Precision Chemistry最新文献_第8页

Positional Isomeric Thiophene-Based π-Conjugated Chromophores: Synthesis, Structure, and Optical Properties 位置异构体噻吩基π共轭发色团:合成、结构和光学性质

Precision Chemistry Pub Date : 2023-10-10 DOI: 10.1021/prechem.3c00080

Huan Yi, Xi Qin, Lei Zhai, Huiyuan Duan, Huafeng Chen, Yulan Zuo, Xin Lian, Kui Tian, Jinling Zhang, Zhengli Liu* and Peng Xu*,

{"title":"Positional Isomeric Thiophene-Based π-Conjugated Chromophores: Synthesis, Structure, and Optical Properties","authors":"Huan Yi, Xi Qin, Lei Zhai, Huiyuan Duan, Huafeng Chen, Yulan Zuo, Xin Lian, Kui Tian, Jinling Zhang, Zhengli Liu* and Peng Xu*, ","doi":"10.1021/prechem.3c00080","DOIUrl":"10.1021/prechem.3c00080","url":null,"abstract":"A series of positional isomeric chromophores o-TC, m-TC, and p-TC, in which electron-rich thiophene moieties were connected by π-conjugated bridges, were divergently synthesized and characterized. Single-crystal X-ray diffraction analysis revealed an intriguing zipper-like packing mode which was adopted by m-TC in the solid state. Subsequently, UV–vis absorption spectra and fluorescence spectra in a series of solvents were investigated. The nearly coplanar para isomer p-TC was found to have the most intense UV–vis absorption, fluorescence emission, and the highest photoluminescence quantum yield. The molecule structure, electronic nature, and origination of the absorption of p-TC were revealed through density functional theory calculations. Interestingly, all three positional isomers exhibited strong and stable electrochemiluminescence emission, which enriched the existing knowledge on the optical properties of thiophene-based oligomers.","PeriodicalId":29793,"journal":{"name":"Precision Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/prechem.3c00080","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136295271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Copper-Catalyzed Enantioconvergent Radical C(sp3)–N Cross-Coupling to Access Chiral α-Amino-β-lactams 铜催化对映体自由基 C（sp3）-N 交叉偶联以获得手性 α-氨基-β-内酰胺

Precision Chemistry Pub Date : 2023-10-10 DOI: 10.1021/prechem.3c00084

Jing-Jing Zheng, Wei-Long Liu, Qiang-Shuai Gu, Zhong-Liang Li, Ji-Jun Chen* and Xin-Yuan Liu*,

引用次数: 0

Informational Polymers with Precise Carbamate Sequences 具有精确氨基甲酸酯序列的信息聚合物

Precision Chemistry Pub Date : 2023-10-08 DOI: 10.1021/prechem.3c00077

Itab Youssef, Svetlana Samokhvalova, Isaure Sergent, Laurence Charles* and Jean-François Lutz*,

引用次数: 0

Tetravalent Terbium Chelates: Stability Enhancement and Property Tuning 四价铽螯合物：稳定性增强和特性调整

Precision Chemistry Pub Date : 2023-10-02 DOI: 10.1021/prechem.3c00065

Tianjiao Xue, You-Song Ding*, Xue-Lian Jiang, Lizhi Tao, Jun Li and Zhiping Zheng*,

{"title":"Tetravalent Terbium Chelates: Stability Enhancement and Property Tuning","authors":"Tianjiao Xue, You-Song Ding*, Xue-Lian Jiang, Lizhi Tao, Jun Li and Zhiping Zheng*, ","doi":"10.1021/prechem.3c00065","DOIUrl":"10.1021/prechem.3c00065","url":null,"abstract":"Coordination chemistry of rare-earth elements has been dominated by the +3 oxidation state. Complexes with higher-valence lanthanide ions are synthetically challenging but are of fundamental research interest and significance as advanced molecular materials. Herein, four tetravalent terbium complexes (2–5) of the common formula [Tb(OSiPh3)4L] (L = ethylene glycol dimethyl ether (DME), 2,2’-bipyridine (bpy), 2,2’-bipyrimidine (bpym), and 1,10-phenanthroline (phen)) are reported. Crystallographic analyses reveal in each of these complexes a hexacoordinate Tb(IV) ion situated in a distorted octahedral coordination environment formed by four triphenylsiloxido ligands and a bidentate chelating ligand. The use of chelating ligands enhances the stability of the resulting complexes over their THF solvate precursor. More significantly, the aromatic N-chelating ligands have been found to tune effectively the electronic structures of the complexes, as evidenced by the sizable potential shifts observed for the quasi-reversible redox Tb(IV/III) process and by the changes in their absorption spectra. The experimental findings are augmented with quantum theoretical calculations in which the ligand π-donation to the 5d orbitals of the Tb(IV) center is found to be primarily responsible for stability enhancement and the corresponding changes of physical properties observed. Magnetic measurements and results from electron paramagnetic resonance studies produced small absolute values of zero-field splittings of these complexes, ranging from 0.1071(22) to 1.1484(112) cm–1 and comparable to the values reported for analogous Tb(IV) complexes.","PeriodicalId":29793,"journal":{"name":"Precision Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/prechem.3c00065","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135900006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Challenges and Prospects of Molecular Spintronics 分子自旋电子学的挑战与前景

