{"title":"Leveraging the One Health concept for arsenic sustainability","authors":"","doi":"10.1016/j.eehl.2024.02.006","DOIUrl":"10.1016/j.eehl.2024.02.006","url":null,"abstract":"<div><p>Arsenic (As) is a naturally occurring chemical element widely distributed in the Earth's crust. Human activities have significantly altered As presence in the environment, posing significant threats to the biota as well as human health. The environmental fates and adverse outcomes of As of various species have been extensively studied in the past few decades. It is imperative to summarize these advances as a whole to provide more profound insights into the As cycle for sustainable development. Embracing the One Health concept, we systematically reviewed previous studies in this work and explored the following three fundamental questions, i.e., what the trends and associated changes are in As contamination, how living organisms interact and cope with As contamination, and most importantly what to do to achieve a sustainable future with As. By focusing on one critical question in each section, this review aims to provide a full picture of the complexity of environmental As. To tackle the significant research challenges and gaps in As pollution and mitigation, we further proposed a One Health framework with potential coping strategies, guiding a coordinated agenda on dealing with legacy As in the environment and ensuring a sustainable As future.</p></div>","PeriodicalId":29813,"journal":{"name":"Eco-Environment & Health","volume":"3 3","pages":"Pages 392-405"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772985024000231/pdfft?md5=235fd01e6a5457522ffa5a8858b8bf9e&pid=1-s2.0-S2772985024000231-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140280983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zhou Cheng , Ming Wu , Yanru Hao , Cehui Mo , Qusheng Li , Jianfeng Wu , Jichun Wu , Bill X. Hu , Guoping Lu
{"title":"Effects of 3D microstructure of porous media on DNAPL migration and remediation by surface active agents in groundwater","authors":"Zhou Cheng , Ming Wu , Yanru Hao , Cehui Mo , Qusheng Li , Jianfeng Wu , Jichun Wu , Bill X. Hu , Guoping Lu","doi":"10.1016/j.eehl.2024.08.003","DOIUrl":"10.1016/j.eehl.2024.08.003","url":null,"abstract":"<div><div>Aquifers composed of porous granular media are important to human beings because they are capable of storing a large amount of groundwater. Contaminant migration and remediation in subsurface environments are strongly influenced by three-dimensional (3D) microstructures of porous media. In this study, fractal models are developed to investigate contaminant transport and surfactant-enhanced aquifer remediation (SEAR) for the regular tetrahedron microstructure (RTM) and right square pyramid microstructure (RSPM). The relationships of permeability and entry pressure are derived for these two kinds of 3D microstructures of granular porous media. Afterward, the difference in perchloroethylene (PCE) migration and SEAR efficiency between RTM and RSPM is investigated by the numerical simulation based on a synthetic heterogeneous granular aquifer. Results indicate that PCE penetrates faster and spreads farther in RSPM-based aquifers compared with RTM-based aquifers. Further, SEAR in RTM-based aquifers can achieve remediation efficiencies of 66.129%–92.214% with a mean of 84.324%, which is clearly lower than the SEAR efficiency of 70.149%–94.773% (with a mean of 89.122%) in RSPM-based aquifers. Findings are significant for understanding the 3D microstructure of porous media and how the microstructure of porous media affects macroscopic contaminant behaviors and remediation.</div></div>","PeriodicalId":29813,"journal":{"name":"Eco-Environment & Health","volume":"3 4","pages":"Pages 466-475"},"PeriodicalIF":0.0,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142660964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shenpan Li , Shuangjian Qin , Huixian Zeng , Weichun Chou , Anna Oudin , Katja M. Kanninen , Pasi Jalava , Guanghui Dong , Xiaowen Zeng
