Environment & Health最新文献

Assessing the Impact of Serum Per- and Polyfluoroalkyl Substance Concentrations on Immune Function in an Industrialized Region of China 评估中国工业化地区血清全氟和多氟烷基物质浓度对免疫功能的影响

Environment & Health Pub Date : 2025-03-03 DOI: 10.1021/envhealth.4c0022410.1021/envhealth.4c00224

Chuanzi Gao, Feng Quan, Wenhui Qiu* and Yi Zheng*,

{"title":"Assessing the Impact of Serum Per- and Polyfluoroalkyl Substance Concentrations on Immune Function in an Industrialized Region of China","authors":"Chuanzi Gao, Feng Quan, Wenhui Qiu* and Yi Zheng*, ","doi":"10.1021/envhealth.4c0022410.1021/envhealth.4c00224","DOIUrl":"https://doi.org/10.1021/envhealth.4c00224https://doi.org/10.1021/envhealth.4c00224","url":null,"abstract":"This study investigates the presence and health implications of per- and polyfluoroalkyl substances (PFAS) in human serum samples collected from white-collar workers in an industrialized region of China. Our research offers fresh insights into the underexplored area of nonoccupational PFAS exposure among white-collar workers, shedding light on health risks linked to industrial PFAS pollution. Seven PFAS compounds were measured. Perfluorooctanoic acid (PFOA) and perfluorooctanesulfonate (PFOS) emerged as predominant pollutants, with Σ7PFAS concentrations averaging 65.486 ng/mL. Gender differences showed higher serum Σ7PFAS levels in males, and age-related analyses suggested PFAS accumulation over time, with higher concentrations in older groups. Additionally, significant correlations were found between PFAS concentrations and biomarkers of oxidative stress and immune interference, specifically malondialdehyde (MDA) and immunoglobulin M (IgM), indicating that PFAS exposure may contribute to oxidative damage and potential immunosuppression. The study highlights regional and international variations in PFAS serum concentrations, underscoring the influence of industrial activities on PFAS exposure and expanding on the established links between PFAS exposure and health outcomes. These findings call for targeted strategies to mitigate PFAS exposure in high-risk regions and warrant further research on PFAS health impacts, especially in regard to immune interference.","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 4","pages":"352–362 352–362"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/envhealth.4c00224","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143842362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Vivo Pathogenicity Characterization of Viable Opportunistic Fungi Aspergillus thermomutatus and Rhodotorula mucilaginosa Recovered from Maritime Antarctic Permafrost 南极海洋永久冻土带生活条件真菌温变曲霉和粘液红曲霉的体内致病性研究

Environment & Health Pub Date : 2025-02-02 DOI: 10.1021/envhealth.4c0021310.1021/envhealth.4c00213

Eldon Carlos Q. Gomes, Vívian N. Gonçalves, Marliete C. da Costa, Gustavo José C. d. Freitas, Daniel A. Santos, Susana Johann, Jefferson Bruno S. Oliveira, Tatiane A. d. Paixão, Peter Convey and Luiz H. Rosa*,

