Environment & Health最新文献

{"title":"Enhancing the Utilization of Nontarget Screening to Holistically Identify Chemical Exposure Fingerprints in Human Blood Biomonitoring and Epidemiological Study","authors":"Pengyang Li, Bao Zhu, Yin Liu, Kai Huang, Jie Fu, Haiyan Zhang, Jianjie Fu* and Guibin Jiang, ","doi":"10.1021/envhealth.4c0025610.1021/envhealth.4c00256","DOIUrl":"https://doi.org/10.1021/envhealth.4c00256https://doi.org/10.1021/envhealth.4c00256","url":null,"abstract":"","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 4","pages":"334–337 334–337"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/envhealth.4c00256","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143842304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cockroach Microbiome Disrupts Indoor Environmental Microbial Ecology with Potential Public Health Implications","authors":"Jiahui Ma,&nbsp;Mengzhen Wang,&nbsp;Ye Sun,&nbsp;Yunhao Zheng,&nbsp;Senchao Lai,&nbsp;Yingyi Zhang,&nbsp;Yan Wu,&nbsp;Chao Jiang and Fangxia Shen*,&nbsp;","doi":"10.1021/envhealth.4c0021610.1021/envhealth.4c00216","DOIUrl":"https://doi.org/10.1021/envhealth.4c00216https://doi.org/10.1021/envhealth.4c00216","url":null,"abstract":"<p >Cockroaches pose a significant global public health concern. However, besides the well-recognized cockroach-induced allergy, the potential impact of the cockroach microbiome on human health through various means is not yet fully elucidated. This study aimed to clarify the health impacts of cockroaches by investigating the microbial interactions among cockroaches, the indoor environment, and humans. We simultaneously collected cockroach, indoor environment (indoor air and floor dust), and human (exhaled breath condensate and skin) samples from residential areas in five cities representing distinct climate zones in China. The 16S rDNA sequencing results revealed that cockroaches harbor diverse bacterial populations that vary across different cities. The prevalence of potential pathogenic bacteria (PPB) in cockroaches ranged from 1.1% to 58.9%, with dominant resistance genes conferring resistance to tetracycline, macrolide, and beta-lactam. The relationships between the cockroach microbiome and the associated environmental and human microbiomes were explored by using fast expectation-maximization microbial source tracking (FEAST). The potential contribution of cockroach bacteria to the floor dust-borne microbiome and indoor airborne microbiome was estimated to be 5.6% and 1.3%, respectively. Similarly, the potential contribution of cockroach PPB to the floor dust-borne microbiome and indoor airborne microbiome was calculated to be 4.0% and 1.2%, respectively. In residences with cockroach infestations, the contribution of other sources to the indoor environment was slightly increased. Collectively, the role of cockroaches in the transmission of microorganisms, particularly pathogenic bacteria and antibiotic resistance genes, cannot be overlooked.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 4","pages":"380–391 380–391"},"PeriodicalIF":0.0,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/envhealth.4c00216","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143842296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developing Methylmercury-Targeted Strategies to Safeguard Rice Consumers.","authors":"Wenli Tang, Huan Zhong","doi":"10.1021/envhealth.4c00257","DOIUrl":"10.1021/envhealth.4c00257","url":null,"abstract":"<p><p>Mitigating mercury (Hg) risk in the rice-paddy system is crucial for safeguarding food safety and human health, as rice is a main source of human exposure to neurotoxic methylmercury (MeHg). Current mitigation strategies predominantly focus on reducing the availability of inorganic Hg (IHg) for Hg methylation, achieved primarily through Hg emission control and <i>in situ</i> Hg immobilization. While these IHg-targeted approaches have effectively reduced MeHg bioaccumulation and subsequent human exposure, their efficacy is largely undermined by Hg transformations and fluctuating environmental conditions due to the complex and protracted pathway linking IHg from environmental sources to MeHg at the point of human exposure. In light of recent advancements in MeHg-related transformations, we emphasize the development of MeHg-targeted strategies to improve the overall efficiency of Hg risk management in rice-paddy systems. MeHg-targeted strategies include microbial regulation to diminish net MeHg production, facilitating MeHg demethylation in soils, and promoting the <i>in vivo</i> MeHg degradation within rice plants. Although these approaches are still in their nascent stages, they hold significant promise due to their potential high mitigation efficacy and reduced uncertainties, owing to the shorter pathway between MeHg production and human exposure. Integrating IHg- and MeHg-targeted strategies offers a comprehensive and synergistic approach, paving the way for more effective mitigation of human exposure to MeHg in rice-paddy systems.