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Long-Term Grazing and Nitrogen Management Impacted Methane Emission Potential and Soil Microbial Community in Grazing Pastures. 长期放牧和氮肥管理对放牧草地甲烷排放潜力和土壤微生物群落的影响。
Environment & Health Pub Date : 2024-09-20 eCollection Date: 2025-01-17 DOI: 10.1021/envhealth.4c00138
Maura Purcell, Jesse DuPont, Anil Somenahally, Javid F McLawrence, Cara L Case, Prasanna Gowda, Nevada King, Monte Jr Rouquette, Ri-Qing Yu
{"title":"Long-Term Grazing and Nitrogen Management Impacted Methane Emission Potential and Soil Microbial Community in Grazing Pastures.","authors":"Maura Purcell, Jesse DuPont, Anil Somenahally, Javid F McLawrence, Cara L Case, Prasanna Gowda, Nevada King, Monte Jr Rouquette, Ri-Qing Yu","doi":"10.1021/envhealth.4c00138","DOIUrl":"10.1021/envhealth.4c00138","url":null,"abstract":"<p><p>Achieving sustainable development in livestock agriculture by balancing livestock production, reduction of greenhouse gas (GHG) emissions, and effective utilization of nitrogen nutrient has indeed been challenging. This study investigated the long-term effects of continuous cattle grazing, stocking rates, and fertilization regimens on methane (CH<sub>4</sub>) emissions, soil microbial communities, and soil organic carbon (SOC) stocks in Bermudagrass pastures in East Texas, USA. Pastures were subjected to high or low stocking rates for over 50 years, with further subdivision based on fertilization: nitrogen-based fertilizer application or no fertilizer but with the growth of annual clover. Seasonal soil cores (0-60 cm) were collected, and laboratory microcosm incubation studies revealed unexpectedly high <i>in vitro</i> CH<sub>4</sub> emissions in surface soils, particularly in the top 0-5 cm soil layer, reaching up to 300 nmol of CH<sub>4</sub> mL<sup>-1</sup>. Higher CH<sub>4</sub> emissions and methanogen abundance, along with lower SOC stocks, were observed in pastures subjected to high stocking rates compared to those with low stocking rates and in clover pastures compared to those with N-fertilized ryegrass. On the contrary, in low-stocked, N-fertilized annual ryegrass pastures, methanogen abundance was lowest, CH<sub>4</sub> emissions were negligible, and SOC stocks were highest. Furthermore, animal excreta deposition significantly contributed to increased CH<sub>4</sub> emissions. Prokaryotic and potential methanotrophic taxa, as compared to fungi, exhibited greater responsiveness to N-fertilization than to cattle stocking treatments with higher levels of methanotrophs observed in pastures subjected to high stocking rates and clover growth. This study suggests that strategic management practices such as optimal grazing and nitrogen management could effectively mitigate CH<sub>4</sub> emissions in grazing lands.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 1","pages":"68-78"},"PeriodicalIF":0.0,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11744396/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143013122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of Machine Learning Based QSAR Models for the Classification of Lung Surfactant Inhibitors. 基于机器学习的QSAR模型在肺表面活性物质抑制剂分类中的评价。
Environment & Health Pub Date : 2024-09-20 eCollection Date: 2024-12-20 DOI: 10.1021/envhealth.4c00118
James Y Liu, Joshua Peeples, Christie M Sayes
{"title":"Evaluation of Machine Learning Based QSAR Models for the Classification of Lung Surfactant Inhibitors.","authors":"James Y Liu, Joshua Peeples, Christie M Sayes","doi":"10.1021/envhealth.4c00118","DOIUrl":"10.1021/envhealth.4c00118","url":null,"abstract":"<p><p>Inhaled chemicals can cause dysfunction in the lung surfactant, a protein-lipid complex with critical biophysical and biochemical functions. This inhibition has many structure-related and dose-dependent mechanisms, making hazard identification challenging. We developed quantitative structure-activity relationships for predicting lung surfactant inhibition using machine learning. Logistic regression, support vector machines, random forest, gradient-boosted trees, prior-data-fitted networks, and multilayer perceptron were evaluated as methods. Multilayer perceptron had the strongest performance with 96% accuracy and an F1 score of 0.97. Support vector machines and logistic regression also performed well with lower computation costs. This serves as a proof-of-concept for efficient hazard screening in the emerging area of lung surfactant inhibition.