Environment & Health最新文献

{"title":"Early-Life Ozone Exposure and Childhood Allergic Rhinitis: Critical Exposure Windows, Exposure-Response Relationships, and Protective Modifiers.","authors":"Tianyi Chen, Zhiping Niu, Dan Norback, Tippawan Prapamontol, Magnus Svartengren, Erjia Ge, Xin Zhang, Chan Lu, Ling Zhang, Wei Yu, Xiaohong Zheng, Tingting Wang, Xia Meng, Jing Wei, Zafar Fatmi, Zhiwei Liu, Yanyi Xu, Zhuohui Zhao","doi":"10.1021/envhealth.5c00319","DOIUrl":"https://doi.org/10.1021/envhealth.5c00319","url":null,"abstract":"<p><p>Childhood allergic rhinitis (AR) is associated with ozone (O₃) exposure, yet the sensitive exposure window (SEW) remains unclear. This multicenter survey of 38,176 children aged 3-6 years across 7 Chinese cities (2019-2020) estimated satellite-based individual maximum daily 8 h average O₃ exposure. The SEW and its exposure-response (<i>E</i>-<i>R</i>) relationship were assessed. Doctor-diagnosed AR prevalence was 11.9%. Average O₃ exposure from prenatal to AR onset ranged from 67.5 to 76.7 μg/m³. The critical SEW was identified as infancy, specifically 30-38 weeks postnatal (7.5-9.5 months). Per interquartile range (IQR) (10.1 μg/m³) increase in O₃, the adjusted odds ratio was 1.29 (95% CI: 1.22-1.36), independent of PM₂.₅. The <i>E</i>-<i>R</i> relationship was nonlinear, J-shaped, and threshold-free. The SEW effect was stronger in southern cities and mitigated by ≥6 months of exclusive breastfeeding. In conclusion, O₃ significantly increases AR risk, with 7.5-9.5 months postnatal being a critical SEW, especially in exclusive breastfeeding <6 months and southern regions.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"4 4","pages":"630-640"},"PeriodicalIF":6.3,"publicationDate":"2025-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13097164/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147783278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current Issues Related to Combustion Byproducts & Human Health: A Summary of the 18th International PIC Congress.","authors":"Julia E Rager, Sarah L Miller, Kate Hoffman, Yong Ho Kim, Brian Gullett, Toddi Steelman, Daniel Jaffe, Linda S Birnbaum, Miriam M Calkins, Marc Durno, Heather M Stapleton","doi":"10.1021/envhealth.5c00246","DOIUrl":"10.1021/envhealth.5c00246","url":null,"abstract":"<p><p>The 18th International Congress on Combustion Byproducts and Human Health Effects (PIC2024) was held in Durham, North Carolina on May 20th-22nd, 2024. The overall goal of this conference, typically organized biannually, is to bring together scholars and researchers from diverse fields including chemistry, toxicology, engineering, epidemiology, and occupational and public health, and from various sectors (academia, government, and industry) to engage on new and emerging issues related to combustion processes, human exposure, and potential health risks. The theme of the 18th International Congress was \"Fire Emissions & Community Impacts at the Wildland Urban Interface and Disaster Sites.\" Specific focus and emphasis was placed on new research concerning wildland fires, climate change, firefighter exposures, and data collected following the East Palestine train derailment in Ohio. Plenary speakers included Drs. Toddi Steelman (Duke University), Daniel Jaffe (University of Washington), Miriam Calkins (NIOSH), Mark Durno (U.S. EPA), and Linda S. Birnbaum (NIEHS, retired). This report summarizes the primary research highlighted during the conference, major discussion points raised, and areas recommended for future research.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"4 3","pages":"341-351"},"PeriodicalIF":6.3,"publicationDate":"2025-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13010299/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147515136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Environment & Health</i> Best Paper and Outstanding Reviewer Awards 2023-2024.","authors":"Guibin Jiang, Qian Liu, K W Michael Siu, Yuming Guo, Maoyong Song","doi":"10.1021/envhealth.5c00588","DOIUrl":"https://doi.org/10.1021/envhealth.5c00588","url":null,"abstract":"","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 11","pages":"1261-1263"},"PeriodicalIF":6.3,"publicationDate":"2025-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12645297/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145640565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PM_2.5 Composition Exposure and