Environment & Health最新文献

{"title":"Impact of Continuously Improved Air Quality on Mental Health: A Quasi-experimental Study Based on Longitudinal Observations for Chinese Adults","authors":"Xiuling Zhao*,&nbsp;Weiqi Zhou* and Andreas M. Neophytou,&nbsp;","doi":"10.1021/envhealth.5c00033","DOIUrl":"https://doi.org/10.1021/envhealth.5c00033","url":null,"abstract":"<p >Long-term exposure to fine particulate matter (PM_2.5) has been linked with adverse mental health outcomes. However, questions remain regarding the nature of lagged effects over time and by extension potential benefits over time of continued reduction in pollution. Here, we aim to estimate the long-term association between exposure to PM_2.5 and depressive symptoms in China utilizing longitudinal models for prolonged exposures as well as a quasi-experimental design utilizing data from 23151 participants over 4 longitudinal waves that occurred in 124 cities in China between 2011 to 2018. Mixed-effects models as well as distributed lag nonlinear mixed models were fitted to assess the relationship between PM_2.5 and depressive symptoms. We also assessed the effect of the Clean Air Policy (CAP) based on a quasi-experimental difference-in-differences (DID) design. The overall average PM_2.5 concentrations generally declined with time from 59.40 to 39.35 μg/m³. A 10 μg/m³ increase in PM_2.5 concentration was associated with a 0.86% increase (95% confidence interval [CI]: 0.1, 1.64%) in depression score based on the first three waves of data. However, the associations were sensitive to secular trends. Flexible exposure–lag–response analysis indicated a potentially influential window for lag-years 0–6. Reduction in PM_2.5 led to 19.51% ([CI]: 11.57%, 26.73%) and 28.18%, ([CI]: 5.87%, 45.2%) lower depressive scores in waves 3 and 4, respectively, compared to no reduction or increase in exposures. Our analysis suggests an association between PM_2.5 and depressive symptoms with potential long-term effects of air pollution as well as potential for continued benefit of air pollution reduction over time.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 9","pages":"1020–1030"},"PeriodicalIF":6.3,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/envhealth.5c00033","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145094314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic Telomere Length Response to Neurodevelopmental Arsenic Exposure: Insights into Transcriptional Regulation and Neuronal Morphogenesis","authors":"Changsong Tian,&nbsp;Qingqing Wu,&nbsp;Fang Chen,&nbsp;Yingxia Wu,&nbsp;Jun Wang,&nbsp;Aihua Zhang* and Wenjuan Wang*,&nbsp;","doi":"10.1021/envhealth.5c00026","DOIUrl":"https://doi.org/10.1021/envhealth.5c00026","url":null,"abstract":"<p >Developmental exposure to arsenic (As) has been linked to irreversible adverse health outcomes in offspring. However, the underlying molecular mechanisms remain a mystery. Here, maternal mice were exposed to As via drinking water. Subsequently, the hippocampi of their offspring were collected at different developmental stages to explore the dynamic changes during hippocampal maturation and the effects of As. Time-series RNA-seq analysis revealed a significant temporal correlation between As neurodevelopmental toxicity and the mRNA expression profile of the hippocampal region during critical postnatal developmental windows. Further, downregulation of genes associated with neurogenesis and telomere maintenance was observed. Notably, dynamic changes in hippocampal telomeres were observed in response to As exposure, with critically shortened telomeres inhibiting neural stem cells (NSCs) proliferation, impairing neuroblast maturation, and reducing the number and size of neurospheres. Additionally, the populations of BrdU⁺ and MAP2⁺ cells were decreased while GFAP⁺ cells were increased, indicating a decline in NSCs stemness. Furthermore, As exposure significantly impaired dendritic complexity in the hippocampus of mice, altered dendritic spine morphology, and disrupted synaptic ultrastructure, ultimately leading to cognitive impairment. These findings highlight the importance of analyzing telomere dynamics in environmental toxicology and offer insights into the neurotoxic mechanisms of maternal As on offspring development.