Environment & Health最新文献

{"title":"Transforming Urbanite Health with Upstream Knowledge","authors":"Zhaowu Yu*, Gaoyuan Yang, Boyi Yang, Jun Yang, Zhuohui Zhao, Lan Wang, Hongxiao Liu, Jinguang Zhang, Bin Jiang and Henrik Vejre, ","doi":"10.1021/envhealth.4c0023710.1021/envhealth.4c00237","DOIUrl":"https://doi.org/10.1021/envhealth.4c00237https://doi.org/10.1021/envhealth.4c00237","url":null,"abstract":"","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 2","pages":"111–113 111–113"},"PeriodicalIF":0.0,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/envhealth.4c00237","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143452397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Benchmark Dose Estimation from Transcriptomics Data for Methylimidazolium Ionic Liquid Hepatotoxicity: Implications for Health Risk Assessment of Green Solvents.","authors":"Qing Yang, Xiaole Zhao, Kejia Wu, Qingqing Yu, Qiao Wang, Jingguang Li, Yongning Wu, Xin Liu","doi":"10.1021/envhealth.4c00120","DOIUrl":"https://doi.org/10.1021/envhealth.4c00120","url":null,"abstract":"<p><p>Ionic liquids (ILs), traditionally considered environmentally benign solvents, have shown potential toxicity to organisms, raising concerns about their safety. Among them, 1-octyl-3-methylimidazolium (M8OI) has been detected at high concentrations in soils and exhibits hepatotoxic properties. To uncover the molecular mechanisms underlying this toxicity, whole-transcriptome sequencing was performed, coupled with benchmark dose (BMD) modeling, to derive transcriptomic points-of-departure (tPOD) through dose-response analysis. The transcriptomic analysis identified 425, 667, and 567 differentially expressed genes (DEGs) following low (10 μmol/L), medium (50 μmol/L), and high (200 μmol/L) doses of M8OI exposure, respectively. Enrichment analysis revealed significant perturbations in pathways related to cytokine-cytokine receptor interaction and IL-17 signaling. BMD modeling yielded tPOD values of 1.51 μmol/L (median of the 20 most sensitive genes, omicBMD₂₀), 2.98 μmol/L (tenth percentile of all genes, omicBMD_10th), 6.83 μmol/L (mode of the first peak of all gene BMDs, omicBMD_mode), and 5.9 μmol/L for pathway-level analysis. These transcriptomics-derived tPODs were at least 105-fold lower than M8OI's hepatotoxic concentration, as indicated by its EC₅₀ of 723.6 μmol/L in HepG2 cells. Functional analysis of the transcriptomic data identified legionellosis, rheumatoid arthritis, and transcriptional misregulation in cancer as the most sensitive pathways affected by M8OI. These findings highlight the molecular mechanisms driving M8OI-induced hepatotoxicity and underscore the utility of transcriptomics in deriving sensitive and quantitative toxicity thresholds. The results provide critical insights for guideline-driven toxicological evaluations and regulatory decision-making, supporting a more comprehensive assessment of IL safety.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 4","pages":"373-379"},"PeriodicalIF":0.0,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12012654/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impacts of Gestational F-53B Exposure on Fetal Neurodevelopment: Insights from Placental and Thyroid Hormone Disruption","authors":"Sujuan Zhao,&nbsp;Yumeng Sun,&nbsp;Jiayao Duan,&nbsp;Tianxu Zhang,&nbsp;Yuchun Xiao,&nbsp;Yumin Zhu,&nbsp;Yibo Jia,&nbsp;Wenjue Zhong and Lingyan Zhu*,&nbsp;","doi":"10.1021/envhealth.4c0015810.1021/envhealth.4c00158","DOIUrl":"https://doi.org/10.1021/envhealth.4c00158https://doi.org/10.1021/envhealth.4c00158","url":null,"abstract":"<p >It has been evidenced that chlorinated polyfluoroalkyl ether sulfonic acids (Cl-PFESAs) have strong potential cross the placental barrier, but their adverse effects on offspring remain unclear. In this study, pregnant mice received daily intraperitoneal injections of chlorinated polyfluorinated ether sulfonate (Cl-PFESA; commercially known as F-53B, primarily comprising 6:2 Cl-PFESA and 8:2 Cl-PFESA) at dosages of 40 and 200 μg/kg from gestational days 6 to 17. Following gestational exposure, distinct accumulation of 6:2 and 8:2 Cl-PFESAs was observed in both the placenta and fetal brain, confirming their penetration across the placental and fetal blood-brain