Cardiovascular Disease: A Multicohort Study Integrating Disease Incidence and Biomarkers.","authors":"Jiajun Luo, Yuqing Yang, Zhihao Jin, Christopher O Olopade, Habibul Ahsan, Jayant M Pinto, Briseis Aschebrook-Kilfoy","doi":"10.1021/envhealth.5c00203","DOIUrl":"10.1021/envhealth.5c00203","url":null,"abstract":"<p><p>The chemical composition of PM_2.5 differentially influences cardiovascular risk, but evidence integrating clinical and subclinical end points is limited. Here, we evaluated the long-term exposure to seven PM_2.5 components in 255,394 All of Us participants (2017-2022) for incident myocardial infarction (MI) and stroke, and in 648 COMPASS participants (2015-2019) for troponin, TNF-α, and MCP-1. Our findings revealed that organic matter (OM), sulfate (SO₄ ^2-), and sea-salt (SS) showed consistent associations. For instance, per interquartile-range OM: hazard ratios of 1.33 (95% CI, 1.07-1.67) for MI and 1.40 (95% CI, 1.08-1.81) for stroke; odds ratio of 1.40 (95% CI, 1.01-1.94) for troponin elevation and 1.40 (95% CI, 1.03-1.90) for TNF-α elevation; linear coefficient of 0.40 (95% CI, 0.18-0.61) for MCP-1. In mixture analysis, OM, SO₄ ^2-, and SS each contributed ≥ 19% of the overall association for all outcomes. We found that long-term exposure to specific PM_2.5 components, particularly OM, SO₄ ^2-, and SS, is associated with increased cardiovascular risk and subclinical dysfunction, underscoring the need for component-based air quality regulation.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"4 3","pages":"533-545"},"PeriodicalIF":6.3,"publicationDate":"2025-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13010298/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147515169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transmission, Health Risks and Attenuation Strategies of Antibiotic Resistance Genes in Soil-Plant Systems.","authors":"Zekai Li, Miao Han, Xinyi Xu, Xiaojie Hu, Chao Qin, Yanzheng Gao","doi":"10.1021/envhealth.5c00385","DOIUrl":"10.1021/envhealth.5c00385","url":null,"abstract":"<p><p>Antibiotic resistance genes (ARGs) represent emerging environmental contaminants that pose a significant global threat to human health. ARGs can spread along the food chain via the soil-plant system, ultimately impacting human health. Agricultural practices, particularly the application of manure, wastewater, and sludge, constitute major anthropogenic sources driving the occurrence and dissemination of ARGs in soils. Understanding ARG transmission within soil-plant systems is crucial for developing control strategies to mitigate associated human health risks in agroecosystems. This review synthesized the primary sources of ARGs in the soil-plant system, elucidates their transmission pathways and key influencing factors, and systematically analyzed their potential health effects alongside attenuation strategies. Finally, current research gaps and future priorities were discussed. By providing a comprehensive overview of ARG environmental behavior, fate, and risks within the soil-plant system, this work aims to inform the development of control strategies and risk mitigation measures for researchers and environmental policymakers.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"4 3","pages":"352-364"},"PeriodicalIF":6.3,"publicationDate":"2025-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13010315/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147515207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultraviolet Absorbers Exhibit Dual Modulatory Effects on Oxidative Stress Biomarkers in Exposed Populations.","authors":"Lu Bai, Zhuangzhuang Feng, Xu Zhang, Juan Li, Yawei Wang, Guibin Jiang","doi":"10.1021/envhealth.5c00404","DOIUrl":"10.1021/envhealth.5c00404","url":null,"abstract":"<p><p>Health risks due to ultraviolet absorbers (UVAs), which are emerging contaminants prevalent in plastics and consumer products, are poorly understood. This study quantified 10 UVA congeners in urinary samples from 254 Beijing residents aged 19-44 years, revealing pervasive exposure to UVAs. The specific gravity-adjusted concentrations of 10 UVAs (∑₁₀UVAs) ranged from 1.90 ng/mL to 2.03 × 10³ ng/mL (geometric mean: 43.7 ng/mL), with UV-P (20.3 ng/mL), UV-360 (11.2 ng/mL), and UV-329 (6.34 ng/mL) as dominant compounds, indicating substantial environmental bioavailability. Women showed 2.7-fold higher ∑₁₀UVAs in the summer (80.0 vs 29.3 ng/mL) and 1.7-fold higher ∑₁₀UVAs in the winter (48.6 vs 28.0 ng/mL) than men, revealing sex-dependent and season-dependent exposure. Congener-specific detection patterns indicated multiple exposure sources and differential bioaccumulation behaviors. Critically, UVA exposure showed congener-specific and nonlinear associations with oxidative stress biomarkers (OSBs). UV-329, in particular, exhibited dual pro-oxidative and antioxidant effects across all four measured urinary OSBs. Bayesian kernel machine regression (BKMR) analyses further revealed significant effect modifications by sex, season, and alcohol consumption, underscoring interactions between chemical coexposure and individual susceptibility. These results illuminate the pathways of UVA exposure, its associated health impacts, and the underlying susceptibilities in reproductive-age populations, thereby providing critical evidence to support enhanced risk management strategies for this vulnerable population.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"4 3","pages":"522-532"},"PeriodicalIF":6.3,"publicationDate":"2025-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13010291/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147515245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterizing Prenatal Exposure to Contemporary and Emerging Chemicals in a Prospective Cohort of Pregnant Women in Atlanta, Georgia.","authors":"Kaegan Ortlund, Anne L Dunlop, Dana Boyd Barr, Donghai Liang, Youran Tan, Jessie P Buckley, Kurunthachalam Kannan, Madeline Chandler, Mengyuan Ren, Stephanie M Eick","doi":"10.1021/envhealth.5c00347","DOIUrl":"https://doi.org/10.1021/envhealth.5c00347","url":null,"abstract":"<p><p>Epidemiological evidence links chemical exposure during pregnancy to adverse maternal and child health outcomes, yet only a fraction of chemicals used in commerce in the United States (US) are biomonitored nationally and have undergone comprehensive safety review. In a cohort of pregnant women in Atlanta, an expansive panel of contemporary and emerging chemicals comprised of 113 analytes in 12 chemical groups were measured in midpregnancy urine samples (<i>N</i> = 168, 2016-2019). We assessed temporal trends in concentrations and performed latent profile analysis jointly with log-binomial regression to uncover patterns of chemical exposures in our population and their associations with sociodemographic, temporal, and behavioral predictors. Parabens, bactericides, and di (2-ethylhexyl phthalate) metabolite concentrations (ng/mL) decreased during our study period. Fungicide and herbicides and phthalate, organophosphorus flame retardant, and polycyclic aromatic hydrocarbon metabolite concentrations (ng/mL) spiked in warmer months. Latent profile analysis identified two distinct profiles: women with moderate levels of most analytes and women with low levels of most analytes. We observed no association between predictors and profile membership. However, chemical groups were significantly associated with season, indicators of low socioeconomic status, and home characteristics and behaviors in linear regression models. We highlight the need for national surveillance systems to incorporate biomonitoring that capture emerging exposures across diverse populations.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"4 2","pages":"331-340"},"PeriodicalIF":6.3,"publicationDate":"2025-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12930317/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147291240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatotoxicity Prediction and Multi-omics Reveal Mitochondrial and Lipid Metabolic Dysregulation in PM _2.5 -Induced Liver Fibrosis","authors":"Hiu‐Lok Ngan, Jialing Zhang, Yi Chen, Yuanyuan Song, Zenghua Qi, Zhu Yang, Hongyuan Yan, Zongwei Cai","doi":"10.1021/envhealth.5c00401","DOIUrl":"https://doi.org/10.1021/envhealth.5c00401","url":null,"abstract":"","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147331908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extreme Cold Events and Adolescent Mental Health: Evidence from a National School-Based Survey in China.","authors":"Yaqi Wang, Jiajia Dang, Jianhui Guo, Di Shi, Ning Ma, Xinyao Lian, Shan Cai, Yunfei Liu, Ziyue Chen, Yihang Zhang, Jiaxin Li, Tianyu Huang, Tianjiao Chen, Guangrong Zhu, Peijin Hu, Jun Ma, Jing Li, Yi Song","doi":"10.1021/envhealth.5c00287","DOIUrl":"10.1021/envhealth.5c00287","url":null,"abstract":"<p><p>Adolescent mental health