Precision Chemistry最新文献_第7页

Precision Chemistry Pub Date : 2025-03-12 eCollection Date: 2025-03-24 DOI: 10.1021/prechem.5c00023

Ben L Feringa

引用次数: 0

Role of Hydrogen Transfer in Functional Molecular Materials and Devices. 氢转移在功能分子材料和器件中的作用。

Precision Chemistry Pub Date : 2025-03-11 eCollection Date: 2025-05-26 DOI: 10.1021/prechem.4c00097

Enyu Zhang, Liping Bai, Zhiping Chen, Aobo Zhang, Yingbo Tang, Jushang Ran, Shuai Wang, Jinying Wang, Chuancheng Jia, Xuefeng Guo

{"title":"Role of Hydrogen Transfer in Functional Molecular Materials and Devices.","authors":"Enyu Zhang, Liping Bai, Zhiping Chen, Aobo Zhang, Yingbo Tang, Jushang Ran, Shuai Wang, Jinying Wang, Chuancheng Jia, Xuefeng Guo","doi":"10.1021/prechem.4c00097","DOIUrl":"10.1021/prechem.4c00097","url":null,"abstract":"Hydrogen transfer is a fundamental chemical process critical to the design and application of organic molecules and functional devices. By uncovering the dynamic interactions between atoms within molecules, hydrogen transfer research offers innovative pathways for creating advanced functional materials and devices. These advancements have driven progress in areas such as optoelectronics, molecular switches, and bioimaging. This review explores the various forms of hydrogen transfer, including hydrogen atom, proton, and hydride transfer, highlighting their mechanisms and key reactions. It also examines the integration of these processes into molecular devices, including single-molecule systems, molecular films, and organic frameworks. Future directions emphasize precise control of hydrogen transfer pathways, development of highly selective and efficient reaction systems, and the design of robust devices based on these processes. These efforts aim to enhance device performance and broaden applications in intelligent materials, integrated functions, and information technology.","PeriodicalId":29793,"journal":{"name":"Precision Chemistry","volume":"3 5","pages":"233-260"},"PeriodicalIF":0.0,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12117429/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144183707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of Hydrogen Transfer in Functional Molecular Materials and Devices 氢转移在功能分子材料和器件中的作用

Precision Chemistry Pub Date : 2025-03-11 DOI: 10.1021/prechem.4c0009710.1021/prechem.4c00097

Enyu Zhang, Liping Bai, Zhiping Chen, Aobo Zhang, Yingbo Tang, Jushang Ran, Shuai Wang, Jinying Wang*, Chuancheng Jia* and Xuefeng Guo*,

{"title":"Role of Hydrogen Transfer in Functional Molecular Materials and Devices","authors":"Enyu Zhang, Liping Bai, Zhiping Chen, Aobo Zhang, Yingbo Tang, Jushang Ran, Shuai Wang, Jinying Wang*, Chuancheng Jia* and Xuefeng Guo*, ","doi":"10.1021/prechem.4c0009710.1021/prechem.4c00097","DOIUrl":"https://doi.org/10.1021/prechem.4c00097https://doi.org/10.1021/prechem.4c00097","url":null,"abstract":"Hydrogen transfer is a fundamental chemical process critical to the design and application of organic molecules and functional devices. By uncovering the dynamic interactions between atoms within molecules, hydrogen transfer research offers innovative pathways for creating advanced functional materials and devices. These advancements have driven progress in areas such as optoelectronics, molecular switches, and bioimaging. This review explores the various forms of hydrogen transfer, including hydrogen atom, proton, and hydride transfer, highlighting their mechanisms and key reactions. It also examines the integration of these processes into molecular devices, including single-molecule systems, molecular films, and organic frameworks. Future directions emphasize precise control of hydrogen transfer pathways, development of highly selective and efficient reaction systems, and the design of robust devices based on these processes. These efforts aim to enhance device performance and broaden applications in intelligent materials, integrated functions, and information technology.","PeriodicalId":29793,"journal":{"name":"Precision Chemistry","volume":"3 5","pages":"233–260 233–260"},"PeriodicalIF":0.0,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/prechem.4c00097","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144133896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Art of Building Small 小型建筑的艺术

Precision Chemistry Pub Date : 2025-03-11 DOI: 10.1021/prechem.5c0002310.1021/prechem.5c00023

Ben L. Feringa,

引用次数: 0

Photoresponsive Coatings by Light-Driven Molecular Motors in Cholesteric Liquid Crystal Microcapsules 胆甾型液晶微胶囊的光响应涂层

Precision Chemistry Pub Date : 2025-03-05 DOI: 10.1021/prechem.4c0010310.1021/prechem.4c00103

Yan Wang, Yang Zhang, Shuhua Li, Wang Sun, Zhen Zhang, Guofu Zhou, Ben L. Feringa* and Jiawen Chen*,