{"title":"Adverse outcome pathway for the neurotoxicity of Per- and polyfluoroalkyl substances: A systematic review","authors":"Shenpan Li , Shuangjian Qin , Huixian Zeng , Weichun Chou , Anna Oudin , Katja M. Kanninen , Pasi Jalava , Guanghui Dong , Xiaowen Zeng","doi":"10.1016/j.eehl.2024.08.002","DOIUrl":"10.1016/j.eehl.2024.08.002","url":null,"abstract":"<div><div>Per- and polyfluoroalkyl substances (PFAS) are endocrine disruptors with unambiguous neurotoxic effects. However, due to variability in experimental models, population characteristics, and molecular endpoints, the elucidation of mechanisms underlying PFAS-induced neurotoxicity remains incomplete. In this review, we utilized the adverse outcome pathway (AOP) framework, a comprehensive tool for evaluating toxicity across multiple biological levels (molecular, cellular, tissue and organ, individual, and population), to elucidate the mechanisms of neurotoxicity induced by PFAS. Based on 271 studies, the reactive oxygen species (ROS) generation emerged as the molecular initiating event 1 (MIE1). Subsequent key events (KEs) at the cellular level include oxidative stress, neuroinflammation, apoptosis, altered Ca<sup>2+</sup> signal transduction, glutamate and dopamine signaling dyshomeostasis, and reduction of cholinergic and serotonin. These KEs culminate in synaptic dysfunction at organ and tissue levels. Further insights were offered into MIE2 and upstream KEs associated with altered thyroid hormone levels, contributing to synaptic dysfunction and hypomyelination at the organ and tissue levels. The inhibition of Na<sup>+</sup>/I<sup>−</sup> symporter (NIS) was identified as the MIE2, initiating a cascade of KEs at the cellular level, including altered thyroid hormone synthesis, thyroid hormone transporters, thyroid hormone metabolism, and binding with thyroid hormone receptors. All KEs ultimately result in adverse outcomes (AOs), including cognition and memory impairment, autism spectrum disorders, attention deficit hyperactivity disorders, and neuromotor development impairment. To our knowledge, this review represents the first comprehensive and systematic AOP analysis delineating the intricate mechanisms responsible for PFAS-induced neurotoxic effects, providing valuable insights for risk assessments and mitigation strategies against PFAS-related health hazards.</div></div>","PeriodicalId":29813,"journal":{"name":"Eco-Environment & Health","volume":"3 4","pages":"Pages 476-493"},"PeriodicalIF":0.0,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142660966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bo Liu , Xiaolu Liu , Yang Li , Muliang Xiao , Zhongshan Chen , Suhua Wang , Hongqing Wang , Xiangke Wang
{"title":"Piezocatalytic techniques and materials for degradation of organic pollutants from aqueous solution","authors":"Bo Liu , Xiaolu Liu , Yang Li , Muliang Xiao , Zhongshan Chen , Suhua Wang , Hongqing Wang , Xiangke Wang","doi":"10.1016/j.eehl.2024.08.001","DOIUrl":"10.1016/j.eehl.2024.08.001","url":null,"abstract":"<div><div>With the rapid development of industry, agriculture, and urbanization, various organic pollutants have accumulated in natural water, posing a potential threat to both the ecological environment and human beings, and removing organic pollutants from water is an urgent priority. Piezoelectric techniques, with the advantages of green, simple operation, and high efficiency, are highly sought after in the degradation of environmental organic pollutants. Moreover, combining piezoelectric techniques with advanced oxidation processes (AOPs), photocatalysis, or electrocatalysis can further effectively promote the efficient degradation of target pollutants. Therefore, a perspective is presented on the recent progress of piezoelectric techniques for the degradation of various organic pollutants from aqueous solutions. The classification of various piezoelectric materials, as well as modification strategies for improving piezocatalysis, are first systematically summarized. Furthermore, the latest research on piezocatalysis and its combination with other technologies, such as AOPs, photocatalysis, and electrocatalysis, in the degradation of environmental pollutants is discussed. The potential mechanisms of piezocatalysis are also analyzed in depth. Finally, the urgent challenges and future opportunities for piezoelectric techniques in the degradation of organic pollutants are provided.</div></div>","PeriodicalId":29813,"journal":{"name":"Eco-Environment & Health","volume":"3 4","pages":"Pages 418-424"},"PeriodicalIF":0.0,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142554589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Linling Yu , Wei Liu , Yongfang Zhang , Qiyou Tan , Jiahao Song , Lieyang Fan , Xiaojie You , Min Zhou , Bin Wang , Weihong Chen
