Environment & Health最新文献_第4页

Environment & Health Pub Date : 2025-06-20

Li He, Ce Liu, Hao Zhao, Zhaoru Yang, Erkai Zhou, Huan Chen, Huanhuan Wei and Bin Luo*,

引用次数: 0

Environment & Health Pub Date : 2025-06-20

Zixuan Wang, Pengyu Li, Wenkai Li, Yingnan Cao, Jianguo Liu, Lin Li, Junxin Liu and Tianlong Zheng*,

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Environment & Health Pub Date : 2025-06-20

Xiangyu Wang, Shijia Cairang, Jingjing Du*, ZeBin Wei, QiTang Wu, Ligang Hu and Ming Xu*,

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Environment & Health Pub Date : 2025-06-20

Rui-Xue Leng*, and , Wenbiao Hu*,

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Exogenous Metals Indirectly Affect Human Semen Quality via Immune Cells at Single-Cell Resolution 外源金属在单细胞分辨率下通过免疫细胞间接影响人类精液质量

IF 6.3

Environment & Health Pub Date : 2025-06-17 DOI: 10.1021/envhealth.5c00082

Nian Liu, Guangming Li, Guohuan Zhang, Yu Li, Tian-Qing Meng, Cheng-Liang Xiong, An Pan, Hua Guo, Yingying Li, Lihong Liu, Bin He, Yongguang Yin, Jianbo Shi, Yong Liang, Yi-Xin Wang*, Ligang Hu* and Guibin Jiang,

{"title":"Exogenous Metals Indirectly Affect Human Semen Quality via Immune Cells at Single-Cell Resolution","authors":"Nian Liu, Guangming Li, Guohuan Zhang, Yu Li, Tian-Qing Meng, Cheng-Liang Xiong, An Pan, Hua Guo, Yingying Li, Lihong Liu, Bin He, Yongguang Yin, Jianbo Shi, Yong Liang, Yi-Xin Wang*, Ligang Hu* and Guibin Jiang, ","doi":"10.1021/envhealth.5c00082","DOIUrl":"https://doi.org/10.1021/envhealth.5c00082","url":null,"abstract":"Immune modulation is crucial for male reproduction and fertility. Metals and metalloids (metals) have been extensively studied for their immunomodulatory effects. Whether metal exposure affects semen quality through immune modulation is unclear. In the present study, we explored the associations between exogenous metals within immune cells, immune cell proportions, and semen quality among 84 healthy men who repeatedly provided 266 semen samples over 90 days. We employed mass cytometry (CyTOF) technology to identify immune cells in semen and measured exogenous metals in these cells at the single-cell resolution. After adjusting for potential confounders, most detected metals in immune cells were inversely associated with the proportion of immune cells in semen samples (all p < 0.05), indicating the adverse effects of exogenous metals on immune cells. The proportion of immune cells showed N-shaped, nonlinear associations with sperm concentration, total count, progressive motility, and total motility. Mediation analyses showed that the percentage of indirect effects of exogenous metals on sperm quality parameters via immune cells ranged from 15.11% to 54.29%. Overall, our findings unravel the indirect effects of exogenous metal exposure on male reproductive health via immune cells, contributing valuable insights into the complex interplay between environmental factors, immune cells, and human semen quality.","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 9","pages":"1083–1093"},"PeriodicalIF":6.3,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/envhealth.5c00082","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145094368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ex Vivo Biosensor Strategy Reveals the Vascular Toxic Effects of Volatile Organic Compounds Derived from Indoor Renovation 体外生物传感器策略揭示了室内装修中挥发性有机化合物的血管毒性作用

IF 6.3

Environment & Health Pub Date : 2025-06-17 DOI: 10.1021/envhealth.5c00016

Peihao Yang, Wenting Cheng, Mengruo Wang, Mengqi Wu, Qingping Liu, Jianzhong Zhang, Yaxian Pang, Yujie Niu, Jinglong Tang* and Rong Zhang*,