barriers. Maternal exposure to F-53B disrupted the placental 11β-hydroxysteroid dehydrogenase type 2 (<i>hsd11b2</i>) barrier, characterized by hypermethylation of its promoter, decreased blood sinusoids in labyrinth layer, and downregulation of the nutrient transport genes, thereby severely impairing the placenta’s protective and nutrient transfer functions. Concomitantly, significant fetal intrauterine growth restriction indicated by decreased fetal weight and crown-rump length was observed. Additionally, changes in thyroid hormones, along with transcriptional and DNA methylation alterations in the promoter regions of transthyretin (<i>ttr</i>) and deiodinase 3 (<i>dio</i>3) genes, were noted in the placenta. These epigenetic changes might affect the maternal-fetal transport of thyroid hormones, possibly leading to disrupted thyroid function in the F1 generation. With the decreased nutrient transport capacity of the placenta, T4 levels in the fetus are significantly reduced, resulting in significant fetal neurodevelopmental abnormalities, reduced nerve cell proliferation (Ki67), and damage to synaptic plasticity. This study reveals unveil the hidden dangers of F-53B, highlighting its neurotoxic effects on fetal development through the disruption of thyroid hormone transport across the placenta.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 3","pages":"308–320 308–320"},"PeriodicalIF":0.0,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/envhealth.4c00158","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143666880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impacts of Gestational F-53B Exposure on Fetal Neurodevelopment: Insights from Placental and Thyroid Hormone Disruption.","authors":"Sujuan Zhao, Yumeng Sun, Jiayao Duan, Tianxu Zhang, Yuchun Xiao, Yumin Zhu, Yibo Jia, Wenjue Zhong, Lingyan Zhu","doi":"10.1021/envhealth.4c00158","DOIUrl":"10.1021/envhealth.4c00158","url":null,"abstract":"<p><p>It has been evidenced that chlorinated polyfluoroalkyl ether sulfonic acids (Cl-PFESAs) have strong potential cross the placental barrier, but their adverse effects on offspring remain unclear. In this study, pregnant mice received daily intraperitoneal injections of chlorinated polyfluorinated ether sulfonate (Cl-PFESA; commercially known as F-53B, primarily comprising 6:2 Cl-PFESA and 8:2 Cl-PFESA) at dosages of 40 and 200 μg/kg from gestational days 6 to 17. Following gestational exposure, distinct accumulation of 6:2 and 8:2 Cl-PFESAs was observed in both the placenta and fetal brain, confirming their penetration across the placental and fetal blood-brain barriers. Maternal exposure to F-53B disrupted the placental 11β-hydroxysteroid dehydrogenase type 2 (<i>hsd11b2</i>) barrier, characterized by hypermethylation of its promoter, decreased blood sinusoids in labyrinth layer, and downregulation of the nutrient transport genes, thereby severely impairing the placenta's protective and nutrient transfer functions. Concomitantly, significant fetal intrauterine growth restriction indicated by decreased fetal weight and crown-rump length was observed. Additionally, changes in thyroid hormones, along with transcriptional and DNA methylation alterations in the promoter regions of transthyretin (<i>ttr</i>) and deiodinase 3 (<i>dio</i>3) genes, were noted in the placenta. These epigenetic changes might affect the maternal-fetal transport of thyroid hormones, possibly leading to disrupted thyroid function in the F1 generation. With the decreased nutrient transport capacity of the placenta, T4 levels in the fetus are significantly reduced, resulting in significant fetal neurodevelopmental abnormalities, reduced nerve cell proliferation (Ki67), and damage to synaptic plasticity. This study reveals unveil the hidden dangers of F-53B, highlighting its neurotoxic effects on fetal development through the disruption of thyroid hormone transport across the placenta.