Ecotoxicology and Environmental Safety最新文献

{"title":"Influence of sulfur and selenium application on wheat growth in arsenic-contaminated soil.","authors":"Huan Luo, Chipeng Zhang, Shunyuan Zhang, Wansheng Song, Han Chen","doi":"10.1016/j.ecoenv.2024.117543","DOIUrl":"https://doi.org/10.1016/j.ecoenv.2024.117543","url":null,"abstract":"<p><p>Wheat could become poisoned when grown in soil with high arsenic (As) content. It is worthwhile to investigate the potential use of sulfur (S) and selenium (Se) for crop protection while detoxifying heavy metal(loid)s. In this study, a pot experiment was conducted under both single and combined application of the two elements. Their effects on wheat growth were analyzed based on As distribution in subcellular tissues and the variation in physiological and biochemical indicators. Despite wheat absorbing and enriching As under S and Se application, its growth status improved. Cell wall and vacuole sequestered majority of elevated As. Phytochelatins (PCs) content increased significantly in the roots, particularly when Se was applied alone. They could chelate with As using thiol groups. Superoxide dismutase (SOD) activity was found to be considerably lower in leaves and without any discernible increase in roots. Peroxidase (POD) activity in roots/stems and/or catalase (CAT) activity in stems increased, and exerted antioxidant effects. The leaf was well protected, and its chlorophyll content significantly increased. The application of S alone had a relatively weaker effect on reducing As content in grains, but the mixed application of Se could induce an inhibitory effect.</p>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"290 ","pages":"117543"},"PeriodicalIF":6.2,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142826813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chlorella's transport inhibition: A powerful defense against high ammonium stress.","authors":"Lihe Xu, Li Chen, Longxing Jiang, Jingni Zhang, Peike Wu, Wenguo Wang","doi":"10.1016/j.ecoenv.2024.117460","DOIUrl":"https://doi.org/10.1016/j.ecoenv.2024.117460","url":null,"abstract":"<p><p>Ammonium (NH₄⁺) is a primary nitrogen source for many species, yet NH₄⁺-rich wastewater presents a substantial risk to environment. Chlorella sorokiniana is widely recognized for wastewater treatment. The development of high NH₄⁺ tolerant strains has the potential to significantly enhance wastewater treatment efficiency and reduce treatment costs. This study reports the identification of a C. sorokiniana strain designated hact (high ammonium concentration tolerance). This strain demonstrates a remarkable tolerance to NH₄⁺ (1000 mg/L). Integrative analyses of physiology, metabolomics, and transcriptomics demonstrated that transport inhibition is the principal resistance mechanism against high NH₄⁺ stress in C. sorokiniana. Notably, under elevated NH₄⁺ conditions, the hact strain maintained robust intracellular homeostasis. In contrast, the wild-type (WT) strain exhibited suppressed metabolic activity, reactive oxygen species (ROS), and an excess of detrimental metabolites such as amines. This research enriches our understanding of microalgal molecular responses to high NH₄⁺ stress, paving the way for the development of engineered optimization strategies for microalgal bioremediation systems treating NH₄⁺-rich wastewater.</p>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"290 ","pages":"117460"},"PeriodicalIF":6.2,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142826900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toxicity of Per- and polyfluoroalkyl substances in elutriates prepared with estuarine and freshwater sediments.","authors":"Paige M Krupa, Guilherme R Lotufo, Jonna Boyda, Nicolas L Melby, Ashley N Kimble","doi":"10.1016/j.ecoenv.2024.117483","DOIUrl":"https://doi.org/10.1016/j.ecoenv.2024.117483","url":null,"abstract":"<p><p>PFAS has a ubiquitous environmental occurrence, posing challenges to sediment management. To address data gaps concerning release of PFAS from sediment to the water column during dredged material aquatic placement or other sediment resuspension activity, we generated elutriates from PFAS-contaminated sediments. Sediments were obtained from both freshwater and estuarine environments, with a field-collected sediment representative of contaminated areas and a spiked sediment with concentrations exceeding levels frequently measured at contaminated sites. We then conducted acute toxicity tests of the elutriates with species standardly