Environment & Health最新文献

Assessing the Impact of Serum Per- and Polyfluoroalkyl Substance Concentrations on Immune Function in an Industrialized Region of China 评估中国工业化地区血清全氟和多氟烷基物质浓度对免疫功能的影响

Environment & Health Pub Date : 2025-03-03 DOI: 10.1021/envhealth.4c0022410.1021/envhealth.4c00224

Chuanzi Gao, Feng Quan, Wenhui Qiu* and Yi Zheng*,

{"title":"Assessing the Impact of Serum Per- and Polyfluoroalkyl Substance Concentrations on Immune Function in an Industrialized Region of China","authors":"Chuanzi Gao, Feng Quan, Wenhui Qiu* and Yi Zheng*, ","doi":"10.1021/envhealth.4c0022410.1021/envhealth.4c00224","DOIUrl":"https://doi.org/10.1021/envhealth.4c00224https://doi.org/10.1021/envhealth.4c00224","url":null,"abstract":"This study investigates the presence and health implications of per- and polyfluoroalkyl substances (PFAS) in human serum samples collected from white-collar workers in an industrialized region of China. Our research offers fresh insights into the underexplored area of nonoccupational PFAS exposure among white-collar workers, shedding light on health risks linked to industrial PFAS pollution. Seven PFAS compounds were measured. Perfluorooctanoic acid (PFOA) and perfluorooctanesulfonate (PFOS) emerged as predominant pollutants, with Σ7PFAS concentrations averaging 65.486 ng/mL. Gender differences showed higher serum Σ7PFAS levels in males, and age-related analyses suggested PFAS accumulation over time, with higher concentrations in older groups. Additionally, significant correlations were found between PFAS concentrations and biomarkers of oxidative stress and immune interference, specifically malondialdehyde (MDA) and immunoglobulin M (IgM), indicating that PFAS exposure may contribute to oxidative damage and potential immunosuppression. The study highlights regional and international variations in PFAS serum concentrations, underscoring the influence of industrial activities on PFAS exposure and expanding on the established links between PFAS exposure and health outcomes. These findings call for targeted strategies to mitigate PFAS exposure in high-risk regions and warrant further research on PFAS health impacts, especially in regard to immune interference.","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 4","pages":"352–362 352–362"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/envhealth.4c00224","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143842362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing the Impact of Serum Per- and Polyfluoroalkyl Substance Concentrations on Immune Function in an Industrialized Region of China. 评估中国工业化地区血清全氟和多氟烷基物质浓度对免疫功能的影响。

Environment & Health Pub Date : 2025-03-03 eCollection Date: 2025-04-18 DOI: 10.1021/envhealth.4c00224

Chuanzi Gao, Feng Quan, Wenhui Qiu, Yi Zheng

{"title":"Assessing the Impact of Serum Per- and Polyfluoroalkyl Substance Concentrations on Immune Function in an Industrialized Region of China.","authors":"Chuanzi Gao, Feng Quan, Wenhui Qiu, Yi Zheng","doi":"10.1021/envhealth.4c00224","DOIUrl":"https://doi.org/10.1021/envhealth.4c00224","url":null,"abstract":"This study investigates the presence and health implications of per- and polyfluoroalkyl substances (PFAS) in human serum samples collected from white-collar workers in an industrialized region of China. Our research offers fresh insights into the underexplored area of nonoccupational PFAS exposure among white-collar workers, shedding light on health risks linked to industrial PFAS pollution. Seven PFAS compounds were measured. Perfluorooctanoic acid (PFOA) and perfluorooctanesulfonate (PFOS) emerged as predominant pollutants, with Σ7PFAS concentrations averaging 65.486 ng/mL. Gender differences showed higher serum Σ7PFAS levels in males, and age-related analyses suggested PFAS accumulation over time, with higher concentrations in older groups. Additionally, significant correlations were found between PFAS concentrations and biomarkers of oxidative stress and immune interference, specifically malondialdehyde (MDA) and immunoglobulin M (IgM), indicating that PFAS exposure may contribute to oxidative damage and potential immunosuppression. The study highlights regional and international variations in PFAS serum concentrations, underscoring the influence of industrial activities on PFAS exposure and expanding on the established links between PFAS exposure and health outcomes. These findings call for targeted strategies to mitigate PFAS exposure in high-risk regions and warrant further research on PFAS health impacts, especially in regard to immune interference.","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 4","pages":"352-362"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12012662/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ambient Temperature and Suicide Risk in Thailand: Evidence from Chiang Mai and Bangkok Provinces 泰国环境温度与自杀风险：来自清迈和曼谷省的证据