{"title":"In Vivo Pathogenicity Characterization of Viable Opportunistic Fungi Aspergillus thermomutatus and Rhodotorula mucilaginosa Recovered from Maritime Antarctic Permafrost","authors":"Eldon Carlos Q. Gomes, Vívian N. Gonçalves, Marliete C. da Costa, Gustavo José C. d. Freitas, Daniel A. Santos, Susana Johann, Jefferson Bruno S. Oliveira, Tatiane A. d. Paixão, Peter Convey and Luiz H. Rosa*, ","doi":"10.1021/envhealth.4c0021310.1021/envhealth.4c00213","DOIUrl":"https://doi.org/10.1021/envhealth.4c00213https://doi.org/10.1021/envhealth.4c00213","url":null,"abstract":"In this study, we evaluated the pathogenic potential of the fungi Aspergillus thermomutatus and Rhodotorula mucilaginosa obtained from maritime Antarctic permafrost using in vivo experiments on immunocompromised BALB/c mice. Despite the low mortality observed, immunosuppressed animals infected with A. thermomutatus and R. mucilaginosa exhibited fluctuations in body mass and induced changes in the neuropsychiatric state of the mice. Fungi were recovered from the lungs, spleen, blood, and brain of infected mice at densities similar to but slightly lower than the inoculum up to 5 days post-inoculation. A. thermomutatus infection induced an inflammatory process in the lungs of infected BALB/c mice. In the target organs of animals infected with R. mucilaginosa, a notable fungal load was detected in the brains of infected animals. These results suggest that viable isolates of fungi such as A. thermomutatus and R. mucilaginosa originating from Antarctic permafrost, which is exposed to increasing melt caused by rising temperatures in the region, may present significant pathogenic potential. This highlights that climate change in Antarctica may facilitate the release and dispersal of fungi and other pathogenic microorganisms capable of infecting humans and animals.","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 4","pages":"436–442 436–442"},"PeriodicalIF":0.0,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/envhealth.4c00213","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143842297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wastewater-Based Surveillance of Respiratory Syncytial Virus Reveals a Temporal Disconnect in Disease Trajectory across an Active International Land Border 基于废水的呼吸道合胞病毒监测揭示了跨越活跃的国际陆地边界的疾病轨迹的时间脱节

Environment & Health Pub Date : 2025-01-29 DOI: 10.1021/envhealth.4c0016810.1021/envhealth.4c00168

Mackenzie Beach, Ryland Corchis-Scott, Qiudi Geng, Ana M. Podadera Gonzalez, Owen Corchis-Scott, Ethan Harrop, John Norton, Andrea Busch, Russell A. Faust, Bridget Irwin, Mehdi Aloosh, Kenneth K. S. Ng and R. Michael McKay*,

{"title":"Wastewater-Based Surveillance of Respiratory Syncytial Virus Reveals a Temporal Disconnect in Disease Trajectory across an Active International Land Border","authors":"Mackenzie Beach, Ryland Corchis-Scott, Qiudi Geng, Ana M. Podadera Gonzalez, Owen Corchis-Scott, Ethan Harrop, John Norton, Andrea Busch, Russell A. Faust, Bridget Irwin, Mehdi Aloosh, Kenneth K. S. Ng and R. Michael McKay*, ","doi":"10.1021/envhealth.4c0016810.1021/envhealth.4c00168","DOIUrl":"https://doi.org/10.1021/envhealth.4c00168https://doi.org/10.1021/envhealth.4c00168","url":null,"abstract":"Conventional metrics for tracking infectious diseases, including case and outbreak data and syndromic surveillance, can be resource-intensive, misleading, and comparatively slow with prolonged data collection, analysis and authentication. This study examined the 2022–2023 Respiratory Syncytial Virus (RSV) season in a contiguous metropolitan area connected by an active international land border, affording an opportunity for comparison of the respiratory virus season spanning two independent public health jurisdictions. Time-lagged cross correlation and qualitative examination of the wastewater signals showed that the peak of the Detroit (MI, USA) RSV season predated the peak in Windsor (ON, Canada) by approximately 5 weeks. A strong positive relationship was observed between RSV N-gene concentrations in wastewater and hospitalization rates in Windsor-Essex (Kendall’s τ = 0.539, p ≤ 0.001, Spearman’s ρ = 0.713, p ≤ 0.001) as well as Detroit (Kendall’s τ = 0.739, p ≤ 0.001, Spearman’s ρ = 0.888, p ≤ 0.001). This study demonstrated that wastewater surveillance can reveal regional differences in infection dynamics between communities and can provide an independent measure of the prevalence of RSV, an underreported disease. These findings support the use of wastewater surveillance as a cost-effective tool in monitoring of RSV to enhance existing surveillance systems and to better inform public health disease mitigation strategies.","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 4","pages":"425–435 425–435"},"PeriodicalIF":0.0,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/envhealth.4c00168","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143842307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toxic Alerts of Endocrine Disruption Revealed by Explainable Artificial Intelligence. 可解释的人工智能揭示内分泌紊乱的毒性警报。

Environment & Health Pub Date : 2025-01-27 eCollection Date: 2025-03-21 DOI: 10.1021/envhealth.4c00218

