Frontiers in Life Sciences and Related Technologies最新文献

Geçmişten Günümüze Potansiyel Hammadde Kaynağı: Likenler 从古至今的潜在原料来源：地衣

Frontiers in Life Sciences and Related Technologies Pub Date : 2023-12-26 DOI: 10.51753/flsrt.1402906

Orçun Toksöz

{"title":"Geçmişten Günümüze Potansiyel Hammadde Kaynağı: Likenler","authors":"Orçun Toksöz","doi":"10.51753/flsrt.1402906","DOIUrl":"https://doi.org/10.51753/flsrt.1402906","url":null,"abstract":"Likenler içerdikleri 1000’den fazla metabolite sayesinde antioksidan, antimikrobiyal, antifungal, instektisidal, antikanser ve boyar madde potansiyelleri gibi biyolojik etkinliklerinden dolayı çeşitli sektörlerde potansiyel bir hammadde kaynağı olarak tercih edilmektedir. Yüzlerce yıldır etnofarmakolojik olarak bir çok hastalığın tedavisinde halk arasında kullanılmasının yanı sıra günümüzde hala likenlerin ilaç potansiyelleri araştırılmaya devam edilmektedir. Likenlerin aromatik ve besleyici özellikleri nedeniyle, gıda sektöründe baharat, ekmekçilik, pastacılık ve çay olarak kullanımları devam etmektedir. Likenlerin ekonomik anlamda en önemli kullanım alanlarından biri olan boyar madde içerikleri nedeniyle başta tekstil sektörü olmak üzere bir çok sektörde tercih edilmektedir. Ayrıca tarımsal alanda ise fitopatojenlere karşı insektisidal ve antifungal etkinliğe sahip oldukları bilinmektedir. Likenlerin ve içerdikleri metabolitlerin yalnızca bir kısmının etkinlikleri biliniyor olsada, tüm özellikleri hala tam olarak aydınlatılmamıştır. Bu bağlamda, liken ve etken maddelerinin biyoaktivitelerinin gelecekte açığa çıkartılmasıyla birlikte, birçok sektörde potansiyel hammadde olarak kullanılması öngörülmektedir.","PeriodicalId":303081,"journal":{"name":"Frontiers in Life Sciences and Related Technologies","volume":"19 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139155350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endüstri 4.0 Sisteminin Kullanıldığı İşyerlerindeki Çalışanlar Üzerindeki Psikososyal Risk Etmenlerinin Çoklu Varyans Analizi (Manova) İle İncelenmesi; Makine ve Ekipman İmalatı Sektörü Örneği 利用多元方差分析（Manova）调查使用工业 4.0 系统的工作场所中员工的社会心理风险因素；以机械设备制造业为例

Frontiers in Life Sciences and Related Technologies Pub Date : 2023-12-01 DOI: 10.51753/flsrt.1374977

