Environment & Health最新文献_第10页

Effect of Elevated Temperatures on Inflammatory Cytokine Release: An In Vitro and Population-Based Study. 温度升高对炎症细胞因子释放的影响：一项体外和基于人群的研究

Environment & Health Pub Date : 2024-05-28 eCollection Date: 2024-10-18 DOI: 10.1021/envhealth.4c00059

Xiaoxu Hu, Hualing Fu, Luou Zhang, Qian Zhang, Tong Xu, Yangsheng Chen, Guomin Chen, Shuai Jiang, Jiajia Ji, Heidi Qunhui Xie, Li Xu, Bin Zhao

引用次数: 0

Predicting Chemical Immunotoxicity through Data-Driven QSAR Modeling of Aryl Hydrocarbon Receptor Agonism and Related Toxicity Mechanisms 通过数据驱动的芳基烃受体激动及相关毒性机制 QSAR 建模预测化学物质的免疫毒性

Environment & Health Pub Date : 2024-05-28 DOI: 10.1021/envhealth.4c00026

Nada J. Daood, Daniel P. Russo, Elena Chung, Xuebin Qin and Hao Zhu*,

{"title":"Predicting Chemical Immunotoxicity through Data-Driven QSAR Modeling of Aryl Hydrocarbon Receptor Agonism and Related Toxicity Mechanisms","authors":"Nada J. Daood, Daniel P. Russo, Elena Chung, Xuebin Qin and Hao Zhu*, ","doi":"10.1021/envhealth.4c00026","DOIUrl":"https://doi.org/10.1021/envhealth.4c00026","url":null,"abstract":"Computational modeling has emerged as a time-saving and cost-effective alternative to traditional animal testing for assessing chemicals for their potential hazards. However, few computational modeling studies for immunotoxicity were reported, with few models available for predicting toxicants due to the lack of training data and the complex mechanisms of immunotoxicity. In this study, we employed a data-driven quantitative structure–activity relationship (QSAR) modeling workflow to extensively enlarge the limited training data by revealing multiple targets involved in immunotoxicity. To this end, a probe data set of 6,341 chemicals was obtained from a high-throughput screening (HTS) assay testing for the activation of the aryl hydrocarbon receptor (AhR) signaling pathway, a key event leading to immunotoxicity. Searching this probe data set against PubChem yielded 3,183 assays with testing results for varying proportions of these 6,341 compounds. 100 assays were selected to develop QSAR models based on their correlations to AhR agonism. Twelve individual QSAR models were built for each assay using combinations of four machine-learning algorithms and three molecular fingerprints. 5-fold cross-validation of the resulting models showed good predictivity (average CCR = 0.73). A total of 20 assays were further selected based on QSAR model performance, and their resulting QSAR models showed good predictivity of potential immunotoxicants from external chemicals. This study provides a computational modeling strategy that can utilize large public toxicity data sets for modeling immunotoxicity and other toxicity endpoints, which have limited training data and complicated toxicity mechanisms.","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"2 7","pages":"474–485"},"PeriodicalIF":0.0,"publicationDate":"2024-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/envhealth.4c00026","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141728547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Canine on the Couch: The New Canary in the Coal Mine for Environmental Health Research 沙发上的犬类环境健康研究煤矿中的新金丝雀

Environment & Health Pub Date : 2024-05-27 DOI: 10.1021/envhealth.4c0002910.1021/envhealth.4c00029