{"title":"Styrene and ethylbenzene exposure and type 2 diabetes mellitus: A longitudinal gene–environment interaction study","authors":"Linling Yu , Wei Liu , Yongfang Zhang , Qiyou Tan , Jiahao Song , Lieyang Fan , Xiaojie You , Min Zhou , Bin Wang , Weihong Chen","doi":"10.1016/j.eehl.2024.07.001","DOIUrl":"10.1016/j.eehl.2024.07.001","url":null,"abstract":"<div><div>Styrene and ethylbenzene (S/EB) are identified as hazardous air contaminants that raise significant concerns. The association between S/EB exposure and the incidence of type 2 diabetes mellitus (T2DM), and the interaction between genes and environment, remains poorly understood. Our study consisted of 2219 Chinese adults who were part of the Wuhan-Zhuhai cohort. A follow-up assessment was conducted after six years. Exposure to S/EB was quantified by determining the concentrations of urinary biomarkers of exposure to S/EB (UBE-S/EB; urinary phenylglyoxylic acid level plus urinary mandelic acid level). Logistic regression models were constructed to investigate the relations of UBE-S/EB and genetic risk score (GRS) with T2DM prevalence and incidence. The interaction effects of UBE-S/EB and GRS on T2DM were investigated on multiplicative and additive scales. UBE-S/EB was dose-dependently and positively related to T2DM prevalence and incidence. Participants with high levels of UBE-S/EB [relative risk (RR) = 1.930, 95% confidence interval (CI): 1.157–3.309] or GRS (1.943, 1.110–3.462) demonstrated the highest risk of incident T2DM, in comparison to those with low levels of UBE-S/EB or GRS. Significant additive interaction between UBE-S/EB and GRS on T2DM incidence was discovered with relative excess risk due to interaction (95% CI) of 0.178 (0.065–0.292). The RR (95% CI) of T2DM incidence was 2.602 (1.238–6.140) for individuals with high UBE-S/EB and high GRS, compared to those with low UBE-S/EB and low GRS. This study presented the initial evidence that S/EB exposure was significantly related to increased risk of T2DM incidence, and the relationship was interactively aggravated by genetic predisposition.</div></div>","PeriodicalId":29813,"journal":{"name":"Eco-Environment & Health","volume":"3 4","pages":"Pages 452-457"},"PeriodicalIF":0.0,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142586468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yichen Xu , Yutong Zhang , Longlong Qiu , Ming Zhang , Jiaojiao Yang , Rong Ji , Davide Vione , Zhanghao Chen , Cheng Gu
{"title":"Photochemical behavior of dissolved organic matter in environmental surface waters: A review","authors":"Yichen Xu , Yutong Zhang , Longlong Qiu , Ming Zhang , Jiaojiao Yang , Rong Ji , Davide Vione , Zhanghao Chen , Cheng Gu","doi":"10.1016/j.eehl.2024.06.002","DOIUrl":"10.1016/j.eehl.2024.06.002","url":null,"abstract":"<div><div>As an important group of widespread organic substances in aquatic ecosystems, dissolved organic matter (DOM) plays an essential role in carbon recycling and transformation processes. The photochemical behavior of DOM is one of the main ways it participates in these processes, and it attracts extensive attention. However, due to a variety of sources and water conditions, including both freshwater and seawater environments, the photochemical properties of DOM exhibit great differences. Nowadays, a large number of studies have focused on the generation process of reactive species (RS) from sunlit DOM, while little effort has been made so far to provide a comprehensive summary of the photochemical behavior of DOM, especially in fresh and saline aquatic ecosystems. In this review, we analyzed the research hotspot on DOM photochemistry over the last 30 years, summarizing the generation of photoreactive species in natural water environments containing DOM (both freshwater and seawater) and listing the main factors affecting the rate, yield, and species of RS photoproduction. Compared with freshwater, seawater has unique characteristics such as high pH value, high ionic strength, and halide ions, which affect the photogeneration of RS, the photoconversion process, as well as the reaction pathways of various environmental substances. In general, DOM-induced surface water photochemistry has important impacts on the environmental transformation and toxic effects of aquatic pollutants and can even contribute significantly to the Earth’s carbon cycle, which would have potential implications for both human and ecological health.