Precision Chemistry Pub Date : 2023-09-26 DOI: 10.1021/prechem.3c00071

Xianrong Gu, Lidan Guo*, Yang Qin, Tingting Yang, Ke Meng, Shunhua Hu and Xiangnan Sun*,

{"title":"Challenges and Prospects of Molecular Spintronics","authors":"Xianrong Gu, Lidan Guo*, Yang Qin, Tingting Yang, Ke Meng, Shunhua Hu and Xiangnan Sun*, ","doi":"10.1021/prechem.3c00071","DOIUrl":"10.1021/prechem.3c00071","url":null,"abstract":"Molecular spintronics, as an emerging field that makes full use of the advantage of ultralong room-temperature spin lifetime and abundant electrical-optical-magnetic properties of molecular semiconductors, has gained wide attention for its great potential for further commercial applications. Despite the significant progress that has been made, there remain several huge challenges that limit the future development of this field. This Perspective provides discussions on the spin transport mechanisms and performances of molecular semiconductors, spinterface effect, and related spin injection in spintronic devices, and current spin-charge interactive functionalities, along with the summarization of the main obstacles of these aspects. Furthermore, we particularly propose targeted solutions, aiming to enhance the spin injection and transport efficiency by molecular design and interface engineering and explore diverse spin-related functionalities. Through this Perspective, we hope it will help the spintronic community identify the research trends and accelerate the development of molecular spintronics.","PeriodicalId":29793,"journal":{"name":"Precision Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/prechem.3c00071","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134960498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Solid State Fabrication of Copper Nanoclusters and Supraparticles 铜纳米团簇和超粒子的固态制备

Precision Chemistry Pub Date : 2023-09-06 DOI: 10.3390/chemistry5030134

Rui Wang, Yu-Bang Zheng, Yunsheng Xia

引用次数: 0

Syntheses, Crystal and Electronic Structures of Rhodium and Iridium Pyridine Di-Imine Complexes with O- and S-Donor Ligands: (Hydroxido, Methoxido and Thiolato) 铑和铱吡啶二亚胺配合物的合成、晶体和电子结构与O和s供体配体:(羟基、甲氧基和硫氧基)

Precision Chemistry Pub Date : 2023-09-05 DOI: 10.3390/chemistry5030133

Michel Stephan, Max Völker, Matthias Schreyer, Peter Burger

引用次数: 0

Encapsulation of Ciprofloxacin into a Cyclodextrin Polymer Matrix: The Complex Formation with Human Serum Albumin and In Vitro Studies 环丙沙星包封环糊精聚合物基质:与人血清白蛋白复合物的形成及体外研究

Precision Chemistry Pub Date : 2023-09-01 DOI: 10.3390/chemistry5030132

A. Skuredina, T. Kopnova, N. G. Belogurova, E. Kudryashova

{"title":"Encapsulation of Ciprofloxacin into a Cyclodextrin Polymer Matrix: The Complex Formation with Human Serum Albumin and In Vitro Studies","authors":"A. Skuredina, T. Kopnova, N. G. Belogurova, E. Kudryashova","doi":"10.3390/chemistry5030132","DOIUrl":"https://doi.org/10.3390/chemistry5030132","url":null,"abstract":"Here, we propose a drug delivery system for ciprofloxacin (CF) based on cyclodextrin (CD) polymer. We obtained a 3D matrix system with encapsulated drug molecules by crosslinking CF+CD non-covalent complexes with 1.6-hexamethylene isocyanate. The obtained polycarbamide (MAX-system) represents particles (~225 nm in diameter) that demonstrate CF’s sustained release. We investigated how the carrier affects the drug’s interaction with the biological macromolecule human serum albumin (HSA) and CF’s antibacterial properties. Compared to a binary CF–HSA system, CD decreases CF’s binding efficiency to HSA by two times, whereas CF encapsulation in a polymer matrix doubles the Ka value and prevents protein aggregation. The changes in HSA’s secondary structure indicate no alterations in the main mechanism of complex formation between CF and HSA in the presence of both CD-based carriers. CD as well as MAX systems practically do not change CF’s activity against E. coli and B. subtilis, but for MAX systems, prolonged action is realized due to CF’s sustained release. We believe that our findings are important for the further development of new, efficient drug forms.","PeriodicalId":29793,"journal":{"name":"Precision Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85465512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ratiometric Detection of Zn²⁺ Using DNAzyme-Based Bioluminescence Resonance Energy Transfer Sensors. 利用基于 DNA 酶的生物发光共振能量转移传感器对 Zn2+ 进行比率检测

