Ecotoxicology and Environmental Safety最新文献

{"title":"Ecotoxicological risk assessment of N-nitrosamines to Selenastrum capricornutum in surface waters: Insights into toxicity mechanisms and environmental Implications","authors":"Decai Liu ,&nbsp;Litang Qin ,&nbsp;Honghu Zeng ,&nbsp;Yi Liang ,&nbsp;Yanpeng Liang ,&nbsp;Yingjie Chen ,&nbsp;Huanfang Huang ,&nbsp;Wenwen Chen","doi":"10.1016/j.ecoenv.2025.118179","DOIUrl":"10.1016/j.ecoenv.2025.118179","url":null,"abstract":"<div><div><em>N</em>-nitrosamines, one of the most common nitrogen-containing organic compounds in freshwater systems such as rivers or reservoirs, are toxic and carcinogenic to human. However, the aquatic hazard of these compounds to algae which is ubiquitous in surface water is still unclear. In this study, nine <em>N</em>-nitrosamines were investigated in the Pearl River Delta, China, with the total concentrations ranged from 27.0 to 727.6 ng/L. After that, four frequently detected <em>N</em>-nitrosamines—<em>N</em>-nitrosodiethylamine, <em>N</em>-nitroso-di-n-propylamine, <em>N</em>-nitrosopyrrolidine, and <em>N</em>-nitrosodibutylamine—were selected to explore their toxic mechanisms when individually or in combination exposed to <em>Selenastrum capricornutum</em>. The results revealed that the four <em>N</em>-nitrosamines and their mixtures all inhibited algal growth, with toxicity ranking as follows: <em>N</em>-nitrosodiethylamine &gt; <em>N</em>-nitroso-di-n-propylamine &gt; <em>N</em>-nitrosodibutylamine &gt; <em>N</em>-nitrosopyrrolidine. Exposure to <em>N</em>-nitrosamines significantly altered the activities of superoxide dismutase and catalase and increased malondialdehyde levels. Additionally, total protein and photosynthetic pigment contents were significantly inhibited, especially under high-concentration exposure, leading to severe impairment of algal photosynthesis and growth. Toxicity modelling indicated that the quaternary mixture exhibited an additive effect on algal toxicity, with an inhibition of 15.6 % at environmental concentrations. However, risk quotients modeled using ECOSAR were significantly overestimated compared to experimental toxicity data. Risk assessments based on measured levels of <em>N</em>-nitrosamines in Pearl River Delta freshwater systems indicated that the risk quotients were all below 0.1. Nevertheless, the ecological risks posed by <em>N</em>-nitrosamines in mixture forms were slightly higher. This study represents the first systematic investigation into the hazardous effects of <em>N</em>-nitrosamines on algae and provides a scientific evaluation of their potential risks to freshwater ecosystems using experimental data<em>.</em></div></div>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"296 ","pages":"Article 118179"},"PeriodicalIF":6.2,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143848193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Particulate matter-shaped Th17 cell plasticity impairs the colonic mucus layer","authors":"Bin Li ,&nbsp;Nannan Huang ,&nbsp;Jing Wang ,&nbsp;Xianan Zhang ,&nbsp;Qingtao Meng ,&nbsp;Shenshen Wu ,&nbsp;Rui Chen","doi":"10.1016/j.ecoenv.2025.118219","DOIUrl":"10.1016/j.ecoenv.2025.118219","url":null,"abstract":"<div><div>The intestine is one of the target organs upon ambient particulate matter (PM) exposure. However, the mechanism underlying PM-induced colonic injury remains unexplained. The present study emphasizes the significance of adaptive T cells crossing circulation-intestine signaling during PM exposure. To investigate this, mononuclear cells in circulation and intestine were isolated and exposed to PM <em>ex vivo</em>. We found that the PM-induced peripheral inflammatory microenvironment promoted inflammatory polarization of T helper 17 (Th17) cells in circulation and intestine in sequence. Further animal models and the Th17 cell adoptive transfer model showed that PM exposure induced the loss of colonic mucus through priming inflammatory Th17 cells <em>in vivo</em>. Mechanistically, PM exposure activated aryl hydrocarbon receptor (AhR) signaling and transcriptionally induced retinoic acid receptor-related orphan receptor C (RORC) expression in circulation Th17 cells, subsequently activating and polarizing colonic Th17 cells, ultimately resulting in the loss of colonic mucus. Moreover, Interleukin (IL)-6 knockout resisted PM exposure-induced colonic injury via inhibiting differentiation of Th17 cells. To conclude, the study results provide clarification on the processes of PM-related immunology response in the colon and the mechanism aiding the development of novel intervention strategies to maintain homeostasis in the colon.