Fahri Oluk, Yasemin Demi̇r, Ecem Şahi̇ner, Ahmet Gökcan, H. Özcan, Göksel Demi̇r

{"title":"Endüstri 4.0 Sisteminin Kullanıldığı İşyerlerindeki Çalışanlar Üzerindeki Psikososyal Risk Etmenlerinin Çoklu Varyans Analizi (Manova) İle İncelenmesi; Makine ve Ekipman İmalatı Sektörü Örneği","authors":"Fahri Oluk, Yasemin Demi̇r, Ecem Şahi̇ner, Ahmet Gökcan, H. Özcan, Göksel Demi̇r","doi":"10.51753/flsrt.1374977","DOIUrl":"https://doi.org/10.51753/flsrt.1374977","url":null,"abstract":"Endüstri 4.0 sisteminin uygulanması neticesinde kullanılacak yeni teknolojiler sayesinde insan gücüne duyulan ihtiyacın ve istihdamın azalacağı varsayılmaktadır. Kullanılan teknolojilerin pozitif etkilerinin yanı sıra negatif etkilerinden de söz etmek mümkündür. Çalışanların bu teknolojilere uyum sağlamaları ve mesleki olarak becerilerinin geliştirmeleri sürecinde bilişsel yeteneklere ihtiyaç duyulacağından psikolojik olarak strese maruz kalınması söz konusu olacaktır. Bu sebeple çalışmamızda Endüstri 4.0 sisteminin kullanıldığı iş yerlerindeki çalışanların maruz kalabileceği psikososyal risklerin incelenmesi amaçlanmıştır. Çalışmanın evrenini makine ekipman imalatı sektöründe Endüstri 4.0 sisteminin kullanıldığı iş yerleri oluşturmaktadır. Belirlenen sektör çalışanlarından elde edilen veriler ile SPSS 26.0 programı kullanılarak normallik testi, faktör analizi ve çoklu varyans analizi gerçekleştirilmiştir. Elde edilen bulgulara göre çalışanların psikososyal risklere ait değerlendirmeleri öğrenim düzeylerine , yaş gruplarına ve tecrübelerine göre ölçeğin alt faktörlerinden en az birisi ile farklılık gösterdiği sonucuna ulaşılmıştır. Elde edilen sonuçlar, sektördeki psikososyal risklerle mücadele edebilmek için önemli ipuçları sağlayacaktır.","PeriodicalId":303081,"journal":{"name":"Frontiers in Life Sciences and Related Technologies","volume":"16 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139187734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determination of Antioxidant Activities of Plant Species Growing in (Serpentine, Gypsum, Limestone) Different Habitats 测定生长在（蛇纹石、石膏、石灰石）不同生境中的植物物种的抗氧化活性

Frontiers in Life Sciences and Related Technologies Pub Date : 2023-11-22 DOI: 10.51753/flsrt.1357325

Tugce Varol, E. Osma, Samed Şi̇mşek, M. Elveren

引用次数: 0

Determination of Antioxidant, Antimicrobial Activities, Total Phenolic and Flavonoid Contents of Allium rumelicum, Jurinea kilaea, Peucedanum obtusifolium 测定薤白、茱丽叶和牡丹的抗氧化、抗菌活性、总酚和类黄酮含量

Frontiers in Life Sciences and Related Technologies Pub Date : 2023-11-22 DOI: 10.51753/flsrt.1365203

A. Karasakal, Orhan Kiliç, Nazan Tokatlı Demirok, E. Cabi̇

{"title":"Determination of Antioxidant, Antimicrobial Activities, Total Phenolic and Flavonoid Contents of Allium rumelicum, Jurinea kilaea, Peucedanum obtusifolium","authors":"A. Karasakal, Orhan Kiliç, Nazan Tokatlı Demirok, E. Cabi̇","doi":"10.51753/flsrt.1365203","DOIUrl":"https://doi.org/10.51753/flsrt.1365203","url":null,"abstract":"A microwave-assisted extraction (MAE) process for polyphenols from Allium rumelicum Koçyigit & Özhatay, Jurinea kilaea Azn., Peucedanum obtusifolium Sibth. & Sm. was used. This research examined the methanolic extracts made from these three species' antioxidant, antimicrobial, total phenolic, and flavonoid contents. By using the 2,2-diphenyl-1-picryl-hydrazyl-hydrate free radical method (DPPH), ABTS/Persulfate, and Cupric reducing antioxidant capacity (CUPRAC) methods, the total antioxidant activities and capacities were examined. Additionally, the Folin-Ciocalteu and AlCl3/KAc techniques were used to calculate the total phenolic and flavonoid contents. In order to ascertain the antibacterial capabilities of plants, the disc diffusion method was applied. The Jurinea kilaea showed the greatest total antioxidant capacity/activity levels when measured using the CUPRAC and ABTS/Persulfate techniques. The Allium rumelicum was found to have the highest quercetin concentration, while Peucedanum obtusifolium had the lowest. In Jurinea kilaea, the gallic acid concentration was greatest.The highest antimicrobial activity values were obtained in Peucedanum obtusifolium","PeriodicalId":303081,"journal":{"name":"Frontiers in Life Sciences and Related Technologies","volume":"8 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139248106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Infuse Herbal Oils: A Comparative Study of Wheat Germ and Tomato Seed Oils 注入草药油:小麦胚芽油和番茄籽油的比较研究

Frontiers in Life Sciences and Related Technologies Pub Date : 2023-08-03 DOI: 10.51753/flsrt.1313038