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 3","pages":"213-217"},"PeriodicalIF":0.0,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934198/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143721619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developing Methylmercury-Targeted Strategies to Safeguard Rice Consumers","authors":"Wenli Tang,&nbsp; and ,&nbsp;Huan Zhong*,&nbsp;","doi":"10.1021/envhealth.4c0025710.1021/envhealth.4c00257","DOIUrl":"https://doi.org/10.1021/envhealth.4c00257https://doi.org/10.1021/envhealth.4c00257","url":null,"abstract":"<p >Mitigating mercury (Hg) risk in the rice-paddy system is crucial for safeguarding food safety and human health, as rice is a main source of human exposure to neurotoxic methylmercury (MeHg). Current mitigation strategies predominantly focus on reducing the availability of inorganic Hg (IHg) for Hg methylation, achieved primarily through Hg emission control and <i>in situ</i> Hg immobilization. While these IHg-targeted approaches have effectively reduced MeHg bioaccumulation and subsequent human exposure, their efficacy is largely undermined by Hg transformations and fluctuating environmental conditions due to the complex and protracted pathway linking IHg from environmental sources to MeHg at the point of human exposure. In light of recent advancements in MeHg-related transformations, we emphasize the development of MeHg-targeted strategies to improve the overall efficiency of Hg risk management in rice-paddy systems. MeHg-targeted strategies include microbial regulation to diminish net MeHg production, facilitating MeHg demethylation in soils, and promoting the <i>in vivo</i> MeHg degradation within rice plants. Although these approaches are still in their nascent stages, they hold significant promise due to their potential high mitigation efficacy and reduced uncertainties, owing to the shorter pathway between MeHg production and human exposure. Integrating IHg- and MeHg-targeted strategies offers a comprehensive and synergistic approach, paving the way for more effective mitigation of human exposure to MeHg in rice-paddy systems.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 3","pages":"213–217 213–217"},"PeriodicalIF":0.0,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/envhealth.4c00257","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143666883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging Perfluorinated Chemical GenX: Environmental and Biological Fates and Risks","authors":"Wanqian Guo,&nbsp;Weidong Hao and Wusheng Xiao*,&nbsp;","doi":"10.1021/envhealth.4c0016410.1021/envhealth.4c00164","DOIUrl":"https://doi.org/10.1021/envhealth.4c00164https://doi.org/10.1021/envhealth.4c00164","url":null,"abstract":"<p >Perfluorinated chemical GenX, formally known as hexafluoropropylene oxide dimer acid (HFPO–DA), has been applied as an alternative to the forever chemical perfluorooctanoic acid (PFOA). The applications of HFPO–DA have rapidly expanded from traditional nonstick coating industries into high-tech semiconductor manufacturing. Because of such facts in conjunction with its low biodegradation rate and high potential of long-distance atmospheric transport, the presence and accumulation of HFPO–DA have been ubiquitously detected in environmental media and biological species, including animals and human beings, posing alarming and urgent needs for the risk assessment of HFPO–DA. Building on the United States Environmental Protection Agency’s evaluation of HFPO–DA in 2021, this review first summarizes the interaction of HFPO–DA with the environment, elaborates on its known toxicities and potential carcinogenicity, along with their possible mechanisms, and briefly addresses its current exposure assessment and risk management strategies. These lines of evidence support that the safety of HFPO–DA necessitates further investigation and monitoring, albeit being considered as a less toxic and low persistence substitute of traditional PFOA.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 4","pages":"338–351 338–351"},"PeriodicalIF":0.0,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/envhealth.4c00164","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143842295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Need for a Holistic Approach to Assessing Sustainable, Green, and Healthy Buildings.","authors":"Nishchaya Kumar Mishra, Sameer Patel","doi":"10.1021/envhealth.4c00161","DOIUrl":"10.1021/envhealth.4c00161","url":null,"abstract":"<p><p>With the rising global population, economic development, and urbanization, building stock is bound to grow, warranting measures for optimizing their embodied and operational energy and resource consumption. Further, a building's indoor environment quality significantly affects occupants' health, productivity, and well-being since people spend almost 90% of their time indoors. Buildings safeguard occupant's well-being by shielding them from the outdoor air pollution and increasing climate extremes. However, buildings can also lead to acute and chronic exposure to pollutants trapped inside. The recent pandemic has demonstrated that indoor environments can prevent and promote airborne disease transmission depending on buildings' design and operation. The current segregated rating systems and regulations to gauge buildings' sustainability, health and safety, and energy efficiency have led to a fragmented approach hampering sustainable and healthy buildings' design, construction, and operations. This work discusses the environmental sustainability of buildings, their impacts on occupants' health and productivity, and if and how the existing global policies and frameworks regulate and promote the same. Developing a holistic and comprehensive framework is critical to ensure buildings' sustainability, occupants' health, and energy efficiency.