Environment & Health最新文献_第10页

Constructing Petroleum-Derived Aryl Hydrocarbon Receptor Related Toxic Source Profiles via Effect-Directed Analysis. 通过效应导向分析构建石油衍生芳基烃受体相关毒源剖面。

IF 6.3

Environment & Health Pub Date : 2025-07-28 eCollection Date: 2025-12-19 DOI: 10.1021/envhealth.5c00193

Zikang Li, Yong He, Xiaoxi Yang, Yi Wang, Yunhe Guo, Yaquan Liu, Shunhao Wang, Jinfeng Peng, Guangbo Qu, Guibin Jiang

{"title":"Constructing Petroleum-Derived Aryl Hydrocarbon Receptor Related Toxic Source Profiles via Effect-Directed Analysis.","authors":"Zikang Li, Yong He, Xiaoxi Yang, Yi Wang, Yunhe Guo, Yaquan Liu, Shunhao Wang, Jinfeng Peng, Guangbo Qu, Guibin Jiang","doi":"10.1021/envhealth.5c00193","DOIUrl":"10.1021/envhealth.5c00193","url":null,"abstract":"Aryl hydrocarbon receptor (AhR)-related toxicity caused by AhR agonists has threatened ecological health, and toxic source apportionment plays an important role in pollution management. However, there are no AhR-related toxic source profiles to date. This study aims to construct petroleum-derived AhR-related toxic source profiles by utilizing the polluted soils after a petroleum leakage accident. Three polluted soils and two unpolluted soils were designed for toxic source profile construction, and we use n-alkanes and their proxy indicators to verify the rationality of classification. Then, the key AhR agonists were identified by effect-directed analysis. We discovered that the key AhR agonists in petroleum-polluted soils are constituted by chrysene, methylated benzo-[a]-anthracene (MeBaA) isomers, and methylated chrysene (MeChr) isomers, where 2-MeChr and 9-MeBaA/3-MeChr contribute the most toxicity. Meanwhile, we also confirmed the existence of synergistic effect. Moreover, the constructed toxic source profile explained most of the toxicity of crude oil, and its specificity was also validated by principal coordinate analysis. In conclusion, this study constructed new petroleum-derived AhR-related toxic source profiles for toxic source apportionment and pollution management, and also provided a new framework for other toxic source profile construction.","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 12","pages":"1501-1509"},"PeriodicalIF":6.3,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12723536/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145828616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sulfidation Affects Macrophage Uptake of Metal-Based Nanomaterials by Dictating Protein Corona Compositions and Aggregation States Collectively. 硫化作用影响巨噬细胞对金属基纳米材料的摄取，通过共同决定蛋白质电晕组成和聚集状态。

IF 6.3

Environment & Health Pub Date : 2025-07-24 eCollection Date: 2025-12-19 DOI: 10.1021/envhealth.5c00097

Tingting Du, Ziyan Wang, Jiao Chen, Guangbo Qu, Tong Zhang, Wei Chen

{"title":"Sulfidation Affects Macrophage Uptake of Metal-Based Nanomaterials by Dictating Protein Corona Compositions and Aggregation States Collectively.","authors":"Tingting Du, Ziyan Wang, Jiao Chen, Guangbo Qu, Tong Zhang, Wei Chen","doi":"10.1021/envhealth.5c00097","DOIUrl":"10.1021/envhealth.5c00097","url":null,"abstract":"Metal-based nanomaterials are one of the most widely used classes of nanomaterials. Understanding their human exposure is critical for the risk management of these nanomaterials. Once released into the environment, metal nanomaterials are prone to undergo sulfidation. This process significantly alters the physicochemical properties of the nanomaterials and subsequently, dictates the extents and pathways of exposure. Here, we show that sulfidation of nanosized Ag, ZnO, CuO, and Cu2O affects their macrophage uptake to varied degrees, by differentially regulating protein corona compositions and aggregation states of the nanomaterials. Sulfidation-induced changes in hydrodynamic diameters determine whether macrophage uptake occurs through endocytosis or phagocytosis. For a given uptake pathway, the extents of uptake depend on macrophage recognition of protein corona, the compositions of which are largely influenced by sulfidation. Specifically, increased abundance of transferrin and low-density apolipoprotein C2 in the corona as affected by sulfidation promotes clathrin-mediated endocytosis, while the enrichment of complement factor H facilitates uptake by complement receptor-mediated phagocytosis. The findings advance our understanding on the nanospecific mechanisms governing environmental behaviors and implications of nanomaterials, and further underline the importance of taking into account the aging processes in the risk management of these materials.","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 12","pages":"1490-1500"},"PeriodicalIF":6.3,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12723541/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145828575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MeP Induces Metabolic Disorder and Liver Damage at Human-Relevant Exposure Levels: Role of the Gut Microbiota. MeP在人体暴露水平下诱导代谢紊乱和肝损伤：肠道微生物群的作用。