Lucca Caiaffa Santos Rosa, Mariam Sarhan, Andre Silva Pimentel

{"title":"Toxic Alerts of Endocrine Disruption Revealed by Explainable Artificial Intelligence.","authors":"Lucca Caiaffa Santos Rosa, Mariam Sarhan, Andre Silva Pimentel","doi":"10.1021/envhealth.4c00218","DOIUrl":"10.1021/envhealth.4c00218","url":null,"abstract":"The local interpretable model-agnostic explanation method was used to unveil substructures (toxic alerts) that cause endocrine disruption in chemical compounds using machine learning models. The random forest classifier was applied to build explainable models with the TOX21 data sets after data curation. Using these models applied to the EDC and EDKB-FDA data sets, the substructures that cause endocrine disruption in chemical compounds were unveiled, providing stable, more specific, and consistent explanations, which are essential for trust and acceptance of the findings, mainly due to the difficulty of finding relevant experimental evidence for different receptors (androgen, estrogen, aryl hydrocarbon, aromatase, and peroxisome proliferator-activated receptors). This approach is significant because of its contribution to the interpretability of explainable machine learning algorithms, particularly in the context of unveiling substructures associated with endocrine disruption in five targets (androgen receptor, estrogen receptor, aryl hydrocarbon receptors, aromatase receptors, and peroxisome proliferator-activated receptors), thereby advancing the relevant field of environmental toxicology, where a careful evaluation of the potential risks of exposure to new compounds is needed. The specific substructures thiophosphate, sulfamate, anilide, carbamate, sulfamide, and thiocyanate are presented as toxic alerts that cause endocrine disruption to better understand their potential risks and adverse effects on human health and the environment.","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 3","pages":"321-333"},"PeriodicalIF":0.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934200/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143721673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toxic Alerts of Endocrine Disruption Revealed by Explainable Artificial Intelligence 可解释的人工智能揭示内分泌紊乱的毒性警报

Environment & Health Pub Date : 2025-01-27 DOI: 10.1021/envhealth.4c0021810.1021/envhealth.4c00218

Lucca Caiaffa Santos Rosa, Mariam Sarhan and Andre Silva Pimentel*,

{"title":"Toxic Alerts of Endocrine Disruption Revealed by Explainable Artificial Intelligence","authors":"Lucca Caiaffa Santos Rosa, Mariam Sarhan and Andre Silva Pimentel*, ","doi":"10.1021/envhealth.4c0021810.1021/envhealth.4c00218","DOIUrl":"https://doi.org/10.1021/envhealth.4c00218https://doi.org/10.1021/envhealth.4c00218","url":null,"abstract":"The local interpretable model-agnostic explanation method was used to unveil substructures (toxic alerts) that cause endocrine disruption in chemical compounds using machine learning models. The random forest classifier was applied to build explainable models with the TOX21 data sets after data curation. Using these models applied to the EDC and EDKB-FDA data sets, the substructures that cause endocrine disruption in chemical compounds were unveiled, providing stable, more specific, and consistent explanations, which are essential for trust and acceptance of the findings, mainly due to the difficulty of finding relevant experimental evidence for different receptors (androgen, estrogen, aryl hydrocarbon, aromatase, and peroxisome proliferator-activated receptors). This approach is significant because of its contribution to the interpretability of explainable machine learning algorithms, particularly in the context of unveiling substructures associated with endocrine disruption in five targets (androgen receptor, estrogen receptor, aryl hydrocarbon receptors, aromatase receptors, and peroxisome proliferator-activated receptors), thereby advancing the relevant field of environmental toxicology, where a careful evaluation of the potential risks of exposure to new compounds is needed. The specific substructures thiophosphate, sulfamate, anilide, carbamate, sulfamide, and thiocyanate are presented as toxic alerts that cause endocrine disruption to better understand their potential risks and adverse effects on human health and the environment.","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 3","pages":"321–333 321–333"},"PeriodicalIF":0.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/envhealth.4c00218","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143666831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fish Skin Mucus Vitellogenin as a Noninvasive, Sensitive Biomarker for Aquatic Xenoestrogens 鱼皮肤黏液卵黄原蛋白作为一种无创、敏感的水生异种雌激素生物标志物

