Ecotoxicology and Environmental Safety最新文献

{"title":"Corrigendum to “Pubertal low dose exposure to benzophenone-3 (BP-3) alters murine mammary stem cell functions” [Ecotoxicol. Environ. Saf. 292 (2025) 117982]","authors":"Hui Gao , Xintong Yang , Pengge Pan , Xueli Liu , Yan Ma , Yadan Chen , Yunxin Liu , Yaqi Sun , Sinan Cao , Yuan Tian , Yanzhou Yang","doi":"10.1016/j.ecoenv.2025.118017","DOIUrl":"10.1016/j.ecoenv.2025.118017","url":null,"abstract":"","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"293 ","pages":"Article 118017"},"PeriodicalIF":6.2,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143592285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between fine particulate matter and its constituents and intrahepatic cholestasis of pregnancy","authors":"Cheng Li ,&nbsp;Ying-Zhou Ge ,&nbsp;Yan-Hui Hao ,&nbsp;Jing-Jing Xu ,&nbsp;Si-Wei Zhang ,&nbsp;Si-Yue Chen ,&nbsp;Hai-Dong Kan ,&nbsp;Xia Meng ,&nbsp;He-Feng Huang ,&nbsp;Yan-Ting Wu","doi":"10.1016/j.ecoenv.2025.118010","DOIUrl":"10.1016/j.ecoenv.2025.118010","url":null,"abstract":"<div><div>Few studies have reported an association between intrahepatic cholestasis of pregnancy (ICP) and preconception exposure to PM_2.5 and sunlight duration, but there has been no in-depth analysis of the correlation between ICP and different constituents of PM_2.5. Thus, we performed this retrospective analysis among 160,544 pregnant women who delivered between 2014 and 2020, to further estimate the impact of different constituents of PM_2.5, as well as the duration of sunlight, on ICP via generalized linear models. During the three months prior to conception, the adjusted odds ratios (aORs) for ICP were 1.176 (95 % CI: 1.066, 1.298) for a 10 μg/m³ increase in PM_2.5, 1.080 (95 % CI: 1.026, 1.138) for a 1 μg/m³ increase in sulfate (SO₄^2–), 1.069 (95 % CI: 1.025, 1.115) for a 1 μg/m³ increase in organic matter (OM), 1.274 (95 % CI: 1.049, 1.546) for a 1 μg/m³ increase in black carbon (BC), and 1.213 (95 % CI: 1.088, 1.353) for a 1-hour decrease in sunlight duration. In addition, during the preconception period, increased exposure to PM_2.5 constituents (including SO₄^2–, OM, and BC) and decreased sunlight duration interactively associated with ICP. Moreover, exposure to OM during the first trimester (aOR=1.043, 95 % CI: 1.004, 1.083) and to BC during both the first trimester (aOR=1.201, 95 % CI: 1.000, 1.442) and the second trimester (aOR=1.278, 95 % CI: 1.048, 1.558) were found to elevate the risk of ICP. In the future, women preparing to conceive should increase sunlight exposure and avoid exposure to air pollution, and the constituents related to anthropogenic emissions should be controlled to prevent these associations.</div></div>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"293 ","pages":"Article 118010"},"PeriodicalIF":6.2,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143592366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interactive and joint effects of toxic metals and oxidative balance score on the risk of mortality in adults with NAFLD","authors":"Hua-nan Chen ,&nbsp;Guo-qiang Chen ,&nbsp;Li-hua Li ,&nbsp;Wei-ping Zhang ,&nbsp;Yong-jun Wang ,&nbsp;Kun Li ,&nbsp;Ying Lian","doi":"10.1016/j.ecoenv.2025.117958","DOIUrl":"10.1016/j.ecoenv.2025.117958","url":null,"abstract":"<div><h3>Background</h3><div>High oxidative balance score (OBS) may mitigate inflammation levels and thereby alleviate the adverse health effects induced by toxic metals. We assessed the independent, joint effects as well as their interactions of toxic metals and OBS on mortality among individuals with non-alcoholic fatty liver diseases (NAFLD).</div></div><div><h3>Methods</h3><div>Participants with NAFLD from the National Health and Nutrition Examination Survey (NHANES) 1999–2018 were included. Mortality and underlying causes of death were certain by National Death Index records through 31 December 2019. Cox regression models were used to estimate hazard ratios (HRs) for all-cause and disease-specific mortality. Additionally, we assessed multiplicative and additive interactions of OBS and toxic metals on mortality.