{"title":"Photoresponsive Coatings by Light-Driven Molecular Motors in Cholesteric Liquid Crystal Microcapsules","authors":"Yan Wang, Yang Zhang, Shuhua Li, Wang Sun, Zhen Zhang, Guofu Zhou, Ben L. Feringa* and Jiawen Chen*, ","doi":"10.1021/prechem.4c0010310.1021/prechem.4c00103","DOIUrl":"https://doi.org/10.1021/prechem.4c00103https://doi.org/10.1021/prechem.4c00103","url":null,"abstract":"Photoresponsive coatings that can change their color in response to light at ambient temperature have large potential applications. Cholesteric liquid crystals (CLCs) are promising photochromic materials, as they are known to reflect light selectively and their optical properties can be modulated with a wide range. However, it remains a major challenge to fabricate photoresponsive coatings that combine fast and good responsivity, fabrication feasibility, and mechanical strength and, more importantly, that can be applied at a large area with excellent stability. In this study, Pickering emulsions containing CLC microdroplets doped with light-driven molecular motors as photoresponsive chiral dopants were prepared via cellulose nanocrystals (CNCs) which serve as both Pickering emulsifiers and alignment agents of CLCs. A melamine–formaldehyde (MF) resin hybrid shell was fabricated via in situ polymerization to form thermally stable CLC microcapsules. These microcapsules were mixed with curable binders, resulting in photoresponsive coatings. The photochromic material which features highly selective addressability of the reflective light wavelength in the visible light region, good reversibility, and viewing angle independence was painted in a large area on both hard and soft substrates, providing a versatile platform for enhanced encryption and smart coatings.","PeriodicalId":29793,"journal":{"name":"Precision Chemistry","volume":"3 3","pages":"149–156 149–156"},"PeriodicalIF":0.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/prechem.4c00103","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143675680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photoresponsive Coatings by Light-Driven Molecular Motors in Cholesteric Liquid Crystal Microcapsules. 胆甾型液晶微胶囊的光响应涂层。

Precision Chemistry Pub Date : 2025-03-05 eCollection Date: 2025-03-24 DOI: 10.1021/prechem.4c00103

Yan Wang, Yang Zhang, Shuhua Li, Wang Sun, Zhen Zhang, Guofu Zhou, Ben L Feringa, Jiawen Chen

{"title":"Photoresponsive Coatings by Light-Driven Molecular Motors in Cholesteric Liquid Crystal Microcapsules.","authors":"Yan Wang, Yang Zhang, Shuhua Li, Wang Sun, Zhen Zhang, Guofu Zhou, Ben L Feringa, Jiawen Chen","doi":"10.1021/prechem.4c00103","DOIUrl":"10.1021/prechem.4c00103","url":null,"abstract":"Photoresponsive coatings that can change their color in response to light at ambient temperature have large potential applications. Cholesteric liquid crystals (CLCs) are promising photochromic materials, as they are known to reflect light selectively and their optical properties can be modulated with a wide range. However, it remains a major challenge to fabricate photoresponsive coatings that combine fast and good responsivity, fabrication feasibility, and mechanical strength and, more importantly, that can be applied at a large area with excellent stability. In this study, Pickering emulsions containing CLC microdroplets doped with light-driven molecular motors as photoresponsive chiral dopants were prepared via cellulose nanocrystals (CNCs) which serve as both Pickering emulsifiers and alignment agents of CLCs. A melamine-formaldehyde (MF) resin hybrid shell was fabricated via in situ polymerization to form thermally stable CLC microcapsules. These microcapsules were mixed with curable binders, resulting in photoresponsive coatings. The photochromic material which features highly selective addressability of the reflective light wavelength in the visible light region, good reversibility, and viewing angle independence was painted in a large area on both hard and soft substrates, providing a versatile platform for enhanced encryption and smart coatings.","PeriodicalId":29793,"journal":{"name":"Precision Chemistry","volume":"3 3","pages":"149-156"},"PeriodicalIF":0.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938165/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143731915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

3D Printed Microfluidic Devices for Integrated Immunoaffinity Extraction, Solid-Phase Extraction, and Fluorescent Labeling of Preterm Birth Biomarkers 3D打印微流控设备集成免疫亲和萃取，固相萃取，早产生物标志物荧光标记

Precision Chemistry Pub Date : 2025-03-03 DOI: 10.1021/prechem.4c0009210.1021/prechem.4c00092

James D. Holladay, Zachary A. Berkheimer, Michael K. Haggard, Jacob B. Nielsen, Gregory P. Nordin and Adam T. Woolley*,

