Environment & Health最新文献_第3页

Fish Skin Mucus Vitellogenin as a Noninvasive, Sensitive Biomarker for Aquatic Xenoestrogens 鱼皮肤黏液卵黄原蛋白作为一种无创、敏感的水生异种雌激素生物标志物

Environment & Health Pub Date : 2025-01-10 DOI: 10.1021/envhealth.4c0023510.1021/envhealth.4c00235

Baili Sun, Chenyan Hu and Lianguo Chen*,

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引用次数: 0

Fish Skin Mucus Vitellogenin as a Noninvasive, Sensitive Biomarker for Aquatic Xenoestrogens. 鱼皮肤黏液卵黄原蛋白作为一种无创、敏感的水生异种雌激素生物标志物。

Environment & Health Pub Date : 2025-01-10 eCollection Date: 2025-04-18 DOI: 10.1021/envhealth.4c00235

Baili Sun, Chenyan Hu, Lianguo Chen

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引用次数: 0

Cardiovascular Emergency Hospitalization Risks of PM_2.5 Transition Metals: A Time-Stratified Case-Crossover Study. PM2.5过渡金属的心血管急诊住院风险：一项时间分层的病例交叉研究

Environment & Health Pub Date : 2025-01-07 eCollection Date: 2025-04-18 DOI: 10.1021/envhealth.4c00204

Lin Wang, Bin Wang, Jiawen Liao, Jieru Zhang, Xin Su, Jinshan Yan, Wei Xu, Jiyi Lin, Guangfeng Sun, Lunche Wang, Lina Tang

{"title":"Cardiovascular Emergency Hospitalization Risks of PM2.5 Transition Metals: A Time-Stratified Case-Crossover Study.","authors":"Lin Wang, Bin Wang, Jiawen Liao, Jieru Zhang, Xin Su, Jinshan Yan, Wei Xu, Jiyi Lin, Guangfeng Sun, Lunche Wang, Lina Tang","doi":"10.1021/envhealth.4c00204","DOIUrl":"https://doi.org/10.1021/envhealth.4c00204","url":null,"abstract":"PM2.5 pollution poses significant health risks in urban areas, yet the specific cardiovascular impacts of its hazardous components, especially transition metals, remain insufficiently understood. This study evaluated the associations of PM2.5 components on acute myocardial infarction (AMI) and acute aortic dissections (AAD) emergency hospitalizations (n = 9985) using a time-stratified case-crossover between 2017 and 2023 in Xiamen, China. We collected comprehensive data on daily air pollutants, PM2.5 components (water-soluble ions, carbon components, metals, and other elements), and meteorological variables. Conditional logistic regressions were used to estimate odds ratios (OR) per the interquartile range (IQR) of exposures. Our finding reveals significant short-term associations of exposures to air pollutants and PM2.5 components with increased cardiovascular emergency hospitalizations. The strongest associations were observed between cumulative 3-day lagged (lag 0-3) PM2.5 transition metals including Mn [odds ratio, OR = 1.106 (95% CI: 1.032-1.186)], Fe [OR = 1.078, (95% CI: 1.015-1.145)], V [OR = 1.117 (95% CI: 1.024-1.219)], and Zn [OR = 1.08, (95% CI: 1.005-1.161)] exposure with AMI. These associations were stronger among older (age >65 years), male patients, and during colder seasons. Our study highlights the underexplored subacute cardiovascular risks of PM2.5 transition metals, underscoring the need to integrate them into urban air quality management to promote environmental sustainability.","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 4","pages":"402-413"},"PeriodicalIF":0.0,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12012663/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiovascular Emergency Hospitalization Risks of PM2.5 Transition Metals: A Time-Stratified Case-Crossover Study PM2.5过渡金属的心血管急诊住院风险：一项时间分层的病例交叉研究

Environment & Health Pub Date : 2025-01-07 DOI: 10.1021/envhealth.4c0020410.1021/envhealth.4c00204

Lin Wang, Bin Wang, Jiawen Liao*, Jieru Zhang, Xin Su, Jinshan Yan, Wei Xu, Jiyi Lin, Guangfeng Sun, Lunche Wang and Lina Tang*,