Catherine F. Wise, Matthew Breen and Heather M. Stapleton*,

{"title":"Canine on the Couch: The New Canary in the Coal Mine for Environmental Health Research","authors":"Catherine F. Wise, Matthew Breen and Heather M. Stapleton*, ","doi":"10.1021/envhealth.4c0002910.1021/envhealth.4c00029","DOIUrl":"https://doi.org/10.1021/envhealth.4c00029https://doi.org/10.1021/envhealth.4c00029","url":null,"abstract":"Human health is intimately connected and tied to the health of our environment and ecosystem, with only a very small fraction of the risk for chronic diseases explained by genetics alone. Companion animals are prone to disease types that are shared with people, including cancers and endocrine disorders, reinforcing the thought that environmental factors contribute to the risks for chronic diseases. These factors include air and water pollution and the built environment. As such, there is increasing interest in pursuing research with companion animals, and specifically dogs, as sentinel species to inform comparative health assessments and identify risk factors for disease. Of the canine diseases for which environmental exposure research has been published, cancers have received the most attention. This review summarizes two main aspects of this comparative approach: (1) cancers that occur in dogs and which are similar to humans and (2) research investigating environmental exposures and health outcomes in dogs. The goal of this review is to highlight the diverse conditions in which pet dogs may provide unique perspectives and advantages to examine relationships between environmental exposures and health outcomes, with an emphasis on chemical pollution and cancer. Furthermore, this review seeks to raise awareness and stimulate discussion around the best practices for the use of companion animals as environmental health sentinels.","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"2 8","pages":"517–529 517–529"},"PeriodicalIF":0.0,"publicationDate":"2024-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/envhealth.4c00029","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141990237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Canine on the Couch: The New Canary in the Coal Mine for Environmental Health Research. 沙发上的犬类：环境健康研究煤矿中的新金丝雀。

Environment & Health Pub Date : 2024-05-27 eCollection Date: 2024-08-16 DOI: 10.1021/envhealth.4c00029

Catherine F Wise, Matthew Breen, Heather M Stapleton

{"title":"Canine on the Couch: The New Canary in the Coal Mine for Environmental Health Research.","authors":"Catherine F Wise, Matthew Breen, Heather M Stapleton","doi":"10.1021/envhealth.4c00029","DOIUrl":"10.1021/envhealth.4c00029","url":null,"abstract":"Human health is intimately connected and tied to the health of our environment and ecosystem, with only a very small fraction of the risk for chronic diseases explained by genetics alone. Companion animals are prone to disease types that are shared with people, including cancers and endocrine disorders, reinforcing the thought that environmental factors contribute to the risks for chronic diseases. These factors include air and water pollution and the built environment. As such, there is increasing interest in pursuing research with companion animals, and specifically dogs, as sentinel species to inform comparative health assessments and identify risk factors for disease. Of the canine diseases for which environmental exposure research has been published, cancers have received the most attention. This review summarizes two main aspects of this comparative approach: (1) cancers that occur in dogs and which are similar to humans and (2) research investigating environmental exposures and health outcomes in dogs. The goal of this review is to highlight the diverse conditions in which pet dogs may provide unique perspectives and advantages to examine relationships between environmental exposures and health outcomes, with an emphasis on chemical pollution and cancer. Furthermore, this review seeks to raise awareness and stimulate discussion around the best practices for the use of companion animals as environmental health sentinels.","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"2 8","pages":"517-529"},"PeriodicalIF":0.0,"publicationDate":"2024-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11334179/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142018903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tracking Source Variations of Inhalation Cancer Risks and Ozone Formation Potential in Hong Kong over Two Decades (2000–2020) Using Toxic Air Pollutant Monitoring Data 利用有毒空气污染物监测数据追踪香港吸入致癌风险和臭氧形成潜力在二十年间（2000-2020 年）的来源变化

