Environment & Health最新文献

{"title":"","authors":"Si-Wei Zhang, Yanhui Hao, Jia-Xin Chen, Si-Yue Chen, Wen Yu, Jia-Ying Wu, Cheng Li*, Xia Meng* and Yan-Ting Wu*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 7","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":0.0,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/envhealth.4c00185","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144646280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Opportunities and Challenges of Multiomics for Discovery and Monitoring of Human Pathogens.","authors":"Zoe Turner, Andrei P Drabovich","doi":"10.1021/envhealth.5c00040","DOIUrl":"10.1021/envhealth.5c00040","url":null,"abstract":"<p><p>Detection and monitoring of pathogens is a central aspect of maintaining public health. Rare and neglected zoonotic viruses have the potential to evolve and expand exponentially, leading to unforeseen outbreaks, epidemics, and pandemics. The emerging multiomics and meta-omics techniques and workflows, such as proteogenomics and meta-genomics, offer the potential for the detection of harmful pathogens, as well as opportunities for the discovery of previously unknown bacterial, parasitic, or viral pathogens. Multiomics and meta-omics workflows provide molecular information for tracking pathogens and understanding the effectiveness of spread mitigation strategies. In addition to environmental monitoring, multiomics and meta-omics approaches have the potential for clinical applications and in-depth characterization of novel pathogens. In this review, we discuss recent applications of multiomics and meta-omics techniques, their advantages over traditional methods, and their potential implementations in biomedical research, environmental studies, and healthcare. We critically assess the benefits and challenges of multiomics and meta-omics studies and discuss their future perspectives.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 10","pages":"1139-1153"},"PeriodicalIF":6.3,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12538332/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145348907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxidation Mechanism and Kinetics of γ‑Terpinene in the Indoor Atmosphere.","authors":"Ahmad Jahanzab, Zihao Fu, Hui Zhao, Jingwen Chen, Hong-Bin Xie","doi":"10.1021/envhealth.5c00100","DOIUrl":"10.1021/envhealth.5c00100","url":null,"abstract":"<p><p>γ-terpinene is widely used in personal care and household cleaning products. The gas-phase oxidation mechanism of γ-terpinene is essential for understanding its influence on atmospheric chemistry and its implications for human health. Utilizing quantum chemical calculations and computational toxicology simulations, we examined the •OH-mediated atmospheric transformation and toxicological progression of γ-terpinene in the indoor environment. The results indicate that •OH additions are the dominant pathways for the reaction of •OH + γ-terpinene. The most favorable reactive intermediates formed from the •OH-addition reactions subsequently react with O₂ to form hydroxy γ-terpinene peroxy radicals (OH-γ-terp-RO₂•). The formed OH-γ-terp-RO₂• follows concerted peroxy radical (RO₂•) and alkoxy radical (RO•) modulated autoxidation, providing a new case for such a mechanism beyond the well-known only RO₂-driven autoxidation mechanism. Our findings also reveal that the transformation of OH-γ-terp-RO₂• demonstrates the competitive nature of the cyclization pathway indoors, with dicarbonyl formation, a rarely observed process in hydroxy terpene RO₂ reaction systems. Toxicological evaluations further indicate that a significant proportion of transformation products (TPs) display higher mutagenicity, carcinogenicity, skin sensitization, and irritation to eyes compared to γ-terpinene. The detailed mechanism for •OH-initiated γ-terpinene advances our understanding of RO₂• and RO• chemistry while also emphasizing the potential adverse effects that arise from the interaction of these chemicals in indoor environments.