Environment & Health最新文献

{"title":"Steam Cooking Methods Promote the Transfer of Viable Antibiotic-Resistant Pathogens from Water into Air.","authors":"Zehua Yan, Jiawen Xie, Ling Jin, Tangtian He, Xiaohua Zhang, Xiangdong Li","doi":"10.1021/envhealth.5c00374","DOIUrl":"https://doi.org/10.1021/envhealth.5c00374","url":null,"abstract":"<p><p>Steam cooking is an ancient and widely used method for sterilizing water and food globally. However, its effectiveness may be compromised by the ubiquitous presence of antibiotic resistance genes (ARGs) and antibiotic-resistant bacteria (ARB) in these media. Here, we combined metagenomic sequencing, quantitative PCR analysis, plate culture, and Sanger sequencing to examine the effects of steam cooking on the profiles of antibiotic resistance in cooked fish, tap water, and indoor air in real cooking environments (i.e., a canteen and a home kitchen) and a laboratory chamber. We found that while steam cooking eliminated over 92.0% of bacteria and ARGs in both tap water and fish, it significantly increased the absolute abundance of bacteria and ARGs in indoor fine particulate matter (PM_2.5) across all settings. Tap water was identified as the primary contributor to the increase, transferring 14.6% of bacteria and 33.2% of ARGs into indoor PM_2.5 during steam cooking. This process also elevated the relative abundance of certain putative human pathogens in indoor PM_2.5, containing ARGs and heat shock proteins and mainly originating from tap water. To test if these transferred ARGs hosts were viable, we conducted plate culture experiments and identified a viable heat-resistant ARB, <i>Bacillus cereus</i>, transferred from water to indoor PM_2.5 via water vapor. Our results highlight the cross-medium transport of ARB and ARGs via steam cooking and underscore the potential microbial safety issues to cooking personnel through inhalational exposure.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"4 4","pages":"730-741"},"PeriodicalIF":6.3,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13097165/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147782920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Gestational Nitrated Polycyclic Aromatic Hydrocarbons Exposure Burden and Newborn Sizes: Mediating the Role of Placental 8‑OHdG.","authors":"Hao Xue, Chang Gao, Ruolan Wang, Lin Tao, Qian-Qun Yang, Yichao Huang, Yijun Fan, De-Xiang Xu","doi":"10.1021/envhealth.5c00174","DOIUrl":"https://doi.org/10.1021/envhealth.5c00174","url":null,"abstract":"<p><p>Nitrated polycyclic aromatic hydrocarbons (nitro-PAHs) are persistent pollutants accompanying air pollution. No research has reported their exposure burden in pregnant women, nor is there epidemiological evidence of associations with newborn size. In this study, we recruited 947 mother-infant pairs from China. A morning spot urine sample was collected to measure the concentration of five nitro-PAHs exposure biomarkers using liquid chromatography tandem mass spectrometry. Three of five measured amino-PAHs were detected in over 50% of the population, and the concentration was 0.044, 0.268, and 0.103 ng/mg creatinine for 1-AP, 2-AF, and 9-APhe, respectively. Using generalized linear regression, we found per ln unit increase in the concentration of 1-AP which was significantly associated with reduced newborn weight Z-Score (-0.12 [-0.20, -0.03]), length Z-Score (-0.11 [-0.17, -0.05]), and weight-for-length Z-Score (-0.09 [-0.16, -0.01]), respectively. The mixture effect model showed a negative association between mixed nitro-PAHs exposure and length Z-Score and weight Z-Score, with 1-AP being the dominant contributor to the effect. To explore how maternal nitro-PAHs exert impact on the developing fetus, the potential mediating role of placental 8-hydroxy-2'-deoxyguanosine (8-OHdG), a classical biomarker of DNA oxidative damage, was measured in a subset of samples (<i>n</i> = 201). We revealed that urinary 1-AP and 2-AF were positively correlated with placental 8-OHdG content. Mediation analysis showed that placental 8-OHdG mediated the associations of gestational 1-AP and 2-AF exposure with neonatal weight Z-Score, with a proportion of mediation of 31.38 and 18.77%, respectively. These results provide preliminary evidence that gestational nitro-PAHs exposure may be a risk factor for reduced newborn size, and placental DNA oxidative damage potentially mediates the effect.