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 9","pages":"1031–1042"},"PeriodicalIF":6.3,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/envhealth.5c00026","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145094315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cohort Evidence Links Phthalate Exposure to Early Onset of Puberty in Chinese Girls","authors":"Yao Yao,&nbsp;Yuchen Li,&nbsp;Meiting Wei,&nbsp;Yu Wu,&nbsp;Yingying Li,&nbsp;Xiaoyi Liu,&nbsp;Congfu Huang,&nbsp;Weiqiang Liu,&nbsp;Fengxiang Wei,&nbsp;Li Zhou,&nbsp;Ying Wen*,&nbsp;Dingyan Chen* and Eddy Y. Zeng,&nbsp;","doi":"10.1021/envhealth.5c00012","DOIUrl":"https://doi.org/10.1021/envhealth.5c00012","url":null,"abstract":"<p >Girls’ age of onset puberty has decreased globally in recent years. Emerging evidence suggests that exposure to phthalate esters (PAEs) could play a role in this trend. However, the relationship between PAE exposure and pubertal development in Chinese girls remains poorly understood. The present study aimed to address this issue by investigating the link between levels of urinary phthalate ester metabolites (mPAEs) and the risk of early puberty among 546 Chinese girls (6–8 years old) over a two-year monitoring program. Poisson regression, restricted cubic spline models, weighted quantile sum regression, and Bayesian kernel machine regression were used to assess both individual and combined effects of PAEs on pubertal development. Significant links were found between urinary concentrations of monoisobutyl phthalate (MiBP), monobutyl phthalate (MnBP), mono-(2-ethyl-5-oxohexyl) phthalate, the total of low molecular weight mPAEs, the total of nine commonly detected mPAEs, and the total of all mPAEs with the risk of early breast development (all <i>P</i>-trend &lt; 0.05). Furthermore, levels of MnBP, MiBP, low molecular weight mPAEs, and mono-(2-ethyl-5-oxohexyl) phthalate were positively associated with early menarche. Mixture effect analysis revealed incidence rate ratios of 1.64 (95% confidence interval (CI): 1.10–2.45) for early breast development and 2.33 (95% CI: 1.22–4.45) for early menarche. Short-chain mPAEs, particularly MiBP and MnBP, were identified as the major contributors to this combined effect. The present study demonstrated that exposure to PAEs, particularly short-chain PAEs, could lead to the early onset of puberty in Chinese girls.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 9","pages":"1043–1052"},"PeriodicalIF":6.3,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/envhealth.5c00012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145094316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Life Exposure to Manure-Fertilized Soil Shapes the Gut Antibiotic Resistome","authors":"Zhi-Qiang Zhai,&nbsp;Li-Kun Yang,&nbsp;Lin-Bin Zhu,&nbsp;Fang-Jie Zhao,&nbsp;Wan-Ying Xie* and Peng Wang*,&nbsp;","doi":"10.1021/envhealth.5c00074","DOIUrl":"https://doi.org/10.1021/envhealth.5c00074","url":null,"abstract":"<p >The global rise of antimicrobial resistance (AMR) presents a pressing public health challenge with agricultural practices such as the use of manure fertilization, excessive antibiotic use in livestock, and the irrigation of crops with contaminated water contributing to the spread of antibiotic resistance genes (ARGs). Despite growing concerns, the pathways through which ARGs migrate from environmental reservoirs to animal microbiomes are poorly understood. In this study, we raised mice from birth in pig manure-fertilized red (Ultisols) and black (Mollisols) soils or unfertilized controls, sampling their gut microbiomes at 8 weeks, to show that early life exposure to manure-fertilized soil profoundly shapes the gut antibiotic resistome in mice. Application of organic manure significantly enriched tetracycline-resistant ARGs in both red and black soils. Mice living in these environments harbored markedly higher abundances of ARGs, particularly the <i>tet(Q)</i> gene, compared to those in nonfertilized environments. Notably, <i>Muribaculaceae</i> and <i>Bacteroidaceae</i> were identified as key hosts of <i>tet(Q)</i>, with evidence suggesting a horizontal gene transfer between these families. These findings indicate that manure fertilization not only increases ARG abundance in soils but also facilitates its transfer to animal microbiomes, thereby amplifying the risk of AMR dissemination. This research underscores the importance of improved agricultural management practices to mitigate the environmental transmission of AMR.