</div></div><div><h3>Results</h3><div>Among 5263 patients with NAFLD, 1097 deaths occurred during a mean follow-up of 10.27 years. Compared with those in the OBS tertile 1, participants in tertile 3 had lower risk of all-cause mortality (HR=0.79, 95 %CI: 0.64, 0.96). Compared with individuals in the lowest lead concentration in blood, those in the highest had an increased risk of mortality, with the HRs (95 %CIs) being 1.23 (1.01, 1.51), 1.53(1.06, 2.20) and 1.94(1.25, 3.01) for all-cause, CVD and cancer mortality, respectively. Similar results were also found for blood cadmium level. Joint associations analyses found that individuals with low lead and high-OBS levels had the lowest risk of all-cause, CVD and cancer mortality, with the HRs(95 %CIs) being 0.58(0.40, 0.85), 0.45(0.21, 0.93) and 0.35(0.15, 0.81), respectively. Multiplicative interactions between OBS and blood cadmium on all-cause death (HR=0.87, 95 %CI: 0.78, 0.97) and CVD death (HR=0.81, 95 %CI: 0.67, 0.99) were found.</div></div><div><h3>Conclusions</h3><div>High OBS and low exposure to toxic metals were associated with lower risk of mortality among participants with NAFLD. Adopting anti-oxidative lifestyle could alleviate the harmful effects of toxic metals in NAFLD patients. Comprehensive strategies are essential to decrease the risk of mortality and potentially mitigate the overall burden of NAFLD.</div></div>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"293 ","pages":"Article 117958"},"PeriodicalIF":6.2,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143592023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exogenous proline enhances salt acclimation in soybean seedlings: Modifying physicochemical properties and controlling proline metabolism through the ornithine-glutamate dual pathway","authors":"Lei Yan ,&nbsp;Mu Lu ,&nbsp;Muhammad Riaz ,&nbsp;Kaiqing Tong ,&nbsp;Hualong Yu ,&nbsp;Guang Gao ,&nbsp;Yusheng Niu","doi":"10.1016/j.ecoenv.2025.118012","DOIUrl":"10.1016/j.ecoenv.2025.118012","url":null,"abstract":"<div><div>Soil salinization has emerged as a major factor negatively affecting soil quality and plant productivity. Proline, functioning as an osmotic regulator, has been proposed as an effective strategy for enhancing plant tolerance to salt stress. This study aimed to investigate the effects of exogenous proline on salt tolerance in soybeans. A hydroponic experiment was conducted with different salt treatments (without NaCl, -NaCl; with 100 mM NaCl, +NaCl) and with or without 150 mM proline (+Pro, -Pro). The results showed that proline application alleviated salt stress-induced reductions in plant growth, photosynthetic parameters, and chlorophyll content while aiding recovery from leaf chlorosis. Proline treatment improved ion homeostasis by reducing Na⁺ levels and increasing K⁺ and Ca²⁺ contents in the leaves. Salt stress increased malondialdehyde (MDA) and reactive oxygen species (ROS) levels, along with leaf peroxidase (POD) and catalase (CAT) activities, while decreasing superoxide dismutase (SOD) activity. Moreover, salt stress obviously enhanced proline accumulation, accompanied by increases in glutamate (Glu), glutamate-1-semialdehyde (GSA), and pyrroline-5-carboxylate (P5C) content, as well as the activities of pyrroline-5-carboxylate synthase (P5CS) and pyrroline-5-carboxylate reductase (P5CR) in the glutamate pathway, while reducing proline dehydrogenase (ProDH) activity. Exogenous proline treatment further elevated proline content and increased key substances and enzyme activities in both the glutamate (Glu and P5C content, P5CS and P5CR activity) and ornithine (Orn content and OAT activity) pathways while also reducing ProDH activity. Collectively, our results revealed that exogenous proline contributed to an attenuation of salt stress in soybeans by regulating both the glutamate and ornithine pathways to stimulate endogenous proline accumulation, mediate Na⁺/K⁺ homeostasis, and inhibit oxidative damage.</div></div>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"294 ","pages":"Article 118012"},"PeriodicalIF":6.2,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143592224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detritivore identity modulates effects of nutrient enrichment and a common fungicide presence on leaf litter decomposition and fungal community","authors":"Rui Dong ,&nbsp;Kai Peng ,&nbsp;Naiara López-Rojo ,&nbsp;Qingji Zhang ,&nbsp;Yongjiu Cai ,&nbsp;Zhijun Gong","doi":"10.1016/j.ecoenv.2025.118019","DOIUrl":"10.1016/j.ecoenv.2025.118019","url":null,"abstract":"<div><div>Understanding the interaction of biotic and abiotic factors on ecosystem function is crucial for freshwater ecosystem management, However, the influence of nutrient enrichment, fungicide presence, and detritivore identity on leaf litter decomposition and associated