</div></div>","PeriodicalId":29813,"journal":{"name":"Eco-Environment & Health","volume":"3 4","pages":"Pages 529-542"},"PeriodicalIF":0.0,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141714484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shuangyu Wu , Jian Peng , Stephanie Ling Jie Lee , Xiaoqing Niu , Yue Jiang , Sijie Lin
{"title":"Let the two sides of the same coin meet—Environmental health and safety-oriented development of functional nanomaterials for environmental remediations","authors":"Shuangyu Wu , Jian Peng , Stephanie Ling Jie Lee , Xiaoqing Niu , Yue Jiang , Sijie Lin","doi":"10.1016/j.eehl.2024.06.001","DOIUrl":"10.1016/j.eehl.2024.06.001","url":null,"abstract":"<div><div>Nanotechnology and engineered nanomaterials have been at the forefront of technological breakthroughs of the 21st century. With the challenges of increasingly complex and emergent environmental pollution, nanotechnology offers exciting complementary approaches to achieve high efficiencies with low or green energy input. However, unknown and unintended hazardous effects and health risks associated with nanotechnology hinder its full-scale implementation. Therefore, the development of safer nanomaterials lies in the critical balance between the applications and implications of nanomaterials. To facilitate constructive dialogue between the two sides (<em>i.e.,</em> applications and implications) of the same coin, this review sets forth to summarize the current progress of the environmental applications of nanomaterials and establish the structure–property-functionality relationship. A systematic analysis of the structure–property-toxicity relationship is also provided to advocate the Safe and Sustainable-by-Design strategy for nanomaterials. Lastly, the review also discusses the future of artificial intelligence-assisted environmental health and safety-oriented development of nanomaterials.</div></div>","PeriodicalId":29813,"journal":{"name":"Eco-Environment & Health","volume":"3 4","pages":"Pages 494-504"},"PeriodicalIF":0.0,"publicationDate":"2024-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142660965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Emergency of per- and polyfluoroalkyl substances in drinking water: Status, regulation, and mitigation strategies in developing countries","authors":"Adewale Adewuyi , Qilin Li","doi":"10.1016/j.eehl.2024.05.008","DOIUrl":"10.1016/j.eehl.2024.05.008","url":null,"abstract":"<div><p>The detection of per- and polyfluoroalkyl substances (PFAS) in water presents a significant challenge for developing countries, requiring urgent attention. This review focuses on understanding the emergence of PFAS in drinking water, health concerns, and removal strategies for PFAS in water systems in developing countries. This review indicates the need for more studies to be conducted in many developing nations due to limited information on the environmental status and fate of PFAS. The health consequences of PFAS in water are enormous and cannot be overemphasized. Efforts are ongoing to legislate a national standard for PFAS in drinking water. Currently, there are few known mitigation efforts from African countries, in contrast to several developing nations in Asia. Therefore, there is an urgent need to develop economically viable techniques that could be integrated into large-scale operations to remove PFAS from water systems in the region. However, despite the success achieved with removing long-chain PFAS from water, more studies are required on strategies for eliminating short-chain moieties in water.</p></div>","PeriodicalId":29813,"journal":{"name":"Eco-Environment & Health","volume":"3 3","pages":"Pages 355-368"},"PeriodicalIF":0.0,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772985024000498/pdfft?md5=c072a0dbaa7f59500f4c8b4edbd05a29&pid=1-s2.0-S2772985024000498-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142089714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ye Li , Xiaoyu Sha , Yuan Wang , Yanfang Zhao , Junjie Zhang , Ping Wang , Xiangfeng Chen , Baoshan Xing , Lei Wang