issues are a growing public health concern, and extreme temperature events (ETEs) driven by climate change may exacerbate these challenges. However, the impact of cold spells, a common ETE, on adolescent mental health remains unclear. The study aims to explore the impacts of cold spells, defined with different intensities and durations, on adolescent mental health across China while also establishing risk-driven thresholds for cold spells and identifying vulnerable subpopulations. The data was derived from the 2019 survey cycle of the Chinese National Surveillance on Students' Constitution and Health, conducted between September and December and encompassing 149,697 adolescents aged 10-18 from 30 provinces. Cold spells were defined by using a series of cutoff temperature thresholds and durations. We assessed cold spell frequency and average cold intensity during the 12 months prior to the survey based on 0.1° × 0.1° gridded apparent temperature data. Troubled symptoms were measured using the Kessler Psychological Distress Scale and the Warwick-Edinburgh Mental Wellbeing Scale. We applied generalized linear mixed models to estimate the associations, and risk-driven thresholds for cold spells were determined based on the distribution of risk estimates. Among participants, 10.9% reported troubled symptoms. Higher cold spell frequency and average cold intensity were associated with increased odds of troubled symptoms. Risk-related thresholds were set using daily apparent temperatures at or below the fifth percentile for ≥3 days (P5_3d) or the 2.5 percentile for ≥2 days (P2.5_2d). Early warning and avoidance of cold spell exposure could potentially prevent 2.8-3.5% of troubled symptoms. Younger adolescents, female adolescents, rural residents, and those in lower GDP regions were more vulnerable. Our findings suggest that cold spells exceeding certain thresholds may adversely impact adolescent mental health, emphasizing the need for targeted cold-health early warning systems.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"4 3","pages":"502-512"},"PeriodicalIF":6.3,"publicationDate":"2025-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13010302/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147515175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Residents Face Severe Environmental Health Risks amid the Spiritual Happiness during the Spring Festival: An Evidence from Rural Northern China.","authors":"Zhi Gao, Zizhen Zhao, Hanning Wang, Zhijian Liu, Jinpei Yang, Ruiyang Ji, Jining Zhao, Dongdong Tian, Fanzheng Meng, Junlu Yang, Jianshun Zhang, Fusuo Xu","doi":"10.1021/envhealth.5c00405","DOIUrl":"https://doi.org/10.1021/envhealth.5c00405","url":null,"abstract":"<p><p>The Spring Festival, a cornerstone of Chinese cultural heritage, fosters family reunions. However, its traditional practices, such as burning incense and setting off fireworks, generate severe air pollution and pose significant health threats. This presents a critical dilemma regarding how rural residents balance the imperatives of cultural preservation against environmental health risks. This study investigates this trade-off using a multidisciplinary approach. Field measurements within a rural household during the 2024 festival revealed alarmingly high indoor PM_2.5 levels, peaking above 1000 μg/m³ on New Year's Eve and averaging over 600 μg/m³. Furthermore, a survey of 1035 residents across nine northern provinces found that 38.7% and 19.7% reported adverse physiological symptoms from high outdoor and indoor pollutant levels, respectively. Notably, of those experiencing symptoms, an overwhelming 81.8% were still willing to tolerate temporary air pollution for cultural fulfillment derived from the festival. This underscores that for these rural residents, the perceived value of traditional observance can outweigh immediate environmental health concerns. Therefore, policymakers must develop strategies that reconcile public health and cultural heritage. Effective interventions could include promoting eco-friendly fireworks, organizing pollution-free community events, and subsidizing advanced ventilation technologies.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"4 2","pages":"189-201"},"PeriodicalIF":6.3,"publicationDate":"2025-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12930316/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147291105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}