Eco-Environment & HealthPub Date : 2026-03-01Epub Date: 2025-12-24DOI: 10.1016/j.eehl.2025.100212
Jie Hou , Ye Li , Qinglin Chen , Mengqi Liu , Yi An , Fengxia Yang , Yanpo Yao
{"title":"Cross-regional dynamics of antibiotic resistance (AR): Genomic evidence of transmission for Escherichia coli carrying last-resort AR gene between food animals and humans in China","authors":"Jie Hou , Ye Li , Qinglin Chen , Mengqi Liu , Yi An , Fengxia Yang , Yanpo Yao","doi":"10.1016/j.eehl.2025.100212","DOIUrl":"10.1016/j.eehl.2025.100212","url":null,"abstract":"<div><div>The rapidly increasing dissemination of antibiotic-resistant bacteria (ARB) among food animals and humans is a burgeoning public health crisis. Yet, our understanding of ARB transmission is largely constrained to regional studies, with a dearth of insights into cross-regional dynamics. In this study, the whole-genome sequences of >800 <em>E. coli</em> strains harboring last-resort antibiotic resistance genes (LARGs) across 20 regions of China were retrieved from the NCBI RefSeq database. Our analysis uncovered that 1767 human–animal isolate pairs exhibited high homology, with the pairwise average nucleotide identity (ANI) values exceeding 99.5%. By employing phylogenetic analysis, transmission cluster identification, ANI, and single-nucleotide polymorphism (SNP) analysis, 42 human–animal transmission clusters and 306 recent transmission events were identified. Strikingly, more than 90% of these human–animal transmission events (284 out of 306) spanned different regions. Counterfactual analysis indicated that the cross-regional transmission significantly contributes to the prevalence of these ARBs in humans (21.62%), while its role in the food-animal epidemic is less pronounced (3.47%). Our findings underscore the urgency of a more integrated, nationwide approach to address the spread of LARG-harboring bacteria, which is essential to preserving the efficacy of our remaining antibiotic arsenal and safeguarding public health on a global scale.</div></div>","PeriodicalId":29813,"journal":{"name":"Eco-Environment & Health","volume":"5 1","pages":"Article 100212"},"PeriodicalIF":17.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145925999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eco-Environment & HealthPub Date : 2026-03-01Epub Date: 2026-01-29DOI: 10.1016/j.eehl.2026.100218
Yiou Zhu , Quang Tri Ho , James P.W. Robinson , Marian Kjellevold , Ruirong Chang , Edvin Fuglebakk , Jianmin Ma , Shijie Song , Lisbeth Dahl , Ole Jakob Nøstbakken , Maria W. Markhus , Bente M. Nilsen , Tanja Kögel , Anne-Katrine Lundebye , Atabak M. Azad , Abimbola Uzomah , Jeppe Kolding , Vidar S. Lien , Martin Wiech , Yanxu Zhang , Michael S. Bank
{"title":"Global marine fish trade networks track international pathways of nutrients and contaminants","authors":"Yiou Zhu , Quang Tri Ho , James P.W. Robinson , Marian Kjellevold , Ruirong Chang , Edvin Fuglebakk , Jianmin Ma , Shijie Song , Lisbeth Dahl , Ole Jakob Nøstbakken , Maria W. Markhus , Bente M. Nilsen , Tanja Kögel , Anne-Katrine Lundebye , Atabak M. Azad , Abimbola Uzomah , Jeppe Kolding , Vidar S. Lien , Martin Wiech , Yanxu Zhang , Michael S. Bank","doi":"10.1016/j.eehl.2026.100218","DOIUrl":"10.1016/j.eehl.2026.100218","url":null,"abstract":"<div><div>Marine fish trade globalizes nutrients and contaminants. Using trade data, human demographic information, and nutrient and contaminant exposure data, the estimated direct consumption of traded fish from Northeast Atlantic Ocean (NEAO) catches varied among 155 importer countries/regions. The associated trade pathways globalised high amounts of important nutrients including iodine, selenium, and eicosapentaenoic acid and docosahexaenoic acid (EPA + DHA) and contributed greatly to annual domestic EPA + DHA requirements for small-population