Proceedings of the Eight Annual ACM International Conference on Nanoscale Computing and Communication最新文献_第2页

On the Co-Design of Quantum Software and Hardware 论量子软硬件协同设计

Proceedings of the Eight Annual ACM International Conference on Nanoscale Computing and Communication Pub Date : 2021-09-07 DOI: 10.1145/3477206.3477464

Gushu Li, Anbang Wu, Yunong Shi, Ali Javadi-Abhari, Yufei Ding, Yuan Xie

引用次数: 21

Application of MIMO Techniques in Macroscopic Air-based Molecular Communication MIMO技术在宏观空气基分子通信中的应用

Proceedings of the Eight Annual ACM International Conference on Nanoscale Computing and Communication Pub Date : 2021-09-07 DOI: 10.1145/3477206.3477465

Martin Damrath, Sunasheer Bhattacharjee, P. Hoeher

引用次数: 1

Cardiac Bio-Nanonetwork: Extracellular Vesicles Release Modeling for Engineered Stem Cell-Derived Cardiomyocyte 心脏生物纳米网络:工程干细胞衍生心肌细胞的细胞外囊泡释放模型

Proceedings of the Eight Annual ACM International Conference on Nanoscale Computing and Communication Pub Date : 2021-09-07 DOI: 10.1145/3477206.3477479

Hamid Khoshfekr Rudsari, M. Veletić, J. Bergsland, I. Balasingham

{"title":"Cardiac Bio-Nanonetwork: Extracellular Vesicles Release Modeling for Engineered Stem Cell-Derived Cardiomyocyte","authors":"Hamid Khoshfekr Rudsari, M. Veletić, J. Bergsland, I. Balasingham","doi":"10.1145/3477206.3477479","DOIUrl":"https://doi.org/10.1145/3477206.3477479","url":null,"abstract":"Molecular communication (MC) is an interdisciplinary research area with vast potential in biomedical applications, including delivery of drugs or other therapeutic molecules in cardiovascular and other pathological conditions. The bio-molecules release modeling in MC systems is an open problem in designing the physical and chemical signal interaction level in the MC hierarchy. This also includes the release of extracellular vesicles (EVs), which are shed by all cell types and serve as nano-vehicles carrying various molecular cargo. In this paper, we propose to use engineered human induced pluripotent stem cells differentiated into atrial cardiomyocytes (ACMs) in a cardiac bio-nanonetwork and mathematically model the release of therapeutic EVs under voltage clamp. We study the stochastic nature of the proposed targeted drug delivery system by modeling the release process from engineered ACMs as a Poisson process. We model the engineered ACMs as an EV emission model, where the input signal is the voltage clamp to modulate the EV release, and the output signal is the rate of released EVs. We also study the non-linearity of the proposed EV emission system by a non-linear autoregressive exogenous model. Future drug delivery applications for cardiovascular diseases can utilize the proposed EV release modeling for engineered ACMs.","PeriodicalId":303880,"journal":{"name":"Proceedings of the Eight Annual ACM International Conference on Nanoscale Computing and Communication","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122435781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Stochastic Spatially-Extended Simulations Predict the Effect of ER Distribution on Astrocytic Microdomain Ca2+ Activity 随机空间扩展模拟预测内质网分布对星形细胞微域Ca2+活性的影响

Proceedings of the Eight Annual ACM International Conference on Nanoscale Computing and Communication Pub Date : 2021-09-07 DOI: 10.1145/3477206.3477456

Audrey Denizot, C. Calì, H. Berry, E. Schutter

{"title":"Stochastic Spatially-Extended Simulations Predict the Effect of ER Distribution on Astrocytic Microdomain Ca2+ Activity","authors":"Audrey Denizot, C. Calì, H. Berry, E. Schutter","doi":"10.1145/3477206.3477456","DOIUrl":"https://doi.org/10.1145/3477206.3477456","url":null,"abstract":"Astrocytes are cells of the central nervous system that can regulate neuronal activity. Most astrocyte-neuron communication occurs at so-called tripartite synapses, where calcium signals are triggered in astrocytes by neuronal activity, resulting in the release of neuroactive molecules by the astrocyte. Most astrocytic Ca2+ signals occur in very thin astrocytic branchlets, containing low copy number of molecules, so that reactions are highly stochastic. As those sub-cellular compartments cannot be resolved by diffraction-limited microscopy techniques, stochastic reaction-diffusion computational approaches can give crucial insights on astrocyte activity. Here, we use our stochastic voxel-based model of IP3R-mediated Ca2+ signals to investigate the effect of the distance between the synapse and the closest astrocytic endoplasmic reticulum (ER) on neuronal activity-induced Ca2+ signals. Simulations are performed in three dimensional meshes characterized by various ER-synapse distances. Our results suggest that Ca2+ peak amplitude, duration and frequency decrease rapidly as ER-synapse distance increases. We propose that this effect mostly results from the increased cytosolic volume of branchlets that are characterized by larger ER-synapse distances. In particular, varying ER-synapse distance with constant cytosolic volume does not affect local Ca2+ activity. This study illustrates the insights that can be provided by three-dimensional stochastic reaction-diffusion simulations on the biophysical constraints that shape the spatio-temporal characteristics of astrocyte activity at the nanoscale.","PeriodicalId":303880,"journal":{"name":"Proceedings of the Eight Annual ACM International Conference on Nanoscale Computing and Communication","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117171472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

