Ecotoxicology and Environmental Safety最新文献

{"title":"Levels of serum per- and polyfluoroalkyl substances and association with dyslipidemia in the Korean population.","authors":"Kangyeon Park, Da-An Huh, Lita Kim, Yun-Hee Choi, Jiyoun Lee, Se Hyun Hwang, Hyeon Jeong Choi, Woohyun Lim, Kyong Whan Moon","doi":"10.1016/j.ecoenv.2025.118633","DOIUrl":"10.1016/j.ecoenv.2025.118633","url":null,"abstract":"<p><p>Per- and polyfluoroalkyl substances (PFAS) are primarily used in coatings for cookware and waterproof clothing, and can enter the body through contaminated food or water, potentially acting as endocrine disruptors. Epidemiological studies have reported associations between PFAS and dyslipidemia; however, these studies have mainly been conducted in Western and other countries. Due to genetic differences and weak regulations in East Asia compared to Western countries, there is a need for studies on the health impact on this population. This cross-sectional study analyzed the association between serum PFAS levels and dyslipidemia in Korean adults. The data were from 2975 participants from the cycle 4 of Korean National Environmental Health Survey conducted between 2018 and 2020. We performed general linear regression, robust Poisson regression, and Bayesian kernel machine regression to analyze the association between the five PFAS and dyslipidemia. All five PFAS were detected in over 99.8 % of the study participants, with geometric mean concentrations as follows: perfluorooctanoic acid (PFOA) = 6.4 ng/mL, perfluorooctane sulfonic acid (PFOS) = 15 ng/mL, perfluorohexane sulfonic acid (PFHxS) = 4.2 ng/mL, perfluorononanoic acid (PFNA) = 2.1 ng/mL, and perfluorodecanoic acid (PFDeA) = 0.91 ng/mL. This study confirmed positive associations between PFOA, PFHxS, PFNA, PFDeA, and low-density lipoprotein cholesterol (LDL_C), as well as a positive association between PFOA, PFNA, and PFDeA and the prevalence of high total cholesterol (TC). Further, an analysis stratified by sex revealed a positive association between PFOA and high-density lipoprotein cholesterol (HDL_C) in men. The PFAS mixture was associated with lipid profiles (TC, HDL_C, and LDL_C) in the general population of Korean adults, which emphasizes the need to strengthen PFAS regulations.</p>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"302 ","pages":"118633"},"PeriodicalIF":6.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144599042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seasonal dynamics and risk assessment of antibiotic resistome in straw-retained agroecosystems.","authors":"Yi Wu, Yi Fan, Yiheng Tao, Quankuan Guo, Shuang Pang, Wei Yang, Ximei Zhang","doi":"10.1016/j.ecoenv.2025.118630","DOIUrl":"10.1016/j.ecoenv.2025.118630","url":null,"abstract":"<p><p>Straw retention (SR) is an essential management practice of sustainable agriculture. However, the seasonal dynamics on the antibiotic resistome and associated ecological risks in seasonally frozen agroecosystems remain unclear. Here, we conducted a multi-site field study in the Sanjiang Plain, a seasonally frozen agricultural region of Northeast China, combining time-series soil sampling with metagenomic sequencing to reveal antibiotic resistome dynamics. SR elevated relative abundance of antibiotic resistance genes (ARGs) across all seasons and induced significant seasonal variations in richness. ARG richness peaked during freezing season favoring the dominance of low-risk ARGs. The soil C/N ratio emerged as the primary driver shaping the relative abundance and diversity of antibiotic resistome, with 23 core low-risk ARGs accounting for 73 % of the observed abundance increase, whereas high-risk ARGs constituted merely 0.44 % of the total resistome abundance. Straw retention also reduced interactions among high-risk ARGs with ecological risk remaining stable, demonstrating decoupling between resistome abundance and environmental risk. Structural equation modeling revealed straw retention exerting both direct effects (0.45) and indirect regulation (-0.16) via modulating nutrient content. Our findings evaluated the antibiotic resistance risks of straw retention with the enrichment of low-risk ARGs and suppression of interactions among high-risk ARGs, promoting its safe adoption in agroecosystems. Overall, this study provides a comprehensive antibiotic risk assessment framework, demonstrating straw retention as a beneficial strategy that enhances soil fertility with practically manageable resistance risks in agroecosystems.