Ecotoxicology and Environmental Safety最新文献

{"title":"Sodium chromate induces acute lung injury via mitogen-activated protein kinase–mediated oxidative stress and inflammation","authors":"Sangryul Cha ,&nbsp;Jooyeon Lee ,&nbsp;Jimin Jang ,&nbsp;Youngcheol Kim ,&nbsp;Dahee Han ,&nbsp;Han Pil Lee ,&nbsp;Seok-Ho Hong ,&nbsp;Seung-Jin Kim ,&nbsp;Se-Ran Yang","doi":"10.1016/j.ecoenv.2025.119090","DOIUrl":"10.1016/j.ecoenv.2025.119090","url":null,"abstract":"<div><div>Sodium chromate (Na₂CrO₄), commonly used in industrial processes, poses significant health hazards due to its well-documented pulmonary toxicity. Despite its known environmental impact, the molecular mechanisms underlying Na₂CrO₄-induced acute lung injury (ALI) remain poorly understood. This study investigates the role of oxidative stress and key inflammatory pathways in Na₂CrO₄-induced pulmonary toxicity both <em>in vivo</em> and <em>in vitro</em>. <em>In vivo</em> C57BL/6 mice were intratracheally exposed to varying doses of Na₂CrO₄ (1–25 mg/kg) to assess lung inflammation, oxidative stress, and tissue damage. Histological analysis, bronchoalveolar lavage fluid (BALF) collection, and enzyme-linked immunosorbent assay (ELISA) were performed to quantify immune cell infiltration and cytokine production (IL-6 and TNF-α). <em>In vitro</em>, MLE-12 alveolar epithelial cells were treated with Na₂CrO₄ to evaluate cytotoxicity, apoptosis, and oxidative stress using MTT, Annexin V/PI staining, and DCF-DA assays. The involvement of NF-κB and MAPK pathways was analyzed via Western blotting, with pathway-specific inhibitors applied to dissect their roles. Na₂CrO₄ exposure induced acute lung inflammation characterized by neutrophil infiltration, increased lung weight-to-body weight ratio, and elevated IL-6 and TNF-α levels. Significant oxidative stress was observed, while NF-κB activation was limited, and robust activation of the MAPK signaling pathway was detected. Pharmacological inhibition of these pathways significantly mitigated Na₂CrO₄-induced pulmonary toxicity. This study highlights oxidative stress and MAPK pathway activation as central mechanisms in Na₂CrO₄-induced pulmonary toxicity. The findings underscore the potential of targeting MAPK signaling to mitigate heavy metal-induced lung injury and emphasize the public health risks associated with environmental Na₂CrO₄ exposure.</div></div>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"304 ","pages":"Article 119090"},"PeriodicalIF":6.1,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145156266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of per- and polyfluoroalkyl substances on glucose and lipid metabolism in healthy adults: The moderating role of caffeine consumption","authors":"Yaqi Xu ,&nbsp;Liyi Zhang ,&nbsp;Pengpeng Wang ,&nbsp;Yuhan Zhou ,&nbsp;Qiang Li ,&nbsp;Hang Wang ,&nbsp;Yue Zhao ,&nbsp;Yashuo Xie ,&nbsp;Feng Wang ,&nbsp;Yingya Zhao ,&nbsp;Yunhui Zhang","doi":"10.1016/j.ecoenv.2025.119092","DOIUrl":"10.1016/j.ecoenv.2025.119092","url":null,"abstract":"<div><div>Per- and polyfluoroalkyl substances (PFAS) are persistent environmental pollutants associated with cardiometabolic diseases, characterized by disruptions in glucose and lipid metabolism. However, comprehensive studies assessing metabolic abnormalities, particularly novel insulin resistance (IR) indices, remain limited. Additionally, caffeine intake is a common lifestyle factor, its potential to modulate PFAS-induced metabolic disturbances remains poorly understood. This cross-sectional study investigated 3468 U.S. adults from NHANES (2007–2018) to assess associations between PFAS and glucose-lipid biomarkers, including total cholesterol (TC), triglyceride, low-density lipoprotein (LDL), high-density lipoprotein, homeostasis model assessment of IR (HOMA-IR), β-cell function (HOMA-β), and triglyceride-glucose indices (TyG, TyG-BMI), while exploring the moderating effect of caffeine intake. Among the seven PFAS analyzed, five (PFOS, PFOA, PFNA, PFDA, and PFUnA) were significantly associated with elevated TC and LDL levels in multivariable survey-weighted regression models. These PFAS compounds were also positively correlated with glucose metabolism indicators, including HOMA-β (β = 7.95, 95 % CI: 1.72, 14.18 for PFNA; β = 7.56, 95 % CI: 1.57, 13.55 for PFOA; β = 7.56, 95 % CI: 2.77, 12.35 for PFOS), the TyG index (β = 0.05, 95 % CI: 0.01, 0.08 for PFNA; β = 0.07, 95 % CI: 0.03, 0.11 for PFOA; β = 0.06, 95 % CI: 0.02, 0.10 for PFOS), and TyG-BMI (β = 1.28, 95 % CI: 0.22, 2.35 for MPAH; β = 1.24, 95 % CI: 0.24, 2.25 for PFNA; β = 2.02, 95 % CI: 1.01, 3.02 for PFOA; β = 1.78, 95 % CI: 0.54, 3.02 for PFOS). Interaction analysis revealed that caffeine intake significantly moderated PFAS associations with LDL, with stronger positive associations observed in the low caffeine intake group. These findings suggest that PFAS exposure may disrupt lipid and glucose metabolism, particularly increased LDL and IR. Caffeine may attenuate some PFAS-related lipid disturbances, underscoring the need for further investigation into its protective role.