season than during the warm season.</p><p><strong>Conclusions: </strong>Results showed that the mass and constituents of PM_2.5 were significantly correlated with ILI. Specifically, the carbonaceous fractions of PM_2.5 were found to have a pronounced effect on ILI. These findings underscore the importance of implementing effective measures to reduce the emission of specific sources of PM_2.5 constituents to mitigate the risk of ILI. Nevertheless, limitations such as potential exposure misclassification and regional constraints should be considered.</p>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"290 ","pages":"117540"},"PeriodicalIF":6.2,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142845461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing the estimation of cadmium content in rice leaves by integrating vegetation indices and color indices using machine learning.","authors":"Xiaoyun Huang, Shengxi Chen, Tianling Fu, Chengwu Fan, Hongxing Chen, Song Zhang, Hui Chen, Song Qin, Zhenran Gao","doi":"10.1016/j.ecoenv.2024.117548","DOIUrl":"https://doi.org/10.1016/j.ecoenv.2024.117548","url":null,"abstract":"<p><p>Cadmium (Cd) is a heavy metal recognized for its notable biotoxicity. Excessive Cd levels can have detrimental effects on crop growth, development, and yield. Real-time, rapid, and nondestructive monitoring of Cd content in leaves (LCd) is essential for food security. Previous research has primarily utilized traditional statistical methods and heavy metal-related vegetation indices (VIs) to develop models for estimating LCd, often resulting in a lack of generalizability. Herein, 252 sets of leaf samples with varying Cd contents were collected under six Cd concentration gradients in hydroponic and soil cultivation conditions. An LCd estimation model was developed by integrating VIs, color indices (CIs), and machine learning (ML) algorithms. Results indicate that VIs and CIs were strongly correlated with LCd, exhibiting correlation coefficients (r) of 0.73 and 0.57, respectively. The ML estimation model, which integrated both indices, was more effective than the single-parameter model developed using traditional statistical methods. Notably, the LCd estimation model developed using the random forest method exhibited the highest accuracy, with a coefficient of determination (R²) of 0.81 and a root-mean-square error of 0.120. These results indicate that multisource index data based on ML algorithms can effectively estimate LCd. This study presents an accurate, reliable, and generalized method to estimate LCd, providing valuable insights for assessing the large-scale heavy metal pollution status of rice using unmanned aerial vehicle remote sensing technology.</p>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"290 ","pages":"117548"},"PeriodicalIF":6.2,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142845374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between alkali and alkaline earth elements in chorionic villus and risk for spontaneous abortion.","authors":"Meng Lin, Yutong Wang, Xiaoye Wang, Lailai Yan, Linlin Wang, Chan Tian","doi":"10.1016/j.ecoenv.2024.117516","DOIUrl":"https://doi.org/10.1016/j.ecoenv.2024.117516","url":null,"abstract":"<p><p>Exposure to specific alkali and alkaline earth elements(AEs/AEEs) has been reported that are linked to an increased risk of spontaneous abortion. However, the direct evidence of exposure in the uterus are absent. Therefore, we collected chorionic villi after spontaneous abortion or induced abortion in Peking University Third Hospital. The concentrations of six alkali and alkaline earth elements in chorionic villi were measured using inductively coupled plasma mass spectrometry (ICP-MS). Through using logistic regression, Bayesian kernel machine regression (BKMR) and Weighted quantile sum regression (WQS) model, we assessed single and mixed exposure effects of alkali and alkaline earth elements on spontaneous abortion. In terms of the individual effect, high concentration group of barium (Ba) increased the risk of spontaneous abortion by 150 % (95 % CI: 1.38-4.51), whereas rubidium (Rb), cesium (Cs) and Magnesium (Mg) all clearly demonstrated dose dependency in reducing the incidence of spontaneous abortion. The BKMR model demonstrated that as the mixed exposure percentile increased, the likelihood of spontaneous abortion decreased almost linearly. For every quartile increasing in the WQS index, the risk of spontaneous abortion decreased (OR: 0.21, 95 % CI: 0.13-0.33), with Mg and Rb having the highest weights at 0.587 and 0.367, respectively. According to our findings, there were negative dose-response relationships between Mg and Rb levels and risk for spontaneous abortion, but exposure to higher concentration of Ba in the chorionic villi was positively associated with the risk of it.