{"title":"Cardiovascular Emergency Hospitalization Risks of PM2.5 Transition Metals: A Time-Stratified Case-Crossover Study","authors":"Lin Wang, Bin Wang, Jiawen Liao*, Jieru Zhang, Xin Su, Jinshan Yan, Wei Xu, Jiyi Lin, Guangfeng Sun, Lunche Wang and Lina Tang*, ","doi":"10.1021/envhealth.4c0020410.1021/envhealth.4c00204","DOIUrl":"https://doi.org/10.1021/envhealth.4c00204https://doi.org/10.1021/envhealth.4c00204","url":null,"abstract":"PM2.5 pollution poses significant health risks in urban areas, yet the specific cardiovascular impacts of its hazardous components, especially transition metals, remain insufficiently understood. This study evaluated the associations of PM2.5 components on acute myocardial infarction (AMI) and acute aortic dissections (AAD) emergency hospitalizations (n = 9985) using a time-stratified case-crossover between 2017 and 2023 in Xiamen, China. We collected comprehensive data on daily air pollutants, PM2.5 components (water-soluble ions, carbon components, metals, and other elements), and meteorological variables. Conditional logistic regressions were used to estimate odds ratios (OR) per the interquartile range (IQR) of exposures. Our finding reveals significant short-term associations of exposures to air pollutants and PM2.5 components with increased cardiovascular emergency hospitalizations. The strongest associations were observed between cumulative 3-day lagged (lag 0–3) PM2.5 transition metals including Mn [odds ratio, OR = 1.106 (95% CI: 1.032–1.186)], Fe [OR = 1.078, (95% CI: 1.015–1.145)], V [OR = 1.117 (95% CI: 1.024–1.219)], and Zn [OR = 1.08, (95% CI: 1.005–1.161)] exposure with AMI. These associations were stronger among older (age >65 years), male patients, and during colder seasons. Our study highlights the underexplored subacute cardiovascular risks of PM2.5 transition metals, underscoring the need to integrate them into urban air quality management to promote environmental sustainability.","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 4","pages":"402–413 402–413"},"PeriodicalIF":0.0,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/envhealth.4c00204","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143842309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Astrocytes Respond to Environment-Relevant Doses TCDD in a Specific Manner Which Is Different from the Endogenous AhR Ligand (FICZ). 星形胶质细胞对环境相关剂量TCDD的反应方式不同于内源性AhR配体（FICZ）。

Environment & Health Pub Date : 2025-01-07 eCollection Date: 2025-04-18 DOI: 10.1021/envhealth.4c00189

Rui Sha, Yangsheng Chen, Tong Xu, Guanglei Yang, Li Xu, Heidi Qunhui Xie, Bin Zhao

{"title":"Astrocytes Respond to Environment-Relevant Doses TCDD in a Specific Manner Which Is Different from the Endogenous AhR Ligand (FICZ).","authors":"Rui Sha, Yangsheng Chen, Tong Xu, Guanglei Yang, Li Xu, Heidi Qunhui Xie, Bin Zhao","doi":"10.1021/envhealth.4c00189","DOIUrl":"https://doi.org/10.1021/envhealth.4c00189","url":null,"abstract":"Astrocytes play an important role in the nervous system's response to external stimulation. Environmental pollutants could activate astrocytes into A1 (toxic) or A2 (protective) types and induce different effects. Meanwhile, the aryl hydrocarbon receptor (AhR) is an environmental molecule sensor in the body and has various ligands. But the difference between exogenous and endogenous AhR ligands on the astrocytic activation is unclear; in this study, we employed rat primary cultured cortical astrocytes to reveal the effects and mechanisms of AhR ligands on astrocytic activation. We found that, after treatment with exogenous AhR ligand (2,3,7,8-tetrachlorodibenzo-p-dioxin, TCDD) ranging from 0.01 to 0.1 nmol/L, astrocytes mainly exhibited A2 type activation. The specific manifestation includes the increase in the expression of A2 marker genes, the enhancement of cellular autonomous movement, the expression and secretion of chemokines, such as Cxcl10, Cxcl2, and Ccl7. And TCDD-induced A2 type astrocytes show a positive impact on neuronal synaptic formation. Although both TCDD and endogenous AhR ligand (6-formylindolo[3,2-b] carbazole, FICZ) could activate AhR pathway in astrocytes, FICZ (50 nmol/L) neither induces activation of A2 type astrocytes nor upregulation of chemokines. Therefore, our findings suggest that AhR is crucial for astrocytes to recognize environmental pollutants and protect the nervous system.","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 4","pages":"392-401"},"PeriodicalIF":0.0,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12012657/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144045335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization and Health Risk Assessment of Airborne Fungi in a Semiunderground Municipal Wastewater Treatment Plant. 半地下城市污水处理厂空气传播真菌的特征及健康风险评价