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"2 12","pages":"912-917"},"PeriodicalIF":0.0,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11667287/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142898689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-Term Grazing and Nitrogen Management Impacted Methane Emission Potential and Soil Microbial Community in Grazing Pastures 长期放牧和氮肥管理对放牧草地甲烷排放潜力和土壤微生物群落的影响
Environment & Health Pub Date : 2024-09-20 DOI: 10.1021/envhealth.4c0013810.1021/envhealth.4c00138
Maura Purcell, Jesse DuPont, Anil Somenahally*, Javid F. McLawrence, Cara L. Case, Prasanna Gowda, Nevada King, Monte Jr. Rouquette and Ri-Qing Yu*, 
{"title":"Long-Term Grazing and Nitrogen Management Impacted Methane Emission Potential and Soil Microbial Community in Grazing Pastures","authors":"Maura Purcell,&nbsp;Jesse DuPont,&nbsp;Anil Somenahally*,&nbsp;Javid F. McLawrence,&nbsp;Cara L. Case,&nbsp;Prasanna Gowda,&nbsp;Nevada King,&nbsp;Monte Jr. Rouquette and Ri-Qing Yu*,&nbsp;","doi":"10.1021/envhealth.4c0013810.1021/envhealth.4c00138","DOIUrl":"https://doi.org/10.1021/envhealth.4c00138https://doi.org/10.1021/envhealth.4c00138","url":null,"abstract":"<p >Achieving sustainable development in livestock agriculture by balancing livestock production, reduction of greenhouse gas (GHG) emissions, and effective utilization of nitrogen nutrient has indeed been challenging. This study investigated the long-term effects of continuous cattle grazing, stocking rates, and fertilization regimens on methane (CH<sub>4</sub>) emissions, soil microbial communities, and soil organic carbon (SOC) stocks in Bermudagrass pastures in East Texas, USA. Pastures were subjected to high or low stocking rates for over 50 years, with further subdivision based on fertilization: nitrogen-based fertilizer application or no fertilizer but with the growth of annual clover. Seasonal soil cores (0–60 cm) were collected, and laboratory microcosm incubation studies revealed unexpectedly high <i>in vitro</i> CH<sub>4</sub> emissions in surface soils, particularly in the top 0–5 cm soil layer, reaching up to 300 nmol of CH<sub>4</sub> mL<sup>–1</sup>. Higher CH<sub>4</sub> emissions and methanogen abundance, along with lower SOC stocks, were observed in pastures subjected to high stocking rates compared to those with low stocking rates and in clover pastures compared to those with N-fertilized ryegrass. On the contrary, in low-stocked, N-fertilized annual ryegrass pastures, methanogen abundance was lowest, CH<sub>4</sub> emissions were negligible, and SOC stocks were highest. Furthermore, animal excreta deposition significantly contributed to increased CH<sub>4</sub> emissions. Prokaryotic and potential methanotrophic taxa, as compared to fungi, exhibited greater responsiveness to N-fertilization than to cattle stocking treatments with higher levels of methanotrophs observed in pastures subjected to high stocking rates and clover growth. This study suggests that strategic management practices such as optimal grazing and nitrogen management could effectively mitigate CH<sub>4</sub> emissions in grazing lands.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 1","pages":"68–78 68–78"},"PeriodicalIF":0.0,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/envhealth.4c00138","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143091797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Theoretical Investigation of Cytochrome P450 Enzyme-Mediated Biotransformation Mechanism of BHPF: Unveiling the Metabolic Safety Aspects of an Alternative to BPA. 细胞色素P450酶介导的BHPF生物转化机制的理论研究:揭示BPA替代品的代谢安全方面。
Environment & Health Pub Date : 2024-09-17 eCollection Date: 2025-02-21 DOI: 10.1021/envhealth.4c00132
Wenxiao Pan, Shuming He, Yinzheng Yang, Yongdie Yang, Qiao Xue, Xian Liu, Jianjie Fu, Aiqian Zhang