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"4 4","pages":"720-729"},"PeriodicalIF":6.3,"publicationDate":"2025-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13097160/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147783202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ambient PM_2.5 and Its Components Associated with Dynamic Progression from Different Blood Pressure States to Cardiovascular Diseases and Mortality: The GOLD-Health Cohort.","authors":"Manting Rao, Weiquan Lin, Liying Luo, Ge Chen, Menghe Wang, Zhonghua Ai, Jiamin Chen, Zhoubin Zhang, Hui Liu, Hualiang Lin","doi":"10.1021/envhealth.5c00258","DOIUrl":"https://doi.org/10.1021/envhealth.5c00258","url":null,"abstract":"<p><p>The relationships between fine particulate matter (PM_2.5) and the risk of hypertension (HTN) and cardiovascular disease (CVD) have been well documented. However, the associations between specific chemical constituents of PM_2.5 and the dynamic progression of hypertensive CVD remain unclear. Using multistate models and mediation analyses in a cohort of 316,087 individuals, we investigated the associations between PM_2.5, PM_2.5 chemical components (sulfate [SO₄ ^2-], nitrate [NO₃ ^-], ammonium [NH₄ ⁺], organic matter [OM], and black carbon [BC]), and the dynamic progression from different blood pressure states to incident CVD and mortality. Our findings revealed that PM_2.5 and its constituents were positively associated with the dynamic HTN progression. For example, with each interquartile range (IQR) increase, PM_2.5, SO₄ ^2-, NO₃ ^-, NH₄ ⁺, OM, and BC were significantly associated with the disease transition from prehypertension (pre-HTN) to HTN, with hazard ratios (HRs) of 1.116 (95% confidence interval [CI]: 1.104-1.128), 1.186 (95% CI: 1.171-1.202), 1.179 (95% CI: 1.166-1.193), 1.171 (95% CI: 1.159-1.184), 1.155 (95% CI: 1.141-1.169), and 1.147 (95% CI: 1.133-1.161), respectively. Mediation analysis demonstrated that pre-HTN and HTN significantly mediated the relationships between PM_2.5, PM_2.5 components, and the increased risk of CVD and cardiovascular mortality. This study provides evidence that ambient PM_2.5 and its chemical constituents may be important determinants in the dynamic progression of HTN. Controlling exposure to PM_2.5 and its components, particularly during the pre-HTN phase, could be an effective strategy to curb the development of hypertensive CVD and alleviate its public health impact.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"4 4","pages":"709-719"},"PeriodicalIF":6.3,"publicationDate":"2025-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13096969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147783072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prenatal Metal Exposome Reprograms Neonatal Metabolism: Trimester-Dependent Effects on Amino Acid and Carnitine Networks.","authors":"Xinning Chen, Yulian Liao, Yubing Ma, Yihui Wu, Jiajia Song, Ruixing Zhang, Shuqi Zhu, Lixia Zhang, Qi Wu, Zhigang Gao, Jing Liu, Zhaoxia Liang","doi":"10.1021/envhealth.5c00429","DOIUrl":"https://doi.org/10.1021/envhealth.5c00429","url":null,"abstract":"<p><p>Pregnant women and newborns are highly vulnerable to metal exposure. However, there is limited evidence regarding how prenatal metal exposome influences newborn metabolic programming. This prospective cohort in 2022-2023 analyzed 432 mother-neonate pairs with complete biospecimens and birth records. We measured maternal urinary concentrations of 18 metals across first and third trimesters as well as neonatal metabolic biomarkers including 12 amino acids, 26 carnitines, thyroid-stimulating hormone (TSH), 17-hydroxyprogesterone (OHP), and glucose-6-phosphate dehydrogenase (G6PD). Multivariable regression, quantile g-computation, and machine learning methods were integrated to evaluate both individual and joint metal effects, with metabolic network and pathway enrichment analyses. Nine neonatal metabolites (tyrosine, glycine, leucine, free carnitine, C3, C5, C5:1, G6PD, and OHP) showed consistent trimester-specific associations with the metal mixtures. Arginine biosynthesis was the primary metal-responsive pathway. First-trimester exposure to zinc, selenium, tin, and chromium inversely correlated with gestational age at birth (β = -0.22 to -0.07; <i>P</i> < 0.05), while zinc and selenium inversely linked to birth weight (β = -83.48 to -51.67; <i>P</i> < 0.05). Mediation analysis revealed G6PD mediated 17.2% (95% CI, 0.11%; 168.00%) of Zn-gestational age association. The present study characterizes distinct metabolic disturbances in newborns associated with trimester-specific metal exposure, establishing novel mechanistic links between metal exposome and adverse birth outcomes.