Environment & Health Pub Date : 2025-01-10 DOI: 10.1021/envhealth.4c0023510.1021/envhealth.4c00235

Baili Sun, Chenyan Hu and Lianguo Chen*,

{"title":"Fish Skin Mucus Vitellogenin as a Noninvasive, Sensitive Biomarker for Aquatic Xenoestrogens","authors":"Baili Sun, Chenyan Hu and Lianguo Chen*, ","doi":"10.1021/envhealth.4c0023510.1021/envhealth.4c00235","DOIUrl":"https://doi.org/10.1021/envhealth.4c00235https://doi.org/10.1021/envhealth.4c00235","url":null,"abstract":"Environmental estrogens (EEs) can induce vitellogenin (VTG) in fish skin mucosa. However, the applicability of mucus VTG in aquatic xenoestrogen monitoring warrants comprehensive exploration. Here, we employed different estrogen exposure scenarios to compare the applicability of mucus VTG and other conventional biomarkers in zebrafish for EE monitoring. After acute exposure to 17α-ethynylestradiol (EE2) at various concentrations, mucus VTG demonstrated higher sensitivity in male zebrafish than in female zebrafish. Mucus VTG change patterns were similar to liver and blood VTG change patterns in males. Time-course exposure experiments revealed that male mucus VTG responded to EE2 much earlier than male liver and blood VTG, underlining the promise of mucus VTG as an early warning signal of aquatic estrogenicity. Exposure to multiple EEs further validated the high sensitivity of male mucus VTG. Proteomics analysis revealed that EE2 exposure potently shifted the proteome structure of male mucosa, and the VTG1 isoform was noted to be the most suitable biomarker. Overall, our results refine the roles of mucus VTG1 from male fish as a noninvasive, rapid, and sensitive biomarker of aquatic xenoestrogens, applicable to ecological risk assessment for animal welfare and ecosystem protection. Future ecological studies may only need to sample male fish mucus without sacrificing females.","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 4","pages":"414–424 414–424"},"PeriodicalIF":0.0,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/envhealth.4c00235","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143842305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiovascular Emergency Hospitalization Risks of PM2.5 Transition Metals: A Time-Stratified Case-Crossover Study PM2.5过渡金属的心血管急诊住院风险：一项时间分层的病例交叉研究

Environment & Health Pub Date : 2025-01-07 DOI: 10.1021/envhealth.4c0020410.1021/envhealth.4c00204

Lin Wang, Bin Wang, Jiawen Liao*, Jieru Zhang, Xin Su, Jinshan Yan, Wei Xu, Jiyi Lin, Guangfeng Sun, Lunche Wang and Lina Tang*,

{"title":"Cardiovascular Emergency Hospitalization Risks of PM2.5 Transition Metals: A Time-Stratified Case-Crossover Study","authors":"Lin Wang, Bin Wang, Jiawen Liao*, Jieru Zhang, Xin Su, Jinshan Yan, Wei Xu, Jiyi Lin, Guangfeng Sun, Lunche Wang and Lina Tang*, ","doi":"10.1021/envhealth.4c0020410.1021/envhealth.4c00204","DOIUrl":"https://doi.org/10.1021/envhealth.4c00204https://doi.org/10.1021/envhealth.4c00204","url":null,"abstract":"PM2.5 pollution poses significant health risks in urban areas, yet the specific cardiovascular impacts of its hazardous components, especially transition metals, remain insufficiently understood. This study evaluated the associations of PM2.5 components on acute myocardial infarction (AMI) and acute aortic dissections (AAD) emergency hospitalizations (n = 9985) using a time-stratified case-crossover between 2017 and 2023 in Xiamen, China. We collected comprehensive data on daily air pollutants, PM2.5 components (water-soluble ions, carbon components, metals, and other elements), and meteorological variables. Conditional logistic regressions were used to estimate odds ratios (OR) per the interquartile range (IQR) of exposures. Our finding reveals significant short-term associations of exposures to air pollutants and PM2.5 components with increased cardiovascular emergency hospitalizations. The strongest associations were observed between cumulative 3-day lagged (lag 0–3) PM2.5 transition metals including Mn [odds ratio, OR = 1.106 (95% CI: 1.032–1.186)], Fe [OR = 1.078, (95% CI: 1.015–1.145)], V [OR = 1.117 (95% CI: 1.024–1.219)], and Zn [OR = 1.08, (95% CI: 1.005–1.161)] exposure with AMI. These associations were stronger among older (age >65 years), male patients, and during colder seasons. Our study highlights the underexplored subacute cardiovascular risks of PM2.5 transition metals, underscoring the need to integrate them into urban air quality management to promote environmental sustainability.","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 4","pages":"402–413 402–413"},"PeriodicalIF":0.0,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/envhealth.4c00204","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143842309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization and Health Risk Assessment of Airborne Fungi in a Semiunderground Municipal Wastewater Treatment Plant. 半地下城市污水处理厂空气传播真菌的特征及健康风险评价