Environment & Health Pub Date : 2025-02-16 DOI: 10.1021/envhealth.4c0015310.1021/envhealth.4c00153

Ramita Thawonmas*, Yoonhee Kim and Masahiro Hashizume,

{"title":"Ambient Temperature and Suicide Risk in Thailand: Evidence from Chiang Mai and Bangkok Provinces","authors":"Ramita Thawonmas*, Yoonhee Kim and Masahiro Hashizume, ","doi":"10.1021/envhealth.4c0015310.1021/envhealth.4c00153","DOIUrl":"https://doi.org/10.1021/envhealth.4c00153https://doi.org/10.1021/envhealth.4c00153","url":null,"abstract":"Suicide is a critical public health issue with rates varying across regions and demographic groups. Recent evidence suggests that ambient temperature may influence suicide risk. This study examines the association between temperature and suicide in Thailand’s tropical climate, focusing on Chiang Mai and Bangkok provinces, and quantifies the attributable burden. Daily suicide and meteorological data from 2002 to 2021 were analyzed using a time-stratified case-crossover approach with a distributed lag nonlinear model, adjusted for relative humidity. Province-specific estimates were pooled through a multivariate meta-regression model. The study found a positive, mostly linear association between temperature and suicide risk, with a relative risk (RR) of 1.70 (95% CI: 1.35, 2.15) across the temperature range. Approximately 24.61% of suicides were attributable to temperature, with 12.05% due to hot temperatures above the 66th percentile. The pooled attributable fractions were higher in the 0–64 age group compared to those aged ≥65, while differences between sexes were not statistically significant. This study highlights the significant association between higher ambient temperatures and increased suicide risks in Thailand, emphasizing the need to integrate climate considerations into mental health and suicide prevention policies. Further research across diverse climatic zones is essential for understanding climate influences on mental health globally.","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 5","pages":"560–570 560–570"},"PeriodicalIF":0.0,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/envhealth.4c00153","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144067789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MPs Entering Human Circulation through Infusions: A Significant Pathway and Health Concern MPs通过输液进入人体循环：一个重要的途径和健康问题

Environment & Health Pub Date : 2025-02-14 DOI: 10.1021/envhealth.4c0021010.1021/envhealth.4c00210

Tingting Huang, Yangyang Liu, Licheng Wang, Xuejun Ruan, Qiuyue Ge, Minglu Ma, Wei Wang, Wenbo You, Liwen Zhang, Ventsislav Kolev Valev* and Liwu Zhang*,

{"title":"MPs Entering Human Circulation through Infusions: A Significant Pathway and Health Concern","authors":"Tingting Huang, Yangyang Liu, Licheng Wang, Xuejun Ruan, Qiuyue Ge, Minglu Ma, Wei Wang, Wenbo You, Liwen Zhang, Ventsislav Kolev Valev* and Liwu Zhang*, ","doi":"10.1021/envhealth.4c0021010.1021/envhealth.4c00210","DOIUrl":"https://doi.org/10.1021/envhealth.4c00210https://doi.org/10.1021/envhealth.4c00210","url":null,"abstract":"Human uptake of microplastic particles (MPs) is causing increasing health concerns, and there is mounting pressure to evaluate the associated risks. While MPs can be ingested, breathed in, or drank in, a very direct entrance channel is available through ingress into the bloodstream. Intravenous infusion usually proceeds from plastic bottles. Many are made of polypropylene (PP), and filtering is applied to limit particle contamination. In this study, we examined the MPs’ content of filtrates using a combination of surface-enhanced Raman spectroscopy and scanning electron microscopy. We find that the number of PP particles is significant (∼7500 particles/L). The MP sizes range from 1 to 62 μm, with a median of ∼8.5 μm. About 90% of particles ranged between 1 and 20 μm in size, with ∼60% in the range 1 to 10 μm. We then discuss the potential number of such particles injected and the consequences of their presence in the bloodstream. We highlight the organs for potential deposition, and we discuss possible clinical effects. Our quantitative data are important to help evaluate the toxicity risks associated with MPs and to accurately balance those risks versus the benefits of using intravenous injections.","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 5","pages":"551–559 551–559"},"PeriodicalIF":0.0,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/envhealth.4c00210","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144067680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of 4-tert-Butylphenol on Inflammation and Glycogen Metabolism in Cyprinus carpio L via the miR-363/PKCδ Axis 4-叔丁基酚通过miR-363/PKCδ轴对鲤炎症和糖原代谢的影响