{"title":"Theoretical Investigation of Cytochrome P450 Enzyme-Mediated Biotransformation Mechanism of BHPF: Unveiling the Metabolic Safety Aspects of an Alternative to BPA.","authors":"Wenxiao Pan, Shuming He, Yinzheng Yang, Yongdie Yang, Qiao Xue, Xian Liu, Jianjie Fu, Aiqian Zhang","doi":"10.1021/envhealth.4c00132","DOIUrl":"10.1021/envhealth.4c00132","url":null,"abstract":"<p><p>Fluorene-9-bisphenol (BHPF), emerging as an alternative to bisphenol A (BPA), is extensively utilized in industry and consumer goods. BHPF exhibits antiestrogenic effects and potential reproductive toxicity. Similar to BPA, BHPF can closely access the active site of the cytochrome P450 (CYP450) enzyme, interact with the Fe=O moiety, and potentially initiate metabolic reactions. Using density functional theory (DFT) calculations, we explored the mechanisms underlying BHPF activation using a CYP450 compound I (Cpd I) model, identifying several plausible products. Compared with the higher energy barriers associated with phenyl ring addition reactions, the formation of a phenoxyl-type radical through phenolic hydrogen atom abstraction, followed by OH rebound or radical coupling, represents an energetically favorable pathway. The OH rebound process yields three primary products: 9-(3,4-dihydroxyphenyl)-9-(4-hydroxyphenyl)fluorene (PRD1), semiquinone radical anion (PRD2), and 9-(4-hydroxyphenyl)fluorene carbocation (PRD3), constituting the major outcomes of the BHPF metabolic reaction. Importantly, a lipophilic ether metabolite, BHPF-O-BHPF (PRD4), formed through the coupling of phenoxyl radicals, reflects a widespread metabolic pathway observed in phenolic molecules. Despite constituting a minor proportion, the toxicity of this product necessitates increased attention. These findings contribute significantly to an enhanced understanding of the potential hazards associated with BHPF and other unknown chemical entities.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 2","pages":"133-142"},"PeriodicalIF":0.0,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11851209/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Theoretical Investigation of Cytochrome P450 Enzyme-Mediated Biotransformation Mechanism of BHPF: Unveiling the Metabolic Safety Aspects of an Alternative to BPA 细胞色素P450酶介导的BHPF生物转化机制的理论研究:揭示BPA替代品的代谢安全方面
Environment & Health Pub Date : 2024-09-17 DOI: 10.1021/envhealth.4c0013210.1021/envhealth.4c00132
Wenxiao Pan, Shuming He, Yinzheng Yang, Yongdie Yang, Qiao Xue*, Xian Liu, Jianjie Fu and Aiqian Zhang*, 
{"title":"Theoretical Investigation of Cytochrome P450 Enzyme-Mediated Biotransformation Mechanism of BHPF: Unveiling the Metabolic Safety Aspects of an Alternative to BPA","authors":"Wenxiao Pan,&nbsp;Shuming He,&nbsp;Yinzheng Yang,&nbsp;Yongdie Yang,&nbsp;Qiao Xue*,&nbsp;Xian Liu,&nbsp;Jianjie Fu and Aiqian Zhang*,&nbsp;","doi":"10.1021/envhealth.4c0013210.1021/envhealth.4c00132","DOIUrl":"https://doi.org/10.1021/envhealth.4c00132https://doi.org/10.1021/envhealth.4c00132","url":null,"abstract":"<p >Fluorene-9-bisphenol (BHPF), emerging as an alternative to bisphenol A (BPA), is extensively utilized in industry and consumer goods. BHPF exhibits antiestrogenic effects and potential reproductive toxicity. Similar to BPA, BHPF can closely access the active site of the cytochrome P450 (CYP450) enzyme, interact with the Fe═O moiety, and potentially initiate metabolic reactions. Using density functional theory (DFT) calculations, we explored the mechanisms underlying BHPF activation using a CYP450 compound I (Cpd I) model, identifying several plausible products. Compared with the higher energy barriers associated with phenyl ring addition reactions, the formation of a phenoxyl-type radical through phenolic hydrogen atom abstraction, followed by OH rebound or radical coupling, represents an energetically favorable pathway. The OH rebound process yields three primary products: 9-(3,4-dihydroxyphenyl)-9-(4-hydroxyphenyl)fluorene (PRD1), semiquinone radical anion (PRD2), and 9-(4-hydroxyphenyl)fluorene carbocation (PRD3), constituting the major outcomes of the BHPF metabolic reaction. Importantly, a lipophilic ether metabolite, BHPF-O-BHPF (PRD4), formed through the coupling of phenoxyl radicals, reflects a widespread metabolic pathway observed in phenolic molecules. Despite constituting a minor proportion, the toxicity of this product necessitates increased attention. These findings contribute significantly to an enhanced understanding of the potential hazards associated with BHPF and other unknown chemical entities.