</p>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"302 ","pages":"118630"},"PeriodicalIF":6.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144598954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urine metabolomic characteristics of people exposed to hexavalent chromium in drinking water.","authors":"Tao Yanan, Hu Miaomiao, Xia Yunting, Peng Fangda, Xiong Chuanlong, Ding Chunguang","doi":"10.1016/j.ecoenv.2025.118670","DOIUrl":"10.1016/j.ecoenv.2025.118670","url":null,"abstract":"<p><p>This study investigated the toxicological mechanisms of hexavalent chromium (Cr(VI)) exposure on human health by analyzing the urinary metabolomics of residents exposed to Cr(VI) through drinking water. The aim of the study was to identify metabolites with significant differences and discover potential biomarkers for early detection and assessment of Cr(VI)-induced toxicity. Local residents aged 18-65 years were selected from both the Cr(VI)-exposed and control groups using simple random sampling. Using untargeted metabolomics technique, ultra-performance liquid chromatography coupled with quadrupole-time of flight mass spectrometry (UPLC-QTOF/MS) to detecte urine metabolites of people exposed to Cr(VI)in drinking water, combining multivariate and single-variable statistical analyses to screen different metabolites, and using MetaboAnalyst 5.0 software to conduct metabolic pathway analysis. 30 differential metabolites including Coproporphyrin Ⅲ, 7-Methylguanosine, Pentosidine, 18-Carboxy-dinor-LTE4, Deoxyguanosine, 4a-Hydroxytetrahydrobiop-terin, Dodecanediacylcarnitine, Allocholic acid, and Thromboxane were screened. Among these, 17 metabolites were up-regulated, such as Pentosidine, 18-Carboxy-dinor-LTE4, Dodecanediacylcarnitine, Allocholic acid, and Thromboxane, etc, while 13 metabolites were down-regulated, including Coproporphyrin III, 7-Methylguanosine, Deoxyguanosine, and 4a-Hydroxytetrahydrobiopterin, etc. N-ceramide-sphingosine, Stearic acid, Lysophosphatidylethanolamine (0:0/24:1), Lithocholic acid-3-O-glucuronide, (2E,4Z)-N-isobutyl-2,4-octadecanediamide, Thromboxane, Glycylcholic acid, and Pentosan were identified as potential biomarkers. Long-term exposure to Cr(VI) in drinking water might impact 13 metabolic pathways, including the urea cycle, androgen and estrogen metabolism, steroid synthesis, as well as arginine, proline, pyrimidine, and purine metabolism. Cr(VI) exposure might lead to damage of some metabolic pathways in drinking water and had potential health risks. Some ssential measures should be taken to reduce and prevent the intake of Cr(VI) from drinking water.</p>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"302 ","pages":"118670"},"PeriodicalIF":6.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144641361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geochemistry of arsenic in paddy soils and its accumulation in rice grains: An updated analysis with human health perspectives.","authors":"Meysam Cheraghi, Karim Shahbazi, Mostafa Marzi, Mojgan Yeganeh, Kobra Sadat Hasheminasab, Arzhang Fathi-Gerdelidani, Meisam Rezaei, Kambiz Bazargan","doi":"10.1016/j.ecoenv.2025.118667","DOIUrl":"10.1016/j.ecoenv.2025.118667","url":null,"abstract":"<p><p>The elevated concentration of arsenic (As) in rice grains poses a major global health concern. This review investigates the geochemical behavior of As in paddy soils and the mechanisms responsible for its accumulation in rice, providing insights into why As concentrations in rice are considerably higher than in other cereals. Our findings highlight that under the strongly reducing and anaerobic conditions typical of flooded paddy soils, the bioavailability of As increases markedly. Multiple As species coexist in these soils, but arsenite (As(III)) predominates due to the low redox potential and absence of oxygen. Arsenite is significantly more mobile and bioavailable than arsenate (As(V)), which dominates under aerobic conditions. In addition, rice roots take up As(III) efficiently through aquaporin channels that also transport silicic acid. These geochemical and physiological factors together result in elevated As accumulation in rice grains. In the second part, we provide a comprehensive overview of As speciation in rice grains and its associated human health risks. Our synthesis highlights substantial variation in exposure levels, carcinogenic risk, and non-carcinogenic hazards across regions, age groups, and dietary habits. Finally, key knowledge gaps are identified to guide future research on As geochemistry, speciation, and risk mitigation strategies in rice systems.