Bioaccumulation and Maternal Transfer of Brominated Flame Retardants in Poultry and the Health Risks from Dietary Exposure.

IF 6.3
Environment & Health Pub Date : 2025-03-17 eCollection Date: 2025-07-18 DOI:10.1021/envhealth.4c00260
Ying Li, Ling Wang, Lei Shi, Yinghua Lou, Aifeng Liu, Yongfeng Lin, Ruixia Yang, Wei Gao, Guangbo Qu
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引用次数: 0

Abstract

The limitation of legacy hexabromocyclododecanes (HBCDs) and increasing usage of emerging brominated flame retardant (BFR) tetrabromobisphenol A (TBBPA) resulted in their co-exposure to organisms. In this study, domestic chicken and environmental samples collected near a BFR manufacturing zone were analyzed to determine the bioaccumulation and transfer of HBCDs and TBBPA. The mean concentrations of ∑3HBCDs, TBBPA, ∑4TBBPA-related derivatives, ∑9TBBPA-related byproducts, and ∑16TBBPA-related transformation products in chicken tissues were 1207, 0.20, 15087, 0.96, and 6384 ng/g lipid weight, respectively. Exposure to sources of BFR contamination (soil, feed, and water) could be the main cause of high BFR levels in chickens. α-HBCD and bis-substituted TBBPA analogues have higher bioaccumulation factor levels than TBBPA and other compounds, indicating greater bioconcentration potential for substances with higher logK ow. HBCDs, TBBPA, and TBBPA analogues tend to be enriched in the chicken comb and spleen and can cross the blood-brain barrier into the brain. However, while these compounds accumulate in the mother, they are also subject to metabolic processes that lead to their eventual excretion. Low-persistence BFRs were more favorable to maternal transfer, while compounds with high persistence tended to be retained in the mother. Although dietary intake of BFRs through chicken consumption poses a low risk to the general population, concerns remain regarding the synergistic risk of BFRs.

溴化阻燃剂在家禽体内的生物积累和母体转移以及饮食暴露的健康风险。
传统六溴环十二烷(hbcd)的局限性和新兴溴化阻燃剂(BFR)四溴双酚A (TBBPA)的使用增加导致它们与生物共暴露。本研究分析了在BFR生产区附近采集的家鸡和环境样本,以确定hbcd和TBBPA的生物积累和转移。鸡组织中∑3hbcd、TBBPA、∑4tbbpa相关衍生物、∑9tbbpa相关副产物和∑16tbbpa相关转化产物的平均脂质质量浓度分别为1207、0.20、15087、0.96和6384 ng/g。暴露于BFR污染源(土壤、饲料和水)可能是鸡体内BFR水平高的主要原因。α-HBCD和双取代TBBPA类似物比TBBPA和其他化合物具有更高的生物积累因子水平,表明logK低越高的物质具有更大的生物富集潜力。hbcd、TBBPA和TBBPA类似物往往富集于鸡冠和脾脏,并可穿过血脑屏障进入大脑。然而,当这些化合物在母体中积累时,它们也会受到代谢过程的影响,最终导致它们被排出体外。持久性低的BFRs更有利于母体转移,而持久性高的化合物倾向于在母体中保留。虽然通过食用鸡肉摄入生物致病菌对一般人群的风险较低,但人们仍然关注生物致病菌的协同风险。
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来源期刊
Environment & Health
Environment & Health 环境科学、健康科学-
自引率
0.00%
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0
期刊介绍: Environment & Health a peer-reviewed open access journal is committed to exploring the relationship between the environment and human health.As a premier journal for multidisciplinary research Environment & Health reports the health consequences for individuals and communities of changing and hazardous environmental factors. In supporting the UN Sustainable Development Goals the journal aims to help formulate policies to create a healthier world.Topics of interest include but are not limited to:Air water and soil pollutionExposomicsEnvironmental epidemiologyInnovative analytical methodology and instrumentation (multi-omics non-target analysis effect-directed analysis high-throughput screening etc.)Environmental toxicology (endocrine disrupting effect neurotoxicity alternative toxicology computational toxicology epigenetic toxicology etc.)Environmental microbiology pathogen and environmental transmission mechanisms of diseasesEnvironmental modeling bioinformatics and artificial intelligenceEmerging contaminants (including plastics engineered nanomaterials etc.)Climate change and related health effectHealth impacts of energy evolution and carbon neutralizationFood and drinking water safetyOccupational exposure and medicineInnovations in environmental technologies for better healthPolicies and international relations concerned with environmental health
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