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 2","pages":"133–142 133–142"},"PeriodicalIF":0.0,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/envhealth.4c00132","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143452630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fifteen Pathways between Electric Vehicles and Public Health: A Transportation-Health Conceptual Framework. 电动汽车与公共健康之间的15条路径:交通-健康概念框架。
Environment & Health Pub Date : 2024-09-17 eCollection Date: 2024-12-20 DOI: 10.1021/envhealth.4c00156
Chunyu Guo, Becky P Y Loo, Kuishuang Feng, H Oliver Gao, Kai Zhang
{"title":"Fifteen Pathways between Electric Vehicles and Public Health: A Transportation-Health Conceptual Framework.","authors":"Chunyu Guo, Becky P Y Loo, Kuishuang Feng, H Oliver Gao, Kai Zhang","doi":"10.1021/envhealth.4c00156","DOIUrl":"10.1021/envhealth.4c00156","url":null,"abstract":"<p><p>The health impact of electric vehicles (EVs) is complex and multifaceted, encompassing reductions in air pollutants, improvements in road safety, and implications for social equity. However, existing studies often provide fragmented insights, lacking a unified framework to comprehensively assess these public health implications. This paper develops a comprehensive framework to summarize the health outcomes of EVs in urban areas, where the health impacts are more pronounced due to higher levels of traffic congestion and air pollution. Building on previous conceptual work that identified pathways linking general transportation and health, our model illustrates how the characteristics of EVs influence public health through various pathways compared to traditional transportation systems. Additionally, we address socioeconomic factors that introduce variability in EV-related health outcomes, emphasizing the need to consider potential health disparities in policy and intervention development. This comprehensive approach aims to inform holistic policies that account for the complex interplay between transportation, environment, and public health.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"2 12","pages":"848-853"},"PeriodicalIF":0.0,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11667283/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142898695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fifteen Pathways between Electric Vehicles and Public Health: A Transportation–Health Conceptual Framework 电动汽车与公共健康之间的 15 条路径:交通-健康概念框架
Environment & Health Pub Date : 2024-09-16 DOI: 10.1021/envhealth.4c0015610.1021/envhealth.4c00156
Chunyu Guo, Becky P. Y. Loo, Kuishuang Feng, H. Oliver Gao and Kai Zhang*, 
{"title":"Fifteen Pathways between Electric Vehicles and Public Health: A Transportation–Health Conceptual Framework","authors":"Chunyu Guo,&nbsp;Becky P. Y. Loo,&nbsp;Kuishuang Feng,&nbsp;H. Oliver Gao and Kai Zhang*,&nbsp;","doi":"10.1021/envhealth.4c0015610.1021/envhealth.4c00156","DOIUrl":"https://doi.org/10.1021/envhealth.4c00156https://doi.org/10.1021/envhealth.4c00156","url":null,"abstract":"<p >The health impact of electric vehicles (EVs) is complex and multifaceted, encompassing reductions in air pollutants, improvements in road safety, and implications for social equity. However, existing studies often provide fragmented insights, lacking a unified framework to comprehensively assess these public health implications. This paper develops a comprehensive framework to summarize the health outcomes of EVs in urban areas, where the health impacts are more pronounced due to higher levels of traffic congestion and air pollution. Building on previous conceptual work that identified pathways linking general transportation and health, our model illustrates how the characteristics of EVs influence public health through various pathways compared to traditional transportation systems. Additionally, we address socioeconomic factors that introduce variability in EV-related health outcomes, emphasizing the need to consider potential health disparities in policy and intervention development. This comprehensive approach aims to inform holistic policies that account for the complex interplay between transportation, environment, and public health.