</p>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"302 ","pages":"118667"},"PeriodicalIF":6.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of long-term ambient air pollutant mixture exposure on incident diabetes: A prospective cohort study in China.","authors":"Aibin Qu, Fuyuan Wen, Bingxiao Li, Pandi Li, Bowen Zhang, Xiaojun Yang, Xinyue Yao, Boya Li, Xiangqian Lao, Ling Zhang","doi":"10.1016/j.ecoenv.2025.118652","DOIUrl":"10.1016/j.ecoenv.2025.118652","url":null,"abstract":"<p><strong>Background: </strong>Although an increasing number of studies have shown air pollution exposure is associated with diabetes, the potential causal effects of air pollutants on incident diabetes and the joint effects of air pollutant mixtures remain unclear.</p><p><strong>Methods: </strong>We conducted a prospective cohort study that included 25,801 adults based on Chronic Disease of the Community Natural Population in the Beijing-Tianjin-Hebei region. Three-year mean concentrations of air pollutants (PM_2.5, PM₁₀, PM₁, and NO₂) and PM_2.5 components (ammonium [NH₄⁺], nitrate [NO₃^-], sulfate [SO₄^2-], and chloride ion [Cl^-]) were obtained from China High Air Pollutants database. Targeted maximum likelihood estimation was used to estimate potential causal relationships between long-term air pollution exposure and diabetes incidence. The joint effects of air pollutant mixtures on diabetes and the contribution of each pollutant were assessed using Quantile G-computation.</p><p><strong>Results: </strong>In single-pollutant models, moderate and high concentrations of PM_2.5, PM₁₀, PM₁, NO₂, NH₄⁺, NO₃^-, SO₄^2-, and Cl^- exposure were significantly associated with diabetes risk compared with low concentrations of air pollutants. In multi-pollutant models, the joint effect of air pollutant mixture (PM_2.5, PM₁₀, PM₁, and NO₂) on diabetes was 1.006 (1.004, 1.009). After replacing PM_2.5 with PM_2.5 components in the mixture, the effect estimates remained robust at 1.015 (1.008, 1.021), and the positive effect was driven primarily by NH₄⁺ at 43.66 %, followed by NO₃^- at 39.20 %.</p><p><strong>Conclusions: </strong>Our results revealed relationships between long-term air pollutant exposure and incident diabetes. Furthermore, NH₄⁺ and NO₃^- might be strong contributors. These findings support targeted air quality interventions to reduce diabetes risk.</p>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"302 ","pages":"118652"},"PeriodicalIF":6.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual-strategy regulation of soil water dynamics: Integrating planting patterns and amendments to mitigate cadmium and arsenic migration in agricultural soils.","authors":"Jiangdi Deng, Toe Toe Maw, Shihong Tang, Xinran Liang, Wenjin Yan, Bo Li, Yongmei He, Yuan Li, Zuran Li","doi":"10.1016/j.ecoenv.2025.118713","DOIUrl":"10.1016/j.ecoenv.2025.118713","url":null,"abstract":"<p><p>Cadmium (Cd) and arsenic (As) contamination in agricultural soils has become a critical environmental challenge threatening food security and ecosystem health globally. While soil hydrological processes are recognized as fundamental drivers of Cd and As migration in agricultural soils, the effects of regulating soil water dynamics through agricultural management practices on Cd and As transport remain unclear. We investigated the effectiveness of two remediation strategies in a Cd and As contaminated potato field: (1) planting pattern optimization (PPO), combining intercropping potato with the Sedum plumbizincicola and rotating with ryegrass; and (2) soil amendment (SA), applying biochar and superabsorbent polymer (SAP). The study evaluated the migration patterns of Cd and As under natural rainfall conditions. Cd exhibited higher water distribution coefficients compared to As (P < 0.05), with soil particles migration being the predominant pathway for their losses. PPO effectively reduced the horizontal migration of Cd and As (Cd: 14 %, As: 36 %; P < 0.05) while modifying As vertical distribution patterns between surface (0-20 cm) and subsurface (20-40 cm) soil layers. The combination of PPO and SA showed superior performance, further reducing horizontal migration (47 %) and vertical migration (53 %) of Cd and As (P < 0.05). PPO inhibited the horizontal migration of Cd and As through reducing runoff and soil erosion, while SA inhibited their vertical migration by altering soil water dynamics and bioavailability. These findings indicate that targeted management of soil water dynamics can effectively control Cd and As migration.