</div></div>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"304 ","pages":"Article 119092"},"PeriodicalIF":6.1,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145156155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GenX induces neuroinflammatory responses in BV2 microglial cells through mTOR signaling-mediated inhibition of autophagy","authors":"Euijun Min ,&nbsp;Minjeong Kim ,&nbsp;Moon Yi Ko ,&nbsp;Sung-Ae Hyun ,&nbsp;Minhan Ka","doi":"10.1016/j.ecoenv.2025.119107","DOIUrl":"10.1016/j.ecoenv.2025.119107","url":null,"abstract":"<div><div>Hexafluoropropylene oxide dimer acid (HFPO-DA), commonly known as GenX, can traverse the blood-brain barrier and infiltrate brain tissue, leading to nervous system damage that primarily manifests as neuroinflammation and neuronal apoptosis. Despite these mounting concerns, few studies have comprehensively examined the molecular neurotoxic mechanisms of GenX exposure. In the present study, we examined the neuroinflammatory responses induced by GenX in BV2 microglial cells. Our results revealed that GenX exposure suppressed autophagy in BV2 microglial cells. We further demonstrated that GenX exposure stimulated the PI3K/AKT/mTOR signaling pathway in BV2 microglial cells. Most significantly, GenX exposure enhanced the expression of pro-inflammatory cytokines in BV2 microglial cells. Additionally, we found that rapamycin treatment, which acts as an mTOR inhibitor, reversed the GenX-mediated enhancement of pro-inflammatory cytokines by restoring the inhibited autophagy in BV2 microglial cells. In summary, our findings demonstrate that GenX stimulates pro-inflammatory cytokine production through PI3K/AKT/mTOR-mediated suppression of autophagy. Consequently, therapeutic targeting of the PI3K/AKT/mTOR pathway may serve as a viable treatment strategy for microglia-mediated neuroinflammation.</div></div>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"304 ","pages":"Article 119107"},"PeriodicalIF":6.1,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145156264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in the bioaccumulation and toxicity of monomeric Al and nano-Al13 in the organs of Corbicula fluminea","authors":"Peiwen Shi ,&nbsp;Yuehan Wu ,&nbsp;Chenghong Feng","doi":"10.1016/j.ecoenv.2025.119120","DOIUrl":"10.1016/j.ecoenv.2025.119120","url":null,"abstract":"<div><div>The chemical reactivity and toxicity of aluminum are related to its speciation, but the differences in bioaccumulation and toxic mechanisms between different Al species remain unclear. In this study, <em>Corbicula fluminea</em> was exposed to polymeric Al (nano-Al₁₃) and monomeric Al (Al_m) to compare their accumulation kinetics and toxicity responses in different organs. Results showed that gills accumulated more Al than digestive glands. Al_m exhibited a slower discharge rate in the gills, whereas Al₁₃ was excreted more slowly from the digestive glands. Higher Al concentrations cause irreversible damage to gill nerves, while the digestive glands could adapt to external Al stress by behavioral regulation. Significant differences existed in the toxic effects of Al_m and Al₁₃. Al_m obstructed gill filament pores, causing swelling and deformation, resulting in pronounced mechanical damage and significant siphoning inhibition. Al₁₃ more easily adhered to gill valve surfaces, exerting milder interference with gill tissue structure and physiological activities, but having more noticeable impacts on the nervous system. AChE inhibition by Al primarily affected gill nerves, diminishing the continuous Al uptake intensity, while potentially stimulating nerves in the digestive gland to promote the expulsion of accumulated Al. These findings reveal distinct organ-specific responses of Al species, contributing to a better understanding of their environmental risks and informing safety assessments of residual Al in aquatic systems.