used in dredging evaluations: the sheepshead minnow (Cyprinodon variegatus), the fathead minnow (Pimephales promelas), the water flea (Ceriodaphnia dubia), and the Mysid shrimp (Americamysis bahia). PFAS partitioning to sediment and organic matter was observed to increase with carbon chain length. PFAS-induced mortality was not observed in any of the four test species, as measured concentrations of PFAS were below levels known to cause negative effects in these organisms. Though PFAS concentrations in the spiked sediment elutriates exceeded concentrations known to cause effects in the most sensitive aquatic species, PFAS levels in the more environmentally relevant field-collected sediment elutriates did not. Consequently, PFAS released from the sediment to the water column is not expected to cause toxicity to pelagic biota during aquatic placement of dredged material.</p>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"290 ","pages":"117483"},"PeriodicalIF":6.2,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142826912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between exposure to ambient air pollutants and metabolic syndrome in the vicinity of the Taklamakan Desert.","authors":"Zhe Wang, Weidong Ji, Yushan Wang, Lin Li, Kai Wang, Hongze Liu, Yining Yang, Yi Zhou","doi":"10.1016/j.ecoenv.2024.117525","DOIUrl":"https://doi.org/10.1016/j.ecoenv.2024.117525","url":null,"abstract":"<p><strong>Background: </strong>Air pollution is a recognized contributor to metabolic syndrome (MetS); but studies in developing regions, including China, remain limited, especially in severely polluted areas near the Taklamakan Desert.</p><p><strong>Methods: </strong>Health data from 2,689,455 individuals aged ≥ 18 years in five regions near the Taklamakan Desert were analyzed. MetS diagnosed followed the 2016 Chinese Adult Dyslipidaemias Management Guidelines. Spatio-temporal data from satellite observations were employed to estimate ambient pollution levels, encompassing particulate matter with diameters of up to 1.0 µm (PM₁), 2.5 µm (PM_2.5), and 10 µm (PM₁₀), along with Ozone (O₃) and Carbon monoxide (CO). To investigate the association between air pollutants and the prevalence of MetS and its components, Spatial Generalized Linear Mixed Models were applied, with adjustments made for relevant covariates. Additional stratified and sensitivity analyses were conducted to further investigate these relationships.</p><p><strong>Results: </strong>The study observed a 20.43 % prevalence of MetS. Non-linear analysis indicated a significant association between all pollutants and MetS prevalence. A 10 μg/m³ increase in concentration was associated with the following respective odds ratios: PM₁ (1.341, 95 % CI: 1.331, 1.351), PM_2.5 (1.036, 95 % CI: 1.034, 1.037), PM₁₀ (1.006, 95 % CI: 1.005, 1.007), O₃ (1.385, 95 % CI: 1.374, 1.396), and CO (1.015,95 %, CI: 1.0147, 1.016). The reliability of these associations was supported by further sensitivity analyses, accounting for variations in age, sex, physical activity, and smoking status. Additional analysis indicated links between pollutants and MetS components, including abdominal obesity, glucose metabolism, and lipid profiles.</p><p><strong>Conclusions: </strong>There is an observed association between long-term exposure to air pollution and a heightened risk of MetS, particularly in men, younger individuals, those who are physically inactive, and smokers.</p>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"290 ","pages":"117525"},"PeriodicalIF":6.2,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142823655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The unseen perils of oral-care products generated micro/nanoplastics on human health.","authors":"Utsa Saha, Snehasmita Jena, Faizan Zarreen Simnani, Dibyangshee Singh, Anmol Choudhury, Shaikh Sheeran Naser, Sudakshya S Lenka, Apoorv Kirti, Aditya Nandi, Adrija Sinha, Swadheena Patro, Małgorzata Kujawska, Mrutyunjay Suar, Narendra Kumar Kaushik, Aishee Ghosh, Suresh K Verma","doi":"10.1016/j.ecoenv.2024.117526","DOIUrl":"https://doi.org/10.1016/j.ecoenv.2024.117526","url":null,"abstract":"<p><p>The extensive use of plastics in modern dentistry, including oral care products and dental materials, has raised significant concerns due to the increasing evidence of potential harm to human health and the environment caused by the unintentional release of microplastics (MPs) and nanoplastics (NPs). Particles from sources like toothpaste, toothbrushes, orthodontic implants, and denture