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 8","pages":"931–941"},"PeriodicalIF":6.3,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/envhealth.5c00074","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144840528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanoplastics Toxicity Is a Subset of Nanotoxicology, Not a Separate Field","authors":"Xiliang Yan,&nbsp;Hanle Chen,&nbsp;Chen Jia,&nbsp;Jing Zhang,&nbsp;Miao Huang,&nbsp;Shenqing Wang,&nbsp;Xing Guo,&nbsp;Tongtao Yue,&nbsp;Lingxin Chen,&nbsp;Qunfang Zhou,&nbsp;Guangbo Qu,&nbsp;Hao Zhu,&nbsp;Guibin Jiang and Bing Yan*,&nbsp;","doi":"10.1021/envhealth.5c00085","DOIUrl":"https://doi.org/10.1021/envhealth.5c00085","url":null,"abstract":"<p >Nanoplastics toxicity has been framed as an emerging, distinct research area, purportedly addressing a new threat. While this focus has heightened public awareness and influenced the regulation of plastics, isolating nanoplastics toxicity risks inefficiently allocating research resources and hindering sustainable management strategies. Here, using data mining and machine learning, we show that research on nanoplastics toxicity closely mirrors that of engineered nanoparticles, a well-established domain of nanotoxicology. Examining 154,745 research articles on nanoparticle and nanoplastics toxicology, we find that both particle types share similar physicochemical properties, biological uptake mechanisms, toxicity profiles, and structure–toxicity relationships. Although nanoplastics pollution is more pervasive in scale and morphological diversity, its toxicological attributes align with those documented for other nanoscale materials. We challenge the notion that nanoplastics pose a distinct, separate risk, proposing instead that integrating nanoplastics toxicity into the broader field of nanotoxicology can streamline research, prevent duplication of effort, and more efficiently guide policies, resource use, and remediation strategies toward globally sustainable outcomes.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 8","pages":"920–930"},"PeriodicalIF":6.3,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/envhealth.5c00085","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144840564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PM2.5 Constituents and Hospitalizations of a Wide Spectrum of Respiratory Diseases: A Nationwide Case-Crossover Study in China","authors":"Ziwei Peng,&nbsp;Yi Guo,&nbsp;Shuo Jiang,&nbsp;Yuan Liu,&nbsp;Fuchao Wang,&nbsp;Huihuan Luo,&nbsp;Yixiang Zhu,&nbsp;Lu Zhou,&nbsp;Ya Gao,&nbsp;Hongliang Zhang,&nbsp;Renjie Chen,&nbsp;Jianwei Xuan,&nbsp;Cong Liu* and Haidong Kan*,&nbsp;","doi":"10.1021/envhealth.5c00022","DOIUrl":"https://doi.org/10.1021/envhealth.5c00022","url":null,"abstract":"<p >Few studies have explored the acute effects of fine particulate matter (PM_2.5) constituents on respiratory diseases (RDs), particularly across a broad spectrum of RD subtypes. We analyzed the associations between PM_2.5 and its five major constituents [organic matter (OM), black carbon (BC), sulfate (SO₄^2–), nitrate (NO₃^–), and ammonium (NH₄⁺)] and RDs (10 major categories and 35 specific) based on the hospitalization records from 153 hospitals in 20 provincial distractions from 2013 to 2020. We found that short-term exposure (lag 0–1) to PM_2.5 constituents per interquartile range increase was associated with higher hospitalization risks for acute upper respiratory infections, influenza and pneumonia, other acute lower respiratory infections, chronic lower respiratory diseases, other diseases of the pleura, and other diseases of the respiratory system; the effect estimates were 2.45–2.99%, 2.02–2.71%, 2.98–3.62%, 3.06–3.65%, 3.22–4.52%, and 2.23–3.66%, respectively. Among 35 specific RDs, 12 were significantly affected by PM_2.5 and its constituents. Individuals aged &gt;60 years were sensitive to PM_2.5 constituent exposure. Our individual-level nationwide study provided a more comprehensive perspective on the associations between PM_2.5 constituents and various major and specific RDs, highlighting the necessity of prioritizing targeted control strategies for key constituents to effectively mitigate the burden of RDs in China.