</div></div>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"304 ","pages":"Article 119120"},"PeriodicalIF":6.1,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145156596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formation of environmentally persistent free radicals on molecular sieves: The role of Lewis acid sites","authors":"Hao Li,&nbsp;Wenjun Duan,&nbsp;Hao Jiang,&nbsp;Manling Zhang,&nbsp;Di Lang,&nbsp;Wei Du,&nbsp;Zhaofeng Chang,&nbsp;Peng Zhang,&nbsp;Bo Pan","doi":"10.1016/j.ecoenv.2025.119121","DOIUrl":"10.1016/j.ecoenv.2025.119121","url":null,"abstract":"<div><div>Environmental persistent free radicals (EPFRs) generated on metal oxide surfaces have garnered significant research interest due to their environmental persistence and biological toxicity. While the catalytic role of Lewis acid sites (LAS) in EPFR formation has been hypothesized, the specific mechanisms underlying LAS-mediated generation at ambient temperature remain poorly understood. This investigation systematically elucidates the critical role of LAS concentration in molecular sieves for EPFR formation through polycyclic aromatic hydrocarbons (PAHs) adsorption under ambient conditions. Our results demonstrate that EPFR generation efficiency follows a distinct hierarchy among ultra-stable Y-type (USY) molecular sieves: USY(5.4) &gt; USY(11) &gt; USY(8), showing a strong positive correlation (p &lt; 0.05) with LAS concentration. The absence of detectable EPFR signals on silica controls confirms LAS as essential active sites for radical stabilization. The concentration of EPFRs generated by different PAHs on the molecular sieve follows the order of pyrene (PYR) &gt; anthracene (ANT) &gt; phenanthrene (PHE) &gt; naphthalene (NAP), which was negatively correlated (p &lt; 0.05) with the ionization potential (IP) of PAHs. This indicates that the electron transfer ability of PAH also affects the generation of EPFRs. In addition, the acute toxicity of EPFRs was evaluated using Photobacterium phosphoreum T3 (PPT₃), and the inhibition rate of the luminescent bacteria was positively correlated with concentration of EPFRs and the mediated generation of ROS. The results of this study can contribute to the understanding of the generation mechanism and environmental risks of EPFRs.</div></div>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"304 ","pages":"Article 119121"},"PeriodicalIF":6.1,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145156154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanistic modeling of chemical bioaccumulation in aquatic invertebrates: A shrimp-based demonstration","authors":"Shaorong Chen,&nbsp;Jie Xiong,&nbsp;Zijian Li","doi":"10.1016/j.ecoenv.2025.119101","DOIUrl":"10.1016/j.ecoenv.2025.119101","url":null,"abstract":"<div><div>Understanding the mechanisms of chemical bioaccumulation in aquatic invertebrates is fundamental to ecological toxicology, as contaminant retention in key species shapes exposure pathways and trophic transfer within aquatic ecosystems. In this study, we developed a physiologically based kinetic (PBK) model to quantify the bioaccumulation factors (BAF) of 101 organic contaminants in adult white-leg shrimp (Litopenaeus vannamei). The model subdivides the organism into hemolymph, digestive tract, gills, muscle, shell, and eggs, and simulates uptake through gill respiration and dietary intake, together with elimination via respiratory exchange, fecal excretion, growth dilution, molting, and spawning. Predictions showed overall good agreement with reported BAF, with 50–80 % of chemicals deviating by less than one order of magnitude. Performance was highest for brominated flame retardants (BFRs) and other hydrophobic compounds (Log K_ow 4–6), whereas substantial biases occurred for Per- and polyfluoroalkyl substances (PFAS) and certain pesticides, likely due to unmodeled metabolic processes and sediment–water interactions. Simulations identified gill and egg tissues as major accumulation sites, reflecting their lipid content and direct environmental exposure. Exposure pathways were chemical-specific: gill uptake dominated for most hydrophobic pollutants (&gt;94 %), while dietary intake was the principal contributor to PFAS accumulation in the digestive system (&gt;90 %). The nonlinear relationship between bioconcentration factor (BCF) and Octanol-Water Partition Coefficient (K_ow) suggested a threshold effect in bioavailability. Overall, this shrimp-based PBK model enhances mechanistic understanding of contaminant dynamics in crustaceans and provides a basis for evaluating chemical risks and exposure heterogeneity in aquatic ecosystems.