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"4 4","pages":"694-708"},"PeriodicalIF":6.3,"publicationDate":"2025-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13097153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147782779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing Nondietary Exposure to Per- and Polyfluoroalkyl Substances (PFASs) in Firefighters Using Silicone Wristbands.","authors":"Taylor Hoxie, Sharon Zhang, Ellen M Cooper, Daniel Ehrlich, Nicholas Herkert, Kate Hoffman, Heather M Stapleton","doi":"10.1021/envhealth.5c00316","DOIUrl":"https://doi.org/10.1021/envhealth.5c00316","url":null,"abstract":"<p><p>Firefighters are uniquely exposed to per- and polyfluoroalkyl substances (PFASs) from use of aqueous film-forming foam (AFFF) and potentially from PFASs-treated turnout gear. This study assessed firefighter's ambient (nondietary) exposure to PFASs using silicone wristbands. Twenty-three firefighters from North Carolina wore a new wristband during each 9-day work period for approximately 4 months. While wearing the wristbands, each firefighter reported on fire calls using an App installed on their phones. Wristbands, and blood plasma samples collected at study completion, were analyzed for PFASs. PFASs were detected in all blood samples and were dominated by TFA, PFOA, PFOS, PFPrA and PFHxS. Several PFASs levels were positively associated with age and years as a firefighter. Analytes commonly detected in wristbands were MeFBSE, MeFOSE, PFHxA, PFUnA, 6:2 diPAP, 8:2 diPAP, and 6:2/8:2 diPAP. Wristband MeFBSE levels were associated with the number of fires and duration of time spent at a fire. MeFOSE levels on wristbands were also significantly and positively correlated with plasma N-MeFOSAA, similar to a previous study in a nonfirefighter cohort. Overall, these findings suggest that silicone wristbands can detect some occupational PFASs exposures among firefighters and highlights the potential for specific PFASs compounds to be associated with firefighting activities.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"4 4","pages":"684-693"},"PeriodicalIF":6.3,"publicationDate":"2025-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13096971/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147783179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Per- and Polyfluoroalkyl Substance Exposure Associated with Later Puberty in Norwegian Girls: Data from the Bergen Growth Study 2.","authors":"Ingvild Halsør Forthun, Mathieu Roelants, Helle Katrine Knutsen, Line Småstuen Haug, Nina Iszatt, Lawrence M Schell, Astanand Jugessur, Kristin Viste, Robert Bjerknes, Ingvild Særvold Bruserud, Petur Benedikt Juliusson","doi":"10.1021/envhealth.5c00436","DOIUrl":"10.1021/envhealth.5c00436","url":null,"abstract":"<p><p>Per- and polyfluoroalkyl substances (PFAS) are a group of endocrine-disrupting chemicals, however their effect on pubertal development remains largely unknown. In this cross-sectional study, we examined associations between PFAS exposure and pubertal timing in a cohort of 618 girls aged 6 to 16 years from the Bergen Growth Study 2 in Norway, 2016. Serum concentrations of 19 PFAS were measured, and pubertal development was assessed using several pubertal markers, including ultrasound-assessed breast development, Tanner staging, pubertal hormone levels, and age at menarche. We applied quantile g-computation, elastic net, and Bayesian regression to evaluate both combined and individual effects of PFAS exposure, in addition to single-pollutant analyses. Higher PFAS concentrations were significantly associated with later thelarche, pubarche, lower serum levels of luteinizing hormone, follicle-stimulating hormone, estrone, and estradiol, and later menarche. Among the PFAS analyzed, perfluorooctanesulfonic acid (PFOS) and perfluorodecanoic acid (PFDA) emerged as the key predictors of later pubertal markers. Our results indicate that PFAS exposure is associated with later puberty in girls.