{"title":"In situ imaging of microplastics in living organisms based on mass spectrometry technology","authors":"Ye Li , Xiaoyu Sha , Yuan Wang , Yanfang Zhao , Junjie Zhang , Ping Wang , Xiangfeng Chen , Baoshan Xing , Lei Wang","doi":"10.1016/j.eehl.2024.05.007","DOIUrl":"10.1016/j.eehl.2024.05.007","url":null,"abstract":"<div><div>Plastic pollution is widely present in terrestrial and aquatic ecosystems, and microplastics (MPs) can be detected in organisms. <em>In situ</em> detection methods for MPs in organisms have attracted widespread attention. Traditional imaging characterization methods of MPs, including stereo microscopes and fluorescence microscopy, are typically used to image artificially added microsphere standards under laboratory conditions. However, they cannot specifically identify MPs in biological samples. Thus, there is a need for a detection technique that can provide spatial distribution information of MPs in biological samples as well as measure their quality and quantity. In this perspective, to obtain high-resolution images with chemical composition analysis, we compared ion sources for ionizing plastic macromolecules and mass analyzers for analyzing macromolecules. Matrix-assisted laser desorption/ionization (MALDI) is suitable for imaging characterization, while time-of-flight (TOF) and Orbitrap mass spectrometry are suitable for polymer mass spectrometry analysis. Furthermore, we propose a technique that combines MALDI with TOF or Orbitrap, which holds promise for the <em>in situ</em> imaging of MPs in biological samples.</div></div>","PeriodicalId":29813,"journal":{"name":"Eco-Environment & Health","volume":"3 4","pages":"Pages 412-417"},"PeriodicalIF":0.0,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142535305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chao Guo , Shiwen Hu , Pengfei Cheng, Kuan Cheng, Yang Yang, Guojun Chen, Qi Wang, Ying Wang, Tongxu Liu
{"title":"Speciation and biogeochemical behavior of perfluoroalkyl acids in soils and their environmental implications: A review","authors":"Chao Guo , Shiwen Hu , Pengfei Cheng, Kuan Cheng, Yang Yang, Guojun Chen, Qi Wang, Ying Wang, Tongxu Liu","doi":"10.1016/j.eehl.2024.05.005","DOIUrl":"10.1016/j.eehl.2024.05.005","url":null,"abstract":"<div><div>Perfluoroalkyl acids (PFAAs) are emerging organic pollutants that have attracted significant attention in the fields of environmental chemistry and toxicology. Although PFAAs are pervasive in soils and sediments, there is a paucity of research regarding their environmental forms and driving mechanisms. This review provides an overview of the classification and biotoxicity of per- and polyfluoroalkyl substances (PFAS), organic pollutant forms, PFAS extraction and analytical methods, the prediction of PFAS distribution in soils, and current PFAS remediation strategies. Four predominant PFAA forms have been proposed in soils: (i) aqueous-extracted PFAAs, (ii) organic-solvent extracted PFAAs, (iii) embedded or sequestered PFAAs, and (iv) covalently bound PFAAs. Furthermore, it suggests suitable extraction methods and predictive models for different PFAA forms, which are instrumental in the research on PFAA speciation and prediction in soils. Simultaneously, it was proposed that elemental cycling and microbial activity may affect the speciation of PFAS. Additionally, the categorization of PFAA forms facilitated the analysis of pollution remediation. Understanding the interplay between PFAA speciation, element cycling, and bacterial activity during soil remediation is essential for understanding remediation mechanisms and assessing the long-term stability of remediation methods. Future studies should expand the investigation of varying PFAA forms in different media, consider the potential binding forms of PFAAs to minerals, organic matter, and microbes, and evaluate the possible mechanisms of PFAA speciation variation.</div></div>","PeriodicalId":29813,"journal":{"name":"Eco-Environment & Health","volume":"3 4","pages":"Pages 505-515"},"PeriodicalIF":0.0,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141409451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}