Environment & Health Pub Date : 2024-05-23 DOI: 10.1021/envhealth.3c00209

Yee Ka Wong, Wai Wai Chan, Dasa Gu, Jian Zhen Yu* and Alexis K. H. Lau*,

{"title":"Tracking Source Variations of Inhalation Cancer Risks and Ozone Formation Potential in Hong Kong over Two Decades (2000–2020) Using Toxic Air Pollutant Monitoring Data","authors":"Yee Ka Wong, Wai Wai Chan, Dasa Gu, Jian Zhen Yu* and Alexis K. H. Lau*, ","doi":"10.1021/envhealth.3c00209","DOIUrl":"10.1021/envhealth.3c00209","url":null,"abstract":"Toxic air pollutants (TAPs) are a class of airborne chemicals known or suspected to cause serious health issues. This study, applying positive matrix factorization and inhalation unit risk estimates of TAPs, quantifies the changes in significant sources contributing to inhalation cancer risks (ICRs) from 2000 to 2020 in Hong Kong, China. Total ICR decreased from 1701 to 451 cases per million between 2000–2004 and 2016–2020, largely attributed to the reduction in diesel particulate matter (DPM), gasoline and solvent use-related volatile organic compounds (VOCs), and coal/biomass combustion-related polycyclic aromatic hydrocarbons and metal(loid)s. The regional contribution of VOCs associated with industrial and halogenated solvent sources increased substantially, representing the largest non-DPM ICR contributor (37%) in 2016–2020, stressing the need for a more comprehensive risk evaluation across the fast-growing and densely populated Greater Bay Area (GBA). ICRs in Hong Kong and the GBA will likely remain over 100 cases per million by 2050. The contributions to ozone formation potential of VOC/carbonyl sources were quantified, which show a notable shift from being solvent/gasoline-dominant in 2000–2004 to being more evenly shared by various sources in 2016–2020. Establishing a similar TAP monitoring network in the GBA is anticipated to provide the monitoring data needed to facilitate the development of more informed air quality management strategies.","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"2 6","pages":"411–421"},"PeriodicalIF":0.0,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/envhealth.3c00209","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141103846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current Phthalate Exposure Risks of Rural Population in the Northwest China: Evidence from an Internal Exposure Study 中国西北地区农村人口邻苯二甲酸盐暴露风险现状：一项内部暴露研究的证据

Environment & Health Pub Date : 2024-05-22 DOI: 10.1021/envhealth.4c0005710.1021/envhealth.4c00057

Yawen Zheng, Liting Hua, Zining Zhang, Lin Zhu, Hongkai Zhu, Hongwen Sun and Hongzhi Zhao*,

{"title":"Current Phthalate Exposure Risks of Rural Population in the Northwest China: Evidence from an Internal Exposure Study","authors":"Yawen Zheng, Liting Hua, Zining Zhang, Lin Zhu, Hongkai Zhu, Hongwen Sun and Hongzhi Zhao*, ","doi":"10.1021/envhealth.4c0005710.1021/envhealth.4c00057","DOIUrl":"https://doi.org/10.1021/envhealth.4c00057https://doi.org/10.1021/envhealth.4c00057","url":null,"abstract":"Phthalates (PAEs) are synthetic chemicals widely used in industrial and personal consumer products as adhesives or plasticizers. PAEs have been demonstrated to have toxic effects on the human body. However, biological monitoring data for the internal PAE exposure levels of Chinese rural residents are still limited. The present study investigated the exposure levels of ten phthalate metabolites (mPAEs) of rural residents in Northwest China. The results showed that mPAEs were wildly prevalent in urine and the geometric mean concentration of Σ10mPAEs was 957.02 ng mL–1 (adjusted by specific gravity). Mono-n-butyl phthalate (MBP) and metabolites of di(2-ethylhexyl)-phthalate (DEHP) were the most dominant mPAEs in urine, with specific gravity adjusted median concentrations of 174.67 and 156.30 ng mL–1, respectively. Urinary concentrations of mPAEs were significantly associated with age, body mass index and economic level (p < 0.05). By calculating the percentage and relative conversion rate of DEHP metabolites, it was found that the degree of oxidative metabolism of DEHP in children was significantly higher than that in adults (p < 0.05), indicating that the pathway and degree of DEHP oxidation were age-related. The risk assessment showed that 59.12% of rural residents may have a noncancer risk from PAE exposure. This study provides important basis for assessing the occurrence and exposure of urinary phthalate metabolites among rural residents in China.","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"2 8","pages":"586–595 586–595"},"PeriodicalIF":0.0,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/envhealth.4c00057","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141990236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dimethylsulfoniopropionate (DMSP) Increases Longevity and Mitochondrial Function in Caenorhabditis elegans: Implications for the Role of the Global Sulfur Cycle in Terrestrial Ecosystems 二甲基硫代丙酸盐（DMSP）可提高秀丽隐杆线虫的寿命和线粒体功能：全球硫循环在陆地生态系统中作用的意义