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 3","pages":"308-320"},"PeriodicalIF":0.0,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934197/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143721666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between Per- and Polyfluoroalkyl Substances Exposures and Bone Mineral: A Systematic Review and Best Evidence Synthesis","authors":"Kai Tao,&nbsp;Bin Zeng,&nbsp;Linghui Deng,&nbsp;Wei Zhang,&nbsp;Xianghong Zhou,&nbsp;Yuming Jin,&nbsp;Zilong Zhang,&nbsp;Weichao Huang,&nbsp;Xiaoli Zou,&nbsp;Yu Zhan,&nbsp;Ping Lu,&nbsp;Shi Qiu,&nbsp;Lu Yang* and Qiang Wei*,&nbsp;","doi":"10.1021/envhealth.4c0014310.1021/envhealth.4c00143","DOIUrl":"https://doi.org/10.1021/envhealth.4c00143https://doi.org/10.1021/envhealth.4c00143","url":null,"abstract":"<p >Per- and polyfluoroalkyl substances (PFAS) are persistent environmental pollutants known for their bioaccumulative nature. Reduced bone mineral density (BMD) is associated with an increased risk of developing osteoporosis. This pioneering study aims to assess the effects of different PFAS compounds on bone mineral. We conducted searches on online databases. Inclusion criteria included the presence of associations between perfluorooctanoic acid (PFOA), perfluorooctanesulfonate (PFOS), perfluorohexanesulfonic acid (PFHxS), perfluorononanoic acid (PFNA), and perfluorodecanoic acid (PFDA) and BMD, BMD z-score, and bone mineral content (BMC). Meta-analyses were performed. Best evidence synthesis (BES) was performed to summarize the results. The results of BES showed that the evidence of PFOS, PFOA and PFNA with reduced bone mineral were moderate. The variability in methods for assessing bone mineral and sex differences are potential sources of heterogeneity in the results. Meta analysis showed that PFOA was associated with BMD (β −0.01, 95% CI −0.01 to −0.00; <i>I</i>² = 0%). Subgroup analysis by sex showed that PFOS (β −0.01, 95% CI −0.01 to −0.00; <i>I</i>² = 50%), PFOA (β −0.01, 95% CI −0.01 to +0.00; <i>I</i>² = 29%) were negatively correlated with BMD. This systematic review and BES revealed negative correlations between exposure to PFOS, PFOA, PFNA and bone mineral. Sex emerged as a potential factor affecting the negative effects of PFAS on bone mineral. The damage of PFAS to bone mineral still requires further exploration.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 4","pages":"363–372 363–372"},"PeriodicalIF":0.0,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/envhealth.4c00143","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143842293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between Per- and Polyfluoroalkyl Substances Exposures and Bone Mineral: A Systematic Review and Best Evidence Synthesis.","authors":"Kai Tao, Bin Zeng, Linghui Deng, Wei Zhang, Xianghong Zhou, Yuming Jin, Zilong Zhang, Weichao Huang, Xiaoli Zou, Yu Zhan, Ping Lu, Shi Qiu, Lu Yang, Qiang Wei","doi":"10.1021/envhealth.4c00143","DOIUrl":"https://doi.org/10.1021/envhealth.4c00143","url":null,"abstract":"<p><p>Per- and polyfluoroalkyl substances (PFAS) are persistent environmental pollutants known for their bioaccumulative nature. Reduced bone mineral density (BMD) is associated with an increased risk of developing osteoporosis. This pioneering study aims to assess the effects of different PFAS compounds on bone mineral. We conducted searches on online databases. Inclusion criteria included the presence of associations between perfluorooctanoic acid (PFOA), perfluorooctanesulfonate (PFOS), perfluorohexanesulfonic acid (PFHxS), perfluorononanoic acid (PFNA), and perfluorodecanoic acid (PFDA) and BMD, BMD z-score, and bone mineral content (BMC). Meta-analyses were performed. Best evidence synthesis (BES) was performed to summarize the results. The results of BES showed that the evidence of PFOS, PFOA and PFNA with reduced bone mineral were moderate. The variability in methods for assessing bone mineral and sex differences are potential sources of heterogeneity in the results. Meta analysis showed that PFOA was associated with BMD (β -0.01, 95% CI -0.01 to -0.00; <i>I</i> ² = 0%). Subgroup analysis by sex showed that PFOS (β -0.01, 95% CI -0.01 to -0.00; <i>I</i> ² = 50%), PFOA (β -0.01, 95% CI -0.01 to +0.00; <i>I</i> ² = 29%) were negatively correlated with BMD. This systematic review and BES revealed negative correlations between exposure to PFOS, PFOA, PFNA and bone mineral. Sex emerged as a potential factor affecting the negative effects of PFAS on bone mineral. The damage of PFAS to bone mineral still requires further exploration.