Environment & Health最新文献_第3页

PFOS and Its Substitute OBS Cause Endothelial Dysfunction to Promote Atherogenesis in ApoE^-/- Mice. PFOS及其替代物OBS引起ApoE-/-小鼠内皮功能障碍促进动脉粥样硬化。

Environment & Health Pub Date : 2025-02-11 eCollection Date: 2025-05-16 DOI: 10.1021/envhealth.4c00206

Boxiang Zhang, Qing Li, Wensheng Wang, Mingming Tian, Dan Xu, Ying Xie

{"title":"PFOS and Its Substitute OBS Cause Endothelial Dysfunction to Promote Atherogenesis in ApoE-/- Mice.","authors":"Boxiang Zhang, Qing Li, Wensheng Wang, Mingming Tian, Dan Xu, Ying Xie","doi":"10.1021/envhealth.4c00206","DOIUrl":"10.1021/envhealth.4c00206","url":null,"abstract":"Perfluorooctanesulfonate (PFOS), an emerging contaminant with widespread concern, has been associated with the pathogenesis of atherosclerosis (AS). As a substitute for PFOS, sodium p-perfluorous nonenoxybenzenesulfonate (OBS) is extensively utilized in various applications and detected in human blood. However, its potential health risk in AS remain unclear. In this study, we investigated the comparative impacts of PFOS and OBS on endothelial dysfunction and atherogenesis. In the in vivo study, Apolipoprotein E knockout (ApoE-/-) mice were exposed to 0.4 or 4 mg/L PFOS/OBS for 12 weeks. We found that dyslipidemia developed more rapidly in the OBS-exposed mice than in the PFOS-exposed mice. PFOS exhibited a higher enrichment capacity in both blood and aortic tissues than OBS. Remarkably, OBS induced a more pronounced inflammatory response and caused a more significant disruption of the endothelial barrier in the aorta of ApoE-/- mice compared to PFOS. In vitro experiments showed that OBS, at the same exposure concentrations and durations as PFOS (0.1-20 μmol/L, 48 h), more effectively inhibited cell viability of human umbilical vein endothelial cells (HUVECs), caused higher levels of lactate dehydrogenase (LDH) release, and enhanced cell adhesion between HUVECs and monocytes. Both PFOS and OBS were found to activate the NF-κB signaling pathway and upregulate the expression of inflammatory factors. Notably, the use of OBS, but not PFOS, was shown to disrupt cell junctions and increase endothelial permeability by activating the MAPK/ERK signaling pathway. Our findings suggest that OBS may lead to endothelial dysfunction and have a greater impact on AS compared to PFOS, presenting significant health risks in cardiovascular diseases.","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 5","pages":"526-538"},"PeriodicalIF":0.0,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12090012/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144120998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PFOS and Its Substitute OBS Cause Endothelial Dysfunction to Promote Atherogenesis in ApoE–/– Mice PFOS及其替代物OBS引起ApoE - / -小鼠内皮功能障碍促进动脉粥样硬化

Environment & Health Pub Date : 2025-02-11 DOI: 10.1021/envhealth.4c0020610.1021/envhealth.4c00206