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 8","pages":"952–962"},"PeriodicalIF":6.3,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/envhealth.5c00022","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144840527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging and Legacy Traffic-Related Nitrogen-Containing Organic Compounds (TNOCs) in Pregnant Women: Exposure Levels, Seasonal Variation, and Health Risks","authors":"Lin Tao,&nbsp;Nan Sun,&nbsp;Yahong Wei,&nbsp;Jun Zhao,&nbsp;Lan Shi,&nbsp;Lin Luo,&nbsp;Ruonan Li,&nbsp;Chang Gao,&nbsp;De-Xiang Xu,&nbsp;Bi-Xian Mai,&nbsp;Yijun Fan*,&nbsp;Adrian Covaci and Yichao Huang*,&nbsp;","doi":"10.1021/envhealth.5c00037","DOIUrl":"https://doi.org/10.1021/envhealth.5c00037","url":null,"abstract":"<p >As policymakers increasingly promote emission control technologies and the use of electric vehicles, urban traffic pollution patterns are shifting. Traffic-related nitrogen-containing organic compounds (TNOCs), which represent a critical yet underexplored group of chemicals, have not been comprehensively monitored in humans, particularly among sensitive populations such as pregnant women. In this study, we assessed the internal exposure of pregnant women to 20 emerging and legacy TNOCs by analyzing urine samples after deconjugation (<i>n</i> = 400). The results revealed a frequent detection of TNOCs (median ΣTNOCs: 34.7 ng/mL, adjusted by specific-gravity), with 2-hydroxy-benzothiazole (2-OH-BTH), <i>N</i>-(1,3-dimethylbutyl)-<i>N</i>′-phenyl-<i>p</i>-phenylenediamine quinone (6PPD-Q), and tolyltriazole (TTR) being the most common. Significantly negative correlations were found between PPDs and nitro-PAHs (<i>r</i> = −0.23 to −0.54, <i>P</i> &lt; 0.01, except for 1-AP), indicating their distinct origins. Comparative analyses suggest higher BTH, 2-thiocyanomethylthio-benzothiazole (TCMTB), and xylyltriazole (XTR) in frequent commuters compared to infrequent ones (<i>P</i> &lt; 0.05), implying their traffic-related origins. Seasonal variations pinpoint higher TNOC exposure burden generally during the winter, possibly due to the increased leaching from winter tires. Moreover, the median daily urinary excretion of ΣTNOCs in pregnant women was estimated to be 978 ng/kg bw/day. Such exposure burden including for 6PPD, 1,2,3-triphenylguanidine (TPG), and 2-OH-BTH had negative associations with fetal birth weight (<i>P</i> &lt; 0.05), suggesting developmental adversity. Our study reiterates the recognition of TNOC contaminants and reflects a potential rise in nonexhaust emissions, further demonstrateing TNOCs’ health risks in fetal development.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 8","pages":"942–951"},"PeriodicalIF":6.3,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/envhealth.5c00037","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144840565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prenatal Persistent Exposure to Organophosphate Esters and Early Childhood Brain Development: A Longitudinal Analysis","authors":"Liyi Zhang,&nbsp;Pengpeng Wang,&nbsp;Yashuo Xie,&nbsp;Yuhan Zhou,&nbsp;Qiang Li,&nbsp;Jinhong Li,&nbsp;Hang Wang,&nbsp;Xinyao Sui,&nbsp;Huijing Shi,&nbsp;Yingya Zhao* and Yunhui Zhang*,&nbsp;","doi":"10.1021/envhealth.5c00018","DOIUrl":"https://doi.org/10.1021/envhealth.5c00018","url":null,"abstract":"<p >Previous studies on the prenatal organophosphate ester (OPE) exposure’s effect on children’s neurodevelopment have yielded inconsistent results. In this study, we employed a longitudinal approach, capitalizing on multitime-point evaluations of exposure to OPEs and two-stage assessments of children’s brain development. The study included 508 mother-child pairs. We measured seven OPEs in maternal serum throughout pregnancy and assessed children’s mental health and developmental milestones at the age of 2 and 5. The group-based trajectory model identified pregnancy exposure trajectories. Generalized estimated equations and quantile-based g-computation were employed to evaluate the effects of OPEs on children’s brain development. Four OPEs, including 2-ethylhexyl diphenyl phosphate (EHDPP), were detected in over 50% of the maternal samples. Each ln-unit increment of EHDPP was associated with an increased peer problem scores (IRR: 1.104, 95% CI: 1.038–1.174) in mental health. Regarding development milestones, EHDPP was related to lower scores in communication, gross motor, personal-social, and total score of the ages and stages questionnaires (ASQ) (IRR: 0.963–0.976). Trajectory analysis confirmed these associations. Notably, boys were more affected in terms of mental health, while girls were more vulnerable in terms of developmental milestones. Prenatal exposure to OPEs, particularly EHDPP, is associated with adverse brain development in early childhood with notable sex-specific differences in vulnerability.