一锅nis促进环化/钯催化羰基化选择性合成含HFIP酯的茚和硫代铬烯。

IF 3.3 Q2 CHEMISTRY, MULTIDISCIPLINARY

ACS Organic & Inorganic Au Pub Date : 2025-02-21 eCollection Date: 2025-04-02 DOI:10.1021/acsorginorgau.5c00005

Pengfei Ji, Xing-Feng Pan, Xinxin Qi, Xiao-Feng Wu

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引用次数: 0

摘要

以相同的丙基硫醚和HFIP为原料，通过nis促进的环化/钯催化羰基化，开发了一锅选择性合成含HFIP酯的吲哚/硫代色素的实用和原子经济的方法。溶剂在这一转化过程中起着重要的作用，反应选择性地、高效地进行，以中等到优异的收率得到各种含HFIP酯的茚和硫代色素。此外，使用甲酸作为CO源可以避免对有毒CO气体的操纵。

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One-Pot NIS-Promoted Cyclization/Palladium-Catalyzed Carbonylation for the Selective Synthesis of HFIP Ester-Containing Indenes and Thiochromenes.

Practical and atom-economic procedures for the selective synthesis of HFIP ester-containing indenes/thiochromenes from the same propargylic thioethers and HFIP have been developed via one-pot NIS-promoted cyclization/palladium-catalyzed carbonylation. Solvent plays an important role in this transformation, and the reactions proceed selectively and efficiently to afford a variety of HFIP ester-containing indenes and thiochromenes in moderate to excellent yields. In addition, the use of formic acid as the CO source could avoid manipulation of toxic CO gas.

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来源期刊

ACS Organic & Inorganic Au 有机化学、无机化学-

CiteScore

4.10

自引率

0.00%

发文量

期刊介绍： ACS Organic & Inorganic Au is an open access journal that publishes original experimental and theoretical/computational studies on organic organometallic inorganic crystal growth and engineering and organic process chemistry. Short letters comprehensive articles reviews and perspectives are welcome on topics that include:Organic chemistry Organometallic chemistry Inorganic Chemistry and Organic Process Chemistry.