Boxiang Zhang, Qing Li, Wensheng Wang, Mingming Tian, Dan Xu* and Ying Xie*,

{"title":"PFOS and Its Substitute OBS Cause Endothelial Dysfunction to Promote Atherogenesis in ApoE–/– Mice","authors":"Boxiang Zhang, Qing Li, Wensheng Wang, Mingming Tian, Dan Xu* and Ying Xie*, ","doi":"10.1021/envhealth.4c0020610.1021/envhealth.4c00206","DOIUrl":"https://doi.org/10.1021/envhealth.4c00206https://doi.org/10.1021/envhealth.4c00206","url":null,"abstract":"Perfluorooctanesulfonate (PFOS), an emerging contaminant with widespread concern, has been associated with the pathogenesis of atherosclerosis (AS). As a substitute for PFOS, sodium p-perfluorous nonenoxybenzenesulfonate (OBS) is extensively utilized in various applications and detected in human blood. However, its potential health risk in AS remain unclear. In this study, we investigated the comparative impacts of PFOS and OBS on endothelial dysfunction and atherogenesis. In the in vivo study, Apolipoprotein E knockout (ApoE–/–) mice were exposed to 0.4 or 4 mg/L PFOS/OBS for 12 weeks. We found that dyslipidemia developed more rapidly in the OBS-exposed mice than in the PFOS-exposed mice. PFOS exhibited a higher enrichment capacity in both blood and aortic tissues than OBS. Remarkably, OBS induced a more pronounced inflammatory response and caused a more significant disruption of the endothelial barrier in the aorta of ApoE–/– mice compared to PFOS. In vitro experiments showed that OBS, at the same exposure concentrations and durations as PFOS (0.1–20 μmol/L, 48 h), more effectively inhibited cell viability of human umbilical vein endothelial cells (HUVECs), caused higher levels of lactate dehydrogenase (LDH) release, and enhanced cell adhesion between HUVECs and monocytes. Both PFOS and OBS were found to activate the NF-κB signaling pathway and upregulate the expression of inflammatory factors. Notably, the use of OBS, but not PFOS, was shown to disrupt cell junctions and increase endothelial permeability by activating the MAPK/ERK signaling pathway. Our findings suggest that OBS may lead to endothelial dysfunction and have a greater impact on AS compared to PFOS, presenting significant health risks in cardiovascular diseases.","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 5","pages":"526–538 526–538"},"PeriodicalIF":0.0,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/envhealth.4c00206","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144067678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective Effects of Octyl Gallate Against Deoxynivalenol-Induced Colon Inflammation: Insights from Proteomic and Metabolomic Analyses 没食子酸辛酯对脱氧雪腐镰刀醇诱导的结肠炎症的保护作用：来自蛋白质组学和代谢组学分析的见解

Environment & Health Pub Date : 2025-02-06 DOI: 10.1021/envhealth.4c0025010.1021/envhealth.4c00250

Chenxin Dongye, Xiangrong Chen*, Yanfang Zhao, Huijuan Li, Mohamed F. Abdallah, Tianliang Li and Xiangfeng Chen*,

{"title":"Protective Effects of Octyl Gallate Against Deoxynivalenol-Induced Colon Inflammation: Insights from Proteomic and Metabolomic Analyses","authors":"Chenxin Dongye, Xiangrong Chen*, Yanfang Zhao, Huijuan Li, Mohamed F. Abdallah, Tianliang Li and Xiangfeng Chen*, ","doi":"10.1021/envhealth.4c0025010.1021/envhealth.4c00250","DOIUrl":"https://doi.org/10.1021/envhealth.4c00250https://doi.org/10.1021/envhealth.4c00250","url":null,"abstract":"Deoxynivalenol (DON) and octyl gallate (OG) are prevalent compounds in the environment and food. DON is frequently detected in cereals such as corn and wheat, while OG is commonly employed as a food additive. As a result, human exposure to these substances is inevitable. Given this, the objective of this experiment was to investigate the impact of co-exposure to DON (10 μg/kg) and OG (10 μg/kg) on intestinal inflammation. The RAW264.7 macrophage cell line was utilized to analyze cytokine levels as well as proteomic and metabolomic changes. In the quantitative real-time PCR experiments, the DON group showed significant difference compared to the control group (* p < 0.05) and the DON-OG group (# p < 0.05) regarding cytokine levels such as IL-10, TNF-α, Il6, Il1b, Ccl2, Il12α, Nos2, Cxcl1, and Cxcl2. In the animal experiment, C57BL/6 mice were utilized to monitor body weight, the presence of bloody stools, and diarrhea. Additionally, the colonic tissues of the mice underwent pathological analysis. The results indicated that cells treated with both DON and OG displayed lower levels of inflammation compared to those treated with DON alone. Furthermore, proteomic and metabolomic analyses revealed that the regulation of the Lancl2 protein and the mTOR signaling pathway contributed to the milder inflammatory response observed in the DON-OG group. These findings were further corroborated by the pathological analysis of the colonic tissues from the mice. In the combined exposure of DON and OG, OG partially mitigated the intestinal inflammation induced by DON.","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 5","pages":"515–525 515–525"},"PeriodicalIF":0.0,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/envhealth.4c00250","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144067793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective Effects of Octyl Gallate Against Deoxynivalenol-Induced Colon Inflammation: Insights from Proteomic and Metabolomic Analyses. 没食子酸辛酯对脱氧雪腐镰刀醇诱导的结肠炎症的保护作用：来自蛋白质组学和代谢组学分析的见解。

Environment & Health Pub Date : 2025-02-06 eCollection Date: 2025-05-16 DOI: 10.1021/envhealth.4c00250

