{"title":"Associating prenatal phthalate exposure with childhood autistic traits: Investigating potential adverse outcome pathways and the modifying effects of maternal vitamin D","authors":"","doi":"10.1016/j.eehl.2024.01.007","DOIUrl":"10.1016/j.eehl.2024.01.007","url":null,"abstract":"<div><div>The association between prenatal phthalate mixture exposure and the risk of autism spectrum disorder (ASD) in children, as well as the potential mechanism and impact of maternal vitamin D, remains unclear. We analyzed data from 3209 mother–child pairs. The associations between prenatal phthalate exposure and autistic traits in children aged 1.5, 3, 5, and 6 years were explored. Furthermore, the modifying effects of maternal vitamin D and the adverse outcome pathway, which elucidates the contribution of phthalates to ASD, were estimated. Exposure to a phthalate mixture was associated with an increased risk of ASD in children aged 1.5–6 years. For mothers with 25(OH)D deficiency, an exposure‒response relationship was observed between phthalate mixtures in early to mid-pregnancy and autistic traits in children aged 3 years. However, this association was not observed for mothers with sufficient prenatal 25(OH)D levels. The potential mechanism of action of di(2-ethylhexyl) phthalate (DEHP) exposure may involve affecting GRIN2B, inhibiting NMDAR in the postsynaptic membrane, disrupting synaptic function, and impairing learning and memory, ultimately leading to ASD development. Importantly, maternal vitamin D supplementation was demonstrated to mitigate the risk of ASD associated with phthalate exposure. Reducing phthalate exposure during pregnancy may be associated with a decreased risk of autistic traits in children. Furthermore, adequate vitamin D supplementation could potentially mitigate the impact of phthalates on these traits. Additionally, the proposed biological mechanism provides insight into how phthalate exposure may contribute to the development of ASD.</div></div>","PeriodicalId":29813,"journal":{"name":"Eco-Environment & Health","volume":"3 4","pages":"Pages 425-435"},"PeriodicalIF":0.0,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139816445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Haoyuan An , Xiangyu Li , Yuming Huang , Weichao Wang , Yuehan Wu , Lin Liu , Weibo Ling , Wei Li , Hanzhu Zhao , Dawei Lu , Qian Liu , Guibin Jiang
{"title":"A new ChatGPT-empowered, easy-to-use machine learning paradigm for environmental science","authors":"Haoyuan An , Xiangyu Li , Yuming Huang , Weichao Wang , Yuehan Wu , Lin Liu , Weibo Ling , Wei Li , Hanzhu Zhao , Dawei Lu , Qian Liu , Guibin Jiang","doi":"10.1016/j.eehl.2024.01.006","DOIUrl":"10.1016/j.eehl.2024.01.006","url":null,"abstract":"<div><p>The quantity and complexity of environmental data show exponential growth in recent years. High-quality big data analysis is critical for performing a sophisticated characterization of the complex network of environmental pollution. Machine learning (ML) has been employed as a powerful tool for decoupling the complexities of environmental big data based on its remarkable fitting ability. Yet, due to the knowledge gap across different subjects, ML concepts and algorithms have not been well-popularized among researchers in environmental sustainability. In this context, we introduce a new research paradigm—“ChatGPT + ML + Environment”, providing an unprecedented chance for environmental researchers to reduce the difficulty of using ML models. For instance, each step involved in applying ML models to environmental sustainability, including data preparation, model selection and construction, model training and evaluation, and hyper-parameter optimization, can be easily performed with guidance from ChatGPT. We also discuss the challenges and limitations of using this research paradigm in the field of environmental sustainability. Furthermore, we highlight the importance of “secondary training” for future application of “ChatGPT + ML + Environment”.</p></div>","PeriodicalId":29813,"journal":{"name":"Eco-Environment & Health","volume":"3 2","pages":"Pages 131-136"},"PeriodicalIF":0.0,"publicationDate":"2024-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772985024000073/pdfft?md5=aae0aa5da2ab781d4921ce0fde424e43&pid=1-s2.0-S2772985024000073-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139822744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jiaming Wang , Peng Wang , Beibei Liu , Patrick L. Kinney , Lei Huang , Kai Chen