{"title":"Ex Vivo Biosensor Strategy Reveals the Vascular Toxic Effects of Volatile Organic Compounds Derived from Indoor Renovation","authors":"Peihao Yang, Wenting Cheng, Mengruo Wang, Mengqi Wu, Qingping Liu, Jianzhong Zhang, Yaxian Pang, Yujie Niu, Jinglong Tang* and Rong Zhang*, ","doi":"10.1021/envhealth.5c00016","DOIUrl":"https://doi.org/10.1021/envhealth.5c00016","url":null,"abstract":"Volatile organic compounds (VOCs) are widespread indoor gaseous pollutants that are associated with vascular diseases. However, due to methodological limitations, the underlying mechanisms of VOC-induced aortic fibrosis remains unclear. To address this gap, we established a real-world indoor renovation VOC inhalation mouse model and used an innovative ex vivo biosensor assay with endothelial cells to respond to serum derived from VOC exposed mice, exploring the adverse health outcomes of total VOCs on the aorta and its potential mechanisms. The ex vivo biosensor assay confirmed that VOCs triggered phenotypic transformation of aortic smooth muscle cells via epigenetic changes in aortic endothelial cells. Mechanistically, VOCs elevated mitochondrial DNA (mtDNA) methylation by upregulating DNMT1, leading to mtDNA leakage and subsequent activation of the cGAS-STING inflammatory pathway. By integrating real-world indoor VOC exposure with mechanistic cellular analysis, this ex vivo biosensor assay offers a physiologically relevant model to elucidate the systemic vascular toxicity of complex environmental mixtures. Overall, this study revealed the molecular mechanism of indoor VOC-induced aortic fibrosis based on increased mtDNA methylation in aortic endothelial cells, which mediated the phenotypic transformation of aortic smooth muscle cells. mtDNA methylation may serve as a potential target for preventing aortic fibrosis or alleviating symptoms in affected patients. Our study highlights the urgent need for improved VOC monitoring in indoor environments and provides strategies for more precise environmental risk assessments.","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 9","pages":"1094–1106"},"PeriodicalIF":6.3,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/envhealth.5c00016","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145094367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Energy Burden and Chronic Kidney Disease: A National Study in the United States 能量负担与慢性肾脏疾病：美国的一项全国性研究

IF 6.3

Environment & Health Pub Date : 2025-06-13 DOI: 10.1021/envhealth.4c00272

Soojin Han, Ming Hu, Youqin Huang, Min Zhang, Changwei Li, Xiang-Qian Lao, Sa Liu, Thilini Wijerathna, Hee Yun Lee, Eun Young Choi, Yeon Jin Choi, Xiuxia Du and Kai Zhang*,

{"title":"Energy Burden and Chronic Kidney Disease: A National Study in the United States","authors":"Soojin Han, Ming Hu, Youqin Huang, Min Zhang, Changwei Li, Xiang-Qian Lao, Sa Liu, Thilini Wijerathna, Hee Yun Lee, Eun Young Choi, Yeon Jin Choi, Xiuxia Du and Kai Zhang*, ","doi":"10.1021/envhealth.4c00272","DOIUrl":"https://doi.org/10.1021/envhealth.4c00272","url":null,"abstract":"Energy burden, the inability to afford sufficient energy sources for basic household needs such as heating, cooling, cooking, and lighting, is one of the major social challenges in the U.S. While limited studies have examined these issues separately, to our knowledge, no study has empirically investigated the implication of energy burden for chronic kidney disease (CKD) within the U.S. context. This study aims to examine the association between energy burden and CKD prevalence across 500 U.S. cities by using nationally representative data sets. Utilizing propensity score matching and a random intercept analysis, we found that census tracts with high energy burden were significantly associated with a 0.195 higher chronic kidney prevalence [95% CI: 0.144–0.246] compared to those with low energy burden, after adjusting key observed characteristics such as living, housing, and sociodemographic conditions of census tracts. Other risk factors contributing to increased CKD prevalence included older building age, higher percentages of nonwhite populations and older adults, lower educational levels, and lower average household incomes. The findings highlight that energy burden is not merely a financial problem but rather a social determinant of CKD health and a significant risk factor for increased CKD prevalence in U.S. urban areas. Our results indicate that state and local energy assistance programs may serve as important interventions not only for improving kidney health outcomes but also for reducing health disparities in the U.S.","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 9","pages":"1074–1082"},"PeriodicalIF":6.3,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/envhealth.4c00272","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145094366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Staged Construction of Pluripotent Stem Cell Lung Models for Assessing Respiratory Toxicity of Environmental Pollutants 多能干细胞肺模型分期构建评估环境污染物的呼吸毒性