Chenxin Dongye, Xiangrong Chen, Yanfang Zhao, Huijuan Li, Mohamed F Abdallah, Tianliang Li, Xiangfeng Chen

{"title":"Protective Effects of Octyl Gallate Against Deoxynivalenol-Induced Colon Inflammation: Insights from Proteomic and Metabolomic Analyses.","authors":"Chenxin Dongye, Xiangrong Chen, Yanfang Zhao, Huijuan Li, Mohamed F Abdallah, Tianliang Li, Xiangfeng Chen","doi":"10.1021/envhealth.4c00250","DOIUrl":"10.1021/envhealth.4c00250","url":null,"abstract":"Deoxynivalenol (DON) and octyl gallate (OG) are prevalent compounds in the environment and food. DON is frequently detected in cereals such as corn and wheat, while OG is commonly employed as a food additive. As a result, human exposure to these substances is inevitable. Given this, the objective of this experiment was to investigate the impact of co-exposure to DON (10 μg/kg) and OG (10 μg/kg) on intestinal inflammation. The RAW264.7 macrophage cell line was utilized to analyze cytokine levels as well as proteomic and metabolomic changes. In the quantitative real-time PCR experiments, the DON group showed significant difference compared to the control group (* p < 0.05) and the DON-OG group (# p < 0.05) regarding cytokine levels such as IL-10, TNF-α, Il6, Il1b, Ccl2, Il12α, Nos2, Cxcl1, and Cxcl2. In the animal experiment, C57BL/6 mice were utilized to monitor body weight, the presence of bloody stools, and diarrhea. Additionally, the colonic tissues of the mice underwent pathological analysis. The results indicated that cells treated with both DON and OG displayed lower levels of inflammation compared to those treated with DON alone. Furthermore, proteomic and metabolomic analyses revealed that the regulation of the Lancl2 protein and the mTOR signaling pathway contributed to the milder inflammatory response observed in the DON-OG group. These findings were further corroborated by the pathological analysis of the colonic tissues from the mice. In the combined exposure of DON and OG, OG partially mitigated the intestinal inflammation induced by DON.","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 5","pages":"515-525"},"PeriodicalIF":0.0,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12090014/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ethical Frameworks for Data-Driven Environmental Health Studies in the AI Era. 人工智能时代数据驱动的环境健康研究的伦理框架

Environment & Health Pub Date : 2025-02-06 eCollection Date: 2025-05-16 DOI: 10.1021/envhealth.4c00273

Miao Yu, Mingliang Fang, Bin Wang

引用次数: 0

Ethical Frameworks for Data-Driven Environmental Health Studies in the AI Era 人工智能时代数据驱动的环境健康研究的伦理框架

Environment & Health Pub Date : 2025-02-05 DOI: 10.1021/envhealth.4c0027310.1021/envhealth.4c00273

Miao Yu*, Mingliang Fang and Bin Wang,

引用次数: 0

In Vivo Pathogenicity Characterization of Viable Opportunistic Fungi Aspergillus thermomutatus and Rhodotorula mucilaginosa Recovered from Maritime Antarctic Permafrost. 南极海洋永久冻土带生活条件真菌温变曲霉和粘液红曲霉的体内致病性研究

Environment & Health Pub Date : 2025-02-03 eCollection Date: 2025-04-18 DOI: 10.1021/envhealth.4c00213

Eldon Carlos Q Gomes, Vívian N Gonçalves, Marliete C da Costa, Gustavo José C D Freitas, Daniel A Santos, Susana Johann, Jefferson Bruno S Oliveira, Tatiane A D Paixão, Peter Convey, Luiz H Rosa

