Environment & Health最新文献

{"title":"Mitigating Environmental Pollutant-Induced Premature Ovarian Insufficiency by Rationally Designed Ultrasmall Gold Nanoparticles via Dual Regulation of ROS and Mitophagy","authors":"Liyuan Xue,&nbsp;Kai Cao,&nbsp;Mingyang Du,&nbsp;Yaqi Jiang,&nbsp;Dongfang Xia,&nbsp;Liang Gao,&nbsp;Cuicui Ji,&nbsp;Xueyun Gao","doi":"10.1021/envhealth.6c00186","DOIUrl":"https://doi.org/10.1021/envhealth.6c00186","url":null,"abstract":"<p>Premature ovarian insufficiency (POI), often inducedby environmentalpollutants such as 4-vinylcyclohexene diepoxide (VCD), is a growingclinical concern, with limited treatment options. Here, we reporta nanotherapeutic strategy using a rationally designed ultrasmallgold nanoparticle templated with reduced glutathione (GGNP). GGNPseffectively alleviate VCD-induced granulosa cell aging through scavengingmitochondrial reactive oxygen species and activating mitophagy. Thisconcomitant effect restores mitochondrial function and prevents mitochondrialDNA release, thereby suppressing the downstream STING-mediated senescence-associatedsecretory phenotype (SASP) pathway. In a VCD-induced POI mouse model,GGNP administration significantly reverses both ovarian and uterineatrophy, normalizes follicle-stimulating hormone levels, and inhibitsSASP signaling without detectable toxicity. Our study thus establishesGGNP as a promising nanomedicine for environmental pollutant-inducedPOI by restoring mitochondrial homeostasis.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"4 10","pages":"2343–2354"},"PeriodicalIF":8.8,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149188033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ABCC1 Deficiency Mediates Susceptibility to Cd-Induced Hearing Loss via the NOX2/ROS Axis","authors":"Shuai Zhang,&nbsp;Yongjia Chen,&nbsp;Yijiang Bai,&nbsp;Bo Pang,&nbsp;Mengzhu Jiang,&nbsp;Zequn Nie,&nbsp;Huping Huang,&nbsp;Lu Wang,&nbsp;Jie Ling,&nbsp;Tianhan Kai,&nbsp;Lingyun Mei","doi":"10.1021/envhealth.6c00120","DOIUrl":"https://doi.org/10.1021/envhealth.6c00120","url":null,"abstract":"<p>Cadmium(Cd), a prevalent environmental contaminant, is associatedwith auditory dysfunction. The cochlear blood–labyrinth barrier(BLB) protects the inner ear from toxic substances, a process in whichthe ATP-binding cassette subfamily C member 1 protein, ABCC1, playsa critical role in expelling toxins from its cells. To understandthe specific contribution of ABCC1 to Cd-induced hearing damage, weemployed both an in vivo model (ABCC1 knockout mice, <em>Abcc1</em>^–/– mice) and an in vitro endothelial model(ABCC1-deficient human umbilical vein endothelial cells, <em>ABCC1</em>^–/–HUVECs). These models were exposed toCdCl₂ to assess auditory responses, histopathology, BLBintegrity, and oxidative stress. We also explored the NOX2-ROS/PI3K-AKTpathway using immunofluorescence, Western blotting, and RNA-seq analyses.The results indicate that ABCC1 deficiency exacerbated Cd-inducedBLB leakage, promoted spiral ganglion neurons and presynaptic ribbonpuncta loss, and increased ABR thresholds. In both animal and cellularmodels, ABCC1 deficiency enhanced NOX2 expression, ROS accumulation,and AKT dephosphorylation. Significantly, pharmacological inhibitionof NOX2 with GSK2795039 attenuated oxidative stress, preserved endothelialbarrier function, and partially restored PI3K-AKT signaling. Thesefindings identify ABCC1 as a critical protector of cochlear vascularintegrity during Cd exposure, acting through the NOX2-ROS/PI3K-AKTaxis, and suggest its potential as a therapeutic target for preventingCd-induced hearing loss.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"4 10","pages":"2385–2400"},"PeriodicalIF":8.8,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149188034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Illuminating Antarctic Microbial Dark Matter: In situ Cultivation Reveals Rare Taxa with Broad Resistome and Virulence Phenotypes","authors":"Jacquelinne J. Acuña,&nbsp;Constanza Venegas,&nbsp;Marco A. Campos,&nbsp;Nicole Huerta,&nbsp;Joaquín Rilling,&nbsp;Ian Pérez,&nbsp;Andrés E. Marcoleta,&nbsp;Verónica Cambiazo,&nbsp;León Bravo,&nbsp;Shan He,&nbsp;Milko A. Jorquera,&nbsp;Francisco P. Chávez","doi":"10.1021/envhealth.5c00857","DOIUrl":"https://doi.org/10.1021/envhealth.5c00857","url":null,"abstract":"<p>Glacial forelands in Maritime Antarctica are