{"title":"Comprehensive evaluation framework for intervention on health effects of ambient temperature","authors":"Jiaming Wang , Peng Wang , Beibei Liu , Patrick L. Kinney , Lei Huang , Kai Chen","doi":"10.1016/j.eehl.2024.01.004","DOIUrl":"10.1016/j.eehl.2024.01.004","url":null,"abstract":"<div><p>Despite the existence of many interventions to mitigate or adapt to the health effects of climate change, their effectiveness remains unclear. Here, we introduce the Comprehensive Evaluation Framework for Intervention on Health Effects of Ambient Temperature to evaluate study designs and effects of intervention studies. The framework comprises three types of interventions: proactive, indirect, and direct, and four categories of indicators: classification, methods, scope, and effects. We trialed the framework by an evaluation of existing intervention studies. The evaluation revealed that each intervention has its own applicable characteristics in terms of effectiveness, feasibility, and generalizability scores. We expanded the framework's potential by offering a list of intervention recommendations in different scenarios. Future applications are then explored to establish models of the relationship between study designs and intervention effects, facilitating effective interventions to address the health effects of ambient temperature under climate change.</p></div>","PeriodicalId":29813,"journal":{"name":"Eco-Environment & Health","volume":"3 2","pages":"Pages 154-164"},"PeriodicalIF":0.0,"publicationDate":"2024-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S277298502400005X/pdfft?md5=a9acf70c6523877bc5297b78da27c682&pid=1-s2.0-S277298502400005X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140521908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hang Yang , Qi Feng , Weixiang Xu , Yadong Tang , Guoliang Bai , Yunli Liu , Zisen Liu , Shibin Xia , Zhenbin Wu , Yi Zhang
{"title":"Unraveling the nuclear isotope tapestry: Applications, challenges, and future horizons in a dynamic landscape","authors":"Hang Yang , Qi Feng , Weixiang Xu , Yadong Tang , Guoliang Bai , Yunli Liu , Zisen Liu , Shibin Xia , Zhenbin Wu , Yi Zhang","doi":"10.1016/j.eehl.2024.01.001","DOIUrl":"10.1016/j.eehl.2024.01.001","url":null,"abstract":"<div><p>Nuclear isotopes, distinct atoms characterized by varying neutron counts, have profoundly influenced a myriad of sectors, spanning from medical diagnostics and therapeutic interventions to energy production and defense strategies. Their multifaceted applications have been celebrated for catalyzing revolutionary breakthroughs, yet these advancements simultaneously introduce intricate challenges that warrant thorough investigation. These challenges encompass safety protocols, potential environmental detriments, and the complex geopolitical landscape surrounding nuclear proliferation and disarmament. This comprehensive review embarks on a deep exploration of nuclear isotopes, elucidating their nuanced classifications, wide-ranging applications, intricate governing policies, and the multifaceted impacts of their unintended emissions or leaks. Furthermore, the study meticulously examines the cutting-edge remediation techniques currently employed to counteract nuclear contamination while projecting future innovations in this domain. By weaving together historical context, current applications, and forward-looking perspectives, this review offers a panoramic view of the nuclear isotope landscape. In conclusion, the significance of nuclear isotopes cannot be understated. As we stand at the crossroads of technological advancement and ethical responsibility, this review underscores the paramount importance of harnessing nuclear isotopes' potential in a manner that prioritizes safety, sustainability, and the greater good of humanity.</p></div>","PeriodicalId":29813,"journal":{"name":"Eco-Environment & Health","volume":"3 2","pages":"Pages 208-226"},"PeriodicalIF":0.0,"publicationDate":"2024-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772985024000024/pdfft?md5=d28a5234f02e076e20021e0d0f23a407&pid=1-s2.0-S2772985024000024-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139540155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mineral-mediated stability of organic carbon in soil and relevant interaction mechanisms","authors":"Zibo Xu , Daniel C.W. Tsang","doi":"10.1016/j.eehl.2023.12.003","DOIUrl":"10.1016/j.eehl.2023.12.003","url":null,"abstract":"<div><p>Soil, the largest terrestrial carbon reservoir, is central to climate change and relevant feedback to environmental health. Minerals are the essential components that contribute to over 60% of