fungal communities remains poorly understood. We conducted a microcosm experiment to examine: 1) the individual and combined effects of nutrient enrichment and a common fungicide on leaf litter decomposition and fungal communities; and 2) how two types of detritivore invertebrates (scrapers vs. shredders) influence these effects. After 35 days, we assessed: 1) leaf litter decomposition, dissolved organic carbon (DOC) production, and the activities of extracellular enzymes; and 2) the diversity, community structure, and co-occurrence networks of fungal communities. We found that both fungicides and nutrient enrichment increased enzymatic activity but did not significantly impact fungal diversity. However, fungicides changed fungal community structure and reduced detritivore-mediated decomposition and DOC production, while nutrient enrichment had the opposite effect. In combination, nutrient enrichment mitigated the negative effects of fungicides on fungal co-occurrence network stability and decomposition. We found that detritivore identity selectively influenced fungal taxa, resulting in distinct co-occurrence patterns under different stressors. The effects of nutrient enrichment and/or fungicide on leaf litter decomposition also depended on detritivore identity. This research underscores the pivotal role of detritivore identity and the interplay of biotic and abiotic factors in shaping fungal communities and modulating leaf litter decomposition, particularly in multiple stressors settings, and its implications for effective management and biodiversity conservation.</div></div>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"293 ","pages":"Article 118019"},"PeriodicalIF":6.2,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143592018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of factors associated with adult skeletal fluorosis in coal-burning type of endemic fluorosis and initial screening model based on machine learning in Guizhou, Southwest China","authors":"Huiyi Shi ,&nbsp;Mingdan You ,&nbsp;Xuan Li ,&nbsp;Boyou Zhang ,&nbsp;Jing Gao ,&nbsp;Demei Zhou ,&nbsp;Ying Tu ,&nbsp;Zihao Xia ,&nbsp;Jun Li ,&nbsp;Guanghong Yang ,&nbsp;Yining Liu ,&nbsp;Hongbing Ye","doi":"10.1016/j.ecoenv.2025.118018","DOIUrl":"10.1016/j.ecoenv.2025.118018","url":null,"abstract":"<div><div>Skeletal fluorosis caused by coal-burning type endemic fluorosis greatly affects the health of the population in the affected areas, but large-scale diagnostic work is limited by human and material resources, making it difficult to implement comprehensively. In this study, we investigate adults in coal-burning type endemic skeletal fluorosis areas in Guizhou. The study areas are selected by a comprehensive analysis of the detection rate of dental fluorosis in children aged 8–12 years in Guizhou for the year 2023. We collect information from questionnaires, physical examinations, and diagnostic X-ray Findings of Skeletal Fluorosis (XRF) in adults. The effective number of people investigated in this study was 2276, and the detection rate of XRF was 79.35 %. The top 5 relevant factors for skeletal fluorosis were age, educational background, height, Mini-Mental State Examination (MMSE) score and family population. Among the 8 models, random forest performed the best with an accuracy of 86.00 %, and the performance was more stable in the prevalence of different sizes, which provides a new idea for the prevention and treatment of skeletal fluorosis in coal-burning type of endemic fluorosis. In this study, the screening of the main correlates of XRF can provide an effective reference for the initial screening of skeletal fluorosis, and the practical application value of machine learning in this research field can be further explored.</div></div>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"293 ","pages":"Article 118018"},"PeriodicalIF":6.2,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143592274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"4,4′-methylenebis(2-chloroaniline) induces chromosome aneuploidy associated with premature chromatid separation in mammalian cells: A possible carcinogenic mechanism","authors":"Saho Kobayashi ,&nbsp;Hiroki Kashiwagi ,&nbsp;Kenichi Kobayashi ,&nbsp;Masaoki Kohzaki","doi":"10.1016/j.ecoenv.2025.117981","DOIUrl":"10.1016/j.ecoenv.2025.117981","url":null,"abstract":"<div><div>In Japan, several workers were diagnosed with bladder cancer 10–40 years after exposure to 