Precision Chemistry Pub Date : 2023-09-01 Epub Date: 2023-08-08 DOI: 10.3390/chemistry5030119

Yuting Wu, Whitney Lewis, Jing Luen Wai, Mengyi Xiong, Jiao Zheng, Zhenglin Yang, Chloe Gordon, Ying Lu, Siu Yee New, Xiao-Bing Zhang, Yi Lu

{"title":"Ratiometric Detection of Zn2+ Using DNAzyme-Based Bioluminescence Resonance Energy Transfer Sensors.","authors":"Yuting Wu, Whitney Lewis, Jing Luen Wai, Mengyi Xiong, Jiao Zheng, Zhenglin Yang, Chloe Gordon, Ying Lu, Siu Yee New, Xiao-Bing Zhang, Yi Lu","doi":"10.3390/chemistry5030119","DOIUrl":"10.3390/chemistry5030119","url":null,"abstract":"While fluorescent sensors have been developed for monitoring metal ions in health and diseases, they are limited by the requirement of an excitation light source that can lead to photobleaching and a high autofluorescence background. To address these issues, bioluminescence resonance energy transfer (BRET)-based protein or small molecule sensors have been developed; however, most of them are not highly selective nor generalizable to different metal ions. Taking advantage of the high selectivity and generalizability of DNAzymes, we report herein DNAzyme-based ratiometric sensors for Zn2+ based on BRET. The 8-17 DNAzyme was labeled with luciferase and Cy3. The proximity between luciferase and Cy3 permiQed BRET when coelenterazine, the substrate for luciferase, was introduced. Adding samples containing Zn2+ resulted in a cleavage of the substrate strand, causing dehybridization of the DNAzyme construct, thus increasing the distance between Cy3 and luciferase and changing the BRET signals. Using these sensors, we detected Zn2+ in serum samples and achieved Zn2+ detection with a smartphone camera. Moreover, since the BRET pair is not the component that determines the selectivity of the sensors, this sensing platform has the potential to be adapted for the detection of other metal ions with other metal-dependent DNAzymes.","PeriodicalId":29793,"journal":{"name":"Precision Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10874629/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77082529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structure, Stability and Binding Properties of Collagen-Binding Domains from Streptococcus mutans 变形链球菌胶原结合域的结构、稳定性和结合特性

Precision Chemistry Pub Date : 2023-09-01 DOI: 10.3390/chemistry5030130

Akari Nishi, Hikaru Matsui, Azumi Hirata, Atsushi Mukaiyama, Shun-ichi Tanaka, Takuya Yoshizawa, Hiroyoshi Matsumura, R. Nomura, K. Nakano, K. Takano

{"title":"Structure, Stability and Binding Properties of Collagen-Binding Domains from Streptococcus mutans","authors":"Akari Nishi, Hikaru Matsui, Azumi Hirata, Atsushi Mukaiyama, Shun-ichi Tanaka, Takuya Yoshizawa, Hiroyoshi Matsumura, R. Nomura, K. Nakano, K. Takano","doi":"10.3390/chemistry5030130","DOIUrl":"https://doi.org/10.3390/chemistry5030130","url":null,"abstract":"Collagen-binding proteins (CBP), Cnm and Cbm, from Streptococcus mutans are involved in infective endocarditis caused by S. mutans because of their collagen-binding ability. In this study, we focused on the collagen-binding domain (CBD), which is responsible for the collagen-binding ability of CBP, and analyzed its structure, binding activity, and stability using CBD domain variants. The CBD consists of the N1 domain, linker, N2 domain, and latch (N1-N2~) as predicted from the amino acid sequences. The crystal structure of the Cnm/CBD was determined at a 1.81 Å resolution. N1_linker_N2 forms a ring structure that can enfold collagen molecules, and the latch interacts with N1 to form a ring clasp. N1 and N2 have similar immunoglobulin folds. The collagen-binding activities of Cbm/CBD and its domain variants were examined using ELISA. N1-N2~ bound to collagen with KD = 2.8 μM, and the latch-deleted variant (N1-N2) showed weaker binding (KD = 28 μM). The linker-deleted variant (N1N2~) and single-domain variants (N1 and N2) showed no binding activity, whereas the domain-swapped variant (N2-N1~) showed binding ability, indicating that the two N-domains and the linker are important for collagen binding. Thermal denaturation experiments showed that N1-N2 was slightly less stable than N1-N2~, and that N2 was more stable than N1. The results of this study provide a basis for the development of CBD inhibitors and applied research utilizing their collagen-binding ability.","PeriodicalId":29793,"journal":{"name":"Precision Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83953544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0