Environment & Health Pub Date : 2024-05-17 DOI: 10.1021/envhealth.3c0020810.1021/envhealth.3c00208

Hongyuan Li, Peng Ji, Yue Cao, Zhitao Cui, Jingwei Gao, Hongshuang Wang, Cong Lin, Yibo Wang and Xiaohui Wang*,

{"title":"Dimethylsulfoniopropionate (DMSP) Increases Longevity and Mitochondrial Function in Caenorhabditis elegans: Implications for the Role of the Global Sulfur Cycle in Terrestrial Ecosystems","authors":"Hongyuan Li, Peng Ji, Yue Cao, Zhitao Cui, Jingwei Gao, Hongshuang Wang, Cong Lin, Yibo Wang and Xiaohui Wang*, ","doi":"10.1021/envhealth.3c0020810.1021/envhealth.3c00208","DOIUrl":"https://doi.org/10.1021/envhealth.3c00208https://doi.org/10.1021/envhealth.3c00208","url":null,"abstract":"Dimethylsulfoniopropionate (DMSP) is a compound synthesized by marine phytoplankton that contributes to the oceanic sulfur cycle. Interestingly, DMSP has also been found in algal species and several terrestrial plants, forming part of the global sulfur cycle. However, compared to its role in the marine environment, the impact of DMSP on terrestrial ecosystems remains relatively unexplored. In this study, DMSP was shown to promote longevity and prevent age-associated functional decline in Caenorhabditis elegans (C. elegans), a soil-dwelling organism. DMSP decreased mitochondrial content and improved mitochondrial function in C. elegans at the old stage, which was via enhancing autophagy flux. It was demonstrated that DMSP significantly increased the expression of autophagy and mitophagy genes during aging. Furthermore, DMSP protected against Parkinson’s disease (PD) induced by α-synuclein (α-syn) aggregation via autophagy. Mechanistic studies showed that DMSP directly activated nuclear translocation of the Skinhead-1 (SKN-1) transcription factor from the cytoplasm. Moreover, SKN-1 was involved in DMSP-induced autophagy and played a key role in lifespan extension and α-syn clearance in C. elegans. In conclusion, DMSP delays physiological aspects of aging in C. elegans, providing insights into the interplay between the global sulfur cycle and terrestrial organisms.","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"2 8","pages":"572–585 572–585"},"PeriodicalIF":0.0,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/envhealth.3c00208","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141990235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extreme Heat Exposure Induced Acute Kidney Injury through NLRP3 Inflammasome Activation in Mice 极热暴露通过激活 NLRP3 炎症小体诱发小鼠急性肾损伤

Environment & Health Pub Date : 2024-05-16 DOI: 10.1021/envhealth.4c0000710.1021/envhealth.4c00007

Jiahui Wang, Kunyi Wang, Xinnu Shi, Zhoufan Hu, Lisha Zhao, Kan Chen, Lu Zhang, Ran Li, Guoqing Zhang* and Cuiqing Liu*,

