Environment & Health最新文献

{"title":"Joint Conference of ISEH, ICEPH, and ISEG on Environment and Health Successfully Held in Galway.","authors":"Chaosheng Zhang","doi":"10.1021/envhealth.4c00184","DOIUrl":"https://doi.org/10.1021/envhealth.4c00184","url":null,"abstract":"","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"2 11","pages":"846-847"},"PeriodicalIF":0.0,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11574625/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Joint Conference of ISEH, ICEPH, and ISEG on Environment and Health Successfully Held in Galway","authors":"Chaosheng Zhang*, ","doi":"10.1021/envhealth.4c0018410.1021/envhealth.4c00184","DOIUrl":"https://doi.org/10.1021/envhealth.4c00184https://doi.org/10.1021/envhealth.4c00184","url":null,"abstract":"","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"2 11","pages":"846–847 846–847"},"PeriodicalIF":0.0,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/envhealth.4c00184","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142640905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Observed Effects on Very Early Pregnancy Linked to Ambient PM_2.5 Exposure in China among Women Undergoing <i>In Vitro</i> Fertilization-Embryo Transfer.","authors":"Changxin Lan, Yichun Guan, Haining Luo, Xiaoling Ma, Yihua Yang, Hongchu Bao, Cuifang Hao, Xiaojin He, Han Zhang, Ning Gao, Weinan Lin, Mengyuan Ren, Tianxiang Wu, Chao Wang, Xiaoqing Ni, Chunyan Shen, Jianrui Zhang, Junfang Ma, Rui Zhang, Yin Bi, Lili Zhuang, Ruichao Miao, Ziyi Song, Tong An, Zhengteng Liu, Bo Pan, Mingliang Fang, Jing Liu, Zhipeng Bai, Fangang Meng, Yuanchen Chen, Xiaoxia Lu, Yuming Guo, Yunxia Cao, Qun Lu, Bin Wang","doi":"10.1021/envhealth.4c00107","DOIUrl":"10.1021/envhealth.4c00107","url":null,"abstract":"<p><p>The adverse effect of ambient PM_2.5 exposure on very early pregnancy (VEP) remains controversial among epidemiological studies but is supported by toxicological evidence. We adopted a multicenter retrospective cohort of 141,040 cycles to evaluate the effect of PM_2.5 exposure on the VEP using the <i>in vitro</i> fertilization and embryo transfer platform and high-resolution PM_2.5 data in China. We first investigated the association between PM_2.5 exposure 1 week before and 1 week after the embryo transfer date and VEP. The average PM_2.5 concentrations of the 2 weeks were approximately 47 μg/m³. The pooled results revealed a negative association between women's accumulated PM_2.5 exposure during the 2 weeks near the day of embryo transfer and success odds of VEP with the relative risk of 0.999 (95% CI: 0.997-0.999) at each increase of 10 μg/m³. The women with the fresh cycle or one transplanted embryo were considered as a vulnerable population. Furthermore, seven periods for the fresh cycle and five periods for the frozen cycle from 85 days before oocyte retrieval to the day of gestational sac detection by ultrasound detection were defined. For these exposure periods, no association between the average PM_2.5 exposure and VEP risk was identified. Our study provided large-scale population evidence for the association between PM_2.5 exposure near embryo transfer day and VEP and identified vulnerable populations among women undergoing <i>in vitro</i> fertilization-embryo transfer.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"2 12","pages":"918-928"},"PeriodicalIF":0.0,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11667290/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142898713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiphase Radical Chemical Processes Induced by Air Pollutants and the Associated Health Effects.","authors":"Qineng Wang, Huan Song, Huabin Dong, Song Guo, Maosheng Yao, Yi Wan, Keding Lu","doi":"10.1021/envhealth.4c00157","DOIUrl":"10.1021/envhealth.4c00157","url":null,"abstract":"<p><p>Air pollution is increasingly recognized as a significant health risk, yet our understanding of its underlying chemical and physiological mechanisms remains incomplete. Fine particulate matter (PM_2.5) and ozone (O₃) interact with biomolecules in intracellular and microenvironments, such as the epithelial lining fluid (ELF), leading to the generation of reactive oxygen species (ROS). These ROS trigger cellular inflammatory responses and oxidative stress, contributing to a spectrum of diseases affecting the respiratory, cardiovascular, and central nervous systems. Extensive