Environment & Health最新文献

{"title":"Association of Per- and Polyfluoroalkyl Substance Exposure with Coronary Stenosis and Prognosis in Acute Coronary Syndrome","authors":"Haoran Li,&nbsp;Ming Yang,&nbsp;Jiaxin Zhao,&nbsp;Zhenzhen Tan,&nbsp;Longfei Li,&nbsp;Ziwen An,&nbsp;Yi Liu,&nbsp;Xuehui Liu,&nbsp;Xiaoguang Zhang,&nbsp;Jingchao Lu,&nbsp;Ang Li* and Huicai Guo*,&nbsp;","doi":"10.1021/envhealth.4c0016610.1021/envhealth.4c00166","DOIUrl":"https://doi.org/10.1021/envhealth.4c00166https://doi.org/10.1021/envhealth.4c00166","url":null,"abstract":"<p >Per- and polyfluoroalkyl substances (PFAS) have been associated with an increased risk of acute coronary syndromes (ACS), but the influence on the degree of coronary stenosis and prognosis is unclear. This study enrolled 571 newly diagnosed ACS cases and investigated the association of 12 PFAS with coronary stenosis severity and prognosis. Coronary stenosis was assessed via Gensini score (GS) and number of lesioned vessels (LVN). Prognosis was estimated by tracking major adverse cardiovascular events (MACE). Statistical analyses included ordered logistic regression, Cox regression, threshold effect models, Bayesian kernel machine regression, and quantile g-computation models. The adverse outcome pathway (AOP) framework was applied to reveal the underlying mechanism. The results showed positive association between perfluorooctanesulfonic acid (PFOS) and coronary stenosis, with an odds ratio (95% confidence interval, CI) of 1.33 (1.06, 1.67) for GS and 1.36 (1.08, 1.71) for LVN. PFOS significantly increased the incidence of poor prognosis, with hazard ratios (95% CI) of 1.96 (1.34, 2.89) for MACE. Threshold effects were observed for PFAS on coronary stenosis and prognosis, with PFOS thresholds of 4.65 ng/mL for GS, 4.54 ng/mL for LVN, and 5.14 ng/mL for MACE, and 5.03 ng/mL for nonfatal myocardial infarction. PFAS mixture exposure increased the occurrence of MACE and nonfatal myocardial infarction. The AOP framework shows that PFAS may impact protein binding, the cytoskeleton, multicellular biological processes, and heart function. In summary, our study revealed the adverse effects of PFAS on the degree of coronary stenosis and prognosis in ACS and identified potentially relevant molecular loci.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 3","pages":"291–307 291–307"},"PeriodicalIF":0.0,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/envhealth.4c00166","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143666885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Per- and Polyfluoroalkyl Substance Exposure with Coronary Stenosis and Prognosis in Acute Coronary Syndrome.","authors":"Haoran Li, Ming Yang, Jiaxin Zhao, Zhenzhen Tan, Longfei Li, Ziwen An, Yi Liu, Xuehui Liu, Xiaoguang Zhang, Jingchao Lu, Ang Li, Huicai Guo","doi":"10.1021/envhealth.4c00166","DOIUrl":"10.1021/envhealth.4c00166","url":null,"abstract":"<p><p>Per- and polyfluoroalkyl substances (PFAS) have been associated with an increased risk of acute coronary syndromes (ACS), but the influence on the degree of coronary stenosis and prognosis is unclear. This study enrolled 571 newly diagnosed ACS cases and investigated the association of 12 PFAS with coronary stenosis severity and prognosis. Coronary stenosis was assessed via Gensini score (GS) and number of lesioned vessels (LVN). Prognosis was estimated by tracking major adverse cardiovascular events (MACE). Statistical analyses included ordered logistic regression, Cox regression, threshold effect models, Bayesian kernel machine regression, and quantile g-computation models. The adverse outcome pathway (AOP) framework was applied to reveal the underlying mechanism. The results showed positive association between perfluorooctanesulfonic acid (PFOS) and coronary stenosis, with an odds ratio (95% confidence interval, CI) of 1.33 (1.06, 1.67) for GS and 1.36 (1.08, 1.71) for LVN. PFOS significantly increased the incidence of poor prognosis, with hazard ratios (95% CI) of 1.96 (1.34, 2.89) for MACE. Threshold effects were observed for PFAS on coronary stenosis and prognosis, with PFOS thresholds of 4.65 ng/mL for GS, 4.54 ng/mL for LVN, and 5.14 ng/mL for MACE, and 5.03 ng/mL for nonfatal myocardial infarction. PFAS mixture exposure increased the occurrence of MACE and nonfatal myocardial infarction. The AOP framework shows that PFAS may impact protein binding, the cytoskeleton, multicellular biological processes, and heart function. In summary, our study revealed the adverse effects of PFAS on the degree of coronary stenosis and prognosis in ACS and identified potentially relevant molecular loci.