F. Barlas

{"title":"Infuse Herbal Oils: A Comparative Study of Wheat Germ and Tomato Seed Oils","authors":"F. Barlas","doi":"10.51753/flsrt.1313038","DOIUrl":"https://doi.org/10.51753/flsrt.1313038","url":null,"abstract":"The utilization of traditional herbal medicine products has seen a resurgence in recent times, with a particular emphasis on the use of herbal oils in non-invasive wound treatment. The extraction of oils from plant seeds is a crucial step in the preparation of these products, and the preservation of active and secondary metabolites is heavily dependent on the ambient temperature at which the extraction process is carried out. In this study, wheat germ oil (WGO) and tomato seed oil (TSO) were obtained from the Central Anatolia Region and the Aegean Region, respectively. Both oils were obtained via cold-pressing, and their infused forms (WGO-TSO) were also prepared. Cytotoxicity, wound healing, and antioxidant capacity tests were conducted on HaCaT (Human keratinocyte) and Vero (Monkey kidney fibroblast-like) cell lines to investigate the in vitro activities of these formulations. The results of the intracellular cytotoxicity analysis revealed that a common dose of 25 µg/mL was non-toxic for all samples, and this dose was subsequently used as the study dose. The hydrogen peroxide-based oxidant quenching studies and wound healing studies yielded positive results for all study groups, with the WGO/TSO group demonstrating statistically superior outcomes. In conclusion, the utilization of oils in infused forms may be more effective in combating oxidative stress and promoting wound healing as compared to the use of oils alone.","PeriodicalId":303081,"journal":{"name":"Frontiers in Life Sciences and Related Technologies","volume":"256 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123612352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Automated comet assay segmentation using combined dot enhancement filters and extended-maxima transform watershed segmentation 使用点增强滤波器和扩展最大变换分水岭分割的自动彗星分析分割

Frontiers in Life Sciences and Related Technologies Pub Date : 2023-07-27 DOI: 10.51753/flsrt.1319546

Lavdie Rada

{"title":"Automated comet assay segmentation using combined dot enhancement filters and extended-maxima transform watershed segmentation","authors":"Lavdie Rada","doi":"10.51753/flsrt.1319546","DOIUrl":"https://doi.org/10.51753/flsrt.1319546","url":null,"abstract":"The comet assay, also known as single-cell gel electrophoresis, is a widely used and trustworthy method for assessing DNA damage and repair in individual cells. It plays a crucial role in assessment of genetic damage potential and human biomonitoring studies in the medical and biological fields. Ensemble of comet assay individual cells and establishing accurate information on the occurrence of cellular injury followed by the process of cellular restoration is a challenging task. This paper introduces an algorithm for the detection of a distinct head, composed of undamaged DNA, and a tail, comprising damaged or fragmented DNA, in genotoxicity testing images, and provides information on the region properties of such images. The proposed approach combines a dot enhancement filter to distinguish and help in the detection of the head in each cell combined with a multilevel segmentation approach consisting of a watershed-geodesic active contour model that is capable to refine the tail estimation. The effectiveness of the suggested algorithm is quantitatively evaluated with annotation data provided by biologists, and its results are compared with those obtained from previous works. The proposed system exhibits comparable or superior performance to the existing systems while avoiding excessive computational cost.","PeriodicalId":303081,"journal":{"name":"Frontiers in Life Sciences and Related Technologies","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127732053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identifying of Phenolic Content, Antimicrobial and Antioxidant Activities of Lonicera caucasica Pallas subsp. Orientalis Leaves 白花忍冬酚类物质含量及抗菌抗氧化活性的鉴定。胶的叶子

Frontiers in Life Sciences and Related Technologies Pub Date : 2023-07-03 DOI: 10.51753/flsrt.1286886

