Environment & Health最新文献

{"title":"Discharges of Wastewater Treatment Plants Needed Further Monitoring to Minimize Potential Risk of <i>Entamoeba</i> and <i>Blastocystis</i> for Public Health.","authors":"Asli Onursal, Bulent Icgen","doi":"10.1021/envhealth.4c00113","DOIUrl":"10.1021/envhealth.4c00113","url":null,"abstract":"<p><p>The protozoan parasites <i>Entamoeba histolytica</i> and <i>Blastocystis hominis</i> are responsible for causing human amebiasis and hominis infections, respectively. These infections are highly prevalent and are often linked to waterborne diseases. Due to the absence of regulations for monitoring these protozoa at the discharge points of wastewater treatment plants (WWTPs), the effluents reaching surface waters contribute to waterborne transmission. This underscores the significance of the removal capacities of WWTPs in reducing the spread of these infectious parasites. Therefore, this study examined five different types of WWTPs in Ankara, Turkey, over a year to assess their capacities to remove <i>E. histolytica</i> and <i>B. hominis</i>. The seasonal abundances of genes specific to these protozoa in both the influents and effluents of each WWTP were measured using a quantitative polymerase chain reaction. The reduction in the number of protozoan rDNA copies between the influent and effluent samples was evaluated as the removal capacity, expressed in log₁₀ reduction (LRV) values. The results elucidated that the removal of <i>E. histolytica</i> and <i>B. hominis</i> was highly affected by the process used. Membrane bioreactor systems displayed the highest removal capacity with LRV > 3. Therefore, discharges of WWTPs with other processes could need further monitoring to minimize the potential risk for public health.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"2 11","pages":"838-845"},"PeriodicalIF":0.0,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11574629/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in Electrostatic Plasma Methods for Purification of Airborne Pathogenic Microbial Aerosols: Mechanism, Modeling and Application.","authors":"Shanlong Tao, Yong Zhu, Mingxia Chen, Wenfeng Shangguan","doi":"10.1021/envhealth.4c00100","DOIUrl":"https://doi.org/10.1021/envhealth.4c00100","url":null,"abstract":"<p><p>The transmission of pathogenic airborne microorganisms significantly impacts public health and societal functioning. Ensuring healthy indoor air quality in public spaces is critical. Among various air purification technologies, electrostatic precipitation and atmospheric pressure nonthermal plasma are notable for their broad-spectrum effectiveness, high efficiency, cost-effectiveness, and safety. This review investigates the primary mechanisms by which these electrostatic methods collect and disinfect pathogenic aerosols. It also delves into recent advancements in enhancing their physical and chemical mechanisms for improve efficiency. Simultaneously, a thorough summary of mathematical models related to the migration and deactivation of pathogenic aerosols in electrostatic purifiers is provided. It will help us to understand the behavior of aerosols in purification systems. Additionally, the review discusses the current research on creating a comprehensive health protection system and addresses the challenges of balancing byproduct control with efficiency. The aim is to establish a foundation for future research and development in electrostatic aerosol purification and develop integrated air purification technologies that are both efficient and safe.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"2 9","pages":"596-617"},"PeriodicalIF":0.0,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11540111/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142606519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in Electrostatic Plasma Methods for Purification of Airborne Pathogenic Microbial Aerosols: Mechanism, Modeling and Application","authors":"Shanlong Tao,&nbsp;Yong Zhu*,&nbsp;Mingxia Chen and Wenfeng Shangguan*,&nbsp;","doi":"10.1021/envhealth.4c0010010.1021/envhealth.4c00100","DOIUrl":"https://doi.org/10.1021/envhealth.4c00100https://doi.org/10.1021/envhealth.4c00100","url":null,"abstract":"<p >The transmission of pathogenic airborne microorganisms significantly impacts public health and societal functioning. Ensuring healthy indoor air quality in public spaces is critical. Among various air purification technologies, electrostatic precipitation and atmospheric pressure nonthermal plasma are notable for their broad-spectrum effectiveness, high efficiency, cost-effectiveness, and safety. This review investigates the primary mechanisms by which these electrostatic methods collect and disinfect pathogenic aerosols. It also delves into recent advancements in enhancing their physical and chemical mechanisms for improve efficiency. Simultaneously, a thorough summary of mathematical models related to the migration and deactivation of pathogenic aerosols in electrostatic purifiers is provided. It will help us to understand the behavior of aerosols in purification systems. Additionally, the review discusses the current research on creating a comprehensive health protection system and addresses the challenges of balancing byproduct control with efficiency. The aim is to establish a foundation for future research and development in electrostatic aerosol purification and develop integrated air purification technologies that are both efficient and safe.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"2 9","pages":"596–617 596–617"},"PeriodicalIF":0.0,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/envhealth.4c00100","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142270005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Exposure to Metals during Pregnancy, Childhood Gut Microbiome, and Risk of Intestinal Inflammation in Late Childhood","authors":"Vishal Midya*,&nbsp;Manasi Agrawal,&nbsp;Jamil M. Lane,&nbsp;Chris Gennings,&nbsp;Leonid Tarassishin,&nbsp;Libni A. Torres-Olascoaga,&nbsp;Joseph Eggers,&nbsp;Jill K. Gregory,&nbsp;Mellissa Picker,&nbsp;Inga Peter,&nbsp;Jeremiah J. Faith,&nbsp;Manish Arora,&nbsp;Martha M. Téllez-Rojo,&nbsp;Robert O. Wright,&nbsp;Jean-Frederic Colombel and Shoshannah Eggers,&nbsp;","doi":"10.1021/envhealth.4c0012510.1021/envhealth.4c00125","DOIUrl":"https://doi.org/10.1021/envhealth.4c00125https://doi.org/10.1021/envhealth.4c00125","url":null,"abstract":"<p >Alterations to the gut microbiome and exposure to metals during pregnancy have been suggested to impact inflammatory bowel disease. Nonetheless, how prenatal exposure to metals eventually results in long-term effects on the gut microbiome, leading to subclinical intestinal inflammation, particularly during late childhood, has not been studied. It is also unknown whether such an interactive effect drives a specific subgroup of children toward elevated susceptibility to intestinal inflammation. We used an amalgamation of machine-learning techniques with a regression-based framework to explore if children with distinct sets of gut microbes and certain patterns of exposure to metals during pregnancy (metal–microbial clique signature) had a higher likelihood of intestinal inflammation, measured based on fecal calprotectin (FC) in late childhood. We obtained samples from a well-characterized longitudinal birth cohort from Mexico City (<i>n</i> = 108), Mexico. In the second and third trimesters of pregnancy, 11 metals were measured in whole blood. Gut microbial abundances and FC were measured in stool samples from children 9–11 years of age. Elevated FC was defined as having FC above 100 μg/g of stool. We identified subgroups of children in whom microbial and metal–microbial clique signatures were associated with elevated FC (false discovery rate (FDR) &lt; 0.05). In particular, we found two metal–microbial clique signatures significantly associated with elevated FC: (1) low cesium (Cs) and copper (Cu) in the third trimester and low relative abundance of <i>Eubacterium ventriosum</i> (OR [95%CI]: 10.27 [3.57,29.52], FDR &lt; 0.001) and (2) low Cu in the third trimester and high relative abundances of <i>Roseburia inulinivorans</i> and <i>Ruminococcus torques</i> (OR [95%CI]: 7.21 [1.81,28.77], FDR &lt; 0.05). This exploratory study demonstrates that children with specific gut microbes and specific exposure patterns to metals during pregnancy may have higher fecal calprotectin levels in late childhood, denoting an elevated risk of intestinal inflammation.