Environment & Health Pub Date : 2025-01-07 eCollection Date: 2025-03-21 DOI: 10.1021/envhealth.4c00195

Xiang Zhang, Bingjie Lu, Shuo Yang, Bingjie Lin, Guang Chen, Lihua Wang, Zhengliang Peng, Huijie Lu, Chao Wang, Dan Li, Jianmin Chen

{"title":"Characterization and Health Risk Assessment of Airborne Fungi in a Semiunderground Municipal Wastewater Treatment Plant.","authors":"Xiang Zhang, Bingjie Lu, Shuo Yang, Bingjie Lin, Guang Chen, Lihua Wang, Zhengliang Peng, Huijie Lu, Chao Wang, Dan Li, Jianmin Chen","doi":"10.1021/envhealth.4c00195","DOIUrl":"10.1021/envhealth.4c00195","url":null,"abstract":"Municipal wastewater treatment plants (WWTPs) are recognized as the significant source of fungal aerosols, which pose a significant threat to human health globally. Herein, the occurrences characterization, community structure, and health risk assessment of airborne fungi were investigated from a semiunderground WWTP. The concentrations of culturable fungi emitted into the air from the WWTP ranged from 30.6 to 1431.1 colony forming units (CFU)/m3, with primary and biochemical treatments constituting the principal sources of emission (P < 0.05). Diversity analysis revealed seasonal and facility-dependent fluctuations in culturable fungal communities. Approximately 13.5% of the total airborne fungal genera detected in the WWTP were culturable. Some airborne fungi in the WWTP with relatively low abundance but high cultivability, such as Cladosporium, Trichoderma, Neurospora, Filobasidium, and Hannaella, tended to be overlooked because of their limited presence in airborne environments. We also developed a health risk assessment method for fungi, utilizing seven indicators to characterize the risk posed by fungal pathogens from multiple perspectives, providing a comprehensive evaluation of potential health impacts. The simulated risk values of the air outlet and biochemical treatment exceeded those of other treatment facilities, with median risks of 2.2 × 102 and 1.4 × 102, respectively. Consequently, management strategies should prioritize enhanced controls for fungal aerosols to mitigate the risk of disease transmission.","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 3","pages":"227-237"},"PeriodicalIF":0.0,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934199/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143721618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization and Health Risk Assessment of Airborne Fungi in a Semiunderground Municipal Wastewater Treatment Plant 半地下城市污水处理厂空气传播真菌的特征及健康风险评价

Environment & Health Pub Date : 2025-01-06 DOI: 10.1021/envhealth.4c0019510.1021/envhealth.4c00195

Xiang Zhang, Bingjie Lu, Shuo Yang, Bingjie Lin, Guang Chen, Lihua Wang, Zhengliang Peng, Huijie Lu, Chao Wang, Dan Li* and Jianmin Chen,

{"title":"Characterization and Health Risk Assessment of Airborne Fungi in a Semiunderground Municipal Wastewater Treatment Plant","authors":"Xiang Zhang, Bingjie Lu, Shuo Yang, Bingjie Lin, Guang Chen, Lihua Wang, Zhengliang Peng, Huijie Lu, Chao Wang, Dan Li* and Jianmin Chen, ","doi":"10.1021/envhealth.4c0019510.1021/envhealth.4c00195","DOIUrl":"https://doi.org/10.1021/envhealth.4c00195https://doi.org/10.1021/envhealth.4c00195","url":null,"abstract":"Municipal wastewater treatment plants (WWTPs) are recognized as the significant source of fungal aerosols, which pose a significant threat to human health globally. Herein, the occurrences characterization, community structure, and health risk assessment of airborne fungi were investigated from a semiunderground WWTP. The concentrations of culturable fungi emitted into the air from the WWTP ranged from 30.6 to 1431.1 colony forming units (CFU)/m3, with primary and biochemical treatments constituting the principal sources of emission (P < 0.05). Diversity analysis revealed seasonal and facility-dependent fluctuations in culturable fungal communities. Approximately 13.5% of the total airborne fungal genera detected in the WWTP were culturable. Some airborne fungi in the WWTP with relatively low abundance but high cultivability, such as Cladosporium, Trichoderma, Neurospora, Filobasidium, and Hannaella, tended to be overlooked because of their limited presence in airborne environments. We also developed a health risk assessment method for fungi, utilizing seven indicators to characterize the risk posed by fungal pathogens from multiple perspectives, providing a comprehensive evaluation of potential health impacts. The simulated risk values of the air outlet and biochemical treatment exceeded those of other treatment facilities, with median risks of 2.2 × 102 and 1.4 × 102, respectively. Consequently, management strategies should prioritize enhanced controls for fungal aerosols to mitigate the risk of disease transmission.","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 3","pages":"227–237 227–237"},"PeriodicalIF":0.0,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/envhealth.4c00195","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143666833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Astrocytes Respond to Environment-Relevant Doses TCDD in a Specific Manner Which Is Different from the Endogenous AhR Ligand (FICZ) 星形胶质细胞对环境相关剂量TCDD的反应方式不同于内源性AhR配体（FICZ）