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 4","pages":"363-372"},"PeriodicalIF":0.0,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12012664/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Per- and Polyfluoroalkyl Substance Exposure with Coronary Stenosis and Prognosis in Acute Coronary Syndrome","authors":"Haoran Li,&nbsp;Ming Yang,&nbsp;Jiaxin Zhao,&nbsp;Zhenzhen Tan,&nbsp;Longfei Li,&nbsp;Ziwen An,&nbsp;Yi Liu,&nbsp;Xuehui Liu,&nbsp;Xiaoguang Zhang,&nbsp;Jingchao Lu,&nbsp;Ang Li* and Huicai Guo*,&nbsp;","doi":"10.1021/envhealth.4c0016610.1021/envhealth.4c00166","DOIUrl":"https://doi.org/10.1021/envhealth.4c00166https://doi.org/10.1021/envhealth.4c00166","url":null,"abstract":"<p >Per- and polyfluoroalkyl substances (PFAS) have been associated with an increased risk of acute coronary syndromes (ACS), but the influence on the degree of coronary stenosis and prognosis is unclear. This study enrolled 571 newly diagnosed ACS cases and investigated the association of 12 PFAS with coronary stenosis severity and prognosis. Coronary stenosis was assessed via Gensini score (GS) and number of lesioned vessels (LVN). Prognosis was estimated by tracking major adverse cardiovascular events (MACE). Statistical analyses included ordered logistic regression, Cox regression, threshold effect models, Bayesian kernel machine regression, and quantile g-computation models. The adverse outcome pathway (AOP) framework was applied to reveal the underlying mechanism. The results showed positive association between perfluorooctanesulfonic acid (PFOS) and coronary stenosis, with an odds ratio (95% confidence interval, CI) of 1.33 (1.06, 1.67) for GS and 1.36 (1.08, 1.71) for LVN. PFOS significantly increased the incidence of poor prognosis, with hazard ratios (95% CI) of 1.96 (1.34, 2.89) for MACE. Threshold effects were observed for PFAS on coronary stenosis and prognosis, with PFOS thresholds of 4.65 ng/mL for GS, 4.54 ng/mL for LVN, and 5.14 ng/mL for MACE, and 5.03 ng/mL for nonfatal myocardial infarction. PFAS mixture exposure increased the occurrence of MACE and nonfatal myocardial infarction. The AOP framework shows that PFAS may impact protein binding, the cytoskeleton, multicellular biological processes, and heart function. In summary, our study revealed the adverse effects of PFAS on the degree of coronary stenosis and prognosis in ACS and identified potentially relevant molecular loci.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 3","pages":"291–307 291–307"},"PeriodicalIF":0.0,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/envhealth.4c00166","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143666885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Per- and Polyfluoroalkyl Substance Exposure with Coronary Stenosis and Prognosis in Acute Coronary Syndrome.","authors":"Haoran Li, Ming Yang, Jiaxin Zhao, Zhenzhen Tan, Longfei Li, Ziwen An, Yi Liu, Xuehui Liu, Xiaoguang Zhang, Jingchao Lu, Ang Li, Huicai Guo","doi":"10.1021/envhealth.4c00166","DOIUrl":"10.1021/envhealth.4c00166","url":null,"abstract":"<p><p>Per- and polyfluoroalkyl substances (PFAS) have been associated with an increased risk of acute coronary syndromes (ACS), but the influence on the degree of coronary stenosis and prognosis is unclear. This study enrolled 571 newly diagnosed ACS cases and investigated the association of 12 PFAS with coronary stenosis severity and prognosis. Coronary stenosis was assessed via Gensini score (GS) and number of lesioned vessels (LVN). Prognosis was estimated by tracking major adverse cardiovascular events (MACE). Statistical analyses included ordered logistic regression, Cox regression, threshold effect models, Bayesian kernel machine regression, and quantile g-computation models. The adverse outcome pathway (AOP) framework was applied to reveal the underlying mechanism. The results showed positive association between perfluorooctanesulfonic acid (PFOS) and coronary stenosis, with an odds ratio (95% confidence interval, CI) of 1.33 (1.06, 1.67) for GS and 1.36 (1.08, 1.71) for LVN. PFOS significantly increased the incidence of poor prognosis, with hazard ratios (95% CI) of 1.96 (1.34, 2.89) for MACE. Threshold effects were observed for PFAS on coronary stenosis and prognosis, with PFOS thresholds of 4.65 ng/mL for GS, 4.54 ng/mL for LVN, and 5.14 ng/mL for MACE, and 5.03 ng/mL for nonfatal myocardial infarction. PFAS mixture exposure increased the occurrence of MACE and nonfatal myocardial infarction. The AOP framework shows that PFAS may impact protein binding, the cytoskeleton, multicellular biological processes, and heart function. In summary, our study revealed the adverse effects of PFAS on the degree of coronary stenosis and prognosis in ACS and identified potentially relevant molecular loci.