</div></div>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"296 ","pages":"Article 118219"},"PeriodicalIF":6.2,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143848489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Roles and mechanisms of boron in reducing cadmium accumulation in crops","authors":"Yingying Huang ,&nbsp;Qiong Liao ,&nbsp;Xuesong Wang ,&nbsp;Huiling Fu ,&nbsp;Baifei Huang ,&nbsp;Junliang Xin ,&nbsp;Chuang Shen","doi":"10.1016/j.ecoenv.2025.118216","DOIUrl":"10.1016/j.ecoenv.2025.118216","url":null,"abstract":"<div><div>Cadmium (Cd) contamination in farmland soil has become a global environmental concern, resulting in Cd pollution in crops. It is urgent to address this issue, and recent research has suggested that exogenous application of nutrient elements, including boron (B), is an effective strategy to decrease Cd accumulation in crops. Boron, an essential micronutrient for plants, plays a key role in maintaining cell integrity, promoting nitrogen metabolism, and enhancing nutrient absorption. Boron enhances Cd tolerance and reduces Cd accumulation in crops by regulating ROS homeostasis, heavy metal transport proteins, and promoting Cd chelation onto cell walls. However, the precise mechanism by which B regulates Cd accumulation remains unclear. This paper summarizes the physiological, biochemical, and molecular mechanisms by which B regulates Cd accumulation in crops. We believe that the rational application of B in light to moderate Cd-contaminated areas could effectively reduce Cd accumulation in crops, ensuring the safety of agricultural products in these regions.</div></div>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"296 ","pages":"Article 118216"},"PeriodicalIF":6.2,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143843457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of ambient air pollution exposure during preconception and pregnancy on risk of gestational diabetes mellitus: A retrospective cohort study in China","authors":"Min Li ,&nbsp;Jiayi Shi ,&nbsp;Xiaoping Fei ,&nbsp;Xiaohong Chen ,&nbsp;Yupei Shen ,&nbsp;Qianxi Zhu ,&nbsp;Zhaofeng Zhang ,&nbsp;Yanyan Mao ,&nbsp;Difei Wang ,&nbsp;Siyu Yi ,&nbsp;Rui Zhao ,&nbsp;Yixiang Zhu ,&nbsp;Jing Du","doi":"10.1016/j.ecoenv.2025.118217","DOIUrl":"10.1016/j.ecoenv.2025.118217","url":null,"abstract":"<div><div>The association between air pollution exposure and gestational diabetes mellitus (GDM) have been studied extensively; however, conclusions regarding the sensitive exposure period and effect of exposure remain inconsistent. We conducted a retrospective cohort study involving 2593 pregnant participants from Kunshan, China. Daily concentrations of particulate matter less than 2.5 μm (PM_2.5) and less than 10 μm (PM₁₀), carbon monoxide (CO), nitrogen dioxide (NO₂), and sulfur dioxide (SO₂) data were collected from the nearest air quality monitoring stations based on each participant’s address. Average pollutant concentrations were then calculated for various window periods. The prevalence rate of GDM was 11.7 %. The first trimester was identified as a critical exposure window using distributed lag non-linear models. Quantile-based g-computation analysis revealed that exposure to a mixture of the five pollutants during the first trimester was significantly associated with GDM risk. Specifically, each quartile increase in combined exposure was associated with a 45 % increased risk of GDM (RR=1.45, 95 % CI: 1.24, 1.70), primarily driven by SO₂ (31.6 %), PM_2.5 (31.6 %), CO (22.0 %), and PM₁₀ (14.8 %). This effect was not observed for exposure to any single pollutant alone. Our study expands the methodology for assessing air pollution exposure and deepens scientific understanding of its impact on pregnancy outcomes.