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 3","pages":"291-307"},"PeriodicalIF":0.0,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934203/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143721614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Environmental Health and Safety Implications of the Interplay Between Microplastics and the Residing Biofilm.","authors":"Xiaohan Wu, Fei He, Xueran Xu, Leilei Wu, Jinyu Rong, Sijie Lin","doi":"10.1021/envhealth.4c00148","DOIUrl":"10.1021/envhealth.4c00148","url":null,"abstract":"<p><p>The increasing prevalence of microplastics in the environment has raised concerns about their potential environmental and health implications. Biofilms readily colonize microplastics upon their entry into the environment, altering their surface characteristics. While most studies have explored how biofilms influence the adsorption and transportation of other contaminants by microplastics, the reciprocal interplay between microplastics and biofilms and the resulting ecological risks remain understudied. This review comprehensively reviews the impact of microplastic properties on biofilm formation and composition, including the microbial community structure. We then explore the dynamic interactions between microplastics and biofilms, examining how biofilms alter the physicochemical properties, migration, and deposition of microplastics. Furthermore, we emphasize the potential of biofilm-colonized microplastics to influence the environmental fate of other pollutants. Lastly, we discuss how biofilm-microplastic interactions may modify the bioavailability, biotoxicity, and potential health implications of microplastics.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 2","pages":"118-132"},"PeriodicalIF":0.0,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11851218/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Environmental Health and Safety Implications of the Interplay Between Microplastics and the Residing Biofilm","authors":"Xiaohan Wu,&nbsp;Fei He,&nbsp;Xueran Xu,&nbsp;Leilei Wu,&nbsp;Jinyu Rong and Sijie Lin*,&nbsp;","doi":"10.1021/envhealth.4c0014810.1021/envhealth.4c00148","DOIUrl":"https://doi.org/10.1021/envhealth.4c00148https://doi.org/10.1021/envhealth.4c00148","url":null,"abstract":"<p >The increasing prevalence of microplastics in the environment has raised concerns about their potential environmental and health implications. Biofilms readily colonize microplastics upon their entry into the environment, altering their surface characteristics. While most studies have explored how biofilms influence the adsorption and transportation of other contaminants by microplastics, the reciprocal interplay between microplastics and biofilms and the resulting ecological risks remain understudied. This review comprehensively reviews the impact of microplastic properties on biofilm formation and composition, including the microbial community structure. We then explore the dynamic interactions between microplastics and biofilms, examining how biofilms alter the physicochemical properties, migration, and deposition of microplastics. Furthermore, we emphasize the potential of biofilm-colonized microplastics to influence the environmental fate of other pollutants. Lastly, we discuss how biofilm–microplastic interactions may modify the bioavailability, biotoxicity, and potential health implications of microplastics.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 2","pages":"118–132 118–132"},"PeriodicalIF":0.0,"publicationDate":"2024-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/envhealth.4c00148","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143452531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Independent and Combined Associations between Metals Exposure and Inflammatory Markers among the General U.S. Adults.","authors":"Xinrui Feng, Yaoyu Luo, Min Zheng, Xiaojie Sun, Xiantao Shen","doi":"10.1021/envhealth.4c00097","DOIUrl":"10.1021/envhealth.4c00097","url":null,"abstract":"<p><p>Exposure to metals can trigger a series of diseases by dysregulating the human immune system, but there is still a lack of systematic studies assessing the independent and combined effects of exposure to metals on immune function in the general