epidemiological and toxicological research highlights the pivotal role of ROS in air pollution-related diseases. It is crucial to comprehend the intricate chemical processes and accompanying physiological effects of ROS from air pollutants. This review aims to systematically summarize ROS generation mechanisms in the ELF and measurement techniques of oxidative potential (OP), taking the kinetic reactions of ROS cycling in the ELF as an example, and discusses the general health implications of ROS in respiratory, cardiovascular, and central nervous systems. Understanding these processes through interdisciplinary research is essential to develop effective and precise strategies as well as air quality standards to mitigate the public health impacts of air pollution globally.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 1","pages":"1-13"},"PeriodicalIF":0.0,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11744397/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiphase Radical Chemical Processes Induced by Air Pollutants and the Associated Health Effects","authors":"Qineng Wang,&nbsp;Huan Song*,&nbsp;Huabin Dong,&nbsp;Song Guo,&nbsp;Maosheng Yao,&nbsp;Yi Wan and Keding Lu*,&nbsp;","doi":"10.1021/envhealth.4c0015710.1021/envhealth.4c00157","DOIUrl":"https://doi.org/10.1021/envhealth.4c00157https://doi.org/10.1021/envhealth.4c00157","url":null,"abstract":"<p >Air pollution is increasingly recognized as a significant health risk, yet our understanding of its underlying chemical and physiological mechanisms remains incomplete. Fine particulate matter (PM_2.5) and ozone (O₃) interact with biomolecules in intracellular and microenvironments, such as the epithelial lining fluid (ELF), leading to the generation of reactive oxygen species (ROS). These ROS trigger cellular inflammatory responses and oxidative stress, contributing to a spectrum of diseases affecting the respiratory, cardiovascular, and central nervous systems. Extensive epidemiological and toxicological research highlights the pivotal role of ROS in air pollution-related diseases. It is crucial to comprehend the intricate chemical processes and accompanying physiological effects of ROS from air pollutants. This review aims to systematically summarize ROS generation mechanisms in the ELF and measurement techniques of oxidative potential (OP), taking the kinetic reactions of ROS cycling in the ELF as an example, and discusses the general health implications of ROS in respiratory, cardiovascular, and central nervous systems. Understanding these processes through interdisciplinary research is essential to develop effective and precise strategies as well as air quality standards to mitigate the public health impacts of air pollution globally.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 1","pages":"1–13 1–13"},"PeriodicalIF":0.0,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/envhealth.4c00157","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143091610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Observed Effects on Very Early Pregnancy Linked to Ambient PM2.5 Exposure in China among Women Undergoing In Vitro Fertilization-Embryo Transfer","authors":"Changxin Lan,&nbsp;Yichun Guan,&nbsp;Haining Luo,&nbsp;Xiaoling Ma,&nbsp;Yihua Yang,&nbsp;Hongchu Bao,&nbsp;Cuifang Hao,&nbsp;Xiaojin He,&nbsp;Han Zhang,&nbsp;Ning Gao,&nbsp;Weinan Lin,&nbsp;Mengyuan Ren,&nbsp;Tianxiang Wu,&nbsp;Chao Wang,&nbsp;Xiaoqing Ni,&nbsp;Chunyan Shen,&nbsp;Jianrui Zhang,&nbsp;Junfang Ma,&nbsp;Rui Zhang,&nbsp;Yin Bi,&nbsp;Lili Zhuang,&nbsp;Ruichao Miao,&nbsp;Ziyi Song,&nbsp;Tong An,&nbsp;Zhengteng Liu,&nbsp;Bo Pan,&nbsp;Mingliang Fang,&nbsp;Jing Liu,&nbsp;Zhipeng Bai,&nbsp;Fangang Meng,&nbsp;Yuanchen Chen,&nbsp;Xiaoxia Lu,&nbsp;Yuming Guo,&nbsp;Yunxia Cao*,&nbsp;Qun Lu* and Bin Wang*,&nbsp;","doi":"10.1021/envhealth.4c0010710.1021/envhealth.4c00107","DOIUrl":"https://doi.org/10.1021/envhealth.4c00107https://doi.org/10.1021/envhealth.4c00107","url":null,"abstract":"<p >The adverse effect of ambient PM_2.5 exposure on very early pregnancy (VEP) remains controversial among epidemiological studies but is supported by toxicological evidence. We adopted a multicenter retrospective cohort of 141,040 cycles to evaluate the effect of PM_2.5 exposure on the VEP using the <i>in vitro</i> fertilization and embryo transfer platform and high-resolution PM_2.5 data in China. We first investigated the association