4,4′-methylenebis(2-chloroaniline) (MOCA), mainly through the skin. MOCA also induces bladder cancer in dogs and nonbladder (breast, liver, lung) cancers in rodents. MOCA with S9 fractions contains mutagenic metabolites after catalysis by N-acetyl transferase (NAT). Similar to benzidine and ortho-toluidine, MOCA is classified as a group 1 carcinogen by the IARC. However, since dogs lack NAT, the common mechanism underlying bladder cancer development across mammalian species remains elusive. We used human liver HepG2, lung A549, breast MCF7, bladder T24, 5637 cells; mouse lung LLC, breast TS/A, and bladder MBT-2 cells; and rat bladder NBT-T2 cells to analyze the mitotic effects of aromatic amines (benzidine, ortho-toluidine, 2-chloroaniline, and 4,4′-methylenedianiline) to elucidate the common mechanism underlying MOCA-induced cancer in mammals. The effects of MOCA metabolites were assessed in liver S9 fractions. <em>In vivo</em>, male F344 rats were administered MOCA (0, 60, or 120 mg/kg/day) percutaneously three times a week for 4 weeks to mimic human exposure, and MOCA-induced chromosomal instability in lung and bladder cells was evaluated one month later. Compared with other aromatic amines or S9-metabolized MOCA, MOCA significantly increased the mitotic index in all the examined cell lines (<em>p </em>&lt; 0.0001) and markedly induced cohesion defects in human and rat cells (<em>p</em> &lt; 0.036). Rats repeatedly exposed to MOCA exhibited dose-dependent chromosome aneuploidies in lung- and bladder-derived cells. Thus, MOCA induces chromosome aneuploidy via cohesion defects independent of hepatic metabolism, contributing to mammalian carcinogenesis <em>in vivo</em>.</div></div>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"293 ","pages":"Article 117981"},"PeriodicalIF":6.2,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143592367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fertilization and intercropping reduce Pb accumulation in plants by influencing rhizosphere soil phosphorus forms in soil-plant systems","authors":"Yongjian He ,&nbsp;Xiuli Hou ,&nbsp;Xiaoni Wu ,&nbsp;Changqun Duan ,&nbsp;Change Liu ,&nbsp;Liqing Yin ,&nbsp;Mei Zhang ,&nbsp;Denggao Fu","doi":"10.1016/j.ecoenv.2025.118011","DOIUrl":"10.1016/j.ecoenv.2025.118011","url":null,"abstract":"<div><div>Fertilization and planting practices in crop systems have become important ways to reduce the uptake of heavy metals in polluted soils. However, the relative effectiveness of different management modes and the underlying mechanisms are not fully understood. In this study, we conducted experiments to assess how fertilization and planting modes affect the bioavailability of lead (Pb) in soil and its accumulation in plants. The results revealed that planting and fertilization modes significantly affected Pb speciation in rhizosphere soil and Pb accumulation characteristics in plants (<em>p</em> &lt; 0.01). Specifically, fertilization with nitrogen–phosphorus–potassium (N-P-K) had stronger effects than did N-K fertilization in terms of a reduction in soil available Pb (APb) and an increase in both chemically stable Pb (CHS-Pb) and the immobilization efficiency of Pb (R). A significantly greater concentration of soil CHS-Pb was detected, at 39.29 mg/kg and 28.43 mg/kg, in the intercropping system under N-P-K and N-K fertilization (<em>p</em> &lt; 0.05), respectively, compared with the control. In addition, the Pb concentration in plants and the enrichment coefficient under the N-P-K fertilization mode were significantly lower than those under the other fertilization modes (<em>p</em> &lt; 0.05). Notably, P fertilization was found to be more effective than intercropping in reducing Pb accumulation in plants. With decreasing soil pH, Pb²⁺ was adsorbed or immobilized through exchange with cations in the soil, and Pb²⁺ further formed precipitates with Fe-P, H₂PO₄^- and Ca²⁺. Therefore, the changes in Pb speciation and the increases in Pb immobilization efficiency induced by changes in pH and P fractions within rhizosphere soil were the primary mechanisms governing the reduction in Pb accumulation in plants.