rapidlyexpandingdue to deglaciation, thereby increasing ecological connectivity amongpreviously isolated microbial reservoirs. From a One Health perspective,this process is relevant because environmental microorganisms representlong-standing reservoirs of antibiotic resistance and virulence-associatedtraits. However, current knowledge is mainly limited to dominant,fast-growing taxa recovered by conventional cultivation, leaving thefunctional potential of slow-growing and rare Antarctic bacteria largelyunexplored. Here, we compared traditional plating methods (PM) and <em>in situ</em> cultivation (ISC) for recovering bacteria from permafrost,moraine, and rhizosphere soils, quantified total culturable diversityusing 16S rRNA metabarcoding, and assessed antibiotic susceptibilityand phenotypic virulence across 158 nonredundant isolates. Culturedcommunities were dominated by Pseudomonadota, Actinomycetota, Bacteroidota,and Bacillota, with <em>Pseudomonas</em> amongthe most prevalent genera, although its relative abundance variedacross soil compartments and cultivation strategies. ISC expandedthe taxonomic breadth of cultured bacteria and enabled the recoveryof rare or underrepresented genera absent from PM collections, including <em>Bosea</em>, <em>Rathayibacter</em>, <em>Rugamonas</em>, <em>Massilia</em>, <em>Phyllobacterium</em>, <em>Polaromonas</em>, and <em>Curtobacterium</em>. Functional profiling revealed a widespread environmental resistome,with high frequencies of resistance to β-lactams, cephalosporins,and oxazolidinones. Notably, isolates affiliated with <em>Flavobacterium</em>, <em>Brucella</em>, <em>Pseudomonas</em>, and <em>Curtobacterium</em> exhibited extreme multidrug resistance,with individual strains resistant to more than 20 antibiotics. Virulence-associatedphenotypes were broadly distributed across cultured taxa, includinglecithinase and hemolytic activity (&gt;35% of isolates), pyocyaninproduction(∼20%), and DNase activity (∼7%). Together, these resultsdemonstrate that <em>in situ</em> cultivation provides accessto underrepresented components of Antarctic microbial diversity andreveals resistance- and virulence-associated traits beyond those ofdominant taxa. Antarctic glacier foreland soils, therefore, representunderexplored environmental reservoirs of health-relevant microbialfunctions, underscoring the value of culturomics for environmentalhealth research amid climate-driven change.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"4 10","pages":"2355–2371"},"PeriodicalIF":8.8,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149173363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bisphenol M Impairs Ovarian Function through Disrupting Estrogen Synthesis in Female Mice: A Comparative Study with Bisphenol A","authors":"Shuang Luo,&nbsp;Fan Wu,&nbsp;Yuzhen Sun,&nbsp;Zhunjie Li,&nbsp;Jing Wang,&nbsp;Mengxi Cao,&nbsp;Shaochen Pang,&nbsp;Ling Wang,&nbsp;Huiming Cao,&nbsp;Jianan Li,&nbsp;Yong Liang","doi":"10.1021/envhealth.6c00098","DOIUrl":"https://doi.org/10.1021/envhealth.6c00098","url":null,"abstract":"<p>Bisphenol M (BPM) has been increasingly used as a substituteforbisphenol A (BPA), yet its reproductive toxicity remains poorly characterized.Unlike BPA, which is well characterized as a weak estrogen receptor(ER) agonist, BPM has been identified as an ER antagonist. In thisstudy, we systematically compared the effects of BPM and BPA on thereproductive neuroendocrine system of female mice during puberty.Five-week-old female ICR mice were exposed to BPM and BPA at dosesof 1 μg/kg bw/day, 50 μg/kg bw/day, and 1 mg/kg bw/dayfor 14 days. Both chemicals induced comparable adverse reproductiveoutcomes at 50 μg/kg bw/day and 1 mg/kg bw/day, including reduceduterine weight, disrupted estrous cyclicity, depletion of primordialfollicles, and increased follicle atresia. However, BPM and BPA haddivergent effects on molecular and hormonal end points. BPM exposuresignificantly elevated ovarian <em>Cyp19a1</em> expression,as well as serum estradiol (E2), follicle-stimulating hormone (FSH),and luteinizing hormone (LH) levels, whereas BPA did not significantlyalter any of these parameters. Mechanistically, BPM acts as an ERantagonist, reducing functional E2–ER complexes and creatinga perceived “E2 signaling deficiency”. This triggerscompensatory upregulation of ovarian ERs and steroidogenic genes (<em>Star</em>, <em>Cyp19a1</em>, and <em>Hsd17b1</em>), leading to enhanced E2 synthesis. The resulting hyperestrogenismexerts positive feedback on hypothalamic GnRH neurons, driving sustainedgonadotropin secretion and creating a self-sustaining high-E2 loopthat disrupts estrous cyclicity and follicle dynamics. In contrast,BPA, as a weak ER agonist, partially substitutes for endogenous E2at ERs, preventing the perception of E2 deficiency. Consequently,no compensatory steroidogenic activation occurs, and hormone levelsremain unchanged. Despite these distinct mechanisms, both compoundsimpair female reproductive function. Importantly, BPM exerted morepronounced endocrine disturbances than BPA, raising concerns regardingits use as a safer alternative. These findings highlight the necessityof comprehensive toxicological evaluation of BPA analogues and emphasizethat ER antagonism does not necessarily imply reduced reproductiverisk.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"4 10","pages":"2289–2300"},"PeriodicalIF":8.8,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149173518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Driving Scenarios Strongly Influence Tire Additive Accumulation in Road Dust: First Field Evidence from China’s Urban Roads","authors":"Pinjie Su,&nbsp;Jie Shen,&nbsp;Zihan Wang,&nbsp;Chenxi Huo,&nbsp;Jiefeng Liang,&nbsp;Guangbo Qu,&nbsp;Runzeng Liu","doi":"10.1021/envhealth.6c00168","DOIUrl":"https://doi.org/10.1021/envhealth.6c00168","url":null,"abstract":"<p>Tireadditives (TAs) are of growing concern due to theirwidespreadoccurrence and potential toxicity. However, the role of driving scenariosin modulating their release remains poorly understood. This studyexamined a broad range of TAs in road dust collected from two typicalurban road scenarios in China. A total of 138 TAs were detected, including14 compounds reported in road dusts for the first time. Driving scenariosstrongly influenced the TA concentrations and composition. On urbanroads, crossroads (characterized by frequent braking, turning, andstop-and-go traffic) exhibited higher TA concentrations (median: 5.46× 10⁴ ng/g) than straight road segments (median: 3.57× 10⁴ ng/g). Vulcanization accelerators (VAs) andantioxidants (AOs) served as sensitive tracers of TA release acrossdifferent driving scenarios. Importantly, TA accumulation in roaddust was also governed by physicochemical properties, with lower molecularweights, stronger hydrophobicity, and higher organic carbon affinityassociated with elevated concentrations. Preliminary exposure assessmentindicated elevated TA exposure risk among children residing near crossroads.These findings indicate that driving scenarios are likely importantfactors influencing the accumulation of traffic-related TAs and highlightthe potential need for scenario-specific mitigation strategies.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"4 10","pages":"2269–2277"},"PeriodicalIF":8.8,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149188079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Source-Specific PM2.5 Exposure and Atrial Fibrillation Risk in U.S. Older Adults: A Nationwide Cohort Study","authors":"Qiao Zhu,&nbsp;Hua Hao,&nbsp;Yanling Deng,&nbsp;Yan V. Sun,&nbsp;Chang Liu,&nbsp;Alvaro Alonso,&nbsp;Yang Liu","doi":"10.1021/envhealth.5c00638","DOIUrl":"https://doi.org/10.1021/envhealth.5c00638","url":null,"abstract":"<p>Fine particulate matter (PM_2.5) is associatedwith anincreased risk of atrial fibrillation (AF), but the effects of individualPM_2.5 sources remain unclear. We evaluated the relationshipbetween long-term exposure to source-specific PM_2.5 andincident AF among 26.3 million U.S. Medicare beneficiaries from 2000to 2019. We resolved PM_2.5 sources using the MultilinearEngine model based on PM_2.5 components data from monitoringstations. Annual ZIP code–level exposures were assigned usinginverse-distance weighting of monitoring stations within a 100 kmbuffer. Cox proportional hazards models were used to estimate AF riskper interquartile range (IQR) increase in source-specific PM_2.5 concentrations, adjusting for demographic and socioeconomic factorsand other environmental covariates. Over 171.6 million person-yearsof follow-up, 4.44 million incident AF cases were identified. Exposureto PM_2.5 from vehicle emissions (HR 1.029, 95% CI 1.028–1.030),heavy oil and coal combustion (HR 