soil carbon storage. However, how the interactions between minerals and organic carbon shape the carbon transformation and stability remains poorly understood. Herein, we critically review the primary interactions between organic carbon and soil minerals and the relevant mechanisms, including sorption, redox reaction, co-precipitation, dissolution, polymerization, and catalytic reaction. These interactions, highly complex with the combination of multiple processes, greatly affect the stability of organic carbon through the following processes: (1) formation or deconstruction of the mineral–organic carbon association; (2) oxidative transformation of the organic carbon with minerals; (3) catalytic polymerization of organic carbon with minerals; and (4) varying association stability of organic carbon according to the mineral transformation. Several pieces of evidence related to the carbon turnover and stability during the interaction with soil minerals in the real eco-environment are then demonstrated. We also highlight the current research gaps and outline research priorities, which may map future directions for a deeper mechanisms-based understanding of the soil carbon storage capacity considering its interactions with minerals.</p></div>","PeriodicalId":29813,"journal":{"name":"Eco-Environment & Health","volume":"3 1","pages":"Pages 59-76"},"PeriodicalIF":0.0,"publicationDate":"2024-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772985024000012/pdfft?md5=67db5d5e1360a6990d01813ba41696fa&pid=1-s2.0-S2772985024000012-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139457883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jie Hou , Meirui Yang , Xinyue Wu , Qiqi Chen , Yuqi Lu , Jianying Zhang , Daohui Lin
{"title":"Epidermal microorganisms contributed to the toxic mechanism of nZVI and TCEP in earthworms by robbing metal elements and nutrients","authors":"Jie Hou , Meirui Yang , Xinyue Wu , Qiqi Chen , Yuqi Lu , Jianying Zhang , Daohui Lin","doi":"10.1016/j.eehl.2023.11.001","DOIUrl":"10.1016/j.eehl.2023.11.001","url":null,"abstract":"<div><p>Disrupting effects of pollutants on symbiotic microbiota have been regarded as an important mechanism of host toxicity, with most current research focusing on the intestinal microbiota. In fact, the epidermal microbiota, which participates in the nutrient exchange between hosts and environments, could play a crucial role in host toxicity via community changes. To compare the contributions of intestinal and epidermal symbiotic microorganisms to host toxicity, this study designed single and combined scenarios of soil contamination [nano zero-valent iron (nZVI) and tris (2-chloroethyl) phosphate (TCEP)], and revealed the coupling mechanisms between intestinal/epidermal symbiotic bacterial communities and earthworm toxicological endpoints. Microbiome analysis showed that 15% of intestinal microbes were highly correlated with host endpoints, compared to 45% of epidermal microbes showing a similar correlation. Functional comparisons revealed that key species on the epidermis were mainly heterotrophic microbes with genetic abilities to utilize metal elements and carbohydrate nutrients. Further verifications demonstrated that when facing the co-contamination of nZVI and TCEP, certain symbiotic microorganisms became dominant and consumed zinc, copper, and manganese along with saccharides and amino acids, which may be responsible for the nutritional deficiencies in the host earthworms. The findings can enrich the understanding of the coupling relationship between symbiotic microorganisms and host toxicity, highlighting the importance of epidermal microorganisms in host resistance to environmental pollution.</p></div>","PeriodicalId":29813,"journal":{"name":"Eco-Environment & Health","volume":"3 1","pages":"Pages 80-88"},"PeriodicalIF":0.0,"publicationDate":"2023-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772985023000686/pdfft?md5=3d0ec417e0bef2620640ee4240c2eacc&pid=1-s2.0-S2772985023000686-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139293070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Reconsidering gas as clean energy: Switching to electricity for household cooking to reduce NO2-attributed disease burden","authors":"Ying Hu , Ye Wang , Zhuohui Zhao , Bin Zhao","doi":"10.1016/j.eehl.2023.10.003","DOIUrl":"10.1016/j.eehl.2023.10.003","url":null,"abstract":"<div><p>Nitrogen dioxide (NO<sub>2</sub>) is a prevalent air pollutant in urban areas, originating from outdoor sources, household gas consumption, and secondhand smoke. The limited