Precision Chemistry最新文献_第9页

The Trend of Nonenzymatic Nucleic Acid Amplification: Strategies and Diagnostic Application. 非酶核酸扩增的趋势：策略和诊断应用。

Precision Chemistry Pub Date : 2025-03-03 eCollection Date: 2025-04-28 DOI: 10.1021/prechem.4c00100

Junyou Li, Ting Li, Zheng Zou, Hung-Wing Li

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引用次数: 0

3D Printed Microfluidic Devices for Integrated Immunoaffinity Extraction, Solid-Phase Extraction, and Fluorescent Labeling of Preterm Birth Biomarkers. 3D打印微流控设备集成免疫亲和萃取，固相萃取，早产生物标志物荧光标记。

Precision Chemistry Pub Date : 2025-03-03 eCollection Date: 2025-05-26 DOI: 10.1021/prechem.4c00092

James D Holladay, Zachary A Berkheimer, Michael K Haggard, Jacob B Nielsen, Gregory P Nordin, Adam T Woolley

{"title":"3D Printed Microfluidic Devices for Integrated Immunoaffinity Extraction, Solid-Phase Extraction, and Fluorescent Labeling of Preterm Birth Biomarkers.","authors":"James D Holladay, Zachary A Berkheimer, Michael K Haggard, Jacob B Nielsen, Gregory P Nordin, Adam T Woolley","doi":"10.1021/prechem.4c00092","DOIUrl":"10.1021/prechem.4c00092","url":null,"abstract":"A miniaturized, biomarker-based diagnostic for preterm birth (PTB) risk will require multiple sample preparation steps to be integrated in a single platform. To this end, we created a 3D printed microfluidic device that combines immunoaffinity extraction (IAE), solid-phase extraction (SPE), and fluorescent labeling. This device uses an antibody-functionalized IAE monolith to selectively extract PTB biomarkers, a lauryl methacrylate reverse-phase SPE monolith to concentrate and facilitate fluorescent labeling of PTB biomarkers, and 3D printed valves to control flow through the monoliths. The advantageous iterative design process for arriving at a functional device is documented. The IAE/SPE device performed selective, reproducible extractions of three PTB biomarkers from buffer and depleted maternal blood serum, demonstrating its utility for single-biomarker and multiplexed extractions. After tandem extraction and fluorescent labeling, biomarkers eluted from the SPE monolith in a concentrated plug, facilitating future integration with downstream analysis techniques including microchip electrophoresis. This device effectively combines and automates orthogonal chromatographic extraction methods and constitutes a substantial step toward a complete microfluidic PTB prediction platform.","PeriodicalId":29793,"journal":{"name":"Precision Chemistry","volume":"3 5","pages":"261-271"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12117449/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144183039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Trend of Nonenzymatic Nucleic Acid Amplification: Strategies and Diagnostic Application 非酶核酸扩增的趋势：策略和诊断应用

Precision Chemistry Pub Date : 2025-03-03 DOI: 10.1021/prechem.4c0010010.1021/prechem.4c00100

Junyou Li, Ting Li, Zheng Zou and Hung-Wing Li*,

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引用次数: 0

Management of Platinum Electronic States through Metal Host–Guest Interactions for Enhanced Oxygen Reduction 通过金属主客体相互作用增强氧还原对铂电子态的管理

Precision Chemistry Pub Date : 2025-03-03 DOI: 10.1021/prechem.4c0007310.1021/prechem.4c00073

Yudan Chen, Yuanhua Sun, Sicheng Li, Xiaokang Liu, Wei Zhang, Qiquan Luo, Dong Liu*, Tao Ding* and Tao Yao*,

{"title":"Management of Platinum Electronic States through Metal Host–Guest Interactions for Enhanced Oxygen Reduction","authors":"Yudan Chen, Yuanhua Sun, Sicheng Li, Xiaokang Liu, Wei Zhang, Qiquan Luo, Dong Liu*, Tao Ding* and Tao Yao*, ","doi":"10.1021/prechem.4c0007310.1021/prechem.4c00073","DOIUrl":"https://doi.org/10.1021/prechem.4c00073https://doi.org/10.1021/prechem.4c00073","url":null,"abstract":"Controlling the electronic states of Pt-based catalysts holds great promise for enhancing the intrinsic activity of the oxygen reduction reaction (ORR). Herein, inspired by first-principles simulations, we propose a strategy using metal host–guest interactions to tune Pt 5d electronic characteristics to optimize the adsorption strength of the key *OH intermediate. The hybrid electrocatalyst of Pt nanoparticles on a single-atom Co–N–C support (Pt@CoL SAs) exhibits a half-wave potential of 0.92 V and a mass activity of 3.2 A·mgPt–1 at 0.9 V in 0.1 M HClO4, which is a 20-fold enhancement compared with commercial Pt/C. Impressively, the Pt loading in the catalyst is as low as 1.70 wt %, which represents the lowest value reported in the relevant literature on Pt-based acidic ORR catalysts. Comprehensive spectroscopy investigations and theoretical simulations revealed that the precise regulatory effect of Co in various dispersion states effectively weakens the intermediate adsorption and reduces the energy barrier for the water decomposition step. Our finding provides valuable insights for the development of advanced ultralow-Pt ORR catalysts via the integration engineering of multiple metal sites.","PeriodicalId":29793,"journal":{"name":"Precision Chemistry","volume":"3 5","pages":"279–288 279–288"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/prechem.4c00073","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144133939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Management of Platinum Electronic States through Metal Host-Guest Interactions for Enhanced Oxygen Reduction. 通过金属主客体相互作用增强氧还原对铂电子态的管理。

Precision Chemistry Pub Date : 2025-03-03 eCollection Date: 2025-05-26 DOI: 10.1021/prechem.4c00073

Yudan Chen, Yuanhua Sun, Sicheng Li, Xiaokang Liu, Wei Zhang, Qiquan Luo, Dong Liu, Tao Ding, Tao Yao

{"title":"Management of Platinum Electronic States through Metal Host-Guest Interactions for Enhanced Oxygen Reduction.","authors":"Yudan Chen, Yuanhua Sun, Sicheng Li, Xiaokang Liu, Wei Zhang, Qiquan Luo, Dong Liu, Tao Ding, Tao Yao","doi":"10.1021/prechem.4c00073","DOIUrl":"10.1021/prechem.4c00073","url":null,"abstract":"Controlling the electronic states of Pt-based catalysts holds great promise for enhancing the intrinsic activity of the oxygen reduction reaction (ORR). Herein, inspired by first-principles simulations, we propose a strategy using metal host-guest interactions to tune Pt 5d electronic characteristics to optimize the adsorption strength of the key *OH intermediate. The hybrid electrocatalyst of Pt nanoparticles on a single-atom Co-N-C support (Pt@CoL SAs) exhibits a half-wave potential of 0.92 V and a mass activity of 3.2 A·mgPt -1 at 0.9 V in 0.1 M HClO4, which is a 20-fold enhancement compared with commercial Pt/C. Impressively, the Pt loading in the catalyst is as low as 1.70 wt %, which represents the lowest value reported in the relevant literature on Pt-based acidic ORR catalysts. Comprehensive spectroscopy investigations and theoretical simulations revealed that the precise regulatory effect of Co in various dispersion states effectively weakens the intermediate adsorption and reduces the energy barrier for the water decomposition step. Our finding provides valuable insights for the development of advanced ultralow-Pt ORR catalysts via the integration engineering of multiple metal sites.","PeriodicalId":29793,"journal":{"name":"Precision Chemistry","volume":"3 5","pages":"279-288"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12117436/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144183422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0