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"2 10","pages":"739–749 739–749"},"PeriodicalIF":0.0,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/envhealth.4c00125","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142450339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of Gestational Exposure to Air Pollution and Polycyclic Aromatic Hydrocarbons with Placental Inflammation.","authors":"Emily A Craig, Yan Lin, Yihui Ge, Xiangtian Wang, Susan K Murphy, Donald K Harrington, Richard K Miller, Sally W Thurston, Philip K Hopke, Emily S Barrett, Thomas G O'Connor, David Q Rich, Junfeng Zhang","doi":"10.1021/envhealth.4c00077","DOIUrl":"10.1021/envhealth.4c00077","url":null,"abstract":"<p><p>Restricted fetal growth (RFG) is a leading contributor to perinatal mortality and has been associated with gestational exposure to air pollution, such as fine particulate matter (PM_2.5), nitrogen dioxide (NO₂), and polycyclic aromatic hydrocarbons (PAHs). This study examines the association between trimester-specific and weekly means of air pollution throughout gestation and placental inflammatory markers at delivery. In a prospective cohort study of 263 pregnant women in Rochester, NY, we measured interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) in placental tissue and estimated gestational exposure to PM_2.5 and NO₂ using a high-resolution spatial-temporal model. Exposure to PAHs was estimated using urinary 1-hydroxypyrene (1-OHP) concentrations collected once per trimester. Using distributed lag models with a penalized spline function, each interquartile range (2.6 μg/m³) increase in PM_2.5 concentration during gestational weeks 6-11 was associated with decreased placental IL-6 levels (-22.2%, 95% CI: -39.0%, -0.64%). Using multiple linear regression models, each interquartile range increase of 1-OHP was associated with an increase in TNF-α in the first trimester (58.5%, 95% CI: 20.7%, 74.2%), third trimester (22.9%, 95% CI: 0.04%, 49.5%), and entire pregnancy (29.6%, 95%CI: 3.9%,60.6%). Our results suggest gestational exposure to air pollution may alter the inflammatory environment of the placenta at delivery.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"2 9","pages":"672-680"},"PeriodicalIF":0.0,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11420950/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142355429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of Gestational Exposure to Air Pollution and Polycyclic Aromatic Hydrocarbons with Placental Inflammation","authors":"Emily A. Craig,&nbsp;Yan Lin,&nbsp;Yihui Ge,&nbsp;Xiangtian Wang,&nbsp;Susan K. Murphy,&nbsp;Donald K. Harrington,&nbsp;Richard K. Miller,&nbsp;Sally W. Thurston,&nbsp;Philip K. Hopke,&nbsp;Emily S. Barrett,&nbsp;Thomas G. O’Connor,&nbsp;David Q. Rich and Junfeng Zhang*,&nbsp;","doi":"10.1021/envhealth.4c0007710.1021/envhealth.4c00077","DOIUrl":"https://doi.org/10.1021/envhealth.4c00077https://doi.org/10.1021/envhealth.4c00077","url":null,"abstract":"<p >Restricted fetal growth (RFG) is a leading contributor to perinatal mortality and has been associated with gestational exposure to air pollution, such as fine particulate matter (PM_2.5), nitrogen dioxide (NO₂), and polycyclic aromatic hydrocarbons (PAHs). This study examines the association between trimester-specific and weekly means of air pollution throughout gestation and placental inflammatory markers at delivery. In a prospective cohort study of 263 pregnant women in Rochester, NY, we measured interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) in placental tissue and estimated gestational exposure to PM_2.5 and NO₂ using a high-resolution spatial-temporal model. Exposure to PAHs was estimated using urinary 1-hydroxypyrene (1-OHP) concentrations collected once per trimester. Using distributed lag models with a penalized spline function, each interquartile range (2.6 μg/m³) increase in PM_2.5 concentration during gestational weeks 6–11 was associated with decreased placental IL-6 levels (−22.2%, 95% CI: −39.0%, −0.64%). Using multiple linear regression models, each interquartile range increase of 1-OHP was associated with an increase in TNF-α in the first trimester (58.5%, 95% CI: 20.7%, 74.2%), third trimester (22.9%, 95% CI: 0.04%, 49.5%), and entire pregnancy (29.6%, 95%CI: 3.9%,60.6%). Our results suggest gestational exposure to air pollution may alter the inflammatory environment of the placenta at delivery.