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"4 3","pages":"546-559"},"PeriodicalIF":6.3,"publicationDate":"2025-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13010314/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147515174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Aryl Hydrocarbon Receptor-Dependent Signaling Pathway in the Profibrotic Effects of Dioxin-like Compounds in Human Renal Tubular Epithelial Cells.","authors":"Ruihong Zhu, Yiyun Liu, Xiaoxu Hu, Yongchao Ma, Wei Yan, Li Xu, Heidi Qunhui Xie, Bin Zhao, Junfa Yin, Hailin Wang","doi":"10.1021/envhealth.5c00494","DOIUrl":"https://doi.org/10.1021/envhealth.5c00494","url":null,"abstract":"<p><p>The aryl hydrocarbon receptor (AhR) signaling pathway mediates nephrotoxic compound effects on the kidney, although its mechanisms are incompletely understood. Given that renal tubulointerstitial fibrosis is a central pathological feature of progressive kidney diseases, we investigated AhR-induced profibrotic events at the molecular and cellular levels in human renal tubular epithelial cells (HKC). We found that the AhR activation by the potent agonist 2,3,7,8-tetrachlorodibenzo-<i>p</i>-dioxin (TCDD) promoted epithelial-mesenchymal transition (EMT) and inflammatory responses. This was evidenced by a 56.19% decrease in E-cadherin; 1.87-, 2.39-, and 8.27-fold increases in fibronectin, MMP9, and IL-6, respectively; and a 37.77% enhancement in cell migration. Transcriptome analysis and experimental validations confirmed the consistent dysregulation of these markers. Moreover, we found the profibrotic effects of the known nephrotoxic phytochemical aristolactam I (AL-I) also involving activation of AhR and consistent regulation of the above marker genes, primarily via the AhR. In addition, the transcriptome data further suggested that AhR activation may indirectly induce the profibrotic epidermal growth factor receptor (EGFR) pathway by upregulating AREG, EREG, and TGF-α, indicating crosstalk between AhR and EGFR. Given the wide variety of AhR-active chemicals, these AhR-EMT/inflammation-related markers could be used to screen nephrotoxicity of emerging dioxin-like pollutants and toxic phytochemicals.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"4 4","pages":"668-683"},"PeriodicalIF":6.3,"publicationDate":"2025-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13097154/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147782867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic Associations between Ambient PM_2.5 and Its Components and Transitions of Clinical Pregnancy and Adverse Reproductive Outcomes among Participants Treated with ART.","authors":"Zhonghua Ai, Yajun Dong, Xuefei Li, Zilong Zhang, Zitong Zhuang, Manting Rao, Yan Jia, Hualiang Lin","doi":"10.1021/envhealth.5c00442","DOIUrl":"https://doi.org/10.1021/envhealth.5c00442","url":null,"abstract":"<p><p>Evidence remains unknown regarding the associations between PM_2.5 and its components exposure and dynamic progression of different assisted reproductive outcomes in participants undergoing fresh embryo transfer. We included infertile participants at a major assisted reproductive specialist hospital in Chengdu, China, between 2019 and 2022. We conducted multistate modeling and the quantile g-computation approach to explore the association between PM_2.5 and its components [black carbon (BC), organic matter (OM), sulfate (SO₄ ^2-), nitrate (NO₃ ^-), ammonium (NH₄ ⁺) ] and the mixtures with six transitions (from infertility status to clinical pregnancy, from clinical pregnancy to preterm birth (PTB), from clinical pregnancy to miscarriage, from clinical pregnancy to pregnancy complications, from pregnancy complications to PTB, and from pregnancy complications to miscarriage). Mediation analyses were further conducted to explore potential mediating role of reproductive parameters in the associations. Among 11,447 infertile participants with in vitro fertilization, we observed that exposure to higher concentrations of PM_2.5 and its components and the mixtures in the 3 months prior to embryo transfer was associated with the progression of the reproductive outcomes, only BC and OM are associated with miscarriage. For example, for each interquartile range increase in OM, the hazard ratios (HRs) were 0.956 [95% confidence interval (CI): 0.927, 0.985] for transition from infertility to clinical pregnancy, 1.176 (95% CI: 1.083, 1.276) for clinical pregnancy to PTB, and 1.115 (95% CI: 1.025, 1.217) for clinical pregnancy to miscarriage. Mediation analysis indicated that the number of high-quality embryos at the cleavage stage accounted for 2.41%, 3.25%, 1.54%, 2.20%, 1.09% and 1.52% of the associations between PM_2.5 and its components and clinical pregnancy, respectively. This study provides novel evidence that PM_2.5 and its components might play an important role in the progression of assisted reproductive outcomes in infertile participants, particularly in the clinical pregnancy to PTB stage. BC and OM seem to show stronger effects. Additionally, the number of high-quality embryos at cleavage may serve as potential mediators.