Journal of Nuclear Medicine and Radiation Therapy最新文献

{"title":"A Comparison of Three Dimensional Ultrasound, Clips and CT for MeasuringInterfractional Breast Lumpectomy Cavity Motion","authors":"R. Heimann, D. Hard, J. Archambault, S. Gross, M. Lachaine","doi":"10.4172/2155-9619.1000280","DOIUrl":"https://doi.org/10.4172/2155-9619.1000280","url":null,"abstract":"Accurate definition of the lumpectomy cavity (LC) is essential for both partial breast and electron boost planning and delivery. The goal of this study is to evaluate CT, 3DUS and clips in the daily target localization of the LC. Twenty whole breast radiation patients, including 10 with clips, underwent two sets of treatment planning CTs (CT1, CT2) with co-registered 3DUS (US1, US2), separated by approximately 6 weeks. The cavities were independently outlined on each CT and 3DUS dataset. Of the 20 patients, 18 had visible cavities. The shifts in cavity position were calculated from CT, 3DUS and clips. The PTV margins required to be added to the CT1 cavity volume in order to fully encompass the CT2 cavity were calculated without and with shifts according to 3DUS or clips. The median cavity displacement ranged from 0.0-3.0 mm with a maximum of up to 17.9 mm. The cavity displacements were not significantly different when calculated based on 3DUS, CT, or clips (p > 0.05). The average PTV margin required to encompass the CT2 cavity was 6.3 mm without shifts, 4.3 mm with 3DUS shifts and 5.2 mm with clip-based shifts. The differences in the margin between no shift and 3DUS or clip-guided shift were found to be significant, while differences between 3DUS and clip-based shifts were not (p > 0.7). With no shift, the mean CT2 volume that lied outside the CT1 was 3.2 cc compared to 2.4 cc (p 0.9). Without adjusting for the changes in the cavity shape and location, a portion of the volume will be undertreated unless the margins are increased. 3DUS may offer an easily implemented solution to localizing the LC without requiring additional ionizing radiation.","PeriodicalId":302578,"journal":{"name":"Journal of Nuclear Medicine and Radiation Therapy","volume":"117 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116187143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraindividual Tumor Heterogeneity in Neuroendocrine Tumors Revealed with 18F-FDG and 68Ga-DOTA-TATE PET/CT","authors":"E. Demirci, B. Vatankulu, R. Akyel, F. Dede, M. Halaç","doi":"10.4172/2155-9619.1000277","DOIUrl":"https://doi.org/10.4172/2155-9619.1000277","url":null,"abstract":"68Ga-DOTA-TATE PET/CT is widely used in functional imaging of neuroendocrine tumors (NETs) and is superior to conventional somatostatin receptor scintigraphy (SRS), which is recommended for low grade NETs according to NANETS/ENETS guidelines. On the contrary 18F-FDG PET is suggested in patients with high grade NETs or when SRS is negative. However, tumor heterogeneity is a common finding along with NETs and causes differential expression of somatostatin receptor (sstr) and various FDG metabolisms. Here, we present a case where tumor heterogeneity is revealed with combined use of 18F-FDG PET/CT and 68Ga-DOTA-TATE PET/CT in the same patient and how does it influence clinical decision-making Conclusion: We here present the first report of FFF-VMAT achieving a comparable plan quality with less delivery time to that of FF-VMAT and HT in head and neck cancer. FFF-VMAT is a highly efficient and feasible option for the treatment of head and neck cancer in clinical practice.","PeriodicalId":302578,"journal":{"name":"Journal of Nuclear Medicine and Radiation Therapy","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125219618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Value of 18F-FDG PET/CT Metabolic Tumor Volume forComplete Pathologic Response and Clinical Outcomes after NeoadjuvantChemoradiation Therapy for Locally Advanced Esophageal Cancer","authors":"P. Venkat, J. Oliver, W. Jin, J. Dault, J. Frakes, S. Hoffe, J. Pimiento, K. Almhanna, J. Fontaine, L. Peña, K. Latifi","doi":"10.4172/2155-9619.1000308","DOIUrl":"https://doi.org/10.4172/2155-9619.1000308","url":null,"abstract":"Purpose/Objective: The prognostic value of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) has not yet been defined in locally advanced esophageal cancer (LAEC). This study aims to elucidate the prognostic role of PET/CT for patients treated with neoadjuvant chemoradiation (CRT) followed by esophagectomy. Materials/Methods: We retrospectively evaluated patients with LAEC treated from 2006 to 2014 with neoadjuvant CRT followed by esophagectomy. A 76 patients had pre-CRT and post CRT PET/CT scans. PET parameters maximum standardized uptake value (SUVmax), mean standardized uptake value (SUVmean), peak standardized uptake value (SUVpeak), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were recorded for both pre-CRT and post-CRT scans. The correlation of the measured parameters with pathologic complete response (pCR) and clinical outcomes was analyzed. Results: Receiver operating characteristic (ROC) analysis was performed to determine the optimal cutoff values for predicting pCR. Binomial logistic regression using these optimal cutoff values was performed for pCR. A pre