1.048, 95% CI 1.046–1.050),secondary sulfate (HR 1.056, 95% CI 1.053–1.058), and secondarynitrate (HR 1.032, 95% CI 1.030–1.034) was significantly associatedwith higher AF risk. In contrast, biomass burning and soil and dustexhibited only modest associations, and secondary organic aerosols(SOA) showed no overall effect. Regional analyses revealed geographicheterogeneity: fossil-fuel–related sources drove AF risk inmost regions, secondary sulfate and nitrate had the strongest effectsin the southern U.S., and SOA was more strongly associated with AFin the West. These findings highlight the differential toxicity andregional heterogeneity of PM_2.5 sources in AF risk andemphasize the need for targeted, region-specific air quality regulationsfocusing on traffic and industrial emissions to mitigate AF incidencein older adults.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"4 10","pages":"2301–2311"},"PeriodicalIF":8.8,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149173517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Immune and Proteomic Markers in Exhaled Breath Condensate: A Feasibility Study","authors":"Evi De Ryck,&nbsp;Eline Verscheure,&nbsp;Vivi Schlünssen,&nbsp;Anne Mette Lund Würtz,&nbsp;Rob Stierum,&nbsp;Sebastien Carpentier,&nbsp;Steven Ronsmans,&nbsp;Anjoeka Pronk,&nbsp;Lode Godderis,&nbsp;Manosij Ghosh","doi":"10.1021/envhealth.6c00175","DOIUrl":"https://doi.org/10.1021/envhealth.6c00175","url":null,"abstract":"<p>Exhaledbreath condensate (EBC) is a promising matrixfor biomarkercharacterization that reflects the condition of the respiratory system.We assessed the practical feasibility of marker characterization inEBC, including quantification, comparison with plasma and saliva levels,and repeated sampling after six months, focusing on immune markersand proteomics. We measured several immune markers twice, six monthsapart, in EBC, saliva, and plasma, including cytokines and matrixmetalloproteinases, and untargeted proteomics in EBC. α-Amylaseactivity was almost 10,000-fold lower in EBC than in saliva, suggestingat most limited saliva contamination during EBC collection. Generally,chemokine and eicosanoid levels were lower and more often below thelimit of quantification in EBC versus plasma and saliva. Participantswere healthy; still, EBC markers could be quantified in ≥50%of samples, except interleukin 12p70 and thromboxane B₂. Correlations across matrices were often low, supporting EBC’smatrix-specific properties. EBC proteomic analysis identified up to209 proteins, several related to lung function. This study highlightsEBC as a promising non-invasive method for respiratory biomarker discoveryand demonstrates the practical feasibility of detecting immune andproteomic markers in EBC. Additionally, we showed that the EBC proteomecan be generated on single EBC samples.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"4 10","pages":"2372–2384"},"PeriodicalIF":8.8,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149188027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CRISPR Technology Applied to the Analysis of Antibiotic Resistance Genes in the Environment","authors":"Jiayin Yan,&nbsp;Xiaoxian Yuan,&nbsp;Zijun Zhu,&nbsp;Zhuang Li,&nbsp;Minghuo Wu,&nbsp;Jing Liu,&nbsp;Lizhong Zhu,&nbsp;Wei Feng","doi":"10.1021/envhealth.5c00855","DOIUrl":"https://doi.org/10.1021/envhealth.5c00855","url":null,"abstract":"<p>Environmentaltransmission of antibiotic resistance posesa riskto human health. Understanding the behavior and health risks of antibioticresistance genes (ARGs) in the environment requires accurate nucleicacid analyses. Technical challenges remain in the sequencing of ARGsin low abundance relative to total environmental DNA and in on-siteanalysis. CRISPR technology has been applied to the characterizationand monitoring of ARGs in various environmental media. For sequencingof ARGs, CRISPR technology has enabled the enrichment of ARGs presentin the environment at a very low abundance. Using CRISPR/Cas9 systemswith a pool of guide RNAs (gRNAs) could simultaneously enrich a largepanel of ARGs in one environmental sample before sequencing for goodcoverage and reading depth. CRISPR/Cas9 also enabled targeted long-readsequencing for understanding the genetic context of low-abundanceARGs. CRISPR-based rapid detection has the potential for on-site analysis.Current applications include the analysis of antibiotic-resistantbacteria (ARB) and ARGs in the air and the urban water cycle. CRISPRtechnology is also useful for differentiating single-nucleotide mutationsbetween antibiotic-susceptible and -resistant variants. Rapid detectionof antibiotics together with ARGs is also possible with the use ofaptamers that specifically bind to antibiotics.