M. Şeker

{"title":"Identifying of Phenolic Content, Antimicrobial and Antioxidant Activities of Lonicera caucasica Pallas subsp. Orientalis Leaves","authors":"M. Şeker","doi":"10.51753/flsrt.1286886","DOIUrl":"https://doi.org/10.51753/flsrt.1286886","url":null,"abstract":": The extracts' antioxidant and antimicrobial properties are linked to phenolic compounds, one of the most abundant classes of secondary metabolites. In order to add new information to the scientific literature, it is crucial to investigate the phenolic content and bioactivity of previously unstudied or unknown plant parts. Lonicera caucasica Pallas subsp. orientalis is an endemic species that grows in a few cities in Turkey. In this study, methanolic extraction of Lonicera caucasica leaves was performed, and the obtained fraction was analyzed by Liquid Chromatography-High Resolution Mass Spectrometry (LC-HRMS) to determine the phenolic content of the extract. The amounts of 22 of the 56 identified phenolic compounds were determined. The three highest of these are chlorogenic acid (2.223 ± 0.065 mg g-1), quinic acid (2.163 ± 0.057 mg g-1) and syringic acid (1.192 ± 0,036 mg g-1). At the same time, the antioxidant activities of the extracts were examined and ABTS•+ and DPPH• (SC50, mg/mL) values were determined as 0.0135 ± 0.0001 and 0.0136 ± 0.0001, respectively. In addition, the obtained extract was tested against three gram-negative (P. aeruginosa, E. aerogenes and E. coli) and three gram-positive (E. fecalis, B. megaterium and S. pyogenes) bacteria and the results were recorded. The best antimicrobial activity was observed at 19.33 mm against P. aeruginosa at a dose of 3.9 mg mL-1. These results show that Lonicera caucasica leaves have rich phenolic content, high antioxidant activity, and a strong antimicrobial effect.","PeriodicalId":303081,"journal":{"name":"Frontiers in Life Sciences and Related Technologies","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122673204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Important Extremophilic Model Microorganisms in Astrobiology 天体生物学中重要的嗜极模式微生物

Frontiers in Life Sciences and Related Technologies Pub Date : 2023-06-15 DOI: 10.51753/flsrt.1299840

Simge Emli̇k, S. Marakli

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Structural, Thermoelectric, and Magnetic Properties of Pure and Ti-Doped Ca3Co4O9 Ceramic Compounds 纯和掺钛Ca3Co4O9陶瓷化合物的结构、热电和磁性能

Frontiers in Life Sciences and Related Technologies Pub Date : 2023-06-11 DOI: 10.51753/flsrt.1249167

C. Boyraz

引用次数: 0

Identification and verification of promising diagnostic genes in bisphenol A-associated breast cancer development via in silico analysis 通过硅分析鉴定和验证双酚a相关乳腺癌发展的有希望的诊断基因

Frontiers in Life Sciences and Related Technologies Pub Date : 2023-05-23 DOI: 10.51753/flsrt.1223888

Mervenur Akkus, Hamid Ceylan

{"title":"Identification and verification of promising diagnostic genes in bisphenol A-associated breast cancer development via in silico analysis","authors":"Mervenur Akkus, Hamid Ceylan","doi":"10.51753/flsrt.1223888","DOIUrl":"https://doi.org/10.51753/flsrt.1223888","url":null,"abstract":"Lifestyle patterns, exposure to toxic chemicals or environmental pollutants are the strongest risk factors for the chances of developing breast cancer, the leading and lethal form of cancer in women. Bisphenol A (BPA), found in various consumer products, is known to deregulate multiple cellular signaling, but its effect on cancer initiation and development in breast tissue has not yet been fully elucidated. Therefore, the identification of hub drivers is necessary to understand the molecular mechanisms underlying BPA-related malignancy and may help determine novel diagnosis and treatment strategies. This study aimed to contribute to the understanding of the molecular mechanism of action of BPA on breast cancer formation using a bioinformatics analysis approach. A microarray dataset appropriate for study purposes was downloaded from the Gene Expression Omnibus (GEO) repository. After the screening of the differentially expressed genes (DEGs), enrichment analysis was performed. A protein-protein interaction (PPI) network was constructed and analyzed to identify the hub genes. mRNA expression and the prognostic impacts of the identified hub genes were verified using GEPIA2 and KM-plotter tools. Finally, correlations between hub genes and immune infiltration levels were validated. According to PPI network results, CCNA2 and CCNB1 were identified as critical hub genes. Validation analyses clearly indicated that the identified genes are extremely critical in the development and progression of BPA-associated breast cancer. Findings from this study revealed that CCNA2 and CCNB1, two cell cycle signaling-related hub genes that are overexpressed as a consequence of BPA exposure, are strongly associated with poor prognosis in patients with breast cancer.","PeriodicalId":303081,"journal":{"name":"Frontiers in Life Sciences and Related Technologies","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121946367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0