CRT MTV <33.1 was 4 times more likely to have a pCR (OR 4.20 95%CI 1.60 to 11.0, p=0.004). Pre CRT TLG <153 was 4.7 times more likely to have a pCR (OR 4.71 95%CI 1.78 to 12.4, p=0.002), and post CRT TLG <53.1 was 4.5 times more likely to have a pCR (OR 4.52 95%CI 1.60 to 12.7, p=0.004). On MVA, pre-CRT MTV and pre CRT TLG remained significant (p=0.006 and p=0.039, respectively). Percent change in MTV independently predicted for OS (p=0.034). By contrast, SUVmax and SUVpeak did not predict for pCR or survival. Conclusions: Pre CRT MTV and pre CRT TLG were independently predictive of pCR, and percentage change in MTV independently predicted for OS in LAEC. Further study is needed to determine if MTV and TLG values can help define which patients will most benefit from radiation dose escalation and esophagectomy","PeriodicalId":302578,"journal":{"name":"Journal of Nuclear Medicine and Radiation Therapy","volume":"150 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123228348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role and Effect of Radiation Therapy for Retinoblastoma Treated with Prior Intra-Arterial Chemotherapy","authors":"K. Turaka, A. Turaka","doi":"10.4172/2155-9619.1000E115","DOIUrl":"https://doi.org/10.4172/2155-9619.1000E115","url":null,"abstract":"RetinoBlastoma (RB) is the most common intraocular tumor in the world among children. It is one of the life threatening tumors in children in underdeveloped countries. In the developed countries, due to early diagnosis and latest treatment techniques, the mortality is less. Systemic chemotherapy either alone or along with periocular injections with or without Radiation Therapy ((RT) External Beam Radiation (EBRT), plaque radiotherapy, proton beam therapy) and focal therapy (laser photocoagulation, or cryotherapy) has been used to treat the retinoblastoma with good success rates. Second Malignant Neoplasms (SMN) are known to occur after treatment with systemic chemoreduction and EBRT among the children of retinoblastoma especially in hereditary RB than sporadic RB cases [1,2]. Therefore, the RB treatment goal is not only to salvage the globe, preserve vision but also to reduce the radiation exposure to reduce the risk of SMN’s.","PeriodicalId":302578,"journal":{"name":"Journal of Nuclear Medicine and Radiation Therapy","volume":"110 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122916870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adult Sacro-Coccygeal Teratoma: A Brief Review","authors":"Ritesh Kumar, Deepak Kumar, Nilesh Kumar, Pawan Kumar","doi":"10.4172/2155-9619.1000278","DOIUrl":"https://doi.org/10.4172/2155-9619.1000278","url":null,"abstract":"Sacrococcygeal teratoma (SCT) is a neoplasm that arises in the sacrococcygeal region and is derived from multiple primitive germ layers. It is the most common congenital neonatal tumor but rarely seen in adults. The standard care for sacrococcygeal teratomas is complete surgical resection of the tumor. The presence of malignant transformation is associated with a less favorable outcome.","PeriodicalId":302578,"journal":{"name":"Journal of Nuclear Medicine and Radiation Therapy","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127209851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pretreatment Dose Verification for Squamous Cell carcinoma of The Tongue","authors":"H. Almohammed","doi":"10.4172/2155-9619.1000279","DOIUrl":"https://doi.org/10.4172/2155-9619.1000279","url":null,"abstract":"The aim of this study is to assess and evaluate the significant of performing patient's specification quality assurance (QA) for patients diagnosed with squamous cell carcinoma of the tongue (SCC) whom treated with intensity modulated radiation therapy (IMRT). The study was done in twelve pre- treatment's plans that been prepared for patients. All the ten selected plans are going to be treated with split-field (SF) technique for intensity modulated radiation therapy (IMRT) planning using 10 MV beams and a prescribed dose between 66Gy and 74 Gy. For quality assurance protocol we are using the two-dimensional ionization-chamber array. The study showed that an agreement between the measured dose and the pre-planned dose using TPS. All the plans passed >95% Gamma with the pixels within 5% distance to agreement 5 mm for IMRT patient-specific quality assurance (QA). It concludes that intensity modulated radiation therapy (IMRT) has the ability to deliver a highly conformal dose distribution to the planning target volume while sparing the organs at risk. However, the result showed a very good agreement between measurements dose and calculations dose which lead and proved that the planning using IMRT treatment are accurately done.","PeriodicalId":302578,"journal":{"name":"Journal of Nuclear Medicine and Radiation Therapy","volume":"310 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122779303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Giant Solitary Fibrous Tumor of Posterior Mediastinum: A Case Report","authors":"Shaoli Song, Panli Li, Qiufang Liu, Zi-Ming Zhao, Daoqiang Tang, Xiaoguang Sun, Jianju Liu, Gang Huang","doi":"10.4172/2155-9619.1000276","DOIUrl":"https://doi.org/10.4172/2155-9619.1000276","url":null,"abstract":"A 