Environment & Health Pub Date : 2025-02-13 DOI: 10.1021/envhealth.4c0024210.1021/envhealth.4c00242

Jiawen Cui, Xinchi Shang, Yuhao Liu, Xiaohua Teng, Li Zhou* and Bing Yan,

{"title":"Impact of 4-tert-Butylphenol on Inflammation and Glycogen Metabolism in Cyprinus carpio L via the miR-363/PKCδ Axis","authors":"Jiawen Cui, Xinchi Shang, Yuhao Liu, Xiaohua Teng, Li Zhou* and Bing Yan, ","doi":"10.1021/envhealth.4c0024210.1021/envhealth.4c00242","DOIUrl":"https://doi.org/10.1021/envhealth.4c00242https://doi.org/10.1021/envhealth.4c00242","url":null,"abstract":"4-tert-Butylphenol (4-tBP), widely used in manufacturing polycarbonate plastics and epoxy resins, is commonly found in aquatic environments globally. This study investigates the chronic (60 days) hepatotoxic effects and the underlying mechanism of 4-tBP on fish, including concentrations with environmental relevance (≤100 μg/L), using Cyprinus carpio L. as the model. Results showed that 1–500 μg/L 4-tBP triggered significant alterations in oxidative stress markers (superoxide dismutase (SOD), glutathione peroxidase (GPx), and malondialdehyde (MDA)) and liver enzymes (alanine aminotransferase (ALT) and aspartate aminotransferase (AST)), with a dose–response relationship confirmed by the Integrated Biomarker Response (IBR) index. Histopathological analysis and molecular experiments revealed inflammatory responses, disruptions in glycogen metabolism, and critical insulin signaling pathways (IRS1, AKT, and GSK3β). Further investigations, including miRNA sequencing and in vitro assays in primary hepatocytes, identified the miR-363/PKCδ axis as a critical regulatory pathway affecting these changes. This study demonstrated that chronic, low-level exposure to 4-tBP can induce hepatotoxicity in Cyprinus carpio L. via the miR-363/PKCδ axis. These findings highlight the potential ecological and health risks posed by 4-tBP in the environment and suggest potential targets for therapeutic intervention.","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 5","pages":"539–550 539–550"},"PeriodicalIF":0.0,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/envhealth.4c00242","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144067679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PFOS and Its Substitute OBS Cause Endothelial Dysfunction to Promote Atherogenesis in ApoE–/– Mice PFOS及其替代物OBS引起ApoE - / -小鼠内皮功能障碍促进动脉粥样硬化

Environment & Health Pub Date : 2025-02-11 DOI: 10.1021/envhealth.4c0020610.1021/envhealth.4c00206

Boxiang Zhang, Qing Li, Wensheng Wang, Mingming Tian, Dan Xu* and Ying Xie*,

{"title":"PFOS and Its Substitute OBS Cause Endothelial Dysfunction to Promote Atherogenesis in ApoE–/– Mice","authors":"Boxiang Zhang, Qing Li, Wensheng Wang, Mingming Tian, Dan Xu* and Ying Xie*, ","doi":"10.1021/envhealth.4c0020610.1021/envhealth.4c00206","DOIUrl":"https://doi.org/10.1021/envhealth.4c00206https://doi.org/10.1021/envhealth.4c00206","url":null,"abstract":"Perfluorooctanesulfonate (PFOS), an emerging contaminant with widespread concern, has been associated with the pathogenesis of atherosclerosis (AS). As a substitute for PFOS, sodium p-perfluorous nonenoxybenzenesulfonate (OBS) is extensively utilized in various applications and detected in human blood. However, its potential health risk in AS remain unclear. In this study, we investigated the comparative impacts of PFOS and OBS on endothelial dysfunction and atherogenesis. In the in vivo study, Apolipoprotein E knockout (ApoE–/–) mice were exposed to 0.4 or 4 mg/L PFOS/OBS for 12 weeks. We found that dyslipidemia developed more rapidly in the OBS-exposed mice than in the PFOS-exposed mice. PFOS exhibited a higher enrichment capacity in both blood and aortic tissues than OBS. Remarkably, OBS induced a more pronounced inflammatory response and caused a more significant disruption of the endothelial barrier in the aorta of ApoE–/– mice compared to PFOS. In vitro experiments showed that OBS, at the same exposure concentrations and durations as PFOS (0.1–20 μmol/L, 48 h), more effectively inhibited cell viability of human umbilical vein endothelial cells (HUVECs), caused higher levels of lactate dehydrogenase (LDH) release, and enhanced cell adhesion between HUVECs and monocytes. Both PFOS and OBS were found to activate the NF-κB signaling pathway and upregulate the expression of inflammatory factors. Notably, the use of OBS, but not PFOS, was shown to disrupt cell junctions and increase endothelial permeability by activating the MAPK/ERK signaling pathway. Our findings suggest that OBS may lead to endothelial dysfunction and have a greater impact on AS compared to PFOS, presenting significant health risks in cardiovascular diseases.","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 5","pages":"526–538 526–538"},"PeriodicalIF":0.0,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/envhealth.4c00206","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144067678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective Effects of Octyl Gallate Against Deoxynivalenol-Induced Colon Inflammation: Insights from Proteomic and Metabolomic Analyses 没食子酸辛酯对脱氧雪腐镰刀醇诱导的结肠炎症的保护作用：来自蛋白质组学和代谢组学分析的见解