Environment & Health Pub Date : 2025-01-07 eCollection Date: 2025-03-21 DOI: 10.1021/envhealth.4c00195

Xiang Zhang, Bingjie Lu, Shuo Yang, Bingjie Lin, Guang Chen, Lihua Wang, Zhengliang Peng, Huijie Lu, Chao Wang, Dan Li, Jianmin Chen

{"title":"Characterization and Health Risk Assessment of Airborne Fungi in a Semiunderground Municipal Wastewater Treatment Plant.","authors":"Xiang Zhang, Bingjie Lu, Shuo Yang, Bingjie Lin, Guang Chen, Lihua Wang, Zhengliang Peng, Huijie Lu, Chao Wang, Dan Li, Jianmin Chen","doi":"10.1021/envhealth.4c00195","DOIUrl":"10.1021/envhealth.4c00195","url":null,"abstract":"Municipal wastewater treatment plants (WWTPs) are recognized as the significant source of fungal aerosols, which pose a significant threat to human health globally. Herein, the occurrences characterization, community structure, and health risk assessment of airborne fungi were investigated from a semiunderground WWTP. The concentrations of culturable fungi emitted into the air from the WWTP ranged from 30.6 to 1431.1 colony forming units (CFU)/m3, with primary and biochemical treatments constituting the principal sources of emission (P < 0.05). Diversity analysis revealed seasonal and facility-dependent fluctuations in culturable fungal communities. Approximately 13.5% of the total airborne fungal genera detected in the WWTP were culturable. Some airborne fungi in the WWTP with relatively low abundance but high cultivability, such as Cladosporium, Trichoderma, Neurospora, Filobasidium, and Hannaella, tended to be overlooked because of their limited presence in airborne environments. We also developed a health risk assessment method for fungi, utilizing seven indicators to characterize the risk posed by fungal pathogens from multiple perspectives, providing a comprehensive evaluation of potential health impacts. The simulated risk values of the air outlet and biochemical treatment exceeded those of other treatment facilities, with median risks of 2.2 × 102 and 1.4 × 102, respectively. Consequently, management strategies should prioritize enhanced controls for fungal aerosols to mitigate the risk of disease transmission.","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 3","pages":"227-237"},"PeriodicalIF":0.0,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934199/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143721618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization and Health Risk Assessment of Airborne Fungi in a Semiunderground Municipal Wastewater Treatment Plant 半地下城市污水处理厂空气传播真菌的特征及健康风险评价

Environment & Health Pub Date : 2025-01-06 DOI: 10.1021/envhealth.4c0019510.1021/envhealth.4c00195

Xiang Zhang, Bingjie Lu, Shuo Yang, Bingjie Lin, Guang Chen, Lihua Wang, Zhengliang Peng, Huijie Lu, Chao Wang, Dan Li* and Jianmin Chen,