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"4 4","pages":"655-667"},"PeriodicalIF":6.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13096970/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147783329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gestational Trichloroacetic Acid Exposure Induces Miscarriage by Disrupting Iron Homeostasis in Trophoblasts via the KEAP1-NRF2 Pathway.","authors":"Yijun Zhang, Hanyu Rao, Zhiyi Pan, Yan Zhao, Liping Jin","doi":"10.1021/envhealth.5c00172","DOIUrl":"https://doi.org/10.1021/envhealth.5c00172","url":null,"abstract":"<p><p>Trichloroacetic acid (TCAA) is one of the most commonly detected non-volatile disinfection byproducts (DBPs) in public water supplies. Previous epidemiological studies have established associations between TCAA exposure and elevated risks of adverse pregnancy outcomes, yet its impacts on pregnancy maintenance remain poorly understood. In this study, we found that gestational TCAA exposure induced pregnancy loss in mice by disrupting trophoblast invasion and impairing the placental structure. Mechanistically, TCAA inhibited the Kelch-like ECH-associated protein 1 (KEAP1)-nuclear factor erythroid 2-related factor 2 (NRF2) interaction, which drove placental iron dyshomeostasis marked by an expanded labile iron pool (LIP) and subsequent reactive oxygen species (ROS) overaccumulation. The iron chelator deferoxamine (DFO) significantly alleviated TCAA-induced pregnancy loss by restoring iron metabolism, reducing oxidative stress, and enhancing trophoblast invasion. Taken together, our findings provided critical insights into the reproductive toxicity of TCAA and underscored the potential of targeting iron homeostasis as a therapeutic strategy.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"4 4","pages":"641-654"},"PeriodicalIF":6.3,"publicationDate":"2025-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13097161/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147783281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Respiratory Exposure to Lithium Nickel Manganese Cobalt Oxide Particles: Evidence for Toxicity and Disruption of Metal Homeostasis in Mice.","authors":"Xu Zhang, Xiu Ye, Qi Sun, Qingping Liu, Fuchang Deng, Wen Gu, Yuanyuan Chen, Yican Wang, Xingyu Zhan, Yuan Jin, Rong Zhang, Yufei Dai","doi":"10.1021/envhealth.5c00419","DOIUrl":"https://doi.org/10.1021/envhealth.5c00419","url":null,"abstract":"<p><p>Lithium nickel manganese cobalt oxide (NMC) is a widely used cathode material in lithium-ion batteries. However, its increasing utilization has raised concerns about environmental contamination and potential health risks, underscoring the need for comprehensive toxicological assessments. In this study, we evaluated the tissue distribution and toxicological effects of NMC in adult male C57BL/6J mice following 28-day intratracheal instillation at doses of 32.5, 162.5, and 325 μg/kg/day. Our findings demonstrated that lithium primarily accumulated in the heart, while nickel also showed high accumulation ability in the heart, followed by the liver and epididymis. Cobalt accumulated predominantly in the spleen, kidneys, and epididymis, whereas manganese was mainly concentrated in the epididymis. Notably, exposure to high doses of NMC resulted in a reduction in body weight, elevated levels of systemic inflammation biomarkers, and significant histopathological changes. These histopathological alterations included alveolar fusion and structural damage in the lungs, loss of distinction between red and white pulp in the spleen, renal tubular dilation, and a decrease in spermatogenic cells in the testes and epididymis. Furthermore, NMC exposure disrupted the homeostasis of trace metals (copper, vanadium, molybdenum, strontium, selenium, and stannum) in mice, suggesting their potential roles in NMC-induced toxicity. This study provides a detailed characterization of the distribution and toxic effects of low-dose NMC exposure, contributing valuable data for the toxicology evaluation of NMC materials.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"4 4","pages":"618-629"},"PeriodicalIF":6.3,"publicationDate":"2025-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13097167/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147782807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}