Environment & Health Pub Date : 2025-02-06 DOI: 10.1021/envhealth.4c0025010.1021/envhealth.4c00250

Chenxin Dongye, Xiangrong Chen*, Yanfang Zhao, Huijuan Li, Mohamed F. Abdallah, Tianliang Li and Xiangfeng Chen*,

{"title":"Protective Effects of Octyl Gallate Against Deoxynivalenol-Induced Colon Inflammation: Insights from Proteomic and Metabolomic Analyses","authors":"Chenxin Dongye, Xiangrong Chen*, Yanfang Zhao, Huijuan Li, Mohamed F. Abdallah, Tianliang Li and Xiangfeng Chen*, ","doi":"10.1021/envhealth.4c0025010.1021/envhealth.4c00250","DOIUrl":"https://doi.org/10.1021/envhealth.4c00250https://doi.org/10.1021/envhealth.4c00250","url":null,"abstract":"Deoxynivalenol (DON) and octyl gallate (OG) are prevalent compounds in the environment and food. DON is frequently detected in cereals such as corn and wheat, while OG is commonly employed as a food additive. As a result, human exposure to these substances is inevitable. Given this, the objective of this experiment was to investigate the impact of co-exposure to DON (10 μg/kg) and OG (10 μg/kg) on intestinal inflammation. The RAW264.7 macrophage cell line was utilized to analyze cytokine levels as well as proteomic and metabolomic changes. In the quantitative real-time PCR experiments, the DON group showed significant difference compared to the control group (* p < 0.05) and the DON-OG group (# p < 0.05) regarding cytokine levels such as IL-10, TNF-α, Il6, Il1b, Ccl2, Il12α, Nos2, Cxcl1, and Cxcl2. In the animal experiment, C57BL/6 mice were utilized to monitor body weight, the presence of bloody stools, and diarrhea. Additionally, the colonic tissues of the mice underwent pathological analysis. The results indicated that cells treated with both DON and OG displayed lower levels of inflammation compared to those treated with DON alone. Furthermore, proteomic and metabolomic analyses revealed that the regulation of the Lancl2 protein and the mTOR signaling pathway contributed to the milder inflammatory response observed in the DON-OG group. These findings were further corroborated by the pathological analysis of the colonic tissues from the mice. In the combined exposure of DON and OG, OG partially mitigated the intestinal inflammation induced by DON.","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 5","pages":"515–525 515–525"},"PeriodicalIF":0.0,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/envhealth.4c00250","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144067793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ethical Frameworks for Data-Driven Environmental Health Studies in the AI Era 人工智能时代数据驱动的环境健康研究的伦理框架

Environment & Health Pub Date : 2025-02-05 DOI: 10.1021/envhealth.4c0027310.1021/envhealth.4c00273

Miao Yu*, Mingliang Fang and Bin Wang,

引用次数: 0

In Vivo Pathogenicity Characterization of Viable Opportunistic Fungi Aspergillus thermomutatus and Rhodotorula mucilaginosa Recovered from Maritime Antarctic Permafrost. 南极海洋永久冻土带生活条件真菌温变曲霉和粘液红曲霉的体内致病性研究

Environment & Health Pub Date : 2025-02-03 eCollection Date: 2025-04-18 DOI: 10.1021/envhealth.4c00213

Eldon Carlos Q Gomes, Vívian N Gonçalves, Marliete C da Costa, Gustavo José C D Freitas, Daniel A Santos, Susana Johann, Jefferson Bruno S Oliveira, Tatiane A D Paixão, Peter Convey, Luiz H Rosa