between PM_2.5 exposure 1 week before and 1 week after the embryo transfer date and VEP. The average PM_2.5 concentrations of the 2 weeks were approximately 47 μg/m³. The pooled results revealed a negative association between women’s accumulated PM_2.5 exposure during the 2 weeks near the day of embryo transfer and success odds of VEP with the relative risk of 0.999 (95% CI: 0.997–0.999) at each increase of 10 μg/m³. The women with the fresh cycle or one transplanted embryo were considered as a vulnerable population. Furthermore, seven periods for the fresh cycle and five periods for the frozen cycle from 85 days before oocyte retrieval to the day of gestational sac detection by ultrasound detection were defined. For these exposure periods, no association between the average PM_2.5 exposure and VEP risk was identified. Our study provided large-scale population evidence for the association between PM_2.5 exposure near embryo transfer day and VEP and identified vulnerable populations among women undergoing <i>in vitro</i> fertilization-embryo transfer.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"2 12","pages":"918–928 918–928"},"PeriodicalIF":0.0,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/envhealth.4c00107","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142858580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Ambient Ultrafine Particles and Neurodevelopmental Delay in Preschoolers in Shanghai, China","authors":"Mengxun Rong,&nbsp;Yang Shen,&nbsp;Yihui Ge,&nbsp;Wenchong Du,&nbsp;Haidong Kan,&nbsp;Jing Cai*,&nbsp;Yan Zhao* and Jing Hua*,&nbsp;","doi":"10.1021/envhealth.4c0010210.1021/envhealth.4c00102","DOIUrl":"https://doi.org/10.1021/envhealth.4c00102https://doi.org/10.1021/envhealth.4c00102","url":null,"abstract":"<p >Previous toxicological research has suggested the potential neurotoxicity of ultrafine particulate matter (UFP, particles ≤0.1 μm in diameter). However, evidence from human beings, particularly regarding the neurodevelopmental impacts of UFP, is still limited. We enrolled 11,230 children aged 3–5.5 years from Shanghai, China. Residential UFP exposure was assessed by a land use regression model with a spatial resolution of 50 m. The neurodevelopment of preschoolers was assessed using the Ages &amp; Stages Questionnaires, Third Edition. Generalized linear mixed models were used to examine the associations of UFP exposure with risk of suspected neurodevelopmental delay. For our participants, the median of UFP exposure was 24,478 [interquartile range (IQR): 22,773–27,657] number per cubic centimeter. We observed that each IQR increase in UFP was associated with 8% [odds ratio (OR), 1.08; 95% CI, 1.02–1.15] and 12% (OR, 1.12; 95% CI, 1.02–1.22) higher odds of suspected neurodevelopmental delay in gross and fine motor skills, respectively. These associations show a monotonically upward dose–response manner across overall UFP concentrations. Our findings suggest that UFP exposure during early childhood is associated with an increased risk of neurodevelopmental delay among Chinese preschoolers.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 1","pages":"102–110 102–110"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/envhealth.4c00102","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143091732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Constituent-Dependent Translocation Mechanism for PM_2.5 to Travel through the Olfactory Pathway.","authors":"Sheng Wei, Ting Xu, Miao Cao, Huan Wang, Yiqun Song, Daqiang Yin","doi":"10.1021/envhealth.4c00129","DOIUrl":"10.1021/envhealth.4c00129","url":null,"abstract":"<p><p>The neurotoxic risk of PM_2.5 is of worldwide concern, but the pathways through which PM_2.5 gets to the central nervous system are still under debate. The olfactory pathway provides a promising shortcut to the brain, which bypasses the blood-brain barrier for PM_2.5. However, direct evidence is lacking, and the translocation mechanism is still unclear. This study used the primary murine olfactory sensory neurons (OSNs) as an <i>in vitro</i> model to explore the translocation mechanism of PM_2.5 in the olfactory system. We found that PM_2.5 can be internalized into the OSNs via vesicle transportation. This process responds only to the water-insoluble compositions of PM_2.5 (WIS-PM_2.5) and cannot be affected by the water-soluble compositions of PM_2.5 (WS-PM_2.5). PM_2.5 can further disrupt the integrity of the barrier constituted by the OSNs, and WS-PM_2.5 plays a heightened role in inducing the damages. Our results suggested that both cellular and paracellular pathways are possibly involved in the translocation of PM_2.5 in the olfactory system. More advanced microscopy techniques need to be developed to explore the whole translocation process in the olfactory-brain pathway in both <i>in vitro</i> and <i>in vivo</i> models.