Role and Effect of Radiation Therapy for Retinoblastoma Treated with Prior Intra-Arterial Chemotherapy

Abstract

RetinoBlastoma (RB) is the most common intraocular tumor in the world among children. It is one of the life threatening tumors in children in underdeveloped countries. In the developed countries, due to early diagnosis and latest treatment techniques, the mortality is less. Systemic chemotherapy either alone or along with periocular injections with or without Radiation Therapy ((RT) External Beam Radiation (EBRT), plaque radiotherapy, proton beam therapy) and focal therapy (laser photocoagulation, or cryotherapy) has been used to treat the retinoblastoma with good success rates. Second Malignant Neoplasms (SMN) are known to occur after treatment with systemic chemoreduction and EBRT among the children of retinoblastoma especially in hereditary RB than sporadic RB cases [1,2]. Therefore, the RB treatment goal is not only to salvage the globe, preserve vision but also to reduce the radiation exposure to reduce the risk of SMN’s.