</div></div>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"296 ","pages":"Article 118217"},"PeriodicalIF":6.2,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143843455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intervention effects of greenspace exposure on human microbiota: A randomized controlled trial in Chinese young adults","authors":"Lu Wang ,&nbsp;Jun-Yi Li ,&nbsp;Xiao-Qi Zhu ,&nbsp;Jian-Cheng Jiang ,&nbsp;Chuang Li ,&nbsp;Zi-Han Zheng ,&nbsp;Zhi Wang ,&nbsp;Tian-Yu Zhao ,&nbsp;Iana Markevych ,&nbsp;Joachim Heinrich ,&nbsp;Payam Dadvand ,&nbsp;Matthew H.E.M. Browing ,&nbsp;Chen Chen ,&nbsp;Ji-Lin Huang ,&nbsp;Guang-Hui Dong ,&nbsp;Bo-Yi Yang","doi":"10.1016/j.ecoenv.2025.118183","DOIUrl":"10.1016/j.ecoenv.2025.118183","url":null,"abstract":"<div><div>Enriching human microbiota has been proposed as a mechanism by which greenspace exposure improves human health. The existing evidence is scarce with few studies able to evaluate causality. We conducted a randomized controlled trial of 30 healthy undergraduate students to explore the intervention effects of greenspace on human gut and oral microbiota alpha-diversity, composition, differential genera and functional pathways. The study participants were divided into three groups, including outdoor greenspace (GS) group, outdoor non-greenspace (NGS) group, and indoor group, who visited a park, an open space without vegetation, and a classroom, respectively, for two hours per day over seven days. Differences in microbial alpha-diversity and composition across various groups were tested using Wilcoxon test and permutational multivariate analysis of variance, respectively. Linear discriminant analysis effect size analysis was performed to test differences in genera and functional pathways. Greenspace intervention significantly increased gut microbiota alpha-diversity, especially the observed Amplicon Sequence variant indexes and the Faith indexes (both <em>p</em> &lt; 0.05). In addition, the intervention substantially changed the composition of gut microbiota, of which the relative abundances of potentially beneficial bacteria increased. Further, the greenspace intervention affected several functional pathways of gut microbiota, including “substance dependence”, “specific types of cancer”, and “viral infectious diseases”. However, we did not find any significant effect of greenspace intervention on oral microbiota. Our results suggest that greenspace intervention diversifies the gut microbiota and alters its composition. These findings could help to reinforce the potential of increasing people’s access to greenspace as a public health intervention.</div></div>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"296 ","pages":"Article 118183"},"PeriodicalIF":6.2,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143843456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The mitochondrial dysfunction regulated by JAK2/STAT3 pathway leads to the necroptosis in the renal cells under patulin exposure","authors":"Yun Liu ,&nbsp;Ruhan Yi ,&nbsp;Xu Zhang ,&nbsp;Xiance Sun ,&nbsp;Jing Li ,&nbsp;Ningning Wang ,&nbsp;Xiaofeng Yao ,&nbsp;Cong Zhang ,&nbsp;Haoyuan Deng ,&nbsp;Shaopeng Wang ,&nbsp;Guang Yang","doi":"10.1016/j.ecoenv.2025.118202","DOIUrl":"10.1016/j.ecoenv.2025.118202","url":null,"abstract":"<div><div>Patulin (PAT) is a common mycotoxin widely found in various agricultural products and fruits, which has obvious toxic effects on animals and humans. Some studies have shown that PAT can cause nephrotoxicity, but the exact mechanism remains to be elucidated. In the present study, we investigated PAT-induced nephrotoxicity and the possible molecular mechanisms involved in its action. <em>In vivo</em>, the results showed that PAT affected the integrity of the glomerular basement membrane and peduncles, leading to necroptosis. We further demonstrated that PAT up-regulated the expression of JAK2, STAT3, RIPK1, RIPK3, and MLKL. This observation was also confirmed in MPC-5 cells. <em>In vitro</em>, pretreatment with Nec-1 (a specific inhibitor of necroptosis) or si-STAT3 resulted in a significant reduction in necroptosis and improved mitochondrial dysfunction. Notably, the pharmacological protection of mitochondrial function by SS-31 significantly attenuated the onset of PAT-induced necroptosis. Taken together, our study suggested that STAT3 activation, and mitochondrial dysfunction played critical roles in PAT-induced necroptosis in the kidney. These findings revealed the mechanisms by which PAT triggered necroptosis, potentially providing a new therapeutic strategy for PAT poisoning.