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"4 10","pages":"2172–2183"},"PeriodicalIF":8.8,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149188078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human Exposure to Micro- and Nanoplastics: Trans-Barrier Transport, Tissue Accumulation, and Health Risks","authors":"Honghuan Xia,&nbsp;Yue Li,&nbsp;Fengbang Wang,&nbsp;Gang Li,&nbsp;Zhiqiang Tan,&nbsp;Maoyong Song","doi":"10.1021/envhealth.6c00122","DOIUrl":"https://doi.org/10.1021/envhealth.6c00122","url":null,"abstract":"<p>Micro- and nanoplastics (MNPs) as emerging pollutantare widespreadin the environment. MNPs have been widely detected in human samples,with reported concentrations in human brain tissue reaching 298.5–47,730μg/g. Furthermore, several clinical and epidemiological studiessuggest that human exposure to MNPs may be associated with adversehealth outcomes. These findings have raised growing concerns aboutthe potential health risks of MNPs. This review summarizes currentknowledge on the exposure pathways, occurrence and distribution, <em>trans</em>-barrier transport, toxicity, and health risks of MNPsin humans. Studies indicate the primary exposure pathways of MNPsto human including ingestion, inhalation, dermal contact, as wellas direct exposure via intravenous injection and surgery. Moreover,MNPs can traverse multiple biological barriers such as intestinalbarrier, blood–alveolar barrier, placental barrier, blood–testisbarrier, and blood–brain barrier, resulting in accumulationin various tissues. Studies in vivo and in vitro demonstrate thatMNPs cause multiple toxic effects. Notably, this review provides anintegrated perspective on the continuous biological cascade from externalexposure through internal processes to adverse health outcomes. Inaddition, we point out that future research should focus on improvingidentification techniques, performing long-term low-dose exposureassessments, and elucidating the underlying mechanisms.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"4 10","pages":"2184–2198"},"PeriodicalIF":8.8,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149173284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occurrence and Health Risk Assessment of Organophosphate Esters in Seafood from Southeastern China: Impacts of Cooking Methods and Dietary Exposure","authors":"Yunshuang Liu,&nbsp;Qian Zou,&nbsp;Mei Liu,&nbsp;Marie Pedersen,&nbsp;Fuxiang Cui,&nbsp;Xinyi Chen,&nbsp;Yin Dong,&nbsp;Gaofeng Zhang,&nbsp;Gaoxin Zhang,&nbsp;Jingzhang Liu,&nbsp;Maoyong Song,&nbsp;Qinghua Zhang","doi":"10.1021/envhealth.6c00114","DOIUrl":"https://doi.org/10.1021/envhealth.6c00114","url":null,"abstract":"<p>Food ingestion is recognized as a major pathway for humanexposureto organophosphate esters (OPEs). However, studies investigating dietaryexternal exposure and human internal exposure within the same regionremain limited. In this study, 17 OPEs were measured in seafood collectedfrom China’s coastal waters and 16 OPEs were measured in serumsamples from local residents. ΣOPE concentrations ranged from1.88 to 9.23 ng/mL (mean: 4.96 ng/mL) in serum and 15.63–39.61ng/g dw (mean: 24.54 ng/g dw) in untreated seafood. The emerging OPE3IPPDPP was detected in untreated seafood at a concentration of 0.07ng/g dw. Among the processing methods, cooking exhibited the mostevident reduction in OPE concentrations, with a mean level of 14.57ng/g dw. TCIPP and TDCIPP were identified as the dominant compoundsin the seafood and serum, respectively. Under the current availabletoxicological data for OPEs and the assumptions of the exposure model,noncarcinogenic risks from dietary exposure to OPEs in processed seafoodwere within acceptable limits. These findings provide new insightsinto dietary exposure to OPEs and their associated health risks.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"4 10","pages":"2208–2218"},"PeriodicalIF":8.8,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149173522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}