{"title":"Bioaccumulation and Maternal Transfer of Brominated Flame Retardants in Poultry and the Health Risks from Dietary Exposure.","authors":"Ying Li, Ling Wang, Lei Shi, Yinghua Lou, Aifeng Liu, Yongfeng Lin, Ruixia Yang, Wei Gao, Guangbo Qu","doi":"10.1021/envhealth.4c00260","DOIUrl":null,"url":null,"abstract":"<p><p>The limitation of legacy hexabromocyclododecanes (HBCDs) and increasing usage of emerging brominated flame retardant (BFR) tetrabromobisphenol A (TBBPA) resulted in their co-exposure to organisms. In this study, domestic chicken and environmental samples collected near a BFR manufacturing zone were analyzed to determine the bioaccumulation and transfer of HBCDs and TBBPA. The mean concentrations of ∑<sub>3</sub>HBCDs, TBBPA, ∑<sub>4</sub>TBBPA-related derivatives, ∑<sub>9</sub>TBBPA-related byproducts, and ∑<sub>16</sub>TBBPA-related transformation products in chicken tissues were 1207, 0.20, 15087, 0.96, and 6384 ng/g lipid weight, respectively. Exposure to sources of BFR contamination (soil, feed, and water) could be the main cause of high BFR levels in chickens. α-HBCD and bis-substituted TBBPA analogues have higher bioaccumulation factor levels than TBBPA and other compounds, indicating greater bioconcentration potential for substances with higher log<i>K</i> <sub>ow</sub>. HBCDs, TBBPA, and TBBPA analogues tend to be enriched in the chicken comb and spleen and can cross the blood-brain barrier into the brain. However, while these compounds accumulate in the mother, they are also subject to metabolic processes that lead to their eventual excretion. Low-persistence BFRs were more favorable to maternal transfer, while compounds with high persistence tended to be retained in the mother. Although dietary intake of BFRs through chicken consumption poses a low risk to the general population, concerns remain regarding the synergistic risk of BFRs.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 7","pages":"723-732"},"PeriodicalIF":6.3000,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12281201/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Environment & Health","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1021/envhealth.4c00260","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/7/18 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
The limitation of legacy hexabromocyclododecanes (HBCDs) and increasing usage of emerging brominated flame retardant (BFR) tetrabromobisphenol A (TBBPA) resulted in their co-exposure to organisms. In this study, domestic chicken and environmental samples collected near a BFR manufacturing zone were analyzed to determine the bioaccumulation and transfer of HBCDs and TBBPA. The mean concentrations of ∑3HBCDs, TBBPA, ∑4TBBPA-related derivatives, ∑9TBBPA-related byproducts, and ∑16TBBPA-related transformation products in chicken tissues were 1207, 0.20, 15087, 0.96, and 6384 ng/g lipid weight, respectively. Exposure to sources of BFR contamination (soil, feed, and water) could be the main cause of high BFR levels in chickens. α-HBCD and bis-substituted TBBPA analogues have higher bioaccumulation factor levels than TBBPA and other compounds, indicating greater bioconcentration potential for substances with higher logKow. HBCDs, TBBPA, and TBBPA analogues tend to be enriched in the chicken comb and spleen and can cross the blood-brain barrier into the brain. However, while these compounds accumulate in the mother, they are also subject to metabolic processes that lead to their eventual excretion. Low-persistence BFRs were more favorable to maternal transfer, while compounds with high persistence tended to be retained in the mother. Although dietary intake of BFRs through chicken consumption poses a low risk to the general population, concerns remain regarding the synergistic risk of BFRs.
期刊介绍:
Environment & Health a peer-reviewed open access journal is committed to exploring the relationship between the environment and human health.As a premier journal for multidisciplinary research Environment & Health reports the health consequences for individuals and communities of changing and hazardous environmental factors. In supporting the UN Sustainable Development Goals the journal aims to help formulate policies to create a healthier world.Topics of interest include but are not limited to:Air water and soil pollutionExposomicsEnvironmental epidemiologyInnovative analytical methodology and instrumentation (multi-omics non-target analysis effect-directed analysis high-throughput screening etc.)Environmental toxicology (endocrine disrupting effect neurotoxicity alternative toxicology computational toxicology epigenetic toxicology etc.)Environmental microbiology pathogen and environmental transmission mechanisms of diseasesEnvironmental modeling bioinformatics and artificial intelligenceEmerging contaminants (including plastics engineered nanomaterials etc.)Climate change and related health effectHealth impacts of energy evolution and carbon neutralizationFood and drinking water safetyOccupational exposure and medicineInnovations in environmental technologies for better healthPolicies and international relations concerned with environmental health