Environment & Health Pub Date : 2025-01-06 DOI: 10.1021/envhealth.4c0018910.1021/envhealth.4c00189

Rui Sha, Yangsheng Chen*, Tong Xu, Guanglei Yang, Li Xu, Heidi Qunhui Xie* and Bin Zhao,

{"title":"Astrocytes Respond to Environment-Relevant Doses TCDD in a Specific Manner Which Is Different from the Endogenous AhR Ligand (FICZ)","authors":"Rui Sha, Yangsheng Chen*, Tong Xu, Guanglei Yang, Li Xu, Heidi Qunhui Xie* and Bin Zhao, ","doi":"10.1021/envhealth.4c0018910.1021/envhealth.4c00189","DOIUrl":"https://doi.org/10.1021/envhealth.4c00189https://doi.org/10.1021/envhealth.4c00189","url":null,"abstract":"Astrocytes play an important role in the nervous system’s response to external stimulation. Environmental pollutants could activate astrocytes into A1 (toxic) or A2 (protective) types and induce different effects. Meanwhile, the aryl hydrocarbon receptor (AhR) is an environmental molecule sensor in the body and has various ligands. But the difference between exogenous and endogenous AhR ligands on the astrocytic activation is unclear; in this study, we employed rat primary cultured cortical astrocytes to reveal the effects and mechanisms of AhR ligands on astrocytic activation. We found that, after treatment with exogenous AhR ligand (2,3,7,8-tetrachlorodibenzo-p-dioxin, TCDD) ranging from 0.01 to 0.1 nmol/L, astrocytes mainly exhibited A2 type activation. The specific manifestation includes the increase in the expression of A2 marker genes, the enhancement of cellular autonomous movement, the expression and secretion of chemokines, such as Cxcl10, Cxcl2, and Ccl7. And TCDD-induced A2 type astrocytes show a positive impact on neuronal synaptic formation. Although both TCDD and endogenous AhR ligand (6-formylindolo[3,2-b] carbazole, FICZ) could activate AhR pathway in astrocytes, FICZ (50 nmol/L) neither induces activation of A2 type astrocytes nor upregulation of chemokines. Therefore, our findings suggest that AhR is crucial for astrocytes to recognize environmental pollutants and protect the nervous system.","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 4","pages":"392–401 392–401"},"PeriodicalIF":0.0,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/envhealth.4c00189","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143842308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing the Utilization of Nontarget Screening to Holistically Identify Chemical Exposure Fingerprints in Human Blood Biomonitoring and Epidemiological Study. 加强非靶点筛选在人体血液生物监测和流行病学研究中的应用

Environment & Health Pub Date : 2025-01-01 eCollection Date: 2025-04-18 DOI: 10.1021/envhealth.4c00256

Pengyang Li, Bao Zhu, Yin Liu, Kai Huang, Jie Fu, Haiyan Zhang, Jianjie Fu, Guibin Jiang

引用次数: 0

Enhancing the Utilization of Nontarget Screening to Holistically Identify Chemical Exposure Fingerprints in Human Blood Biomonitoring and Epidemiological Study 加强非靶点筛选在人体血液生物监测和流行病学研究中的应用

Environment & Health Pub Date : 2025-01-01 DOI: 10.1021/envhealth.4c0025610.1021/envhealth.4c00256

Pengyang Li, Bao Zhu, Yin Liu, Kai Huang, Jie Fu, Haiyan Zhang, Jianjie Fu* and Guibin Jiang,

引用次数: 0