IF 6.3

Environment & Health Pub Date : 2025-07-23 eCollection Date: 2025-11-21 DOI: 10.1021/envhealth.5c00111

Henglin Zhang, Yanan Zhao, Haitao Tu, Yuxian Liu, Yiling Lin, Yanpeng Cai, Liang Chi, Tao Zhang, Bingling Dai, Jingchuan Xue

引用次数: 0

Cerebral to Systemic Representations of Alzheimer's Pathogenesis Stimulated by Polystyrene Nanoplastics. 聚苯乙烯纳米塑料刺激阿尔茨海默病发病机制的大脑到系统表征。

IF 6.3

Environment & Health Pub Date : 2025-07-22 eCollection Date: 2025-11-21 DOI: 10.1021/envhealth.5c00160

Yue Wang, Xiufang Liang, Nicholas Andrikopoulos, Shufang Zheng, Yuhuan Li, Pu Chun Ke

{"title":"Cerebral to Systemic Representations of Alzheimer's Pathogenesis Stimulated by Polystyrene Nanoplastics.","authors":"Yue Wang, Xiufang Liang, Nicholas Andrikopoulos, Shufang Zheng, Yuhuan Li, Pu Chun Ke","doi":"10.1021/envhealth.5c00160","DOIUrl":"https://doi.org/10.1021/envhealth.5c00160","url":null,"abstract":"Plastics discharged into the ecosphere can transform into micro- and nanoparticles to instigate interactions with biosystems, posing a threat to environmental sustainability and human health. While nanoplastics have recently been identified in abundance in the human brain, especially in the decedent brain tissues of dementia subjects, how these exogenous miniatures mediate neurological as well as systemic pathologies remains unclear. Here, we first investigated how environmental-level nanoplastic exposure influences the progression of Alzheimer's disease, from cerebral to systemic representations. Specifically, polystyrene nanoplastics aggravated Alzheimer's-like symptoms in both wild-type and APP/PS1 mice and stimulated microglial activation and hippocampal neuronal death, accentuated by peripheral abnormalities of lipid accumulation, hepatic steatosis, inflammation, adipocyte enlargement, and gut microbiota imbalance. These findings implicate that nanoplastic-induced neurological damage is not confined within the brain but expands systemically through the gut-liver-brain axis, thereby contributing to the multiscale and multidirectional progression of Alzheimer's pathophysiology.","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 11","pages":"1380-1392"},"PeriodicalIF":6.3,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12645312/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145639397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent Advances in Implementation of Machine Learning for Environmental Nontarget Identification. 机器学习在环境非目标识别中的应用进展。

IF 6.3

Environment & Health Pub Date : 2025-07-19 eCollection Date: 2025-11-21 DOI: 10.1021/envhealth.5c00091

Qinyu Bao, Nanyang Yu, Qinting Jiang, Xuebing Wang, Zhaoyu Jiao, Si Wei

{"title":"Recent Advances in Implementation of Machine Learning for Environmental Nontarget Identification.","authors":"Qinyu Bao, Nanyang Yu, Qinting Jiang, Xuebing Wang, Zhaoyu Jiao, Si Wei","doi":"10.1021/envhealth.5c00091","DOIUrl":"https://doi.org/10.1021/envhealth.5c00091","url":null,"abstract":"The continuous emergence of new pollutants poses significant threats to both human health and ecological environments. Nontarget analysis based on mass spectrometry has become prevalent for detecting new pollutants due to its high throughput capabilities. However, structural elucidation remains a major challenge in nontarget analysis. Here, we review the implementation of machine learning techniques to accelerate nontarget structural elucidation, with particular focus on spectral library matching, structural database retrieval, and de novo structure generation. We investigated the design principles, technical characteristics, and comparative evaluation of these computational approaches. In addition, we show their applications in environmental nontarget analysis for new pollutant identification. Finally, we discuss the challenges of current approaches and the future development trends. This review aims to deepen the understanding of existing computational approaches, promote the application of machine learning techniques in nontarget identification, and facilitate the integration of artificial intelligence with environmental pollutant analysis.","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 11","pages":"1286-1298"},"PeriodicalIF":6.3,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12645304/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145640500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0