</div></div>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"304 ","pages":"Article 119101"},"PeriodicalIF":6.1,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145156269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-specific analyses of early-life tobacco smoke exposure and later-life irritable bowel syndrome: Sensitive window, mediation pathway, and genetic predisposition","authors":"Wenya Bai ,&nbsp;Yudan Zheng ,&nbsp;Yuru Pan ,&nbsp;Miaohong Zhuang ,&nbsp;Yiqiang Zhan ,&nbsp;Weiqing Chen ,&nbsp;Miao Liu","doi":"10.1016/j.ecoenv.2025.119099","DOIUrl":"10.1016/j.ecoenv.2025.119099","url":null,"abstract":"<div><div>Tobacco smoke can relax colonic smooth muscles and increase intestinal permeability, but whether early-life exposure affects later-life irritable bowel syndrome (IBS) and its underlying pathway remain unknown. We obtained the data from a large-scale cohort study in UK biobank, including information on age of smoking initiation (in utero period, childhood, adolescence, and adulthood), levels of C-reactive protein (CRP), genetic risk score (GRS), and IBS onset. We employed Cox proportional hazards models to examine the association between tobacco smoke exposure at different stages of life and incident IBS, and recognize the sensitive window. We further analyzed the interaction and joint effects of tobacco smoke exposure and GRS on IBS, as well as the mediation of CRP. Participants with initiating exposure to tobacco smoke in utero showed a higher IBS risk with hazard ratio (HR) of 1.149 (95 % CI: 1.093, 1.207), compared to unexposed individuals. Those who started smoking in childhood showed a greater risk with HR of 1.274 (95 % CI: 1.161, 1.399) than never smokers. Dose-response relationship showed the incident IBS increased with the earlier initiation and the longer duration of tobacco smoke. Notably, joint effect of initiating tobacco smoke at different stages presented participants initiating in utero and childhood had the strongest impact on IBS onset, with HR of 1.516 (95 % CI: 1.313, 1.751). The relations of early-life tobacco smoke exposure and IBS differed with genetic susceptibilities, being stronger in individuals with higher GRS. Furthermore, CRP partially mediated the associations of early-life tobacco smoke exposure at different stages of life with the incident IBS, with mediating proportions ranging from 5.73 % to 9.10 %. What’s more, these aforementioned relationships are more pronounced in females than males. Accordingly, early-life tobacco smoke exposure, particularly during utero period and childhood in females, elevated the IBS onset, differing with genetic predisposition and mediated by the inflammation pathway.</div></div>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"304 ","pages":"Article 119099"},"PeriodicalIF":6.1,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145119865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-cell RNA sequencing across diverse cell types to identify PFOA-induced ovarian cellular senescence","authors":"Ning Li ,&nbsp;Jiahao Hu ,&nbsp;Yuhan Zhao ,&nbsp;Jiaqi Tian ,&nbsp;Qiang Li ,&nbsp;Lin Zhang","doi":"10.1016/j.ecoenv.2025.119089","DOIUrl":"10.1016/j.ecoenv.2025.119089","url":null,"abstract":"<div><div>Perfluorooctanoic acid (PFOA) is a persistent environmental pollutant that has been associated with reproductive dysfunction, yet cellular mechanism underlying its ovarian toxicity remain poorly understood. From the perspective of cellular senescence, we conducted this study by establishing a murine (female ICR mice) PFOA exposure (10 mg/kg/day administered orally via gavage for 28 consecutive days), then examined changes in ovarian structure, cellular composition, and transcriptional profiles. Compared with the control group, we found significant reductions in follicle numbers across all developmental stages following PFOA exposure. To understand mechanisms underlying PFOA induced ovarian dysfunction, we performed single-cell RNA ovarian tissues and obtained 29,000 + cells with 8 distinct cell populations, where cumulus cells showed particular vulnerability to PFOA-induced depletion. Cell cycle analysis demonstrated widespread G1 phase accumulation, most prominently in granulosa and cumulus cells. Differential gene expression analysis revealed cell type-specific upregulation of senescence markers such as <em>Cdkn1a, Smoc2, and Igfbp4</em> in follicular somatic cells. Integration of transcriptional profiling with cell cycle analysis established a mechanistic link between PFOA exposure, cell cycle arrest, and premature cellular senescence, which directly corresponded to the observed follicular depletion and structural abnormalities in histological analysis. In conclusion, PFOA exposure triggers ovarian pathology partially through induction of cell type-specific senescence programs that disrupt normal follicular development and function, which highlights cellular senescence as a potential contributor to environmental pollutant-mediated reproductive dysfunction.