{"title":"Extreme Heat Exposure Induced Acute Kidney Injury through NLRP3 Inflammasome Activation in Mice","authors":"Jiahui Wang, Kunyi Wang, Xinnu Shi, Zhoufan Hu, Lisha Zhao, Kan Chen, Lu Zhang, Ran Li, Guoqing Zhang* and Cuiqing Liu*, ","doi":"10.1021/envhealth.4c0000710.1021/envhealth.4c00007","DOIUrl":"https://doi.org/10.1021/envhealth.4c00007https://doi.org/10.1021/envhealth.4c00007","url":null,"abstract":"Climate change has resulted in a marked increase in heat extremes that carry a severe risk for morbidity and mortality. Kidney is sensitive to heat stimulation, and acute kidney injury (AKI) is the early event. In this study, we investigated the adverse effects of heat extremes and their underlying mechanism. A total of 16 wild-type C57BL/6N mice were randomly divided into groups of control (exposed to 22 ± 0.5 °C) and heat (exposed to 39.5 ± 0.5 °C until the core body temperature reached the maximum). First, extreme heat exposure induced AKI evidenced by kidney dysfunction and morphological impairment. In addition, heat exposure suppressed expression of molecules for mitochondrial energetics and fatty acid beta-oxidation and disturbed the balance of oxidative stress in the kidney. Moreover, heat exposure enhanced the protein levels in the upstream signaling pathway for NLRP3 inflammasome formation, followed by NLRP3 inflammasome activation and inflammatory cytokine production. These findings demonstrated that acute extreme heat exposure may induce AKI through the NLRP3 inflammasome formation and activation.","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"2 8","pages":"563–571 563–571"},"PeriodicalIF":0.0,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/envhealth.4c00007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141990234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New Identities of Micro- and Nanoplastics Formed from Biological Effects (Bio-MNPs) 生物效应形成的微塑料和纳米塑料（Bio-MNPs）的新特性

Environment & Health Pub Date : 2024-05-16 DOI: 10.1021/envhealth.4c0007210.1021/envhealth.4c00072

Yulong Wang, Fengbang Wang and Maoyong Song*,

引用次数: 0

Advancing Toxicity Predictions: A Review on in Vitro to in Vivo Extrapolation in Next-Generation Risk Assessment 推进毒性预测：新一代风险评估中的体内外推断综述

Environment & Health Pub Date : 2024-05-08 DOI: 10.1021/envhealth.4c00043

Peiling Han, Xuehua Li*, Jingyuan Yang, Yuxuan Zhang and Jingwen Chen,

{"title":"Advancing Toxicity Predictions: A Review on in Vitro to in Vivo Extrapolation in Next-Generation Risk Assessment","authors":"Peiling Han, Xuehua Li*, Jingyuan Yang, Yuxuan Zhang and Jingwen Chen, ","doi":"10.1021/envhealth.4c00043","DOIUrl":"10.1021/envhealth.4c00043","url":null,"abstract":"As a key step in next-generation risk assessment (NGRA), in vitro to in vivo extrapolation (IVIVE) aims to mobilize a mechanism-based understanding of toxicology to translate bioactive chemical concentrations obtained from in vitro assays to corresponding exposures likely to induce bioactivity in vivo. This conversion can be achieved via physiologically-based toxicokinetic (PBTK) models and machine learning (ML) algorithms. The last 5 years have witnessed a period of rapid development in IVIVE, with the number of IVIVE-related publications increasing annually. This Review aims to (1) provide a comprehensive overview of the origin of IVIVE and initiatives undertaken by multiple national agencies to promote its development; (2) compile and sort out IVIVE-related publications and perform a clustering analysis of their high-frequency keywords to capture key research hotspots; (3) comprehensively review PBTK and ML model-based IVIVE studies published in the last 5 years to understand the research directions and methodology developments; and (4) propose future perspectives for IVIVE from two aspects: expanding the scope of application and integrating new technologies. The former includes focusing on metabolite toxicity, conducting IVIVE studies on susceptible populations, advancing ML-based quantitative IVIVE models, and extending research to ecological effects. The latter includes combining systems biology, multiomics, and adverse outcome networks with IVIVE, aiming at a more microscopic, mechanistic, and comprehensive toxicity prediction. This Review highlights the important value of IVIVE in NGRA, with the goal of providing confidence for its routine use in chemical prioritization, hazard assessment, and regulatory decision making.","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"2 7","pages":"499–513"},"PeriodicalIF":0.0,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/envhealth.4c00043","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140997719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0