{"title":"Characterization and Health Risk Assessment of Airborne Fungi in a Semiunderground Municipal Wastewater Treatment Plant","authors":"Xiang Zhang, Bingjie Lu, Shuo Yang, Bingjie Lin, Guang Chen, Lihua Wang, Zhengliang Peng, Huijie Lu, Chao Wang, Dan Li* and Jianmin Chen, ","doi":"10.1021/envhealth.4c0019510.1021/envhealth.4c00195","DOIUrl":"https://doi.org/10.1021/envhealth.4c00195https://doi.org/10.1021/envhealth.4c00195","url":null,"abstract":"Municipal wastewater treatment plants (WWTPs) are recognized as the significant source of fungal aerosols, which pose a significant threat to human health globally. Herein, the occurrences characterization, community structure, and health risk assessment of airborne fungi were investigated from a semiunderground WWTP. The concentrations of culturable fungi emitted into the air from the WWTP ranged from 30.6 to 1431.1 colony forming units (CFU)/m3, with primary and biochemical treatments constituting the principal sources of emission (P < 0.05). Diversity analysis revealed seasonal and facility-dependent fluctuations in culturable fungal communities. Approximately 13.5% of the total airborne fungal genera detected in the WWTP were culturable. Some airborne fungi in the WWTP with relatively low abundance but high cultivability, such as Cladosporium, Trichoderma, Neurospora, Filobasidium, and Hannaella, tended to be overlooked because of their limited presence in airborne environments. We also developed a health risk assessment method for fungi, utilizing seven indicators to characterize the risk posed by fungal pathogens from multiple perspectives, providing a comprehensive evaluation of potential health impacts. The simulated risk values of the air outlet and biochemical treatment exceeded those of other treatment facilities, with median risks of 2.2 × 102 and 1.4 × 102, respectively. Consequently, management strategies should prioritize enhanced controls for fungal aerosols to mitigate the risk of disease transmission.","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 3","pages":"227–237 227–237"},"PeriodicalIF":0.0,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/envhealth.4c00195","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143666833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Astrocytes Respond to Environment-Relevant Doses TCDD in a Specific Manner Which Is Different from the Endogenous AhR Ligand (FICZ) 星形胶质细胞对环境相关剂量TCDD的反应方式不同于内源性AhR配体（FICZ）

Environment & Health Pub Date : 2025-01-06 DOI: 10.1021/envhealth.4c0018910.1021/envhealth.4c00189

Rui Sha, Yangsheng Chen*, Tong Xu, Guanglei Yang, Li Xu, Heidi Qunhui Xie* and Bin Zhao,

{"title":"Astrocytes Respond to Environment-Relevant Doses TCDD in a Specific Manner Which Is Different from the Endogenous AhR Ligand (FICZ)","authors":"Rui Sha, Yangsheng Chen*, Tong Xu, Guanglei Yang, Li Xu, Heidi Qunhui Xie* and Bin Zhao, ","doi":"10.1021/envhealth.4c0018910.1021/envhealth.4c00189","DOIUrl":"https://doi.org/10.1021/envhealth.4c00189https://doi.org/10.1021/envhealth.4c00189","url":null,"abstract":"Astrocytes play an important role in the nervous system’s response to external stimulation. Environmental pollutants could activate astrocytes into A1 (toxic) or A2 (protective) types and induce different effects. Meanwhile, the aryl hydrocarbon receptor (AhR) is an environmental molecule sensor in the body and has various ligands. But the difference between exogenous and endogenous AhR ligands on the astrocytic activation is unclear; in this study, we employed rat primary cultured cortical astrocytes to reveal the effects and mechanisms of AhR ligands on astrocytic activation. We found that, after treatment with exogenous AhR ligand (2,3,7,8-tetrachlorodibenzo-p-dioxin, TCDD) ranging from 0.01 to 0.1 nmol/L, astrocytes mainly exhibited A2 type activation. The specific manifestation includes the increase in the expression of A2 marker genes, the enhancement of cellular autonomous movement, the expression and secretion of chemokines, such as Cxcl10, Cxcl2, and Ccl7. And TCDD-induced A2 type astrocytes show a positive impact on neuronal synaptic formation. Although both TCDD and endogenous AhR ligand (6-formylindolo[3,2-b] carbazole, FICZ) could activate AhR pathway in astrocytes, FICZ (50 nmol/L) neither induces activation of A2 type astrocytes nor upregulation of chemokines. Therefore, our findings suggest that AhR is crucial for astrocytes to recognize environmental pollutants and protect the nervous system.","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 4","pages":"392–401 392–401"},"PeriodicalIF":0.0,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/envhealth.4c00189","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143842308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0