</div></div>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"304 ","pages":"Article 119089"},"PeriodicalIF":6.1,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metagenomic profiling of antibiotic resistance genes in terrestrial ecosystems across China","authors":"Yulong Duan ,&nbsp;Junbiao Zhang ,&nbsp;Evangelos Petropoulos ,&nbsp;Jianhua Zhao ,&nbsp;Yun Chen ,&nbsp;Lilong Wang ,&nbsp;Xuyang Wang ,&nbsp;Rongliang Jia ,&nbsp;Fasi Wu ,&nbsp;Yuqiang Li","doi":"10.1016/j.ecoenv.2025.119096","DOIUrl":"10.1016/j.ecoenv.2025.119096","url":null,"abstract":"<div><div>Soil represents a significant reservoir of antibiotic resistance genes (ARGs), yet their distribution across diverse terrestrial ecosystems remains poorly characterized. To address this knowledge gap, we conducted a large-scale, cross-regional soil survey spanning 4300 km in China, collecting samples at 42 intervals across six distinct terrestrial ecosystems. High diversity (18 ARG types and 129 ARG subtypes) and abundance (mean value: 724.9 [coverage, ×/Gb]) of ARGs were observed in the topsoil (0–20 cm depth) across the six terrestrial ecosystems, with tetracycline resistance and efflux pump being the prevailing class and resistance mechanism respectively. Notably, only <em>aac</em> (6′)-I ranked among the highest-risk ARGs (Rank I), indicating that merely 0.78 % of detected ARGs pose a severe pathogenic threat. Meanwhile, horizontal gene transfer (HGT) is likely the primary transmission mechanism for ARGs in these soils. While most ARGs currently present minimal direct public health risks, their high transmission potential warrants attention. Furthermore, stochastic processes dominate the spread of soil ARGs, though both stochastic and deterministic processes contribute to the spread of their hosts. Collectively, these results provide timely insights into the resistance mode of soil ARGs in terrestrial ecosystems.</div></div>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"304 ","pages":"Article 119096"},"PeriodicalIF":6.1,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combining dissolved organic matter correlation and water quality parameters to unravel the fate of organophosphate esters in Uliastai Lake","authors":"Yu Qiao ,&nbsp;Weiying Feng ,&nbsp;Chenglian Feng ,&nbsp;Bo Ren ,&nbsp;Yao Li ,&nbsp;Jing Xue ,&nbsp;Shu Liu ,&nbsp;Wenhong Fan ,&nbsp;Su Kong Ngien ,&nbsp;Jos´e Manuel Gonçalves ,&nbsp;Isabel Maria Duarte","doi":"10.1016/j.ecoenv.2025.119061","DOIUrl":"10.1016/j.ecoenv.2025.119061","url":null,"abstract":"<div><div>Environmental risk of organophosphate esters (OPEs) have garnered increasing attention as emerging contaminants in the global world. However, there is limited understanding regarding the concentration of OPEs and the impact of eutrophication lakes. Therefore, this study comprehensively examined the distribution characteristics of OPEs in water and sediments of Uliastai Lake, analysed their potential sources and pathways, explored the correlations between OPEs and dissolved organic matter (DOM) and water quality parameters, and conducted a risk assessment of OPEs. The study revealed that the average concentration of Σ₁₁OPEs in the water was 694.71 ng/L, and the Σ₁₂OPEs in the sediments was 105.99 ng/g (dw). OPEs primarily originated from domestic and tourism-related waste, boat and architectural coatings, wastewater treatment plants, industrial effluent discharge and transportation emissions. Triethyl phosphate (TEP) showed significant negative correlations with dissolved oxygen and turbidity (p &lt; 0.05), whereas TEP, Tri (2-chloroethyl) phosphate (TCEP), Tri (2-chloroisopropyl) phosphate (TCPP) and alkyl-OPEs showed significant positive correlations with conductivity (p &lt; 0.05). In addition, alkyl-OPEs exhibited a significant negative correlation with the fluorescence index of DOM and a significant positive correlation with the freshness index. The risk assessment results indicated that TEP and TECP have ecological risks and require strengthened management and control. This study comprehensively analysed the environmental behaviour of OPEs, providing new insights into the migration and transformation of emerging contaminants.</div></div>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"304 ","pages":"Article 119061"},"PeriodicalIF":6.1,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}