importers (e.g., Lithuania: 62.8%) but not for high-population importers (e.g., Chinese mainland). Traded amounts of mercury, dioxin, and dioxin-like polychlorinated biphenyls (dl-PCBs) from the NEAO fish were low, and associated pathway contributions to total domestic mercury exposures were <4%. Changes in fish body size affected nutrient and contaminant fillet concentrations and subsequently trade dynamics of nutrients and contaminants. Our study provides valuable insights regarding seafood globalization and marine fish trade that can be used to support adaptive management strategies for contaminants and nutrition-sensitive policies.</div></div>","PeriodicalId":29813,"journal":{"name":"Eco-Environment & Health","volume":"5 1","pages":"Article 100218"},"PeriodicalIF":17.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146173431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eco-Environment & HealthPub Date : 2026-03-01Epub Date: 2026-02-03DOI: 10.1016/j.eehl.2026.100220
Ning Chen , Feipeng Cui , Yudiyang Ma , Jianing Wang , Linxi Tang , Lei Zheng , Meiqi Xing , Xinru Zhao , Yaohua Tian
{"title":"Association between residential greenness and risks of diabetic complications among individuals with type 2 diabetes and the roles of healthy lifestyle behaviors","authors":"Ning Chen , Feipeng Cui , Yudiyang Ma , Jianing Wang , Linxi Tang , Lei Zheng , Meiqi Xing , Xinru Zhao , Yaohua Tian","doi":"10.1016/j.eehl.2026.100220","DOIUrl":"10.1016/j.eehl.2026.100220","url":null,"abstract":"<div><div>Prospective evidence on the associations between residential greenness and risks of major diabetic complications remains limited. We explored the associations of residential greenness with incident diabetic macrovascular and microvascular complications among individuals with type 2 diabetes (T2D), and further assessed the roles of lifestyle factors in these associations. Our study included 13,848 patients with T2D. The Normalised Difference Vegetation Index (NDVI) within a 300-m buffer was used as the indicator of residential greenness. Eight lifestyle factors were included to construct a weighted healthy lifestyle score. Cox proportional hazard models were performed to assess the links between residential greenness and diabetic complication risks. We found that each interquartile range increase of NDVI within 300-m buffer was significantly associated with decreased diabetic complication risks, with hazard ratios (95% confidence intervals) of 0.921 (0.881, 0.964) for composite macrovascular complications, 0.886 (0.805, 0.975) for stroke, 0.901 (0.825, 0.985) for heart failure, 0.914 (0.866, 0.965) for coronary artery disease, 0.909 (0.865, 0.956) for composite microvascular complications, 0.842 (0.757, 0.937) for diabetic neuropathy, and 0.899 (0.841, 0.961) for diabetic nephropathy. Air pollutants and physical activity partly mediated these associations. Lifestyle factors modified some residential greenness-complications associations, and no significant associations between residential greenness and diabetic complications were observed among participants with poor lifestyles. Higher residential greenness levels were linked with lower risks of diabetic complications, and lifestyle factors might modify these associations.</div></div>","PeriodicalId":29813,"journal":{"name":"Eco-Environment & Health","volume":"5 1","pages":"Article 100220"},"PeriodicalIF":17.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146173437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eco-Environment & HealthPub Date : 2026-03-01Epub Date: 2025-12-24DOI: 10.1016/j.eehl.2025.100210
Yongbin Zhao , Huijun Wang , Yanzhen Hu , Zongyao Li , Xi Kang , Chang Su , Zhenyu Wu , Tao Zhang , Aidong Liu