</p>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"290 ","pages":"117516"},"PeriodicalIF":6.2,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142845452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The concentration of selected organophosphorus pesticides associated with PM10 in agricultural ambient air in Iran: Health risk assessment using Monte Carlo simulation.","authors":"Asma Tabanasl, Amin Mohammadpour, Aboozar Soltani, Mohammad Hoseini, Mohammadali Baghapour","doi":"10.1016/j.ecoenv.2024.117521","DOIUrl":"https://doi.org/10.1016/j.ecoenv.2024.117521","url":null,"abstract":"<p><p>Organophosphate pesticides, widely utilized for pest management globally, are associated with various adverse health effects upon exposure. This study aimed to investigate the presence of organophosphate pesticides in particulate matter (PM10) and evaluate the potential risks to human health using both deterministic and probabilistic approaches in urban and suburban areas of Yasuj City, Iran. A total of 32 air samples were collected during the study period. Active sampling was conducted using a SKC pump with a selective air inlet, and the samples were analyzed via liquid chromatography-mass spectrometry. The results indicated that Diazinon exhibited the highest average concentration among PM10-bound organophosphate pesticides, measuring 4.23 ng/m³ in suburban areas and 2.51 ng/m³ in urban environments. Although no significant overall difference was observed in organophosphate pesticide levels in PM10 between urban and suburban areas, suburban regions generally exhibited higher concentrations, with the exceptions of Parathion and Butachlor. The hazard index (HI) percentiles for children exposed to these pesticides in Yasuj's air were calculated as 0.0047 (5th percentile), 0.0141 (50th percentile), and 0.0291 (95th percentile). For adults, the corresponding values were 0.0016, 0.0050, and 0.0101, respectively. The median carcinogenic risk (CR) values were estimated at 1.40E-9 for children and 2.49E-9 for adults. Notably, the concentration of Diazinon and its interaction with inhalation rates were critical determinants of HI, while Malathion concentration and its interaction with inhalation rates significantly impacted CR for both demographic groups. Our findings suggest that pesticide levels in urban and suburban air are relatively low and pose minimal health risks. However, the study underscores the necessity for ongoing monitoring and increased public awareness regarding pesticide exposure.</p>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"290 ","pages":"117521"},"PeriodicalIF":6.2,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142845375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficient adsorption of ofloxacin in a novel nanocomposite formed by nano-hexagonal boron nitride fused with zeolite imidazolite skeleton-8: Experimental and molecular dynamics simulation studies.","authors":"Zefang Huang, Yuankai Hong, Yiqun Cui, Huiying Guo, Yan Long, Jinshao Ye","doi":"10.1016/j.ecoenv.2024.117536","DOIUrl":"https://doi.org/10.1016/j.ecoenv.2024.117536","url":null,"abstract":"<p><p>With the widespread application of antibiotics in the medical field, associated wastewater pollution has become a critical environmental issue, creating potential risks to ecosystems and public health. This study synthesized three novel nanocomposite materials, ZIF-8@h-BN-X, using an in-situ growth method by adjusting h-BN content. Compared to pure two-dimensional hexagonal boron nitride (h-BN), their adsorption capacities for ofloxacin (OFL) in solution were evaluated. Results showed that zeolitic imidazolate framework-8 (ZIF-8) attached and grew on the h-BN surface, altering surface functional groups and significantly enhancing the nanocomposite's adsorption effect on OFL. Adsorption capacity depended on the initial h-BN content, with lower X content resulting in more active sites and stronger adsorption capacity. Equilibrium adsorption capacities were 145.46, 124.91, and 58.16 mg·g^-1 for X values of 29.82 %, 45.93 %, and 62.95 %, respectively. Molecular dynamics simulations revealed interaction energies of -109.13 kcal·mol^-1 between ZIF-8@h-BN-X and OFL, compared to -84.78 kcal·mol^-1 between pure h-BN and OFL, demonstrating the superior adsorption performance of ZIF-8@h-BN-X. OFL adsorption on ZIF-8@h-BN-X followed the Langmuir isotherm model and pseudo-second-order adsorption kinetics. Thermodynamic parameters indicated that the adsorption process of ZIF-8@h-BN-X was exothermic and spontaneous when compared to h-BN alone. This study highlights the significant potential of ZIF-8@h-BN-X in treating antibiotic-contaminated wastewater, while providing theoretical and practical insights for developing novel, efficient two-dimensional nanocomposite adsorbents.</p>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"290 ","pages":"117536"},"PeriodicalIF":6.2,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142826801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perfluorooctane sulfonate (PFOS) induced bone loss by inhibiting FoxO1-mediated defense against oxidative stress in osteoblast.","authors":"Liming Xue, Jiale Xu, Ping Xiao, Yiping Jiang, Yuanjie Lin, Chao Feng, Yu'e Jin, Zhijun Zhou, Guoquan Wang, Dasheng Lu","doi":"10.1016/j.ecoenv.2024.117524","DOIUrl":"https://doi.org/10.1016/j.ecoenv.2024.117524","url":null,"abstract":"<p><p>Exposure to perfluorooctane sulfonate (PFOS) has been associated with lower bone density and the occurrence of osteoporosis in human studies, but the effects and mechanisms of PFOS induces bone loss is not well understood. Our research is aimed at examining the effects of PFOS on osteoblastic activity and investigating the toxicological mechanisms of PFOS-induced bone loss. Cell proliferation, ALP activity, bone nodule formation, ROS levels, and cell apoptosis were assessed after treating osteoblasts with different concentrations of PFOS. Through transcriptome analysis, the differentially expressed genes (DEGs) were screened and the biofunctions were elucidated by Kyoto Encyclopedia of Genes and Genomes (KEGG) and The Gene Set Enrichment Analysis (GSEA). Vation of important genes and protein expression was accomplished using RT-PCR and Western blot methods, respectively. The results show that PFOS can reduce bone formation markers and improve oxidative stress and cell apoptosis. The DEGs in PFOS-treated groups were involved in multiple pathways, including FoxO, HIF-1, Rap1, Hippo, and sphingolipid signaling. FoxO1 was validated as the key gene which regulates osteogenic differentiation and redox status. Our findings suggest that PFOS reduces bone formation through FoxO1-mediated oxidative stress and apoptosis, as well as inhibition of the OPG/RANKL and FoxO1/β-catenin pathways. It will be beneficial for early intervention or treatment of PFOS-induced bone loss, highlighting the importance of regulatory measures to limit human exposure to PFOS.