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"2 9","pages":"672–680 672–680"},"PeriodicalIF":0.0,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/envhealth.4c00077","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142273760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Balancing the Functionality and Biocompatibility of Materials with a Deep-Learning-Based Inverse Design Framework","authors":"Xiaofang Li,&nbsp;Hanle Chen,&nbsp;Jiachen Yan,&nbsp;Guohong Liu,&nbsp;Chengjun Li,&nbsp;Xiaoxia Zhou,&nbsp;Yan Wang,&nbsp;Yinbao Wu,&nbsp;Bing Yan and Xiliang Yan*,&nbsp;","doi":"10.1021/envhealth.4c0008810.1021/envhealth.4c00088","DOIUrl":"https://doi.org/10.1021/envhealth.4c00088https://doi.org/10.1021/envhealth.4c00088","url":null,"abstract":"<p >The rational design of molecules with the desired functionality presents a significant challenge in chemistry. Moreover, it is worth noting that making chemicals safe and sustainable is crucial to bringing them to the market. To address this, we propose a novel deep learning framework developed explicitly for inverse design of molecules with both functionality and biocompatibility. This innovative approach comprises two predictive models and one generative model, facilitating the targeted screening of novel molecules from created virtual chemical space. Our method’s versatility is highlighted in the inverse design process, where it successfully generates molecules with specified motifs or composition, discovers synthetically accessible molecules, and jointly targets functional and safe properties beyond the training regime. The utility of this method is demonstrated in its ability to design ionic liquids (ILs) with enhanced antibacterial properties and reduced cytotoxicity, addressing the issue of balancing functionality and biocompatibility in molecular design.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"2 12","pages":"875–885 875–885"},"PeriodicalIF":0.0,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/envhealth.4c00088","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142858714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moving beyond Wastewater: Perspectives on Environmental Surveillance of Infectious Diseases for Public Health Action in Low-Resource Settings","authors":"Jeseth Delgado Vela*,&nbsp;Sarah E. Philo,&nbsp;Joe Brown,&nbsp;Mami Taniuchi,&nbsp;Molly Cantrell,&nbsp;Alexandra Kossik,&nbsp;Maya Ramaswamy,&nbsp;Sitara SR Ajjampur,&nbsp;Fatma Z. Guerfali,&nbsp;Rochelle H. Holm,&nbsp;John Scott Meschke,&nbsp;Maria Catherine B. Otero,&nbsp;Amy J. Pickering,&nbsp;Mahbubur Rahman,&nbsp;Alexander G. Shaw,&nbsp;Abhilasha Shrestha,&nbsp;Kwanrawee Sirikanchana,&nbsp;Vivi Maketa Tevuzula,&nbsp;Rolf U. Halden,&nbsp;Alexandria B. Boehm and Kyle Bibby,&nbsp;","doi":"10.1021/envhealth.4c0011910.1021/envhealth.4c00119","DOIUrl":"https://doi.org/10.1021/envhealth.4c00119https://doi.org/10.1021/envhealth.4c00119","url":null,"abstract":"","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"2 10","pages":"684–687 684–687"},"PeriodicalIF":0.0,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/envhealth.4c00119","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142450454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishing a Multifaceted Comprehensive Maternity Cohort Facilitates Understanding of How Environmental Exposures Impact Perinatal Health","authors":"Haitong Zhe Sun,&nbsp;Haiyang Tang,&nbsp;Qingyi Xiang,&nbsp;Siyuan Xu,&nbsp;Yijia Tian,&nbsp;Huan Zhao,&nbsp;Jing Fang,&nbsp;Haizhen Dai,&nbsp;Rui Shi,&nbsp;Yuxia Pan,&nbsp;Ting Luo,&nbsp;Hangbiao Jin,&nbsp;Chenyang Ji,&nbsp;Yuanchen Chen,&nbsp;Hengyi Liu,&nbsp;Meirong Zhao,&nbsp;Kun Tang,&nbsp;Sheena Nishanti Ramasamy,&nbsp;Evelyn Xiu-Ling Loo,&nbsp;Lynette P. Shek,&nbsp;Yuming Guo,&nbsp;Wei Xu and Xiaoxia Bai*,&nbsp;","doi":"10.1021/envhealth.4c0010410.1021/envhealth.4c00104","DOIUrl":"https://doi.org/10.1021/envhealth.4c00104https://doi.org/10.1021/envhealth.4c00104","url":null,"abstract":"<p >China’s “three-child policy”, implemented in response to population aging, has made the protection of maternal and infant health an urgent priority. In this environmental and medical big-data era, the Zhejiang Environmental and Birth Health Research Alliance (ZEBRA) maternity cohort was established with the aim of identifying risk factors for perinatal morbidity and mortality from the perspectives of both observational epidemiology and experimental etiology. Compared with conventional birth cohorts, the inclusion of a maternity cohort allows greater scope for research and places an emphasis on maternal health. In particular, it allows us to focus on pregnant women with a history of pregnancy-related illnesses and those planning to have a second or third child. There are currently many pressing issues in perinatal health, including the risk associations between exogenous together with endogenous factors and the occurrence of perinatal abnormalities, pregnancy complications, and adverse pregnancy outcomes. It is crucial to explore the interaction between environmental exposures and genetic factors affecting perinatal health if we are to improve it. It is also worthwhile to assess the feasibility of the early stage prediction of major perinatal abnormalities. We hope to study this in the ZEBRA cohort and also seek nationwide and international collaborations to establish a multicenter cohort consortium, with the ultimate goal of contributing epidemiological evidence to literature and providing evidence-based insights for global maternal and child healthcare.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"2 11","pages":"766–775 766–775"},"PeriodicalIF":0.0,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/envhealth.4c00104","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142640738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Indoor Environment and Health Effects: Protocol of an Exploratory Panel Study among Young Adults in China (China IEHE Study)","authors":"Shan Liu,&nbsp;Wanzhou Wang,&nbsp;Yetong Zhao,&nbsp;Luyi Li,&nbsp;Wenlou Zhang,&nbsp;Xuezhao Ji,&nbsp;Di Yang,&nbsp;Yahong Chen,&nbsp;Xinbiao Guo and Furong Deng*,&nbsp;","doi":"10.1021/envhealth.4c0005110.1021/envhealth.4c00051","DOIUrl":"https://doi.org/10.1021/envhealth.4c00051https://doi.org/10.1021/envhealth.4c00051","url":null,"abstract":"<p >Indoor environment and health have drawn public attention worldwide. However, the joint health effects and mechanisms of exposure to different types of indoor environmental factors remain unclear. We established an exploratory panel study on indoor environment and health effects among young adults in China (the China IEHE Study) to comprehensively investigate 3M issues, including multiple indoor environmental factors, multiple health effects, and multiple omics methods for mechanism exploration. This protocol aims to systematically introduce the entire China IEHE Study. Eighty-one young adults aged 18–28 years from a university adjacent to traffic arteries in Beijing were recruited and followed up four times. Sham/real air purification intervention was simultaneously applied in a randomized crossover order. A broad range of indoor physical, chemical, and biological factors were characterized through real-time monitoring and external and internal exposure analyses. Subclinical health indices reflecting cardiopulmonary, sleep, and cognitive health were repeatedly measured in a prospective order. Various biosamples including fasting venous blood, morning urine, nasal mucosal lining fluid, and exhaled breath condensate were collected to explore the underlying biological mechanisms. The China IEHE Study comes up with an enlightening framework for future prospective studies associated with the exploration of multisystem health effects and underlying biological mechanisms of indoor exposure.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 1","pages":"26–39 26–39"},"PeriodicalIF":0.0,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/envhealth.4c00051","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143091262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}