{"title":"Serum perfluoroalkyl and polyfluoroalkyl substances and the risk of cardiometabolic diseases: Unraveling the mediating role of inflammatory markers","authors":"Yongbin Zhao , Huijun Wang , Yanzhen Hu , Zongyao Li , Xi Kang , Chang Su , Zhenyu Wu , Tao Zhang , Aidong Liu","doi":"10.1016/j.eehl.2025.100210","DOIUrl":"10.1016/j.eehl.2025.100210","url":null,"abstract":"<div><div>The persistence and biotoxicity of perfluoroalkyl and polyfluoroalkyl substances (PFASs) have raised concerns about cardiometabolic diseases (CMDs). Inflammation is thought to underlie the pathology of various CMDs. We aimed to comprehensively assess the risk of CMDs associated with PFASs and quantify the mediating effects of two kinds of inflammatory markers. Nine PFASs, a direct marker (high-sensitivity C-reactive protein [hs-CRP]), and an indirect marker (serum ferritin [SF]) were analyzed. A total of 12 CMDs of five types were defined based on 15 cardiometabolic biomarkers. The PFAS mixture had significant adverse effects on hypercholesterolemia (HC; OR = 1.20, 95% CI: 1.03–1.39), high low-density lipoprotein cholesterol (high LDL-C; OR = 1.13, 95% CI: 1.01–1.30), hypertension (OR = 1.10, 95% CI: 1.03–1.19), and hyperuricemia (OR = 1.31, 95% CI: 1.16–1.48) in the quantile-based g-computation (QGC) model, with PFNA and PFTrDA contributing the most. PFHxS was found to significantly impact all five types of CMDs simultaneously. The exposure-response analysis exhibited complex nonlinear patterns, with significant heterogeneity across diseases. Both inflammatory markers significantly mediated the effects of multiple PFASs on CMDs, with SF contributing a higher proportion of the mediating effects for obesity, dyslipidemia, and hyperuricemia. The highest mediation proportion reached 85.78% for abdominal obesity (FDR = 0.024). These results suggest that inflammation may serve as a key pathological mechanism linking PFAS exposure to CMDs, highlighting the potential value of SF as an iron status and indirect inflammatory marker in assessing PFAS-related cardiometabolic health risks.</div></div>","PeriodicalId":29813,"journal":{"name":"Eco-Environment & Health","volume":"5 1","pages":"Article 100210"},"PeriodicalIF":17.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145925996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eco-Environment & HealthPub Date : 2026-03-01Epub Date: 2026-02-12DOI: 10.1016/j.eehl.2026.100224
Lan Jiang , Jia Wang , Mengya Gao , Howard Bergman , Lei Cheng , Yanan Liu , Hongmei Ji , Ru Yan , Vijaya Raghavan , Jin Wang
{"title":"Health and environmental evidence, challenges, and sustainable strategies of Planetary Health Diet: A mixed-methods review","authors":"Lan Jiang , Jia Wang , Mengya Gao , Howard Bergman , Lei Cheng , Yanan Liu , Hongmei Ji , Ru Yan , Vijaya Raghavan , Jin Wang","doi":"10.1016/j.eehl.2026.100224","DOIUrl":"10.1016/j.eehl.2026.100224","url":null,"abstract":"<div><div>The Planetary Health Diet (PHD) was proposed by the Lancet Commission in 2019. It is a new way of eating that aims to improve both human health and the environment simultaneously. However, recent practice demonstrates persistent cognitive gaps in terms of systematic quantification of health benefits, robust evidence of environmental impacts, and region-specific implementation pathways. This study systematically integrates epidemiological evidence to clarify the associations between PHD and reduced risks of diseases, including cardiovascular disease, diabetes, and certain cancers. Additionally, the study talks about how it affects the demand for agricultural land, the stress on freshwater resources, the release of greenhouse gases, and the imbalance in nitrogen and phosphorus cycles. The study elucidates various multidimensional obstacles to global PHD adoption, including limitations in natural resources, regional economic inequalities, scaling challenges in food technology innovation, and resistance to cultural and intergenerational transmission. To tackle these issues, the study proposes a four-dimensional synergistic approach: encouraging innovation in food production systems, creating fair food distribution systems, building policy intervention toolkits, and designing behavioral incentives. These evidence-based solutions offer both theoretical foundations and actionable paradigms for sustainable food system transformation.