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"2 12","pages":"856-864"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11667289/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142898720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Ambient Ultrafine Particles and Neurodevelopmental Delay in Preschoolers in Shanghai, China.","authors":"Mengxun Rong, Yang Shen, Yihui Ge, Wenchong Du, Haidong Kan, Jing Cai, Yan Zhao, Jing Hua","doi":"10.1021/envhealth.4c00102","DOIUrl":"10.1021/envhealth.4c00102","url":null,"abstract":"<p><p>Previous toxicological research has suggested the potential neurotoxicity of ultrafine particulate matter (UFP, particles ≤0.1 μm in diameter). However, evidence from human beings, particularly regarding the neurodevelopmental impacts of UFP, is still limited. We enrolled 11,230 children aged 3-5.5 years from Shanghai, China. Residential UFP exposure was assessed by a land use regression model with a spatial resolution of 50 m. The neurodevelopment of preschoolers was assessed using the Ages & Stages Questionnaires, Third Edition. Generalized linear mixed models were used to examine the associations of UFP exposure with risk of suspected neurodevelopmental delay. For our participants, the median of UFP exposure was 24,478 [interquartile range (IQR): 22,773-27,657] number per cubic centimeter. We observed that each IQR increase in UFP was associated with 8% [odds ratio (OR), 1.08; 95% CI, 1.02-1.15] and 12% (OR, 1.12; 95% CI, 1.02-1.22) higher odds of suspected neurodevelopmental delay in gross and fine motor skills, respectively. These associations show a monotonically upward dose-response manner across overall UFP concentrations. Our findings suggest that UFP exposure during early childhood is associated with an increased risk of neurodevelopmental delay among Chinese preschoolers.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 1","pages":"102-110"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11744390/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143013117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Constituent-Dependent Translocation Mechanism for PM2.5 to Travel through the Olfactory Pathway","authors":"Sheng Wei,&nbsp;Ting Xu*,&nbsp;Miao Cao,&nbsp;Huan Wang,&nbsp;Yiqun Song and Daqiang Yin*,&nbsp;","doi":"10.1021/envhealth.4c0012910.1021/envhealth.4c00129","DOIUrl":"https://doi.org/10.1021/envhealth.4c00129https://doi.org/10.1021/envhealth.4c00129","url":null,"abstract":"<p >The neurotoxic risk of PM_2.5 is of worldwide concern, but the pathways through which PM_2.5 gets to the central nervous system are still under debate. The olfactory pathway provides a promising shortcut to the brain, which bypasses the blood–brain barrier for PM_2.5. However, direct evidence is lacking, and the translocation mechanism is still unclear. This study used the primary murine olfactory sensory neurons (OSNs) as an <i>in vitro</i> model to explore the translocation mechanism of PM_2.5 in the olfactory system. We found that PM_2.5 can be internalized into the OSNs via vesicle transportation. This process responds only to the water-insoluble compositions of PM_2.5 (WIS-PM_2.5) and cannot be affected by the water-soluble compositions of PM_2.5 (WS-PM_2.5). PM_2.5 can further disrupt the integrity of the barrier constituted by the OSNs, and WS-PM_2.5 plays a heightened role in inducing the damages. Our results suggested that both cellular and paracellular pathways are possibly involved in the translocation of PM_2.5 in the olfactory system. More advanced microscopy techniques need to be developed to explore the whole translocation process in the olfactory–brain pathway in both <i>in vitro</i> and <i>in vivo</i> models.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"2 12","pages":"856–864 856–864"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/envhealth.4c00129","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142858579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}