{"title":"In Vivo Pathogenicity Characterization of Viable Opportunistic Fungi Aspergillus thermomutatus and Rhodotorula mucilaginosa Recovered from Maritime Antarctic Permafrost.","authors":"Eldon Carlos Q Gomes, Vívian N Gonçalves, Marliete C da Costa, Gustavo José C D Freitas, Daniel A Santos, Susana Johann, Jefferson Bruno S Oliveira, Tatiane A D Paixão, Peter Convey, Luiz H Rosa","doi":"10.1021/envhealth.4c00213","DOIUrl":"https://doi.org/10.1021/envhealth.4c00213","url":null,"abstract":"In this study, we evaluated the pathogenic potential of the fungi Aspergillus thermomutatus and Rhodotorula mucilaginosa obtained from maritime Antarctic permafrost using in vivo experiments on immunocompromised BALB/c mice. Despite the low mortality observed, immunosuppressed animals infected with A. thermomutatus and R. mucilaginosa exhibited fluctuations in body mass and induced changes in the neuropsychiatric state of the mice. Fungi were recovered from the lungs, spleen, blood, and brain of infected mice at densities similar to but slightly lower than the inoculum up to 5 days post-inoculation. A. thermomutatus infection induced an inflammatory process in the lungs of infected BALB/c mice. In the target organs of animals infected with R. mucilaginosa, a notable fungal load was detected in the brains of infected animals. These results suggest that viable isolates of fungi such as A. thermomutatus and R. mucilaginosa originating from Antarctic permafrost, which is exposed to increasing melt caused by rising temperatures in the region, may present significant pathogenic potential. This highlights that climate change in Antarctica may facilitate the release and dispersal of fungi and other pathogenic microorganisms capable of infecting humans and animals.","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 4","pages":"436-442"},"PeriodicalIF":0.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12012655/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Vivo Pathogenicity Characterization of Viable Opportunistic Fungi Aspergillus thermomutatus and Rhodotorula mucilaginosa Recovered from Maritime Antarctic Permafrost 南极海洋永久冻土带生活条件真菌温变曲霉和粘液红曲霉的体内致病性研究

Environment & Health Pub Date : 2025-02-02 DOI: 10.1021/envhealth.4c0021310.1021/envhealth.4c00213

Eldon Carlos Q. Gomes, Vívian N. Gonçalves, Marliete C. da Costa, Gustavo José C. d. Freitas, Daniel A. Santos, Susana Johann, Jefferson Bruno S. Oliveira, Tatiane A. d. Paixão, Peter Convey and Luiz H. Rosa*,

{"title":"In Vivo Pathogenicity Characterization of Viable Opportunistic Fungi Aspergillus thermomutatus and Rhodotorula mucilaginosa Recovered from Maritime Antarctic Permafrost","authors":"Eldon Carlos Q. Gomes, Vívian N. Gonçalves, Marliete C. da Costa, Gustavo José C. d. Freitas, Daniel A. Santos, Susana Johann, Jefferson Bruno S. Oliveira, Tatiane A. d. Paixão, Peter Convey and Luiz H. Rosa*, ","doi":"10.1021/envhealth.4c0021310.1021/envhealth.4c00213","DOIUrl":"https://doi.org/10.1021/envhealth.4c00213https://doi.org/10.1021/envhealth.4c00213","url":null,"abstract":"In this study, we evaluated the pathogenic potential of the fungi Aspergillus thermomutatus and Rhodotorula mucilaginosa obtained from maritime Antarctic permafrost using in vivo experiments on immunocompromised BALB/c mice. Despite the low mortality observed, immunosuppressed animals infected with A. thermomutatus and R. mucilaginosa exhibited fluctuations in body mass and induced changes in the neuropsychiatric state of the mice. Fungi were recovered from the lungs, spleen, blood, and brain of infected mice at densities similar to but slightly lower than the inoculum up to 5 days post-inoculation. A. thermomutatus infection induced an inflammatory process in the lungs of infected BALB/c mice. In the target organs of animals infected with R. mucilaginosa, a notable fungal load was detected in the brains of infected animals. These results suggest that viable isolates of fungi such as A. thermomutatus and R. mucilaginosa originating from Antarctic permafrost, which is exposed to increasing melt caused by rising temperatures in the region, may present significant pathogenic potential. This highlights that climate change in Antarctica may facilitate the release and dispersal of fungi and other pathogenic microorganisms capable of infecting humans and animals.","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 4","pages":"436–442 436–442"},"PeriodicalIF":0.0,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/envhealth.4c00213","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143842297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0