materials are generated through mechanical friction, pH changes, and thermal fluctuations. These processes cause surface stress, weaken material integrity, and induce wear, posing health risks such as exposure to harmful monomers and additives, while contributing to environmental contamination. MPs/NPs released during dental procedures can be ingested, leading to immune suppression, tissue fibrosis, and systemic toxicities. The gut epithelium absorbs some particles, while others are excreted, entering ecosystems, accumulating through the food chain, and causing ecological damage. Although analytical techniques have advanced in detecting MPs/NPs in oral care products, more robust methods are needed to understand their release mechanisms. This review explores the prevalence of MPs/NPs in dentistry, the mechanisms by which MPs/NPs are released into the oral environment, and their implications for human and ecological health. It underscores the urgency of public awareness and sustainable dental practices to mitigate these risks and promote environmental well-being.</p>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"290 ","pages":"117526"},"PeriodicalIF":6.2,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142823716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A proposed methodology for the definition of background and reference values for trace elements in fluvial sediments.","authors":"F Barrio-Parra, R Álvarez, H Serrano-García, M Izquierdo-Díaz, A Ordóñez, C C García-Fernández, E De Miguel","doi":"10.1016/j.ecoenv.2024.117517","DOIUrl":"https://doi.org/10.1016/j.ecoenv.2024.117517","url":null,"abstract":"<p><p>The Water Framework Directive (WFD, 2000/60/EC) mandates member states to consider trace element background values when establishing environmental quality standards (EQS) for sediments. This study proposes defining the \"background\" value as the trace element concentration that is consistently present in the unaltered natural environment, and the \"reference\" value as an upper limit of variation of naturally occurring concentrations, suggestive of anthropogenic enrichment if exceeded. We argue that background and reference values can be computed as the upper limits of the one-sided 95 % confidence interval for the median and for the 90th percentile, respectively. This proposition has been tested in two European river basins with different historical anthropogenic impacts: the Nalón (impacted by mining activities) and the Esva (mostly unpolluted) basins. For 110 bottom sediment samples collected from both pristine (background) and potentially impacted (non-background) locations, 19 elements were analyzed by ICP-MS/ICP-AES. The proposed background and reference values, calculated using the Bootstrap method, demonstrated consistency despite geological differences between the basins. The methodology proved particularly effective in datasets with a limited sample size and highly skewed data distributions. In the Nalón basin, with higher anthropogenic activity, the percentage of samples exceeding reference values was higher than in the Esva basin (e.g., 29 % vs 7 % for As and 11 % vs 0 % for Pb), suggesting the utility of these values in discerning potential impacts of historic mining activities. In the Esva basin, background and reference values were either near or below generic thresholds for good ecological status (LEL, TEL) unlike the Nalón basin, in which reference values for all elements, except three, exceeded these thresholds.</p>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"290 ","pages":"117517"},"PeriodicalIF":6.2,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142823648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reliea® combination of Codonopsis lanceolata and Chaenomeles sinensis extract alleviates airway inflammation on particulate matter 10 plus diesel exhaust particles (PM₁₀D) ‑induced respiratory disease mouse model.","authors":"Yoon-Young Sung, Won-Kyung Yang, Jong Hoon Kim, Dongseok Shin, Seok June Son, Seung-Hyung Kim","doi":"10.1016/j.ecoenv.2024.117538","DOIUrl":"https://doi.org/10.1016/j.ecoenv.2024.117538","url":null,"abstract":"<p><p>Particulate matter (PM, diameter < 10 μm) and Diesel exhaust particles (DEP) exposure can cause severe respiratory disorders. This investigation explored the protective effects of Reliea® (RelA), combination of Codonopsis lanceolata and Chaenomeles sinensis extract, against airway inflammation related to PM₁₀D exposure. RelA treatment suppressed reactive oxygen species, nitric