{"title":"In Vivo Pathogenicity Characterization of Viable Opportunistic Fungi Aspergillus thermomutatus and Rhodotorula mucilaginosa Recovered from Maritime Antarctic Permafrost.","authors":"Eldon Carlos Q Gomes, Vívian N Gonçalves, Marliete C da Costa, Gustavo José C D Freitas, Daniel A Santos, Susana Johann, Jefferson Bruno S Oliveira, Tatiane A D Paixão, Peter Convey, Luiz H Rosa","doi":"10.1021/envhealth.4c00213","DOIUrl":"https://doi.org/10.1021/envhealth.4c00213","url":null,"abstract":"In this study, we evaluated the pathogenic potential of the fungi Aspergillus thermomutatus and Rhodotorula mucilaginosa obtained from maritime Antarctic permafrost using in vivo experiments on immunocompromised BALB/c mice. Despite the low mortality observed, immunosuppressed animals infected with A. thermomutatus and R. mucilaginosa exhibited fluctuations in body mass and induced changes in the neuropsychiatric state of the mice. Fungi were recovered from the lungs, spleen, blood, and brain of infected mice at densities similar to but slightly lower than the inoculum up to 5 days post-inoculation. A. thermomutatus infection induced an inflammatory process in the lungs of infected BALB/c mice. In the target organs of animals infected with R. mucilaginosa, a notable fungal load was detected in the brains of infected animals. These results suggest that viable isolates of fungi such as A. thermomutatus and R. mucilaginosa originating from Antarctic permafrost, which is exposed to increasing melt caused by rising temperatures in the region, may present significant pathogenic potential. This highlights that climate change in Antarctica may facilitate the release and dispersal of fungi and other pathogenic microorganisms capable of infecting humans and animals.","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 4","pages":"436-442"},"PeriodicalIF":0.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12012655/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Vivo Pathogenicity Characterization of Viable Opportunistic Fungi Aspergillus thermomutatus and Rhodotorula mucilaginosa Recovered from Maritime Antarctic Permafrost 南极海洋永久冻土带生活条件真菌温变曲霉和粘液红曲霉的体内致病性研究

Environment & Health Pub Date : 2025-02-02 DOI: 10.1021/envhealth.4c0021310.1021/envhealth.4c00213

Eldon Carlos Q. Gomes, Vívian N. Gonçalves, Marliete C. da Costa, Gustavo José C. d. Freitas, Daniel A. Santos, Susana Johann, Jefferson Bruno S. Oliveira, Tatiane A. d. Paixão, Peter Convey and Luiz H. Rosa*,

{"title":"In Vivo Pathogenicity Characterization of Viable Opportunistic Fungi Aspergillus thermomutatus and Rhodotorula mucilaginosa Recovered from Maritime Antarctic Permafrost","authors":"Eldon Carlos Q. Gomes, Vívian N. Gonçalves, Marliete C. da Costa, Gustavo José C. d. Freitas, Daniel A. Santos, Susana Johann, Jefferson Bruno S. Oliveira, Tatiane A. d. Paixão, Peter Convey and Luiz H. Rosa*, ","doi":"10.1021/envhealth.4c0021310.1021/envhealth.4c00213","DOIUrl":"https://doi.org/10.1021/envhealth.4c00213https://doi.org/10.1021/envhealth.4c00213","url":null,"abstract":"In this study, we evaluated the pathogenic potential of the fungi Aspergillus thermomutatus and Rhodotorula mucilaginosa obtained from maritime Antarctic permafrost using in vivo experiments on immunocompromised BALB/c mice. Despite the low mortality observed, immunosuppressed animals infected with A. thermomutatus and R. mucilaginosa exhibited fluctuations in body mass and induced changes in the neuropsychiatric state of the mice. Fungi were recovered from the lungs, spleen, blood, and brain of infected mice at densities similar to but slightly lower than the inoculum up to 5 days post-inoculation. A. thermomutatus infection induced an inflammatory process in the lungs of infected BALB/c mice. In the target organs of animals infected with R. mucilaginosa, a notable fungal load was detected in the brains of infected animals. These results suggest that viable isolates of fungi such as A. thermomutatus and R. mucilaginosa originating from Antarctic permafrost, which is exposed to increasing melt caused by rising temperatures in the region, may present significant pathogenic potential. This highlights that climate change in Antarctica may facilitate the release and dispersal of fungi and other pathogenic microorganisms capable of infecting humans and animals.","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 4","pages":"436–442 436–442"},"PeriodicalIF":0.0,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/envhealth.4c00213","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143842297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wastewater-Based Surveillance of Respiratory Syncytial Virus Reveals a Temporal Disconnect in Disease Trajectory across an Active International Land Border. 基于废水的呼吸道合胞病毒监测揭示了跨越活跃的国际陆地边界的疾病轨迹的时间脱节。

Environment & Health Pub Date : 2025-01-29 eCollection Date: 2025-04-18 DOI: 10.1021/envhealth.4c00168

Mackenzie Beach, Ryland Corchis-Scott, Qiudi Geng, Ana M Podadera Gonzalez, Owen Corchis-Scott, Ethan Harrop, John Norton, Andrea Busch, Russell A Faust, Bridget Irwin, Mehdi Aloosh, Kenneth K S Ng, R Michael McKay