population, particularly concerning inflammation markers. This cross-sectional study was designed to mainly examine the associations between urinary metal mixtures and inflammatory markers, including white blood cell (WBC), platelet count (PLT), mean platelet volume (MPV), MPV/PLT ratio (MPR), platelet-to-lymphocyte ratio (PLR), and neutrophil-to-lymphocyte ratio (NLR). A total of 3451 participants aged ≥20 years were selected from the 2013-2016 National Health and Nutrition Examination Survey. Generalized linear models were used to investigate the relationships of exposure to single metals on inflammatory markers. Associations between coexposure to multiple metals and inflammatory markers were determined using weighted quantile sum regression and quantile g-computation. Barium, cadmium, lead, thallium, and cobalt showed significant associations with MPV, PLR, and NLR. Metal mixtures showed a negative association with MPV, while they had positive associations with PLR and NLR. Overall, our study highlights the significant effects of multiple metals exposure on inflammation markers, including MPV, PLR, and NLR, among U.S. adults. Thereinto, uranium, cadmium, and cobalt were identified as major contributors. Further prospective studies representative of other countries are warranted to either validate or refute our findings.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 3","pages":"282-290"},"PeriodicalIF":0.0,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934204/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143721667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gestational Exposure to Endocrine-Disrupting Chemicals of Emerging Concern and the Risk of Developing Gestational Diabetes Mellitus: A Comprehensive Investigation of Sex-Specific and Trimester-Specific Associations","authors":"Jinfeng Fu,&nbsp;Yao Yao,&nbsp;Zhihong Huang,&nbsp;Zhihui Guo,&nbsp;Xinxin Tang,&nbsp;Xulong Chen,&nbsp;Xinjie Li,&nbsp;Yiming Ge,&nbsp;Bingjun Lu,&nbsp;Yujie Sha and Shaoyou Lu*,&nbsp;","doi":"10.1021/envhealth.4c0020210.1021/envhealth.4c00202","DOIUrl":"https://doi.org/10.1021/envhealth.4c00202https://doi.org/10.1021/envhealth.4c00202","url":null,"abstract":"<p >Gestational diabetes mellitus (GDM) is a type of diabetes that arises during pregnancy, leading to long-term adverse consequences for maternal health and fetal development. However, the specific role of endocrine-disrupting chemicals (EDCs) in the pathogenesis of GDM remains controversial. This prospective cohort study sought to investigate how coexposure to bisphenols, parabens, triclosan (TCS), benzophenone-type UV filters, and neonicotinoids (NEOs) affects the odds of GDM. Quantile-based g-computation and Bayesian kernel machine regression showed a significant inverse relationship between EDC mixtures and the reduced risk of GDM (OR = 0.34, 95% CI: 0.13–0.87), which was mainly explained by bisphenol (OR = 0.49, 95% CI: 0.29–0.80) and paraben (OR = 0.60, 95% CI: 0.40–0.91) exposure. Bisphenol S (BPS), bisphenol Z (BPZ), ethylparaben (EtP), propylparaben (PrP), and butylparaben (BuP) were identified as key contributors to the joint effect. In addition, subgroup analyses suggested that the bisphenols-GDM association was more pronounced in younger/normal-weight participants. The sex-specific impact of exposure to bisphenols on the development of GDM was observed, whereas the second trimester represented a critical window for EDC exposure. Continued research efforts, focusing on causal pathways and nonmonotonic relationships, will be crucial to elucidate the complex influence of EDC exposure on the development of GDM.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 3","pages":"271–281 271–281"},"PeriodicalIF":0.0,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/envhealth.4c00202","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143667138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Independent and Combined Associations between Metals Exposure and Inflammatory Markers among the General U.S. Adults","authors":"Xinrui Feng,&nbsp;Yaoyu Luo,&nbsp;Min Zheng,&nbsp;Xiaojie Sun* and Xiantao Shen*,&nbsp;","doi":"10.1021/envhealth.4c0009710.1021/envhealth.4c00097","DOIUrl":"https://doi.org/10.1021/envhealth.4c00097https://doi.org/10.1021/envhealth.4c00097","url":null,"abstract":"<p >Exposure to metals can trigger a series of diseases by dysregulating the human immune system, but there is still a lack of systematic