</div></div>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"296 ","pages":"Article 118202"},"PeriodicalIF":6.2,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143838730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revealing the role of bisphenol A on prostate cancer progression and identifying potential targets: A comprehensive analysis from population cohort to molecular mechanism","authors":"Xianghong Zhou ,&nbsp;Chuzhong Wei ,&nbsp;Xing Liu ,&nbsp;Zilong Zhang ,&nbsp;Yuwei Wu ,&nbsp;Bin Zeng ,&nbsp;Yumin Jin ,&nbsp;Yixiao Shi ,&nbsp;Zengnan Mo ,&nbsp;Jiwen Cheng ,&nbsp;Xiaoli Zou ,&nbsp;Qiang Wei ,&nbsp;Lu Yang ,&nbsp;Shi Qiu","doi":"10.1016/j.ecoenv.2025.118209","DOIUrl":"10.1016/j.ecoenv.2025.118209","url":null,"abstract":"<div><div>Bisphenol A (BPA) is a widespread environmental pollutant whose exact effects on prostate cancer (PCa) progression remain understudied. This study aims to investigate the effect and underlying molecular mechanisms between BPA exposure and PCa in a comprehensive approach. The multicenter cohort study found that BPA exposure plays an important role in promoting biochemical recurrence and death of PCa. BPA exposure significantly promoted PCa progression in both the animal model and in vitro experiments. RNA sequencing revealed a disruption of mitochondrial energy homeostasis in BPA-treated cells. In multiple datasets, 17 prognostic genes such as PFKFB4 were obtained to construct and verify a mitochondrial energy metabolism Score system. Based on network toxicology methods and transcriptome sequencing data, ESR1 was identified as a potential transcription factor targeting glycolytic enzyme PFKFB4 under BPA exposure. With the support of lncRNA and circRNA sequencing data, a molecular regulatory network of BPA promoting prostate cancer through mitochondrial energy metabolism reprogramming was constructed. Further molecular docking revealed that BPA has higher binding free energy to ERα than its natural ligand estradiol. Given the widespread presence of BPA in the environment, minimizing exposure to this chemical could represent a feasible approach in improving clinical outcomes.</div></div>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"296 ","pages":"Article 118209"},"PeriodicalIF":6.2,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143838727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Organic pollutants in a large shallow lake, and the potential of the local quagga mussel population for their removal","authors":"Csilla Balogh ,&nbsp;Nóra Faragó ,&nbsp;Tamás Faludi ,&nbsp;Zsófia Kovács ,&nbsp;Jarosław Kobak ,&nbsp;Zoltán Serfőző","doi":"10.1016/j.ecoenv.2025.118201","DOIUrl":"10.1016/j.ecoenv.2025.118201","url":null,"abstract":"<div><div>Filter feeders, like mussels, can significantly lower the concentration of harmful substances in the water body. In the present study, we examined the distribution of organic pollutants (polycyclic aromatic hydrocarbons [PAHs], non-steroidal anti-inflammatory drugs [NSAIDs]) in Lake Balaton, the largest shallow lake of Central Europe. We also investigated the sensitivity of the invasive quagga mussel to these substances and its potential to reduce their concentration in the water column. Our findings show that organic pollutant levels in Lake Balaton were generally below concentrations known to harm mussels, as indicated by the stress gene activity patterns observed along the lake’s longitudinal axis. However, in the most urbanized eastern part of the lake, especially in spring, we detected signs of environmental contamination from certain pollutants (e.g. diclofenac), highlighting potential risks to local ecosystems and communities. Removal capacity of the mussels for PAHs reached the maximum after four days of exposure to 5–10 % diluted water accommodated fraction of fuel-oil fraction #4 when the mussels (20 ind. L⁻¹) reduced the PAH level by 100–85 %. Mussels (50 ind. L⁻¹) removed 28 % and 21 % of ibuprofen and ketoprofen, respectively, from 1 µg L⁻¹ concentrated solutions within 24 h. Many of the stress response genes were activated in the quagga mussel after their exposure to PAHs. These results suggest a significant role of gregarious invasive bivalves in the removal of organic pollutants from lake water.