</div></div>","PeriodicalId":29813,"journal":{"name":"Eco-Environment & Health","volume":"5 1","pages":"Article 100224"},"PeriodicalIF":17.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147384829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eco-Environment & HealthPub Date : 2026-03-01Epub Date: 2025-12-16DOI: 10.1016/j.eehl.2025.100209
Wen Li , Qingbin Yuan , Xiaolong Wang , Wei Wang , Xinda Wu , Yanxu Zhang , Xiaoli Zhao , Yi Luo , Fengchang Wu
{"title":"Integrated global assessment of Escherichia coli emissions from wastewater treatment plants","authors":"Wen Li , Qingbin Yuan , Xiaolong Wang , Wei Wang , Xinda Wu , Yanxu Zhang , Xiaoli Zhao , Yi Luo , Fengchang Wu","doi":"10.1016/j.eehl.2025.100209","DOIUrl":"10.1016/j.eehl.2025.100209","url":null,"abstract":"<div><div>Wastewater treatment plants (WWTPs) are critical for mitigating anthropogenic contaminants, yet their effectiveness in controlling waterborne pathogens has not been assessed globally. This study presents the first global assessment of <em>Escherichia coli</em> (<em>E. coli</em>) emissions from 58,502 WWTPs across 188 countries and territories, utilizing a CatBoost machine learning model based on actual data from 230 facilities. Our results reveal pervasive <em>E. coli</em> contamination in global WWTP effluents, with a median concentration of 3.83 log Most Probable Number (MPN)/100 mL (range: 0–5.86 log MPN/100 mL), and 78.3% of WWTPs exceeding 3 log MPN/100 mL, particularly in Africa, South America, and Southeast Asia. The primary driver of this contamination is insufficient disinfection coverage, which is closely linked to the lack of enforceable microbial discharge standards rather than the development level alone. Furthermore, <em>E. coli</em> emissions from WWTPs compromise the microbial quality of downstream drinking and recreational waters, posing serious public health threats. To address this gap, we propose Human Development Index (HDI)-stratified <em>E. coli</em> discharge standards based on reverse risk modeling aligned with WHO health-based targets. Scenario analyses indicate that combining these risk-informed thresholds with targeted disinfection upgrades could reduce global non-compliance of WWTPs by 47% for drinking water and 58% for recreational water exposure, with the greatest benefits in regions with limited infrastructure. This study provides the first global, health-based framework for microbial water quality management in WWTPs, offering actionable guidance to reduce inequities in waterborne disease risk and improve global water safety.</div></div>","PeriodicalId":29813,"journal":{"name":"Eco-Environment & Health","volume":"5 1","pages":"Article 100209"},"PeriodicalIF":17.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145884736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eco-Environment & HealthPub Date : 2026-03-01Epub Date: 2026-01-20DOI: 10.1016/j.eehl.2026.100215
Yunhui Zhang , Lite Meng , Wenfei Yu , Yang Wen , Hui Wang , Mengchen Sun , Yuanchen Chen , Bin Dong , Jörg Rinklebe