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"2 12","pages":"848–853 848–853"},"PeriodicalIF":0.0,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/envhealth.4c00156","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142867754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unveiling the Origin of Copper Accumulation in Plasma with Aging. 揭示铜在血浆中随年龄累积的来源。
Environment & Health Pub Date : 2024-09-11 eCollection Date: 2025-01-17 DOI: 10.1021/envhealth.4c00096
Weichao Wang, Dawei Lu, Hang Yang, Zigu Chen, Weibo Ling, Shanjun Song, Linyi Peng, Qian Liu, Guibin Jiang
{"title":"Unveiling the Origin of Copper Accumulation in Plasma with Aging.","authors":"Weichao Wang, Dawei Lu, Hang Yang, Zigu Chen, Weibo Ling, Shanjun Song, Linyi Peng, Qian Liu, Guibin Jiang","doi":"10.1021/envhealth.4c00096","DOIUrl":"10.1021/envhealth.4c00096","url":null,"abstract":"<p><p>Aging is intricately linked to various diseases including cancers, neurodegenerative disorders, and metabolic irregularities. Copper (Cu) overexposure has been found to be linked to many diseases during aging, particularly neurodegenerative diseases. Meanwhile, as an essential element, Cu has been implicated in key processes associated with aging, raising questions about its role in age-related health issues. This study delves into the mechanisms behind the copper imbalance during aging. By analyzing blood copper concentrations of healthy individuals (including data from healthy subjects (26 ≤ age ≤ 90, <i>n</i> = 62) and publicly available data from the National Health and Nutrition Examination Survey (18 ≤ age < 80, <i>n</i> = 1624)) and employing C57BL/6N male mice models (<i>n</i> = 22), we reveal a consistent age-related increase in copper levels, particularly in plasma. Utilizing stable copper isotopic analysis, copper-associated protein analysis, and metabolomic analysis, we trace the sources of Cu imbalance associated with aging. Our findings reveal that aged mice had a higher copper concentrations and an enrichment of light copper isotope (<sup>63</sup>Cu) in plasma compared to controls. Additionally, copper reductases and copper transporters are upregulated in the intestine tract, associated with the AMPK and mTOR signaling pathways. We suggest that aged mice have an abnormally high copper intake requirement, probably due to deregulated nutrient sensing, leading to increased expression levels of copper reductases and copper transporters for extra copper absorption in the intestines. This research provides a copper-centric perspective on the connection between deregulated nutrient sensing and aging, thus shedding light on the aspect of aging and copper overexposure.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 1","pages":"58-67"},"PeriodicalIF":0.0,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11744393/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unveiling the Origin of Copper Accumulation in Plasma with Aging 揭示铜在血浆中随年龄累积的来源
Environment & Health Pub Date : 2024-09-11 DOI: 10.1021/envhealth.4c0009610.1021/envhealth.4c00096
Weichao Wang, Dawei Lu, Hang Yang, Zigu Chen, Weibo Ling, Shanjun Song, Linyi Peng, Qian Liu* and Guibin Jiang, 
{"title":"Unveiling the Origin of Copper Accumulation in Plasma with Aging","authors":"Weichao Wang,&nbsp;Dawei Lu,&nbsp;Hang Yang,&nbsp;Zigu Chen,&nbsp;Weibo Ling,&nbsp;Shanjun Song,&nbsp;Linyi Peng,&nbsp;Qian Liu* and Guibin Jiang,&nbsp;","doi":"10.1021/envhealth.4c0009610.1021/envhealth.4c00096","DOIUrl":"https://doi.org/10.1021/envhealth.4c00096https://doi.org/10.1021/envhealth.4c00096","url":null,"abstract":"<p >Aging is intricately linked to various diseases including cancers, neurodegenerative disorders, and metabolic irregularities. Copper (Cu) overexposure has been found to be linked to many diseases during