oxide release, cytokine expression (IL-6, IL-1β, iNOS, CXCL-2, MCP-1, and TNF-α), and the related inflammatory mechanisms in PM₁₀-induced alveolar macrophage cells. BALB/c mice were injected with PM₁₀D via intranasal trachea three times over a period of 12 days and RelA were orally dispensed for 12 days. RelA inhibited infiltrating neutrophils, total number of immunocytes in lung and bronchoalveolar lavage fluid (BALF). RelA decreased the expression of interleukin (IL)-17, chemokine (C-X-C motif) ligand (CXCL)-1, thymus and activation-regulated chemokine, macrophage inflammatory protein-2, IL-1α, TNF-α, mucin 5AC, cyclooxygenase-2, and transient receptor potential cation channel subfamily A or V member 1 in BALF and lung, and inhibited IL-1α and macrophage marker F4/80 localization in lung of PM₁₀D-induced mice. RelA treatment decreased serum symmetric dimethyl arginine levels. RelA restored histopathological damage via inhibition of NF-κB and MAPK pathways in the trachea and lung. Lancemaside A and protocatechuic acid as major active compounds of RelA was identified. In addition, RelA showed better expectoration through increased phenol red secretion. These results indicate that Reliea® combination of C. lanceolata and C. sinensis extract might be effective in prevention and treatment of airway inflammation and respiratory diseases.</p>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"290 ","pages":"117538"},"PeriodicalIF":6.2,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142823712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of trimester-specific urinary aluminum concentrations on ultrasound measures of fetal growth and size at birth: A longitudinal cohort study in Chinese women.","authors":"Haiying Chen, Wenjing Yan, Xueyan Wu, Yuanyuan Li","doi":"10.1016/j.ecoenv.2024.117509","DOIUrl":"https://doi.org/10.1016/j.ecoenv.2024.117509","url":null,"abstract":"<p><strong>Objective: </strong>Aluminum (Al) has been proposed as a potential factor influencing fetal growth. However, the existing study findings are inconsistent and there is a lack of population-based epidemiological studies. Our study aimed to evaluate the trimester-specific correlations of Al exposure with fetal development characteristics.</p><p><strong>Methods: </strong>Between 2013 and 2016, 3599 women from Wuhan, China were enrolled in the prospective cohort study. The concentrations of Al were quantified in urine samples obtained from pregnant women during the 1st, 2nd and 3rd trimesters by inductively coupled plasma mass spectrometry. The study used linear regressions with generalized estimating equation to determine the connections between specific gravity-adjusted urinary Al concentrations in each trimester and fetal growth parameters and birth size indicators.</p><p><strong>Results: </strong>Trimester-specific Al exposure throughout pregnancy was found to have a negative impact on fetal growth and birth parameters. Besides, statistically significant interactions were detected between biparietal diameter (BPD) (P_interaction = 0.007), head circumference (P_interaction = 0.026) at 16 weeks' gestation in the first trimester, BPD (P_interaction = 0.015) at 24 weeks' gestation in the second trimester, BPD (P_interaction = 0.014) at 31 weeks' gestation in the second trimester and BPD (P_interaction = 0.035) at 37 weeks' gestation in the third trimester and fetal sex, and the strength of the association between the level of Al exposure and BPD was significantly stronger in female fetuses than in male fetuses. Furthermore, we observed three distinct trajectories of trimester-specific Al concentrations during pregnancy. Compared to participants with low-stable group of Al concentrations trajectory, high-stable group was associated with more decrease level of fetal growth parameters and birth size indicators.</p><p><strong>Conclusion: </strong>Our study results reveal that Al might have harmful effects on fetal growth and birth size indicators, especially in female fetuses. Further study is required to examine our findings in other populations.