</div></div>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"293 ","pages":"Article 118011"},"PeriodicalIF":6.2,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143592272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Promotion of microplastic degradation on the conjugative transfer of antibiotic resistance genes in the gut of macrobenthic invertebrates","authors":"Jing Ma ,&nbsp;Chunhong Lv ,&nbsp;Zheng Gong ,&nbsp;Kai Zhang ,&nbsp;Shu Wang ,&nbsp;Rui Li ,&nbsp;Kang Chen ,&nbsp;Feng Zhu ,&nbsp;Deya Wang ,&nbsp;Zhigang Qiu ,&nbsp;Chengshi Ding","doi":"10.1016/j.ecoenv.2025.117999","DOIUrl":"10.1016/j.ecoenv.2025.117999","url":null,"abstract":"<div><div>Microplastics and antibiotic resistance genes are two new pollutants in water environments, and they have potential risks to human health and ecological safety. On the basis of the accumulation of pollutants and microorganisms in sediment, macrobenthic invertebrates are considered as potential practitioners of microplastic degradation and antibiotic resistance gene (ARG) transfer. However, whether microplastic degradation can affect ARG transfer in aquatic environments, especially in the gut of macrobenthic invertebrates, remains unclear. In this study, we demonstrated that microplastics including polyethylene terephthalate (PET), polyvinyl chloride(PVC), polyamide (PA), polystyrene (PS), polypropylene (PP), polyethylene (PE), and polyurethane (PU), and ARGs including <em>tetA</em>, <em>sul1</em>, <em>sul2</em>, and <em>sul3</em> were widely distributed in sediment and benthic invertebrates in Nansi lake. The distribution of ARGs was related to the number and size of microplastic particles. In particular, it was found for the first time that the content of ARGs corresponding to individual particles was linearly and negatively correlated with the size of microplastics. The results of animal feeding experiments showed that microplastic degradation in the gut of Chironomidae larvae could promote the conjugative transfer of ARGs. The underlying molecular mechanism was SOS response. This study provides a new method for the analysis of the interaction effect of multiple pollutants in freshwater environments.</div></div>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"293 ","pages":"Article 117999"},"PeriodicalIF":6.2,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143592276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cobalt exposure was associated with the risk of hepatic steatosis and advanced liver fibrosis based on a cross-sectional study from NHANES","authors":"Ling Zhang ,&nbsp;Shijie Ma ,&nbsp;Rui Sun ,&nbsp;Rui Xie ,&nbsp;Peng Shen","doi":"10.1016/j.ecoenv.2025.118003","DOIUrl":"10.1016/j.ecoenv.2025.118003","url":null,"abstract":"<div><h3>Background</h3><div>Although Emerging evidence suggests the association of environmental factors with hepatic steatosis and fibrosis, the relationship between Cobalt exposure and hepatic steatosis and fibrosis was not clear.</div></div><div><h3>Aim</h3><div>Our study was aimed to explore the association between blood Cobalt level and hepatic steatosis and advanced liver fibrosis diagnosed by vibration controlled transient elastography (VCTE) in US adults.</div></div><div><h3>Methods</h3><div>This study analyzed data from 3193 individuals participating in the 2017–2018 National Health and Nutrition Examination Surveys. Participants were classified into four groups according to the quartiles of blood cobalt concentration. Liver stiffness and fat content were assessed through vibration-controlled transient elastography (VCTE), including measurements of the controlled attenuation parameter (CAP). The association between blood cobalt levels and the prevalence of hepatic steatosis and advanced liver fibrosis was explored using logistic regression models and stratified subgroup analyses.</div></div><div><h3>Results</h3><div>The CAP values showed a significant decline across increasing cobalt quartiles. Participants in the highest quartile had a 41 % lower risk of hepatic steatosis compared to those in the lowest quartile (odds ratio: 0.59, 95 % confidence interval: 0.46–0.76, p &lt; 0.001). However, no significant association existed between blood Cobalt and advanced liver fibrosis. Subgroup analysis revealed that the relationship was consistent across age, gender and body mass index subgroups.</div></div><div><h3>Conclusions</h3><div>This study showed that blood Cobalt level was negatively association with hepatic steatosis. This may be due to increased development from hepatic steatosis to advanced liver fibrosis upon Cobalt exposure.</div></div>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"293 ","pages":"Article 118003"},"PeriodicalIF":6.2,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143592279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}