54-year-old male was taken to a hospital after experiencing persistent back pain for a month. A spinal column MRI showed a mass in T5-T8 fanterior edge. After four months follow-up, another MRI revealed the mass had grown up to the site of T3-T9. An 18F-FDG PET/CT imaging was underwent and the imaging showed three tumors mass which all had a high uptake of 18F-FDG locating in thorax, abdomen and pelvis, respectively. The thoracoscopic biopsy histological revealed the mass was mesenchymal tumor and immunohistochemistry showed positive for CD34 and CD39, that all proved the mass is solitary fibrous tumor.","PeriodicalId":302578,"journal":{"name":"Journal of Nuclear Medicine and Radiation Therapy","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126314742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ALK Rearrangement in Anaplastic Thyroid Carcinoma: A Discovery Towards a Personalized Approach?","authors":"E. Blais, A. Dutertre, Y. Godbert","doi":"10.4172/2155-9619.1000275","DOIUrl":"https://doi.org/10.4172/2155-9619.1000275","url":null,"abstract":"Anaplastic thyroid carcinoma (ATC) represents about 1% of all thyroid carcinomas [1]. ATC is the most aggressive form of thyroid carcinoma especially when metastatic accounting for 14-50% of all thyroid cancer related deaths [2]. Prognosis and outcomes following local progression or metastasis are poor using conventional therapies such as surgery, chemotherapy, and external beam radiation therapy with only 20% survival at 1 year [3]. So far, previous attempts to use multi-target tyrosine kinase inhibitors have not improved survival outcomes [4]. Therefore, molecular screening for specific genetic alterations in ATC tumors may provide an opportunity for an efficient, targeted therapy.","PeriodicalId":302578,"journal":{"name":"Journal of Nuclear Medicine and Radiation Therapy","volume":"193 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129542329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Dosimetric Comparison of Volumetric Modulated Arc Therapy (VMAT) with Unflattened Beams to VMAT with Flattened Beams and Tomotherapy for Head and Neck Cancer","authors":"T. Ogata, H. Nishimura, H. Mayahara, A. Harada, Yoshiro Matsuo, M. Nakayama, K. Uehara, S. Tsudou, Y. Ejima, R. Sasaki, T. Okayama","doi":"10.4172/2155-9619.1000274","DOIUrl":"https://doi.org/10.4172/2155-9619.1000274","url":null,"abstract":"Background: The purpose of this study was to compare the dose distributions and treatment delivery efficiency of volumetric modulated arc therapy (VMAT) with flattening filter free (FFF) beams (FFF-VMAT) against VMAT with flattening filter (FF) beams (FF-VMAT) and Helical TomoTherapy (HT) for head and neck cancer. \u0000Methods: Ten patients with nasopharyngeal and oropharyngeal cancer were chosen for this planning comparison study. Three treatment plans (dual arc FFF-VMAT, dual arc FF-VMAT, and HT) were created for each patient. The three prescription dose levels of the planning target volumes were 69.96, 60, and 54 Gy in 33 fractions, using the simultaneous integrated boost technique. Comparisons of the plan quality were performed by analyzing the homogeneity, conformity, dose to the organs at risk (OARs), the number of monitor units (MUs), and beam-on time (BOT) necessary for delivering the plans. \u0000Results: The target coverage and sparing of the OARs for FFF-VMAT were almost equivalent to those for FFVMAT and HT. Compared to FF-VMAT, FFF-VMAT and HT significantly increased the number of MUs. The BOTs were the same for FFF-VMAT and FF-VMAT but significantly increased for HT. \u0000Conclusion: We here present the first report of FFF-VMAT achieving a comparable plan quality with less delivery time to that of FF-VMAT and HT in head and neck cancer. FFF-VMAT is a highly efficient and feasible option for the treatment of head and neck cancer in clinical practice.","PeriodicalId":302578,"journal":{"name":"Journal of Nuclear Medicine and Radiation Therapy","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128924838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dosimetric Evidences in Radioiodine Customized Hyperthyroidism Treatments","authors":"A. Ostinelli, M. Duchini, G. Frigerio, A. Corso, R. Posterli, M. Cacciatori","doi":"10.4172/2155-9619.1000273","DOIUrl":"https://doi.org/10.4172/2155-9619.1000273","url":null,"abstract":"The radioiodine therapy is considered an almost definitive and successful hyperthyroidism treatment, alternative to surgery. Unlike a standardized activity approach is still adopted, a customized dosimetric study offers the significant advantage to take into account the individual variabilities in the structures to be treated. In the present work, some of the current issues relating to customized radioiodine treatment are discussed. The experience acquired during several years of customized hyperthyroidism radioiodine treatments performed at the S. Anna Hospital in Como (Italy) is presented, together with the main results of an extensive follow up analysis.","PeriodicalId":302578,"journal":{"name":"Journal of Nuclear Medicine and Radiation Therapy","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121900243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}