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 10","pages":"1231-1244"},"PeriodicalIF":6.3,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12538334/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145348167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liquid Crystal Monomers as Emerging Contaminants: Contaminated Distribution, Environmental Behavior, Detection Technologies, and Future Challenges.","authors":"Xinyue Li, Pengfei Li, Yanke Lu, Junfa Yin, Hongyuan Yan","doi":"10.1021/envhealth.5c00071","DOIUrl":"10.1021/envhealth.5c00071","url":null,"abstract":"<p><p>Liquid crystal monomers (LCMs) are synthetically produced organic compounds widely used in liquid crystal displays (LCDs) and have recently emerged as a significant environmental concern. Characterized by environmental persistence, bioaccumulation, toxicity, and long-range transport, LCMs are now recognized as emerging contaminants with the potential to pose serious ecological and human health risks. In recent years, as the researches grows increasingly, LCMs have been confirmed to be ubiquitous in a variety of environmental media and biological samples worldwide. This has led to more research on the toxicology, environmental behavior and environmental governance of LCMs. However, due to the ambiguity of contamination levels and environmental distribution, there remains a substantial gap in data on the human health impacts of LCMs exposure. This review provides a comprehensive overview of recent literature on LCMs, with a particular focus on their environmental distribution, biological toxicity, bioaccumulation pathways, potential health risks, as well as advances in sample pretreatment and detection technologies. We also discuss key challenges and future research directions in reducing LCMs environmental release and improving detection technologies, highlighting the necessity of interdisciplinary approaches to better assess and mitigate the risks of LCMs. This review provides critical insights into the ecotoxicology, health effect, and detection of LCM pollution.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 10","pages":"1125-1138"},"PeriodicalIF":6.3,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12538329/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145348903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aging Enhances the Ecotoxicological Effects of Biobased Microplastic Poly(Lactic Acid) and Its Adsorbed Tris(1-chloro-2-propyl)phosphate on Mussels.","authors":"Zhen Zhong, Menghong Hu, Fei Yu, Peiwen Yang, Li'ang Li, Jiacheng Wang, Youji Wang","doi":"10.1021/envhealth.5c00035","DOIUrl":"10.1021/envhealth.5c00035","url":null,"abstract":"<p><p>The biodegradable plastic poly-(lactic acid) (PLA) has been widely used to reduce plastic pollution in the environment, but PLA does not readily degrade completely and is more prone to form microplastics (MPs) and age. In this study, MP-PLA was aged by simulating the behavior of the marine environment and combined with plastic additive tris-(1-chloro-2-propyl)-phosphate (TCPP) according to their susceptibility to adsorb environmental pollutants. Mussels were the exposed subjects, and exposure concentrations of MPs and TCPP were set at 0.2 mg/L, 1 mg/L, and 0.5 μg/L, respectively. The ecotoxicity of PLA, aged-PLA, TCPP, and TCPP+aged-PLA was compared based on the result that aged-PLA could adsorb more TCPP. Biomarker assays revealed that mussels ingesting and accumulating contaminants underwent a severe oxidative (ROS) and immune stress response in the organism, with disruption of energy metabolism for energy supply, leading to apoptosis, resulting in tissue damage, and disruption of the homeostasis of the symbiotic intestinal microbiota. Comparisons showed that aging enhanced the adverse effects of PLA and ecotoxicological effects are further exacerbated by the adsorption of TCPP on aged-PLA. Therefore, with the widespread use of degradable plastics, long-term environmental impacts such as incomplete degradation and release of additives must be a concern.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 10","pages":"1245-1260"},"PeriodicalIF":6.3,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12538331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145348750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review of the Evidence of the Toxicity of Chemical Substances Included in the European Union Ambient Air Quality and Drinking Water Directives: Perspectives for Health Impact Assessments","authors":"Hans Orru*,&nbsp;Wasif Raza,&nbsp;Francesco Forastiere,&nbsp;Joseph Spadaro,&nbsp;Henrik Olstrup,&nbsp;Nataša Dragic,&nbsp;Ivana Radic,&nbsp;Sanja Harhaji,&nbsp;Sanja Bijelovic,&nbsp;Lars Modig,&nbsp;Mike Holland,&nbsp;Sandrine Andres,&nbsp;Adrien Troise,&nbsp;Antoine Guion,&nbsp;Alicia Gressent,&nbsp;Jörg Schullehner and Johan Nilsson Sommar,&nbsp;","doi":"10.1021/envhealth.4c00277","DOIUrl":"https://doi.org/10.1021/envhealth.4c00277","url":null,"abstract":"<p >The European Union (EU) Ambient Air Quality Directive (AAQD) and Drinking Water Directive (DWD) are aimed at maintaining