studies assessing the independent and combined effects of exposure to metals on immune function in the general population, particularly concerning inflammation markers. This cross-sectional study was designed to mainly examine the associations between urinary metal mixtures and inflammatory markers, including white blood cell (WBC), platelet count (PLT), mean platelet volume (MPV), MPV/PLT ratio (MPR), platelet-to-lymphocyte ratio (PLR), and neutrophil-to-lymphocyte ratio (NLR). A total of 3451 participants aged ≥20 years were selected from the 2013–2016 National Health and Nutrition Examination Survey. Generalized linear models were used to investigate the relationships of exposure to single metals on inflammatory markers. Associations between coexposure to multiple metals and inflammatory markers were determined using weighted quantile sum regression and quantile g-computation. Barium, cadmium, lead, thallium, and cobalt showed significant associations with MPV, PLR, and NLR. Metal mixtures showed a negative association with MPV, while they had positive associations with PLR and NLR. Overall, our study highlights the significant effects of multiple metals exposure on inflammation markers, including MPV, PLR, and NLR, among U.S. adults. Thereinto, uranium, cadmium, and cobalt were identified as major contributors. Further prospective studies representative of other countries are warranted to either validate or refute our findings.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 3","pages":"282–290 282–290"},"PeriodicalIF":0.0,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/envhealth.4c00097","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143667139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gestational Exposure to Endocrine-Disrupting Chemicals of Emerging Concern and the Risk of Developing Gestational Diabetes Mellitus: A Comprehensive Investigation of Sex-Specific and Trimester-Specific Associations.","authors":"Jinfeng Fu, Yao Yao, Zhihong Huang, Zhihui Guo, Xinxin Tang, Xulong Chen, Xinjie Li, Yiming Ge, Bingjun Lu, Yujie Sha, Shaoyou Lu","doi":"10.1021/envhealth.4c00202","DOIUrl":"10.1021/envhealth.4c00202","url":null,"abstract":"<p><p>Gestational diabetes mellitus (GDM) is a type of diabetes that arises during pregnancy, leading to long-term adverse consequences for maternal health and fetal development. However, the specific role of endocrine-disrupting chemicals (EDCs) in the pathogenesis of GDM remains controversial. This prospective cohort study sought to investigate how coexposure to bisphenols, parabens, triclosan (TCS), benzophenone-type UV filters, and neonicotinoids (NEOs) affects the odds of GDM. Quantile-based g-computation and Bayesian kernel machine regression showed a significant inverse relationship between EDC mixtures and the reduced risk of GDM (OR = 0.34, 95% CI: 0.13-0.87), which was mainly explained by bisphenol (OR = 0.49, 95% CI: 0.29-0.80) and paraben (OR = 0.60, 95% CI: 0.40-0.91) exposure. Bisphenol S (BPS), bisphenol Z (BPZ), ethylparaben (EtP), propylparaben (PrP), and butylparaben (BuP) were identified as key contributors to the joint effect. In addition, subgroup analyses suggested that the bisphenols-GDM association was more pronounced in younger/normal-weight participants. The sex-specific impact of exposure to bisphenols on the development of GDM was observed, whereas the second trimester represented a critical window for EDC exposure. Continued research efforts, focusing on causal pathways and nonmonotonic relationships, will be crucial to elucidate the complex influence of EDC exposure on the development of GDM.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 3","pages":"271-281"},"PeriodicalIF":0.0,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934205/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143721664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Environmental Enrichment Exposure Alleviates Geriatric Depressive-Like Symptoms through Regulating Neurogenesis and Neuroinflammation.","authors":"Wei Zhang, Guangyu Jiang, Huiwen Kang, Jingyu Wang, Ziyan Liu, Ziyan Wang, Danyang Huang, Ai Gao","doi":"10.1021/envhealth.4c00186","DOIUrl":"10.1021/envhealth.4c00186","url":null,"abstract":"<p><p>Environmental enrichment (EE) is a significant approach to influencing brain function by altering the environment and changing living conditions and has been shown to modulate mood-related diseases, including