How molecular packets improve cell-to-cell communication 分子包如何改善细胞间的通讯

Proceedings of the Eight Annual ACM International Conference on Nanoscale Computing and Communication Pub Date : 2021-09-07 DOI: 10.1145/3477206.3477469

F. Pappalardo, N. Iraci, L. Leggio, A. Lombardo, G. Morabito

引用次数: 0

RAP-NoC: Reliability Assessment of Photonic Network-on-Chips, A simulator 光子片上网络的可靠性评估，仿真器

Proceedings of the Eight Annual ACM International Conference on Nanoscale Computing and Communication Pub Date : 2021-09-07 DOI: 10.1145/3477206.3477455

Meisam Abdollahi, M. Baharloo, Fateme Shokouhinia, M. Ebrahimi

{"title":"RAP-NoC: Reliability Assessment of Photonic Network-on-Chips, A simulator","authors":"Meisam Abdollahi, M. Baharloo, Fateme Shokouhinia, M. Ebrahimi","doi":"10.1145/3477206.3477455","DOIUrl":"https://doi.org/10.1145/3477206.3477455","url":null,"abstract":"Nowadays, optical network-on-chip is accepted as a promising alternative solution for traditional electrical interconnects due to lower transmission delay and power consumption as well as considerable high data bandwidth. However, silicon photonics struggles with some particular challenges that threaten the reliability of the data transmission process. The most important challenges can be considered as temperature fluctuation, process variation, aging, crosstalk noise, and insertion loss. Although several attempts have been made to investigate the effect of these issues on the reliability of optical network-on-chip, none of them modeled the reliability of photonic network-on-chip in a system-level approach based on basic element failure rate. In this paper, an analytical model-based simulator, called Reliability Assessment of Photonic Network-on-Chips (RAP-NoC), is proposed to evaluate the reliability of different 2D optical network-on-chip architectures and data traffic. The experimental results show that, in general, Mesh topology is more reliable than Torus considering the same size. Increasing the reliability of Microring Resonator (MR) has a more significant impact on the reliability of an optical router rather than a network.","PeriodicalId":303880,"journal":{"name":"Proceedings of the Eight Annual ACM International Conference on Nanoscale Computing and Communication","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115034832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

DNA-Based Molecular Communication as a Paradigm for Multi-Parameter Detection of Diseases 基于dna的分子通讯是疾病多参数检测的范例

Proceedings of the Eight Annual ACM International Conference on Nanoscale Computing and Communication Pub Date : 2021-09-07 DOI: 10.1145/3477206.3477480

F. Lau, R. Wendt, Stefan Fischer

引用次数: 3

A Hardware Implementation of BitSurfing for Communication without Packet Creation 不创建包的位冲浪通信的硬件实现

Proceedings of the Eight Annual ACM International Conference on Nanoscale Computing and Communication Pub Date : 2021-09-07 DOI: 10.1145/3477206.3477466

D. Karagounis, C. Liaskos, A. Tsioliaridou, S. Ioannidis

引用次数: 0

Research Challenges in Implementation of Edge Interfaces for the Internet of Bio-Nano Things 生物纳米物联网边缘接口实现的研究挑战

Proceedings of the Eight Annual ACM International Conference on Nanoscale Computing and Communication Pub Date : 2021-09-07 DOI: 10.1145/3477206.3477476

Yutaka Okaie

引用次数: 0

Astrocytes in modulating subcellular, cellular and intercellular molecular neuronal communication 星形胶质细胞在调节亚细胞、细胞和细胞间分子神经元通讯中的作用

Proceedings of the Eight Annual ACM International Conference on Nanoscale Computing and Communication Pub Date : 2021-09-07 DOI: 10.1145/3477206.3477460

J. Hyttinen, B. Genocchi, A. Ahtiainen, J. Tanskanen, K. Lenk, Michael Taynnan Barros

引用次数: 0