and improving air quality and ensuring high standards for potable water across the EU. Besides several other indicators, the AAQD and DWD consist of chemical parameters (substances or substance groups) that are regulated within this framework. All the substances are associated with various health outcomes, and many of them are classified as carcinogenic or probably/possibly carcinogenic with causal links. To quantify the health burden of the chemical substances included in the AAQD and DWD, we need information regarding population exposure, current baseline mortality/morbidity rates in the populations, and exposure–response functions (ERFs) or unit risks (URs) from previous epidemiological studies. During this study, we analyzed the availability of ERFs or URs and discussed their applicability in health impact assessments (HIAs). From the HIA perspective, ERFs─in terms of relative risk (RR), standardized mortality ratio (SMR), odds ratio (OR), or UR data─were available for many of the analyzed substances. However, for some substances such as acrylamide, antimony, boron, chlorate and chlorite, copper, microcystin-LR, and selenium, no risk measures could be identified. The aim of this study is to derive ERFs, which will allow HIAs for a larger number of chemicals when exposure data and baseline mortality/morbidity data are available. Currently, HIAs have largely focused only on main ambient pollutants such as particulate matter (PM₁₀), fine particulate matter (PM_2.5), nitrogen oxides (NO_X), and ozone (O₃). In contrast, health risks related to exposure to chemicals are much more diverse, and the health burdens should be quantified to a much greater extent.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 9","pages":"970–997"},"PeriodicalIF":6.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/envhealth.4c00277","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145094417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbial Metabolites: An Underexploited Arsenal to Combat Antibiotic Resistance Dissemination.","authors":"Xinyi Li, Litao Wei, Ling Li, Haining Huang, Yinguang Chen","doi":"10.1021/envhealth.5c00183","DOIUrl":"10.1021/envhealth.5c00183","url":null,"abstract":"<p><p>The relentless global proliferation of antibiotic resistance genes (ARGs) poses a profound threat to public health and ecological stability. Unlike static chemical pollutants, ARGs propagate through horizontal gene transfer (HGT)a dynamic biological process that facilitates the cross-taxa dissemination of resistance determinants among environmental, commensal, and pathogenic microbes. This ecological amplification of resistance undermines both clinical therapies and environmental resilience, rendering the understanding and control of ARG dissemination a critical challenge in the fight against antibiotic resistance.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 10","pages":"1121-1124"},"PeriodicalIF":6.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12538325/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145348905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Organophosphate Flame Retardants, Obesity, and Depressive Symptoms among 1019 Young Healthy Men.","authors":"Qingqing Xu, Keyi Si, Wenqing Wang, Yaping Li, Yu Zhang, Audrey J Gaskins, Carmen Messerlian, Vicente Mustieles, Cheng-Liang Xiong, An Pan, Huiling Shao, Surong Mei, Yi-Xin Wang","doi":"10.1021/envhealth.5c00051","DOIUrl":"10.1021/envhealth.5c00051","url":null,"abstract":"<p><p>Organophosphate flame retardants (OPFRs) can increase fat accumulation and exert neurotoxic effects. In this study, we enrolled 1019 young men who provided 3,550 urine samples over a 3-month follow-up period. We measured nine OPFR metabolite concentrations in urine samples and assessed depressive symptoms using the Beck Depression Inventory questionnaire. In the fully adjusted linear regression models, a 2.7-fold increase in urinary diphenyl phosphate (DPHP) concentrations was associated with a 0.44 unit (95% confidence interval (CI): 0.06, 0.82) higher depressive symptom scores. When men were categorized as having any depressive symptoms (score: > 10 vs ≤ 10), Poisson regression models showed an increased risk of depression across DPHP tertiles (<i>P</i> _trend = 0.08). Further, we found stronger associations between urinary OPFR metabolite concentrations and depressive symptom scores among men with a higher waist circumference, waist-hip ratio, or waist-height ratio (<i>P</i> _interaction < 0.15). The machine learning algorithm identified three different patterns of obesity, and the strongest association between urinary DPHP concentrations and depressive symptom scores was observed among men with a waist-hip ratio of ≥ 0.89 and a body mass index of <24 kg/m². In summary, exposure to OPFRs may be associated with depressive symptoms among young men, especially in those with abdominal obesity.