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 9","pages":"1008–1019"},"PeriodicalIF":6.3,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/envhealth.5c00018","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145094313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Genomic Surveillance of SARS-CoV-2 in Campus Wastewater Depicts Lineage Trends and Public Health Implications during and after Omicron Waves","authors":"Rinka Pramanik,&nbsp;Vinay Rajput,&nbsp;Vinita Malik,&nbsp;Kiran Nannaware,&nbsp;Sejal Matra,&nbsp;Sai Joshi,&nbsp;Shubham Kumar,&nbsp;Rachel Samson,&nbsp;Rakesh Kumar Yadav,&nbsp;Priyanki Shah,&nbsp;LS Shashidhara,&nbsp;Syed Dastager,&nbsp;Krishanpal Karmodiya and Mahesh Dharne*,&nbsp;","doi":"10.1021/envhealth.5c00048","DOIUrl":"https://doi.org/10.1021/envhealth.5c00048","url":null,"abstract":"<p >SARS-CoV-2 transmission and detection on academic campuses in low- to middle-income countries has not been explored. The present study explored wastewater surveillance of SARS-CoV-2 in a campus setting in Pune, Maharashtra, India, offering insights into variant-specific trends and their correlation with clinical cases over a 2.5 year period from November 2021 to April 2024. We collected 242 wastewater samples from the campus sewershed and processed them to extract RNA and perform RT-qPCR and sequencing, followed by lineage assignment using the LCS tool. Early signals of different SARS-CoV-2 variants, such as BA.2.X, JN.1.X, and KP.2.X, were detected in wastewater prior to its first clinical report in Maharashtra, India. Wastewater viral load strongly correlated with clinical cases during the Omicron phase (ρ = 0.73–0.81) compared to the post-Omicron phase (ρ = −0.06 to 0.31). This study also highlights that alerts and warnings issued on the basis of wastewater viral hikes have proven instrumental in preventing outbreaks of SARS-CoV-2 variants on campus. However, downgrading COVID-19 from pandemic status by the WHO resulted in a subsequent decrease in public vigilance, changing the viral dynamic in the last phase of the study. This study showcases the utility of wastewater surveillance in a campus setting as an early warning system and understands the interplay of public health policy effects in viral dynamics within controlled ecosystems, such as campuses or offices.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 8","pages":"908–919"},"PeriodicalIF":6.3,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/envhealth.5c00048","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144840526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dermal Exposure to Organophosphorus Compounds in Home Video Game Controllers","authors":"Yuna Nishiyama,&nbsp;Masahiro Tokumura*,&nbsp;Qi Wang,&nbsp;Takashi Amagai and Masakazu Makino*,&nbsp;","doi":"10.1021/envhealth.5c00065","DOIUrl":"https://doi.org/10.1021/envhealth.5c00065","url":null,"abstract":"<p >Organophosphorus compounds, widely used as flame retardants and plasticizers in plastic products, present significant health risks due to their potential adverse effects. While inhalation and ingestion are well-studied exposure pathways, dermal exposure remains underexplored. In recent years, the growing popularity of gaming─driven by extended home stays during the COVID-19 pandemic and the inclusion of e-sports in international competitions─has led to prolonged contact with gaming devices, particularly among young people and professional gamers. This study investigates dermal exposure to triphenyl phosphate (TPhP) from 37 home-use video game controllers. TPhP was detected in 5 first-party and 22 third-party controllers, with concentrations reaching up to 530 μg g^–1. Using artificial skin (EPISKIN), we measured a TPhP skin permeation rate of 0.42 ng cm^–2 h^–1. Monte Carlo simulations were used to estimate daily dermal intake rates; professional gamers (5th percentile–50th percentile–95th percentile, 9.0–22–45 ng kg^–1 day^–1) and e-sports students (5.3–8.5–18 ng kg^–1 day^–1) were identified as the most exposed groups due to prolonged gaming sessions. Remarkably, dermal exposure from the controller was found to rival or exceed other pathways, including dust ingestion and inhalation. This study highlights the urgent need for strategies to mitigate dermal exposure risks from gaming devices.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 8","pages":"898–907"},"PeriodicalIF":6.3,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/envhealth.5c00065","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144840525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}