{"title":"Fate, occurrence, and regional-scale emissions of neonicotinoid pesticides and their metabolites in wastewater treatment plants in suburban Shanghai, China","authors":"Yunhui Zhang , Lite Meng , Wenfei Yu , Yang Wen , Hui Wang , Mengchen Sun , Yuanchen Chen , Bin Dong , Jörg Rinklebe","doi":"10.1016/j.eehl.2026.100215","DOIUrl":"10.1016/j.eehl.2026.100215","url":null,"abstract":"<div><div>Neonicotinoid pesticides (NEOs) are emerging contaminants with potential ecological and human health risks. However, their sources, transformation dynamics, and emission pathways in urban wastewater systems remain poorly quantified. This study systematically investigates the spatial distribution, sources, and transformation of 8 parent NEOs (pNEOs) and 6 metabolites (mNEOs) in the influents of 21 wastewater treatment plants (WWTPs) in suburban Shanghai, China. The average concentrations of ΣpNEOs and ΣmNEOs were 568.17 ng/L and 478.20 ng/L, respectively, with significant spatial variations. pNEOs were dominated by nitenpyram (NIT) and dinotefuran (DIN), while mNEOs, such as desnitro-imidacloprid (DN-IMI) and dinotefuran-urea (DIN-U), showed higher abundances. Correlation and cluster analyses reveal pNEOs primarily originate from agricultural activities, whereas mNEOs likely stem from both agricultural and industrial sources, including pesticide production residues. A novel model incorporating Monte Carlo simulations estimates point-source emissions from the 21 WWTPs at 264.57 kg/a for pNEOs and 269.34 kg/a for mNEOs, with total Shanghai-wide emissions reaching 2947.03 kg/a and 1056.56 kg/a, respectively. This study highlights the critical role of WWTPs in discharging NEOs into receiving water bodies, underscoring the need for integrated management strategies targeting agricultural and industrial inputs to WWTPs as well as for the advancement of WWTP processes designed to eliminate emerging contaminants.</div></div>","PeriodicalId":29813,"journal":{"name":"Eco-Environment & Health","volume":"5 1","pages":"Article 100215"},"PeriodicalIF":17.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146173433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eco-Environment & HealthPub Date : 2026-03-01Epub Date: 2026-01-08DOI: 10.1016/j.eehl.2026.100214
Chaofa Chen , Kanglu Chen , Qingqing Wu , Yan Lin , Yuxiao Shao , Miaozhen Cai , Yongming Luo , Hua Zhang
{"title":"Charge-selective polystyrene nanoplastic retention by plant cell walls: Pectin domains dictate differential accumulation in rice seedling roots and shoots","authors":"Chaofa Chen , Kanglu Chen , Qingqing Wu , Yan Lin , Yuxiao Shao , Miaozhen Cai , Yongming Luo , Hua Zhang","doi":"10.1016/j.eehl.2026.100214","DOIUrl":"10.1016/j.eehl.2026.100214","url":null,"abstract":"<div><div>The escalating global plastic pollution necessitates urgent investigation into the distribution and accumulation pathways of nanoplastics (NPs) in crops to assess their threats to food security. Here, we reveal that plant cell walls serve as a charge-selective barrier governing the differential uptake of polystyrene (PS) NPs with distinct surface charges (PS-COOH NPs and PS-NH<sub>2</sub> NPs) in rice. Quantitative tracking showed that PS-COOH NPs accumulated 1.84- and 4.43-fold more in roots and shoots, respectively, than PS-NH<sub>2</sub>, with >92% of both NPs restricted to roots. Crucially, root cell walls selectively retained NPs based on charge: PS-NH<sub>2</sub> NPs accumulated 1.91–2.45-fold more than PS-COOH NPs within walls, primarily through binding to pectin (74.04%–87.28% sequestration). Furthermore, NPs induced cell wall remodeling, including pectin enrichment, hemicellulose I deposition, thereby reinforcing charge-selective retention and differential uptake. These findings reveal an adaptive mechanism of plant cell walls under NPs stress and provide mechanistic insights into charge-dependent NPs accumulation pathways in edible crops.</div></div>","PeriodicalId":29813,"journal":{"name":"Eco-Environment & Health","volume":"5 1","pages":"Article 100214"},"PeriodicalIF":17.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146173434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}