evaluation of the disease burden attributable to NO<sub>2</sub>, encompassing different health effects and contributions from various sources, impedes our understanding from a public health perspective. Based on modeled NO<sub>2</sub> exposure concentrations, their exposure–response relationships with lung cancer, chronic obstructive pulmonary disease, and diabetes mellitus, and baseline disability-adjusted life years (DALYs), we estimated that 1,675 (655–2,624) thousand DALYs were attributable to NO<sub>2</sub> in urban China in 2019 [138 (54–216) billion Chinese yuan (CNY) economic losses]. The transition from gas to electricity for household cooking was estimated to reduce the attributable economic losses by 35%. This reduction falls within the range of reductions achieved when outdoor air meets the World Health Organization interim target 3 and air quality guidelines for annual NO<sub>2</sub>, highlighting the significance of raising awareness of gas as a polluting household energy for cooking. These findings align with global sustainable development initiatives, providing a sustainable solution to promote public health while potentially mitigating climate change.</p></div>","PeriodicalId":29813,"journal":{"name":"Eco-Environment & Health","volume":"3 2","pages":"Pages 174-182"},"PeriodicalIF":0.0,"publicationDate":"2023-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772985023000674/pdfft?md5=d247c27073f4125c985f08963894aeea&pid=1-s2.0-S2772985023000674-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139299175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Qian Song , Nannan Zhang , Yanning Zhang , Dejia Yin , Jiming Hao , Shuxiao Wang , Shengyue Li , Wenshuai Xu , Weijun Yan , Xinxin Meng , Xinghong Xu , Xiaochen Wu , Donghai Xie , Yun Zhu , Qipeng Qu , Xuan Hou , Yueqi Jiang , Zhaoxin Dong , Haotian Zheng , Yisheng Sun , Bin Zhao
{"title":"The development of local ambient air quality standards: A case study of Hainan Province, China","authors":"Qian Song , Nannan Zhang , Yanning Zhang , Dejia Yin , Jiming Hao , Shuxiao Wang , Shengyue Li , Wenshuai Xu , Weijun Yan , Xinxin Meng , Xinghong Xu , Xiaochen Wu , Donghai Xie , Yun Zhu , Qipeng Qu , Xuan Hou , Yueqi Jiang , Zhaoxin Dong , Haotian Zheng , Yisheng Sun , Bin Zhao","doi":"10.1016/j.eehl.2023.10.002","DOIUrl":"10.1016/j.eehl.2023.10.002","url":null,"abstract":"<div><p>The ambient air quality standard (AAQS) is a vital policy instrument for protecting the environment and human health. Hainan Province is at the forefront of China's efforts to protect its ecological environment, with an official goal to achieve world-leading air quality by 2035. However, neither the national AAQS nor the World Health Organization guideline offers sufficient guidance for improving air quality in Hainan because Hainan has well met the former while the latter is excessively stringent. Consequently, the establishment of Hainan's local AAQS becomes imperative. Nonetheless, research regarding the development of local AAQS is scarce, especially in comparatively more polluted countries such as China. The relatively high background values and significant interannual fluctuations in air pollutant concentrations in Hainan present challenges in the development of local AAQS. Our research proposes a world-class local AAQS of Hainan Province by reviewing the AAQS in major countries or regions worldwide, analyzing the influence of different statistical forms, and carefully evaluating the attainability of the standard. In the proposed AAQS, the annual mean concentration limit for PM<sub>2.5</sub>, the annual 95th percentile of daily maximum 8-h mean (MDA8) concentration limit for O<sub>3</sub>, and the peak season concentration limit for O<sub>3</sub> are set at 10, 120, and 85 μg/m<sup>3</sup>, respectively. Our study indicates that, with effective control policies, Hainan is projected to achieve compliance with the new standard by 2035. The implementation of the local AAQS is estimated to avoid 1,526 (1,253–1,789) and 259 (132–501) premature deaths attributable to long-term exposure to PM<sub>2.5</sub> and O<sub>3</sub> in Hainan in 2035, respectively.</p></div>","PeriodicalId":29813,"journal":{"name":"Eco-Environment & Health","volume":"3 1","pages":"Pages 11-20"},"PeriodicalIF":0.0,"publicationDate":"2023-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772985023000662/pdfft?md5=58b9cda01aa82a81affc25401f9dc00b&pid=1-s2.0-S2772985023000662-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136160772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}