depression. Among the elderly, depression is particularly prevalent and is often linked to social isolation. However, the specific role of EE in social isolation-related geriatric depression remains imprecise. This study was intended to explore the status of EE exposure in geriatric depression and to uncover its underlying mechanisms. We utilized 19-month-old male C57BL/6J mice, which are equivalent to humans aged 50-60 years, and induced depression through social isolation. After 2 weeks of social isolation, mice were identified as depressive by using the sugar preference test and then classified into either standard or enrichment environment groups for 4 weeks. Subsequently, conventional indices associated with depression, including neurogenesis, neurotrophic factors, and neuroinflammation, were measured. Results display that EE alleviated the depressive-like symptoms in elderly mice and enriched their social activities. Concurrently, EE regulated levels of certain neurotransmitters in the hippocampus, including the systems of glutamate, tyrosine, and histamine. Moreover, the ability of neurogenesis also increased in the hippocampus of EE mice. At the neuroinflammation level, the activation of Natural Killer (NK) cells and ARG1⁺ microglia is considered a major contributor to mediating the effects of EE-regulated geriatric depression. Collectively, these results underline the importance of EE in the treatment of geriatric depression and partially elucidate its underlying mechanism, offering valuable suggestions for treating social isolation--related depression via environmental modulation.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 3","pages":"259-270"},"PeriodicalIF":0.0,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934201/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143721663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Environmental Enrichment Exposure Alleviates Geriatric Depressive-Like Symptoms through Regulating Neurogenesis and Neuroinflammation","authors":"Wei Zhang,&nbsp;Guangyu Jiang,&nbsp;Huiwen Kang,&nbsp;Jingyu Wang,&nbsp;Ziyan Liu,&nbsp;Ziyan Wang,&nbsp;Danyang Huang and Ai Gao*,&nbsp;","doi":"10.1021/envhealth.4c0018610.1021/envhealth.4c00186","DOIUrl":"https://doi.org/10.1021/envhealth.4c00186https://doi.org/10.1021/envhealth.4c00186","url":null,"abstract":"<p >Environmental enrichment (EE) is a significant approach to influencing brain function by altering the environment and changing living conditions and has been shown to modulate mood-related diseases, including depression. Among the elderly, depression is particularly prevalent and is often linked to social isolation. However, the specific role of EE in social isolation-related geriatric depression remains imprecise. This study was intended to explore the status of EE exposure in geriatric depression and to uncover its underlying mechanisms. We utilized 19-month-old male C57BL/6J mice, which are equivalent to humans aged 50–60 years, and induced depression through social isolation. After 2 weeks of social isolation, mice were identified as depressive by using the sugar preference test and then classified into either standard or enrichment environment groups for 4 weeks. Subsequently, conventional indices associated with depression, including neurogenesis, neurotrophic factors, and neuroinflammation, were measured. Results display that EE alleviated the depressive-like symptoms in elderly mice and enriched their social activities. Concurrently, EE regulated levels of certain neurotransmitters in the hippocampus, including the systems of glutamate, tyrosine, and histamine. Moreover, the ability of neurogenesis also increased in the hippocampus of EE mice. At the neuroinflammation level, the activation of Natural Killer (NK) cells and ARG1⁺ microglia is considered a major contributor to mediating the effects of EE-regulated geriatric depression. Collectively, these results underline the importance of EE in the treatment of geriatric depression and partially elucidate its underlying mechanism, offering valuable suggestions for treating social isolation--related depression via environmental modulation.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 3","pages":"259–270 259–270"},"PeriodicalIF":0.0,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/envhealth.4c00186","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143667137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}