</p>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"302 ","pages":"118713"},"PeriodicalIF":6.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the expression profile and biological function of plasma miRNAs in chronic lymphocytic leukemia and multiple myeloma patients occupationally exposed to pesticides.","authors":"Luiza Flavia Veiga Francisco, Willian Garcia Birolli, Welinton Hirai, Caroline Rocha Nunes, Iara Zapparoli Gonçalves, Fabiana de Lima Vazquez, Álvaro José Dos Santos Neto, Fernando Barbosa Junior, Márcia Maria Chiquitelli Marques, Henrique C S Silveira","doi":"10.1016/j.ecoenv.2025.118627","DOIUrl":"10.1016/j.ecoenv.2025.118627","url":null,"abstract":"<p><p>Acute and chronic exposure to pesticides is associated with several negative effects on human health, such as an increased risk of cancer, including mature B-cell neoplasms such as chronic lymphocytic leukemia (CLL) and multiple myeloma (MM). However, the biological mechanism linking pesticide exposure to the development of CLL and MM has not yet been elucidated. Thus, this study aimed to explore miRNA expression profiles in patients with CLL and MM who were occupationally exposed and not exposed to pesticides. For this purpose, 24 patients with MM and CLL were recruited from a cohort in Brazil and the miRNA expression profiles between the groups were analyzed using Nanostring technology. The study revealed the downregulation of miR-423-3p, miR-1193, miR-576-5p, miR-509-5p, miR-548b-3p, miR-1469, miR-329-3p, and miR-548j-3p, and the upregulation of miR-301b-5p and miR-548ah-5p in patients with CLL and MM were associated with occupational exposure to pesticides. The integrated network analysis of the differentially expressed miRNAs and their target genes in the exposed group demonstrated that miRNAs can participate in the regulation of signaling pathways, such as PI3K/Akt/mTOR and MAPK. Additionally, these miRNAs were found to be associated with an increased risk of developing neurological diseases and various types of cancer. In the present study, we demonstrate, for the first time, altered expression of plasma-derived miRNAs in patients with CLL and MM exposed to pesticides. The plasma miRNAs identified may serve as promising candidates for biomarkers of pesticides effects, potentially contributing to the emerging field of Precision Environmental Health.</p>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"302 ","pages":"118627"},"PeriodicalIF":6.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144673520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overlooked risk of antibiotic resistance genes in typical landfill plumes and their influencing factors.","authors":"Dongsheng Shen, Xin Gao, Cai Hui, Yuyang Long, Jiali Shentu, Li Lu, Shengqi Qi","doi":"10.1016/j.ecoenv.2025.118765","DOIUrl":"10.1016/j.ecoenv.2025.118765","url":null,"abstract":"<p><p>Landfills are one of the primary reservoirs of antibiotic resistance genes (ARGs). Previous studies always focus on the distribution of ARGs in landfill leachate, while the distribution of ARGs in groundwater around the landfill and the corresponding influencing factors are always overlooked. In this study, seven groundwater samples and one leachate sample were collected from a typical landfill in Yueqing, China. Sulfonamide was the most abundant antibiotic in groundwater with its concentration of 1.2-23.1 ng L^-1. Metagenomic analysis revealed 13 major types and 88 subtypes of antibiotic resistance genes (ARGs) in the leachate and surrounding groundwater. Multidrug (23.2-51.4 %), sulfonamide (2.6-24.1 %), tetracycline (3.0-35.8 %), macrolides-lincosamide-streptogramin (MLS, 1.1-26.3 %) and aminoglycoside (0.9-13.1 %) resistance genes were the top five types in the detected ARGs, while the ARGs abundance in groundwater increased with landfill age. Heavy metals (Ni, Pb, Cr, Cd) were strongly correlated with certain ARG subtypes, while no significant correlations were observed between antibiotics and their corresponding ARGs due to their low concentrations. Through co-occurrence network analysis, it was found that ARGs were tightly correlated with mobile genetic elements (MGEs), while several types of virulence factors such as flmH, cylG and clbF were also tightly correlated with MGEs. Besides, ARGs were also correlated with some denitrification genes such as nirB and norC, showing that the denitrification process would enhance the dissemination of ARGs. This study provides important insights for assessing the risk of ARGs spreading through leachate leakage in groundwater and can help optimize the management strategy of landfill.