</div></div>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"296 ","pages":"Article 118201"},"PeriodicalIF":6.2,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143838731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liver organoids uncover tire-derived 6-PPDQ-induced hepatotoxicity of: A preliminary application of environmental toxicology and safety assessment","authors":"Yiling Ge ,&nbsp;Sheng Yang ,&nbsp;Tianyi Zhang ,&nbsp;Kai Luo ,&nbsp;Juan Zhang ,&nbsp;Yuan Wei ,&nbsp;Yuepu Pu ,&nbsp;Zaozao Chen ,&nbsp;Geyu Liang","doi":"10.1016/j.ecoenv.2025.118215","DOIUrl":"10.1016/j.ecoenv.2025.118215","url":null,"abstract":"<div><div>The novel pollutant, N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine quinone (6-PPDQ) leaked out of the tire and has attracted extensive concerns due to its high lethal toxicity of salmon. However, the potential hepatotoxicity of 6-PPDQ exposure and its mechanisms are unknown. As a novel 3D cell culture, liver organoids (LOs) are more similar to real organ invitro in structure and function, which showed great potential for toxicity assessment. Herein, stable LOs were generated and their applicability on hepatotoxicity assessment was evaluated with four hepatotoxic compounds. The negative effect of 6-PPDQ was explored in LOs, live/dead staining visually demonstrated the damage to the liver, and the changes of ATP, LDH, ALT, and AST effectively reflected its hepatotoxicity. Meanwhile, machine learning-based quantitative assessments of LOs morphology changes provided objective data on area, circularity, and luminance changes, enabling sensitive detection of 6-PPDQ-induced hepatotoxicity. Furthermore, transcriptomic analysis revealed that the pathways related to DNA replication and repairment, cancers, and inflammation were significantly involved in the process of 6-PPDQ-induced liver injury; Disease enrichment analysis highlighted an increased risk of chronic liver diseases, and biliary atresia were validated by Cholyl-Lys-Fluorescein (CLF). Moreover, molecular docking analysis identified potential molecular targets of 6-PPDQ, including Slc6a9, Yes1, and Nos2. This study underscored the potential of LOs for toxicological studies and highlighted the toxic effects of 6-PPDQ on the liver, suggesting the need for further investigations to understand its long-term impact on human health.</div></div>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"296 ","pages":"Article 118215"},"PeriodicalIF":6.2,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143843585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights into the impact of different phytoremediation strategies on antibiotic resistance genes at the metagenomic level in real scenarios","authors":"Wei-Guo Zhang ,&nbsp;Sizhou Liang ,&nbsp;Yonghui Liao ,&nbsp;Guangcan Ran ,&nbsp;Shenyang Ji ,&nbsp;Yan Gao ,&nbsp;Zhongfang Lei","doi":"10.1016/j.ecoenv.2025.118211","DOIUrl":"10.1016/j.ecoenv.2025.118211","url":null,"abstract":"<div><div>Engineered phytoremediation strategies provide cost effective options for eliminating antibiotics and antibiotic resistance genes (ARGs) from wastewater. However, there is a knowledge gap in understanding the impact of these phytoremediation strategies on the on the diversity and composition of ARGs as well as the key driving biotic and biological factors of ARGs at the metagenomic level in real scenarios. Through metagenomic sequencing, this study demonstrates that phytoremediation with <em>Iris pseudacorus</em> L., <em>Myriophyllum verticillatum</em> L., <em>Eichhornia crassipes</em> (Mart.) Solms and <em>Oenanthe javanica</em> (Bl. DC) significantly alters the pattern of antibiotic resistome. This study is the first to reveal, at the omics level, that phytoremediation enhances the diversity of ARGs (3.2 %∼11.6 % improvement), despite reducing their absolute abundances. Furthermore, this study highlights that plant varieties have a significant impact on the performance of phytoremediation in mitigating ARGs. The non-dominant bacterial taxa, specifically Verrucomicrobia, Planctomycetes, and Actinobacteria, play a crucial role in shaping the pattern of the antibiotic resistome during the wastewater treatment. The changes in the total organic carbon, total nitrogen and antibiotics robustly influence the environmental behaviors of antibiotic resistome and microbiome. In summary, this study gives insight into the impact of different phytoremediation strategies on mitigating ARGs at the omics level in real scenarios.</div></div>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"296 ","pages":"Article 118211"},"PeriodicalIF":6.2,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143843583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}