</p>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"290 ","pages":"117524"},"PeriodicalIF":6.2,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142826829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of blood cadmium and physical activity with mortality: A prospective cohort study.","authors":"Yilin Chen, Cien Zhen, Lin Zeng, Hongliang Feng, Jinyu Wang, Qi Yong H Ai, Sizhi Ai, Jihui Zhang, Yannis Yan Liang, Huachen Xue, Yujing Zhou","doi":"10.1016/j.ecoenv.2024.117541","DOIUrl":"https://doi.org/10.1016/j.ecoenv.2024.117541","url":null,"abstract":"<p><p>Physical activity (PA) may be considered an alternative method to ameliorate the elevated mortality risks associated with cadmium exposure. In this prospective cohort study, a total of 20,253 participants (weighted mean age, 47.79 years), including 10,247 men (weighted prevalence: 50.1 %), aged 18 years or older, were selected from the National Health and Nutrition Examination Survey from 2007 to 2018. Multivariable Cox proportional hazards regression models were utilized to evaluate the associations between blood cadmium levels, PA, and the risks of mortality. Restricted cubic spline analyses were employed to investigate the nonlinear relationships between blood cadmium and PA levels and mortality risks. During a median follow-up of 7.6 years, a total of 2002 (9.89 %) all-cause deaths occurred, of which 581 (2.87 %) participants were due to cardiovascular disease (CVD) and 498 (2.46 %) died of cancer. J-shaped associations were observed for blood cadmium with risks of mortality (all P_overall < 0.001; all P_nonlinearity < 0.001). Blood cadmium and PA had multiplicative interactions on mortality risk (all P_interaction < 0.05). Compared with the subgroup with the lowest quartile of blood cadmium and recommended PA, the combination of the highest quartile of blood cadmium and without recommended PA was associated with the highest risks of all-cause and cancer mortality, followed by those meeting recommended PA but in the highest quartile of blood cadmium (hazard ratios, 2.43; 95 % confidence interval, 1.95-3.02). Achieving recommended PA significantly attenuated the detrimental effects of blood cadmium on all-cause, CVD, and cancer mortality risks.</p>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"290 ","pages":"117541"},"PeriodicalIF":6.2,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142826899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification and functional analysis of hub genes involved in deoxynivalenol-induced enterotoxicity in porcine (Sus scrofa).","authors":"Jinhua He, Geng Zhao, Mingxia Chen, Ximing Ren, Peizhi Zhu, Zhizhong Liu, Jiayi Zhou, Hanwei Chen, Chuqiao Xiao, Xiang-Guang Li","doi":"10.1016/j.ecoenv.2024.117544","DOIUrl":"https://doi.org/10.1016/j.ecoenv.2024.117544","url":null,"abstract":"<p><p>Deoxynivalenol (DON) is a type of mycotoxin commonly found in food and animal feed. When consumed, it can have harmful effects on the intestine. The porcine digestive system is physiologically similar to that of humans, making pigs a suitable model for studying DON-induced enterotoxicity. However, the exact ways DON causes intestinal damage in pigs still need to be fully understood. To address this knowledge gap, this study aimed to identify hub genes associated with enterotoxicity caused by DON exposure. Transcriptomic datasets from porcine jejunal explants exposed to DON were extensively analyzed using bioinformatic techniques in this study. A total of 265 differentially expressed genes (DEGs) were identified, with 238 being up-regulated and 27 being down-regulated, indicating that exposure to DON tends to increase gene expression. Further analysis revealed that the up-regulated DEGs were enriched in tumor necrosis factor, nuclear factor kappa-B, mitogen-activated protein kinases, and Janus kinase/signal transducer and activator of transcription-related signaling pathways. In addition, Weighted gene co-expression network analysis was performed to identify highly co-expressed modules. Then, genes in the highest co-expressed module were intersected with the up-regulated DEGs to construct a Protein-Protein Interaction network, resulting in 237 overlapping genes. Subsequently, 6 hub genes (CXCR4, PTGS2, ICAM1, IL-1A, IL-1B, and IL-10) that played a central role in the response to DON were identified using cytohubba in conjunction with the Molecular Complex Detection. In summary, exposure to DON is more likely to result in increased rather than decreased gene expression. Six of the upregulated genes, which are involved in immunoregulation and inflammation, were identified as hub genes related to DON-induced enterotoxicity in pigs. This study provides new insights into the mechanisms underlying DON-induced enterotoxicity and could guide interventions for this condition.</p>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"290 ","pages":"117544"},"PeriodicalIF":6.2,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142826808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}