{"title":"Wastewater-Based Surveillance of Respiratory Syncytial Virus Reveals a Temporal Disconnect in Disease Trajectory across an Active International Land Border.","authors":"Mackenzie Beach, Ryland Corchis-Scott, Qiudi Geng, Ana M Podadera Gonzalez, Owen Corchis-Scott, Ethan Harrop, John Norton, Andrea Busch, Russell A Faust, Bridget Irwin, Mehdi Aloosh, Kenneth K S Ng, R Michael McKay","doi":"10.1021/envhealth.4c00168","DOIUrl":"https://doi.org/10.1021/envhealth.4c00168","url":null,"abstract":"Conventional metrics for tracking infectious diseases, including case and outbreak data and syndromic surveillance, can be resource-intensive, misleading, and comparatively slow with prolonged data collection, analysis and authentication. This study examined the 2022-2023 Respiratory Syncytial Virus (RSV) season in a contiguous metropolitan area connected by an active international land border, affording an opportunity for comparison of the respiratory virus season spanning two independent public health jurisdictions. Time-lagged cross correlation and qualitative examination of the wastewater signals showed that the peak of the Detroit (MI, USA) RSV season predated the peak in Windsor (ON, Canada) by approximately 5 weeks. A strong positive relationship was observed between RSV N-gene concentrations in wastewater and hospitalization rates in Windsor-Essex (Kendall's τ = 0.539, p ≤ 0.001, Spearman's ρ = 0.713, p ≤ 0.001) as well as Detroit (Kendall's τ = 0.739, p ≤ 0.001, Spearman's ρ = 0.888, p ≤ 0.001). This study demonstrated that wastewater surveillance can reveal regional differences in infection dynamics between communities and can provide an independent measure of the prevalence of RSV, an underreported disease. These findings support the use of wastewater surveillance as a cost-effective tool in monitoring of RSV to enhance existing surveillance systems and to better inform public health disease mitigation strategies.","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 4","pages":"425-435"},"PeriodicalIF":0.0,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12012658/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144045338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comprehensive Characterization of Organic Chemicals Associated with Urban Particulate Matter in China 中国城市颗粒物有机化学综合表征

Environment & Health Pub Date : 2025-01-29 DOI: 10.1021/envhealth.4c0022910.1021/envhealth.4c00229

Linlin Yao, Yunhe Guo, Yi Wang, Junya Li, Jiazheng Sun, Yanna Liu*, Jianbo Shi, Guangbo Qu* and Guibin Jiang,

{"title":"Comprehensive Characterization of Organic Chemicals Associated with Urban Particulate Matter in China","authors":"Linlin Yao, Yunhe Guo, Yi Wang, Junya Li, Jiazheng Sun, Yanna Liu*, Jianbo Shi, Guangbo Qu* and Guibin Jiang, ","doi":"10.1021/envhealth.4c0022910.1021/envhealth.4c00229","DOIUrl":"https://doi.org/10.1021/envhealth.4c00229https://doi.org/10.1021/envhealth.4c00229","url":null,"abstract":"Atmospheric particulate matter (PM) is considered a health hazard; however, the inadequate identification of the components of PM limits our understanding of its specific toxic pollutants. Herein, by combining three extraction solvents with different polarities (dichloromethane, hexane, and acetonitrile) and three ionization modes (electron ionization and the positive and negative modes of electrospray ionization), we comprehensively analyzed the organic chemicals in the PM2.5 and PM10 samples collected during summer and winter in Beijing. Suspect screening was facilitated by comparison with the mzCloud and the National Institute of Standards and Technology databases for tentatively characterizing chemical identities. Results showed that more compounds were identified in the winter PM2.5/PM10 samples than in the summer samples and that PM2.5 contained a greater number of chemicals than PM10. Based on peak areas of compounds, the predominant pollutants in the winter PM2.5/PM10 samples were phenols, amines, and aromatic compounds; however, significantly high responses of one phenol and two ester compounds were detected in the summer PM2.5/PM10 samples. Based on the Tox21 toxicological database, a total of 60 identified pollutants were associated with 28 biological targets, and ∼50% of the active compounds were phenolic and aromatic compounds. The biological targets most affected by these pollutants were related to metabolic homeostasis, reproduction, and developmental functions. This study underscores the importance of a multiapproach analysis in comprehensively identifying environmental pollutants and highlights the potential health risks posed by PM.","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 5","pages":"504–514 504–514"},"PeriodicalIF":0.0,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/envhealth.4c00229","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144067832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0