</p>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"290 ","pages":"117509"},"PeriodicalIF":6.2,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142823705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in soil Cd immobilization and blockage of rice Cd uptake by biochar derived from crop residue and bone - A 2-year field experiment.","authors":"Zhongjun Xue, Fengfeng Sui, Yanjie Qi, Siyu Pan, Ning Wang, Rongjun Bian, Stephen Joseph, Xuhui Zhang, Lianqing Li, Genxing Pan","doi":"10.1016/j.ecoenv.2024.117533","DOIUrl":"https://doi.org/10.1016/j.ecoenv.2024.117533","url":null,"abstract":"<p><p>Biochar is widely recognized as an effective amendment for soils contaminated with cadmium (Cd). However, the properties and elemental compositions of biochar derived from different feedstocks may significantly impact the transfer of Cd in the soil-rice system. This study conducted a two-year field trial in Cd-contaminated paddy soil. Rapeseed straw biochar (REB), rice husk biochar (RHB), and bone char (BOC) were applied once at rates of 0 t ha^-1 (CK) and 15 t ha^-1, respectively. The results indicated that biochar significantly decreased grain Cd concentrations by on average of 60.1 % and 22.9 % in 2021 and 2022, respectively. BOC significantly decreased CaCl₂-Cd concentration by on average of 52.1 % and 64.7 % during two rice growing seasons, which was higher than that of crop biochar (22.7 % and 17.8 %). Soil exchangeable Ca and dissolved P in BOC treatment were higher, and had significantly negatively correlated with CaCl₂-Cd (r = -0.50; r = -0.724). REB with higher S content efficiently increased the proportion of organics and sulfides bounding Cd. Except for BOC, REB and RHB significantly enhanced Cd fixation in IP by 44.4 %-92.0 % and 42.8 %-59.5 % in two years, in which IP-bound Fe and IP-bound Cd in REB were by 10.9 % and by 9.11 %-27.4 % higher than those of RHB respectively. The electron donating capacity of REB was 2.21-folds higher than that of RHB, which could promote IP formation by enhancing Fe(Ⅲ) reduction. RHB decreased Cd transformation from roots to shoots by 20.6 %-30.3 % compared to REB and BOC. Higher Si content in rice root in RHB treatment may promote complexation and deposition of Si hemicellulose-bound Cd in the root cell walls. This study reveals the important role of biochar's elemental composition and properties in soil Cd immobilization and the mitigation of rice Cd uptake.</p>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"290 ","pages":"117533"},"PeriodicalIF":6.2,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142823703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chitosan oligosaccharide alleviates DON-induced liver injury via suppressing ferroptosis in mice.","authors":"Mengjie Liu, Zhenlin Li, Jie Li, Guorong Yan, Chaoqi Liu, Qingqiang Yin, Yeqiang Liu, Xiaoxiang Xu","doi":"10.1016/j.ecoenv.2024.117530","DOIUrl":"https://doi.org/10.1016/j.ecoenv.2024.117530","url":null,"abstract":"<p><p>Chitosan oligosaccharide (COS), a water-soluble derivative of chitin, has been recognized for its diverse biological properties. Deoxynivalenol (DON) is a prevalent mycotoxin, causing extreme liver damage. However, the mechanism whereby COS alleviates DON-induced liver injury remains unclear. In the present study, C57BL/6 mice were randomly divided into four groups: control (CON), DON (1.0 mg/d/kg BW DON), COS (200 mg/d/kg BW COS), and COS+DON (200 mg/d/kg BW COS + 1.0 mg/d/kg BW DON), with a period of 28 days. The results indicated that COS effectively reversed DON-induced weight loss, elevated liver index, and liver hemorrhage and swelling in mice. Moreover, COS significantly reduced liver reactive oxygen species (ROS) levels, malondialdehyde (MDA) content, and lactate dehydrogenase (LDH) release in DON-exposed mice, while restoring the activity of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) and total antioxidant capacity (T-AOC). Further investigations revealed that COS modulated the expressions of pro-inflammatory cytokines and anti-apoptotic proteins through stimulation of the Nrf2/HO-1 signaling pathway and suppression of the NF-κB signaling pathway. Additionally, COS inhibited ferroptosis by modulating the SLC7A11/GSH/GPX4 pathway and the expression of FTH1 and FLC proteins, thereby reducing lipid peroxidation accumulation and iron overload. In summary, this research showed that COS mitigated DON-induced liver injury in mice by alleviating DON-induced oxidative stress, inflammation, apoptosis, and ferroptosis via modulating the Nrf2/HO-1/NF-κB and GPX4 signaling pathways. These results offer a theoretical basis for the development and application of COS as a novel liver protectant and propose innovative therapeutic strategies for combating DON-induced liver damage.</p>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"290 ","pages":"117530"},"PeriodicalIF":6.2,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142823699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}