aging, particularly neurodegenerative diseases. Meanwhile, as an essential element, Cu has been implicated in key processes associated with aging, raising questions about its role in age-related health issues. This study delves into the mechanisms behind the copper imbalance during aging. By analyzing blood copper concentrations of healthy individuals (including data from healthy subjects (26 ≤ age ≤ 90, <i>n</i> = 62) and publicly available data from the National Health and Nutrition Examination Survey (18 ≤ age &lt; 80, <i>n</i> = 1624)) and employing C57BL/6N male mice models (<i>n</i> = 22), we reveal a consistent age-related increase in copper levels, particularly in plasma. Utilizing stable copper isotopic analysis, copper-associated protein analysis, and metabolomic analysis, we trace the sources of Cu imbalance associated with aging. Our findings reveal that aged mice had a higher copper concentrations and an enrichment of light copper isotope (<sup>63</sup>Cu) in plasma compared to controls. Additionally, copper reductases and copper transporters are upregulated in the intestine tract, associated with the AMPK and mTOR signaling pathways. We suggest that aged mice have an abnormally high copper intake requirement, probably due to deregulated nutrient sensing, leading to increased expression levels of copper reductases and copper transporters for extra copper absorption in the intestines. This research provides a copper-centric perspective on the connection between deregulated nutrient sensing and aging, thus shedding light on the aspect of aging and copper overexposure.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 1","pages":"58–67 58–67"},"PeriodicalIF":0.0,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/envhealth.4c00096","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143091697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Historically Polluted Area Increases Human Exposure Risks to Polychlorinated Naphthalenes through Waterfowl Egg Consumption. 历史污染地区通过食用水禽蛋增加人类接触多氯萘的风险。
Environment & Health Pub Date : 2024-09-10 eCollection Date: 2025-01-17 DOI: 10.1021/envhealth.4c00134
Xingyi Wu, Jianxi Yi, Su Zhang, Jianing Xin, Yaqun Fan, Han Yan, Jun Cao, Yun Zou, Shujun Dong, Peilong Wang
{"title":"Historically Polluted Area Increases Human Exposure Risks to Polychlorinated Naphthalenes through Waterfowl Egg Consumption.","authors":"Xingyi Wu, Jianxi Yi, Su Zhang, Jianing Xin, Yaqun Fan, Han Yan, Jun Cao, Yun Zou, Shujun Dong, Peilong Wang","doi":"10.1021/envhealth.4c00134","DOIUrl":"10.1021/envhealth.4c00134","url":null,"abstract":"<p><p>Polychlorinated naphthalenes (PCNs), which are ubiquitous in the environment, are listed as persistent organic pollutants under the Stockholm Convention. Poultry can be exposed to PCNs via feed and breeding environments, leading to PCNs accumulation in eggs. However, information on PCNs in eggs from waterfowl raised in contaminated regions is scarce. In this study, waterfowl and chicken eggs were collected from a historically polluted area in Hunan Province, China. In addition, waterfowl eggs were collected from Guangxi Province as a control. The mean concentrations of Σ<sub>75</sub>PCNs in waterfowl (30.8 pg/g wet weight [ww]) and chicken eggs (26.1 pg/g ww) from Hunan were significantly higher than in waterfowl eggs (15.6 pg/g ww) from Guangxi. The PCN homologue profiles in poultry eggs from the two regions varied, but both were dominated by lower chlorinated CNs. Correlation analysis showed that breeding environment made a greater contribution to PCNs in waterfowl eggs. Interestingly, PCNs and polychlorinated biphenyls (PCBs) showed a significant positive correlation in samples from Hunan, but not in those from Guangxi. Human exposure to PCNs and PCBs was higher through consumption of poultry eggs from historically contaminated areas.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 1","pages":"48-57"},"PeriodicalIF":0.0,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11744388/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143013121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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