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 10","pages":"1220-1230"},"PeriodicalIF":6.3,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12538333/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145348908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microplastic Contamination of Human Sperm before In Vitro Fertilization Warrants Attention for Early Life Exposure Risks.","authors":"Yu Su, Chenqi Yang, Hong Liao, Zhenbo Zhang, Yuan Xu, Yang Zhao, Yanhua Wang, Dayong Wang, Lei Wang, Rong Ji, Xiaoli Zhao, Baoshan Xing","doi":"10.1021/envhealth.5c00098","DOIUrl":"10.1021/envhealth.5c00098","url":null,"abstract":"<p><p>The global prevalence of infertility boosts the demands for assisted reproduction technology (ART) and medical plasticware for processing human reproductive cells. The direct exposure risks of these cells to microplastic (MPs) potentially released from the plasticware, especially when sperm is extracted by mincing testicular tissues with sharp tools, remain unknown. Also, there are methodological challenges in confirming the actual occurrence and visualizing the original morphology of MPs in the retrieved sperm samples. Here, we identified sub-10-μm polystyrene (PS) MPs with protein coronas in mechanically retrieved sperm specimens on PS plastic Petri dishes through optical photothermal infrared imaging. The particles were mainly generated by the tools that induced local polymer cutting deformation on the dishes, and a few originated from resin particles remaining on the dishes during manufacture. Each 5 mm scratch by the tools could produce 2.0-13 MPs (1.9-560 μm), depending on the extent of surface damage to the dishes. Most of the MPs (41.7-81.5%) derived from scratching could be retrieved along with sperm cells, with an estimated exposure dose of 100-22,000 particles/mL. We offered reliable evidence of direct human sperm exposure to MPs and advocate limiting plasticware use to reduce early life health risks for ART-conceived babies.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 10","pages":"1208-1219"},"PeriodicalIF":6.3,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12538326/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145348906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced Levels of a Broad Range of Synthetic Antioxidants in Human Hands after Playing Basketball: Implications for Dermal Exposure.","authors":"Jiale Liu, Wenzhuo Xu, Pinjie Su, Yuna Li, Cuijuan Jiang, Xiaoxia Feng, Qingzhe Zhang, Qifan Liu, Guangbo Qu, Runzeng Liu","doi":"10.1021/envhealth.5c00116","DOIUrl":"10.1021/envhealth.5c00116","url":null,"abstract":"<p><p>Synthetic antioxidants (SAs) are additives used to inhibit the oxidative degradation of materials. Due to their potential toxicity to humans, studies on identifying human exposure pathways of SAs are important. Herein, a broad range of SAs were analyzed in hand wipe samples collected before and after basketball, with 37 SAs detected. Playing basketball significantly increases the concentration of SAs in human hands, with a median concentration of ΣSAs increased from 629 ng/wipe before playing basketball to 1.51 × 10³ ng/wipe after playing basketball (<i>p</i> < 0.05). Tris-(2,4-di-<i>tert</i>-butylphenyl) phosphate (AO168O) was the predominant chemical, with the median concentration enhanced from 310 to 767 ng/wipe. The estimated daily exposure via the dermal exposure pathway of SAs was assessed to be 19.6 ng/kg bw/day after basketball, indicating minimal risks. Handwashing experiments demonstrated that most SAs can be removed from hands with tap water (removal efficiency: 19.4-34.0%) and liquid soap (removal efficiency: 32.3-81.8%) (<i>p</i> < 0.05), while the removal efficiency of AO168O was low, contributing to its high residual levels in human hands. This is the first study to elucidate the dermal exposure to SAs via playing basketball, further indicating the importance of washing hands to reduce SA exposure.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 10","pages":"1199-1207"},"PeriodicalIF":6.3,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12538327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145348784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}