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 3","pages":"291-307"},"PeriodicalIF":0.0,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934203/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143721614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Environmental Health and Safety Implications of the Interplay Between Microplastics and the Residing Biofilm.","authors":"Xiaohan Wu, Fei He, Xueran Xu, Leilei Wu, Jinyu Rong, Sijie Lin","doi":"10.1021/envhealth.4c00148","DOIUrl":"10.1021/envhealth.4c00148","url":null,"abstract":"<p><p>The increasing prevalence of microplastics in the environment has raised concerns about their potential environmental and health implications. Biofilms readily colonize microplastics upon their entry into the environment, altering their surface characteristics. While most studies have explored how biofilms influence the adsorption and transportation of other contaminants by microplastics, the reciprocal interplay between microplastics and biofilms and the resulting ecological risks remain understudied. This review comprehensively reviews the impact of microplastic properties on biofilm formation and composition, including the microbial community structure. We then explore the dynamic interactions between microplastics and biofilms, examining how biofilms alter the physicochemical properties, migration, and deposition of microplastics. Furthermore, we emphasize the potential of biofilm-colonized microplastics to influence the environmental fate of other pollutants. Lastly, we discuss how biofilm-microplastic interactions may modify the bioavailability, biotoxicity, and potential health implications of microplastics.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 2","pages":"118-132"},"PeriodicalIF":0.0,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11851218/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Environmental Health and Safety Implications of the Interplay Between Microplastics and the Residing Biofilm","authors":"Xiaohan Wu,&nbsp;Fei He,&nbsp;Xueran Xu,&nbsp;Leilei Wu,&nbsp;Jinyu Rong and Sijie Lin*,&nbsp;","doi":"10.1021/envhealth.4c0014810.1021/envhealth.4c00148","DOIUrl":"https://doi.org/10.1021/envhealth.4c00148https://doi.org/10.1021/envhealth.4c00148","url":null,"abstract":"<p >The increasing prevalence of microplastics in the environment has raised concerns about their potential environmental and health implications. Biofilms readily colonize microplastics upon their entry into the environment, altering their surface characteristics. While most studies have explored how biofilms influence the adsorption and transportation of other contaminants by microplastics, the reciprocal interplay between microplastics and biofilms and the resulting ecological risks remain understudied. This review comprehensively reviews the impact of microplastic properties on biofilm formation and composition, including the microbial community structure. We then explore the dynamic interactions between microplastics and biofilms, examining how biofilms alter the physicochemical properties, migration, and deposition of microplastics. Furthermore, we emphasize the potential of biofilm-colonized microplastics to influence the environmental fate of other pollutants. Lastly, we discuss how biofilm–microplastic interactions may modify the bioavailability, biotoxicity, and potential health implications of microplastics.</p>","PeriodicalId":29795,"journal":{"name":"Environment & Health","volume":"3 2","pages":"118–132 118–132"},"PeriodicalIF":0.0,"publicationDate":"2024-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/envhealth.4c00148","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143452531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}