IF 6.3

Environment & Health Pub Date : 2025-06-11 DOI: 10.1021/envhealth.4c00270

Shuxian Zhang, Renjun Yang*, Nuoya Yin and Francesco Faiola,

{"title":"Staged Construction of Pluripotent Stem Cell Lung Models for Assessing Respiratory Toxicity of Environmental Pollutants","authors":"Shuxian Zhang, Renjun Yang*, Nuoya Yin and Francesco Faiola, ","doi":"10.1021/envhealth.4c00270","DOIUrl":"https://doi.org/10.1021/envhealth.4c00270","url":null,"abstract":"Due to factors such as smoking, air pollution, and an aging population, the prevention and control of chronic respiratory diseases in China are becoming more severe. Combining current epidemiological investigations, exposure to environmental pollutants such as atmospheric pollutants, persistent organic pollutants, and heavy metals may have adverse effects on lung development. Lung differentiation models are crucial tools for elucidating the process of lung development. Through the combined effect of various cell growth factors and small molecules, pluripotent stem cells are successively induced to the definitive endoderm, the anterior foregut endoderm, lung progenitor cells, and alveolar epithelial cells and eventually form matured lung alveolar organoids, revealing the complex mechanisms of lung tissue formation. This Review compares various differentiation schemes based on in vitro culture protocols and conducts in-depth discussions for the current research on the toxicity of environmental pollutants using lung differentiation models. It aims to offer model selection criteria for scientists with different research purposes and provide scientific evidence to further research the impact of environmental pollution on respiratory diseases, as well as to provide important references for protecting public health.","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 8","pages":"854–865"},"PeriodicalIF":6.3,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/envhealth.4c00270","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144840524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrating Disease Data and Toxicology Studies to Uncover the Mechanisms of Indium Tin Oxide (ITO) Nanoparticle-Induced Pulmonary Fibrosis and Develop an Adverse Outcome Pathway (AOP) Framework 整合疾病数据和毒理学研究，揭示氧化铟锡（ITO）纳米颗粒诱导肺纤维化的机制，并开发不良结果通路（AOP）框架

IF 6.3

Environment & Health Pub Date : 2025-06-11 DOI: 10.1021/envhealth.5c00053

Chunhui Zhang, Yuna Cao, Jing Qu, Haopeng Zhang, Yanting Pang, Qing Liu, Jingying Wu, Xinmo Ma, Shile Wang, Ying Ma, Daming Wu and Ting Zhang*,

{"title":"Integrating Disease Data and Toxicology Studies to Uncover the Mechanisms of Indium Tin Oxide (ITO) Nanoparticle-Induced Pulmonary Fibrosis and Develop an Adverse Outcome Pathway (AOP) Framework","authors":"Chunhui Zhang, Yuna Cao, Jing Qu, Haopeng Zhang, Yanting Pang, Qing Liu, Jingying Wu, Xinmo Ma, Shile Wang, Ying Ma, Daming Wu and Ting Zhang*, ","doi":"10.1021/envhealth.5c00053","DOIUrl":"https://doi.org/10.1021/envhealth.5c00053","url":null,"abstract":"Exposure to indium tin oxide (ITO) nanoparticles (NPs) is strongly correlated with the development of indium lung disease. Preliminary studies have explored mechanisms of ITO NP-induced pulmonary toxicity, but a gap remains in effective methods for risk assessments. To address this issue, we integrated data from population disease databases with traditional toxicology and RNA sequencing to conduct mechanistic studies and establish an adverse outcome pathway (AOP) for ITO NP-induced lung injury. Our findings demonstrate that exposure to ITO NPs induces early pulmonary fibrosis, characterized by a persistent inflammatory response in mice. Mechanistic analysis reveals that lung injury is driven by the activation of the NF-κB signaling pathway mediated by IL-17A in macrophages. In the AOP framework for ITO-induced pulmonary fibrosis, IL-17A serves as a molecular initiating event, initiating the activation of the NF-κB signaling pathway in macrophages. This activation results in the production of inflammatory cytokines (IL-1β and TNF-α) and fibrogenic factors (TGF-β1), ultimately triggering a cellular-level inflammatory response. The sustained inflammation further promotes microvascular leakage, which is a key contributor to the progression of pulmonary fibrosis. The qualitative and quantitative evaluations of supportive inconsistent evidence for MIE and KEs show that the confidence of this AOP is moderate.","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 9","pages":"1053–1073"},"PeriodicalIF":6.3,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/envhealth.5c00053","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145094365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing the Efficiency of Active Chemical Identification in Environmental and Biological Mixtures 提高环境和生物混合物中活性化学物质的鉴定效率

IF 6.3

Environment & Health Pub Date : 2025-06-10 DOI: 10.1021/envhealth.5c00153

Bo Peng, and , Mingliang Fang*,

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