</p>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"302 ","pages":"118765"},"PeriodicalIF":6.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144740694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Propylparaben impairs muscle development in zebrafish via the PI3K-mTOR pathway.","authors":"Yong Huang, Runhao Zhu, Yan Lei, Liting Liu, Huan Xu, Xiaomei Chen, Yuwei Zhao, Jing Hu, Yebing Zhong, Bo Cheng, Xiaochang Huang, Huiqiang Lu, Zhenjiang Zech Xu","doi":"10.1016/j.ecoenv.2025.118985","DOIUrl":"https://doi.org/10.1016/j.ecoenv.2025.118985","url":null,"abstract":"<p><p>Congenital myopathies are genetically inherited muscle disorders that impair muscle function and strength. While primarily linked to genetic mutations, emerging evidence suggests environmental toxins may exacerbate disease progression. Despite its widespread use as a preservative, the impact of propylparaben (PP) remains insufficiently characterized in current research. This study investigates the mechanisms underlying PP-induced muscle toxicity using Tg (-1.9mylpfa: EGFP) zebrafish. Imaging analysis revealed that PP adversely affected early muscle development, impairing fast and slow muscle fibers as well as precursor cells. Behavioral assessments demonstrated reduced spontaneous motor activity in larvae, resulting in decreased total movement distance, speed, acceleration, and overall activity levels. Mechanistic studies via qPCR and in situ hybridization indicated that PP inhibited the expression of myogenic differentiation factor (MyoD) and myogenic factor 5 (Myf5). Furthermore, PP suppressed the PI3K-mTOR signaling pathway, inhibited muscle cell proliferation, and triggered reactive oxygen species (ROS) accumulation. Notably, co-treatment with mTOR activators (MHY1485 and 3BDO) alleviated PP-induced developmental toxicity and behavioral deficits, confirming PI3K-mTOR pathway inhibition as a key mechanism. This study uncovers the mechanisms underlying PP-induced muscle toxicity, highlighting the interplay between environmental preservatives and genetic susceptibility in congenital myopathies. These findings provide critical insights into how common preservatives may exacerbate muscle-related genetic disorders.</p>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"303 ","pages":"118985"},"PeriodicalIF":6.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144937767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response mechanisms of denitrifying anaerobic methane oxidation (DAMO) processes to typical quinolone antibiotics in freshwater wetland sub-surface sediments.","authors":"Yuewen Zhao, Xinbo Zhang, Qichen Hao, Wenzhi Cao, Yuanjing Zhang, Chunlei Liu, Shengwei Cao, Yaci Liu, Yasong Li","doi":"10.1016/j.ecoenv.2025.118624","DOIUrl":"10.1016/j.ecoenv.2025.118624","url":null,"abstract":"<p><p>Sub-surface sediments in freshwater wetlands function as active habitats for microbial denitrifying anaerobic methane oxidation (DAMO) processes and as hotspots for antibiotic accumulation. Focusing on the Baiyangdian wetland, which is contaminated with quinolone antibiotics (QNs) and hosts active DAMO processes, this study employed ¹³C-labeled microcosm incubation experiments, RT-qPCR, and gene sequencing to decipher the response mechanisms of DAMO processes to prevalent QNs in the sub-surface sediments (0.5 20 cm) of study area. Short-term exposure (24 h) to typical QNs at 200 ng·g^-1 reduced nitrite-DAMO activities by approximately 33 %, primarily through selective inhibition of antibiotic-sensitive species within NC10 bacteria. In contrast, exposure to the same concentration of QNs enhanced nitrate-DAMO activities by about 450 %, likely due to hormetic stimulation of antibiotic-resistant ANME-2d archaea, combined with the inhibition of substrate competitor. Long-term exposure (90 days) to typical QNs mitigated these effects as bacterial adaptation to antibiotics occurred, resulting in a time-dependent attenuation of their impacts. This study underscores the significance of DAMO processes as methane sinks in changing environments and broadens the understanding of the ecological risks posed by antibiotics.</p>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"302 ","pages":"118624"},"PeriodicalIF":6.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144606995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}