ACS Organic & Inorganic Au最新文献_第8页

Cationic Au(I) Complexes of Indoles. 吲哚类阳离子Au(I)配合物。

IF 3.3

ACS Organic & Inorganic Au Pub Date : 2025-09-18 eCollection Date: 2025-12-03 DOI: 10.1021/acsorginorgau.5c00075

Pierre Milcendeau, Mohammed Ramdani, Elsa van Elslande, Xavier Guinchard

引用次数: 0

Arylazo Sulfones as 1,3-Dipole Acceptors in the (Photo)-Micellar van Leusen Triazole Synthesis. 芳偶氮砜作为1,3偶极子受体在胶束van Leusen三唑合成中的应用。

IF 3.3

ACS Organic & Inorganic Au Pub Date : 2025-09-15 eCollection Date: 2025-12-03 DOI: 10.1021/acsorginorgau.5c00080

Carmine Volpe, Luca Nicchio, Federica Santoro, Teresa Silvestri, Anna Di Porzio, Camilla Russo, Fabiana Quaglia, Antonio Randazzo, Alfonso Carotenuto, Diego Brancaccio, Stefano Protti, Mariateresa Giustiniano

{"title":"Arylazo Sulfones as 1,3-Dipole Acceptors in the (Photo)-Micellar van Leusen Triazole Synthesis.","authors":"Carmine Volpe, Luca Nicchio, Federica Santoro, Teresa Silvestri, Anna Di Porzio, Camilla Russo, Fabiana Quaglia, Antonio Randazzo, Alfonso Carotenuto, Diego Brancaccio, Stefano Protti, Mariateresa Giustiniano","doi":"10.1021/acsorginorgau.5c00080","DOIUrl":"10.1021/acsorginorgau.5c00080","url":null,"abstract":"Arylazo sulfones represent a valuable class of organic compounds, which can be exploited as safer and bench-stable analogues of diazonium salts. Notwithstanding their significant applications in light-triggered reactions as precursors of either diazenyl or aryl radicals, their reactivity as 1,3-dipole acceptors has been poorly investigated. The present manuscript addresses the study of a [3 + 2] cycloaddition reaction between arylazo sulfones and α-acidic isonitriles such as TosMIC and related analogues. Reaction conditions have been optimized in a micellar medium, namely CTAC 2% aq solution, in order to afford sustainable synthetic access to 1,2,4-triazole derivatives, a relevant scaffold in medicinal and material chemistry. The substrate scope has been showcased with 24 examples (24-90% yield) with good functional group tolerability. Worthy of note, solution NMR techniques have been applied to characterize the reaction at the molecular level, providing a groundwork to drive a rational choice of the micellar medium on the basis of the substrates' chemical nature. Moreover, the recyclability of the micellar medium was investigated via dynamic light scattering (DLS) analyses.","PeriodicalId":29797,"journal":{"name":"ACS Organic & Inorganic Au","volume":"5 6","pages":"539-547"},"PeriodicalIF":3.3,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12679303/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145702123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Access to N‑Fluorinated Azapeptides and Azapeptoids as Peptidomimetic Scaffolds. 氮杂化氮杂肽和氮杂肽类作为拟肽支架的获取。

IF 3.3

ACS Organic & Inorganic Au Pub Date : 2025-09-09 eCollection Date: 2025-12-03 DOI: 10.1021/acsorginorgau.5c00073

Dimitra Kyrko, Tingting Cao, Pascal Retailleau, Julia Kaffy, Benoît Crousse

引用次数: 0

Identifying Reactivity Differences of Two-Carbon-Atom-Based Legacy Refrigerants at Group 9 Metal Pincer Complexes. 9族金属螯合物中两碳原子基遗留制冷剂反应性差异的鉴定。

IF 3.3

ACS Organic & Inorganic Au Pub Date : 2025-08-28 eCollection Date: 2025-12-03 DOI: 10.1021/acsorginorgau.5c00071

Luc A Mauro, Isabelle A Herlinger, Shane J Hall, Russell P Hughes, Roger E Cramer, Lisa A Fredin, David A Vicic

{"title":"Identifying Reactivity Differences of Two-Carbon-Atom-Based Legacy Refrigerants at Group 9 Metal Pincer Complexes.","authors":"Luc A Mauro, Isabelle A Herlinger, Shane J Hall, Russell P Hughes, Roger E Cramer, Lisa A Fredin, David A Vicic","doi":"10.1021/acsorginorgau.5c00071","DOIUrl":"10.1021/acsorginorgau.5c00071","url":null,"abstract":"We describe the first comparative data on metal-mediated C-H activation and functionalization reactions at two-carbon-atom legacy refrigerants and density functional theory (DFT) analyses on the resulting organometallic products. We reveal that, depending on the degree of fluorination in the refrigerant, C-H activation could lead either to stable M-(H)-Rf products or to a M-(fluoroolefin) complex. The first example of a metal-mediated dehydrofluorination of R-143a is described, resulting from a β-fluoride elimination reaction of a putative [Ir-(H)-(CH2CF3)] intermediate and the loss of hydrogen fluoride. This work also reports the first examples of metal-mediated activation of R-125 (CF3-CF2H) and R-134a (CF3-CFH2) where the direct C-H activation products can be observed spectroscopically and, in the case of R-125, structurally characterized. The stability of the [Ir-(H)-(Rf)] complexes is notable, given that the direct products of C-H activation of nonchelating alkanes at transition metals remains relatively rare. The clean formation of isolable [Ir-(H)-(Rf)] complexes is expected to facilitate studies of migratory insertion reactions in these species, which bodes well for efforts to repurpose high-global-warming-potential legacy refrigerants. Finally, DFT calculations provide insight into how the degree of fluorination affects CC bond lengths and energies of propellor-like rotations in the coordinated fluoroolefins, the relative free energies of fluoroolefin binding, and the role of observed CH···F contacts in the calculated structures.","PeriodicalId":29797,"journal":{"name":"ACS Organic & Inorganic Au","volume":"5 6","pages":"518-530"},"PeriodicalIF":3.3,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12679306/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145701851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis of (P^N^C)Gold(III) Complexes via Tandem Oxidative Addition/C-H Auration. （P^N^C）金（III）配合物的串联氧化加成/碳氢化反应合成。

IF 3.3

ACS Organic & Inorganic Au Pub Date : 2025-08-23 eCollection Date: 2025-10-01 DOI: 10.1021/acsorginorgau.5c00057

Michał Biedrzycki, Jaime Martín, Alexandre Genoux, Elia Boschi, Cristina Nevado

引用次数: 0

IF 3.3