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 3","pages":"218-226"},"PeriodicalIF":0.0,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934202/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143721668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Need for a Holistic Approach to Assessing Sustainable, Green, and Healthy Buildings","authors":"Nishchaya Kumar Mishra,&nbsp; and ,&nbsp;Sameer Patel*,&nbsp;","doi":"10.1021/envhealth.4c0016110.1021/envhealth.4c00161","DOIUrl":"https://doi.org/10.1021/envhealth.4c00161https://doi.org/10.1021/envhealth.4c00161","url":null,"abstract":"<p >With the rising global population, economic development, and urbanization, building stock is bound to grow, warranting measures for optimizing their embodied and operational energy and resource consumption. Further, a building’s indoor environment quality significantly affects occupants’ health, productivity, and well-being since people spend almost 90% of their time indoors. Buildings safeguard occupant’s well-being by shielding them from the outdoor air pollution and increasing climate extremes. However, buildings can also lead to acute and chronic exposure to pollutants trapped inside. The recent pandemic has demonstrated that indoor environments can prevent and promote airborne disease transmission depending on buildings’ design and operation. The current segregated rating systems and regulations to gauge buildings’ sustainability, health and safety, and energy efficiency have led to a fragmented approach hampering sustainable and healthy buildings’ design, construction, and operations. This work discusses the environmental sustainability of buildings, their impacts on occupants’ health and productivity, and if and how the existing global policies and frameworks regulate and promote the same. Developing a holistic and comprehensive framework is critical to ensure buildings’ sustainability, occupants’ health, and energy efficiency.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 3","pages":"218–226 218–226"},"PeriodicalIF":0.0,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/envhealth.4c00161","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143666881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transforming Urbanite Health with Upstream Knowledge.","authors":"Zhaowu Yu, Gaoyuan Yang, Boyi Yang, Jun Yang, Zhuohui Zhao, Lan Wang, Hongxiao Liu, Jinguang Zhang, Bin Jiang, Henrik Vejre","doi":"10.1021/envhealth.4c00237","DOIUrl":"10.1021/envhealth.4c00237","url":null,"abstract":"","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 2","pages":"111-113"},"PeriodicalIF":0.0,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11851204/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Benchmark Dose Estimation from Transcriptomics Data for Methylimidazolium Ionic Liquid Hepatotoxicity: Implications for Health Risk Assessment of Green Solvents","authors":"Qing Yang,&nbsp;Xiaole Zhao,&nbsp;Kejia Wu,&nbsp;Qingqing Yu,&nbsp;Qiao Wang,&nbsp;Jingguang Li,&nbsp;Yongning Wu and Xin Liu*,&nbsp;","doi":"10.1021/envhealth.4c0012010.1021/envhealth.4c00120","DOIUrl":"https://doi.org/10.1021/envhealth.4c00120https://doi.org/10.1021/envhealth.4c00120","url":null,"abstract":"<p >Ionic liquids (ILs), traditionally considered environmentally benign solvents, have shown potential toxicity to organisms, raising concerns about their safety. Among them, 1-octyl-3-methylimidazolium (M8OI) has been detected at high concentrations in soils and exhibits hepatotoxic properties. To uncover the molecular mechanisms underlying this toxicity, whole-transcriptome sequencing was performed, coupled with benchmark dose (BMD) modeling, to derive transcriptomic points-of-departure (tPOD) through dose–response analysis. The transcriptomic analysis identified 425, 667, and 567 differentially expressed genes (DEGs) following low (10 μmol/L), medium (50 μmol/L), and high (200 μmol/L) doses of M8OI exposure, respectively. Enrichment analysis revealed significant perturbations in pathways related to cytokine–cytokine receptor interaction and IL-17 signaling. BMD modeling yielded tPOD values of 1.51 μmol/L (median of the 20 most sensitive genes, omicBMD₂₀), 2.98 μmol/L (tenth percentile of all genes, omicBMD_10th), 6.83 μmol/L (mode of the first peak of all gene BMDs, omicBMD_mode), and 5.9 μmol/L for pathway-level analysis. These transcriptomics-derived tPODs were at least 105-fold lower than M8OI’s hepatotoxic concentration, as indicated by its EC₅₀ of 723.6 μmol/L in HepG2 cells. Functional analysis of the transcriptomic data identified legionellosis, rheumatoid arthritis, and transcriptional misregulation in cancer as the most sensitive pathways affected by M8OI. These findings highlight the molecular mechanisms driving M8OI-induced hepatotoxicity and underscore the utility of transcriptomics in deriving sensitive and quantitative toxicity thresholds. The results provide critical insights for guideline-driven toxicological evaluations and regulatory decision-making, supporting a more comprehensive assessment of IL safety.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 4","pages":"373–379 373–379"},"PeriodicalIF":0.0,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/envhealth.4c00120","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143842294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transforming Urbanite Health with Upstream Knowledge","authors":"Zhaowu Yu*,&nbsp;Gaoyuan Yang,&nbsp;Boyi Yang,&nbsp;Jun Yang,&nbsp;Zhuohui Zhao,&nbsp;Lan Wang,&nbsp;Hongxiao Liu,&nbsp;Jinguang Zhang,&nbsp;Bin Jiang and Henrik Vejre,&nbsp;","doi":"10.1021/envhealth.4c0023710.1021/envhealth.4c00237","DOIUrl":"https://doi.org/10.1021/envhealth.4c00237https://doi.org/10.1021/envhealth.4c00237","url":null,"abstract":"","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 2","pages":"111–113 111–113"},"PeriodicalIF":0.0,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/envhealth.4c00237","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143452397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}