{"title":"3D Printed Microfluidic Devices for Integrated Immunoaffinity Extraction, Solid-Phase Extraction, and Fluorescent Labeling of Preterm Birth Biomarkers","authors":"James D. Holladay, Zachary A. Berkheimer, Michael K. Haggard, Jacob B. Nielsen, Gregory P. Nordin and Adam T. Woolley*, ","doi":"10.1021/prechem.4c0009210.1021/prechem.4c00092","DOIUrl":"https://doi.org/10.1021/prechem.4c00092https://doi.org/10.1021/prechem.4c00092","url":null,"abstract":"A miniaturized, biomarker-based diagnostic for preterm birth (PTB) risk will require multiple sample preparation steps to be integrated in a single platform. To this end, we created a 3D printed microfluidic device that combines immunoaffinity extraction (IAE), solid-phase extraction (SPE), and fluorescent labeling. This device uses an antibody-functionalized IAE monolith to selectively extract PTB biomarkers, a lauryl methacrylate reverse-phase SPE monolith to concentrate and facilitate fluorescent labeling of PTB biomarkers, and 3D printed valves to control flow through the monoliths. The advantageous iterative design process for arriving at a functional device is documented. The IAE/SPE device performed selective, reproducible extractions of three PTB biomarkers from buffer and depleted maternal blood serum, demonstrating its utility for single-biomarker and multiplexed extractions. After tandem extraction and fluorescent labeling, biomarkers eluted from the SPE monolith in a concentrated plug, facilitating future integration with downstream analysis techniques including microchip electrophoresis. This device effectively combines and automates orthogonal chromatographic extraction methods and constitutes a substantial step toward a complete microfluidic PTB prediction platform.","PeriodicalId":29793,"journal":{"name":"Precision Chemistry","volume":"3 5","pages":"261–271 261–271"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/prechem.4c00092","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144133938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Trend of Nonenzymatic Nucleic Acid Amplification: Strategies and Diagnostic Application. 非酶核酸扩增的趋势：策略和诊断应用。

Precision Chemistry Pub Date : 2025-03-03 eCollection Date: 2025-04-28 DOI: 10.1021/prechem.4c00100

Junyou Li, Ting Li, Zheng Zou, Hung-Wing Li

{"title":"The Trend of Nonenzymatic Nucleic Acid Amplification: Strategies and Diagnostic Application.","authors":"Junyou Li, Ting Li, Zheng Zou, Hung-Wing Li","doi":"10.1021/prechem.4c00100","DOIUrl":"https://doi.org/10.1021/prechem.4c00100","url":null,"abstract":"Nonenzymatic nucleic acid amplification reactions, especially nonenzymatic DNA amplification reactions (NDARs), are thermodynamically driven processes that operate without enzymes, relying on toehold-mediated strand displacement (TMSD) and branch migration. With their sensitive and efficient signal amplification capabilities, NDARs have become essential tools for biomarker detection and intracellular imaging. They encompass four primary amplification methods: catalytic hairpin assembly (CHA), hybridization chain reaction (HCR), DNAzyme-based amplification, and entropy-driven circuits (EDC). Based on amplification mechanisms, NDARs can be categorized into three types: stimuli-responsive NDARs, which employ single amplification strategies triggered by specific stimuli like pH, light, or biomolecules; cascade NDARs, which integrate two or more amplification reactions for stepwise signal enhancement; and autocatalytic NDARs, which achieve exponential amplification through self-sustained cycling. These advanced designs progressively improve amplification efficiency, enhance sensitivity, and minimize background noise, enabling precise detection of proteins, viruses, and nucleic acids as well as applications in cancer cell imaging and therapy. Compared with classical NDARs, these approaches significantly reduce signal leakage, offering broader applicability in diagnostics, imaging, and therapeutic contexts. This review summarizes recent advancements, addresses existing challenges, and explores future directions, providing insights into the development and applications of NDARs.","PeriodicalId":29793,"journal":{"name":"Precision Chemistry","volume":"3 4","pages":"187-205"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12042136/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144003612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

3D Printed Microfluidic Devices for Integrated Immunoaffinity Extraction, Solid-Phase Extraction, and Fluorescent Labeling of Preterm Birth Biomarkers. 3D打印微流控设备集成免疫亲和萃取，固相萃取，早产生物标志物荧光标记。

Precision Chemistry Pub Date : 2025-03-03 eCollection Date: 2025-05-26 DOI: 10.1021/prechem.4c00092

James D Holladay, Zachary A Berkheimer, Michael K Haggard, Jacob B Nielsen, Gregory P Nordin, Adam T Woolley

{"title":"3D Printed Microfluidic Devices for Integrated Immunoaffinity Extraction, Solid-Phase Extraction, and Fluorescent Labeling of Preterm Birth Biomarkers.","authors":"James D Holladay, Zachary A Berkheimer, Michael K Haggard, Jacob B Nielsen, Gregory P Nordin, Adam T Woolley","doi":"10.1021/prechem.4c00092","DOIUrl":"10.1021/prechem.4c00092","url":null,"abstract":"A miniaturized, biomarker-based diagnostic for preterm birth (PTB) risk will require multiple sample preparation steps to be integrated in a single platform. To this end, we created a 3D printed microfluidic device that combines immunoaffinity extraction (IAE), solid-phase extraction (SPE), and fluorescent labeling. This device uses an antibody-functionalized IAE monolith to selectively extract PTB biomarkers, a lauryl methacrylate reverse-phase SPE monolith to concentrate and facilitate fluorescent labeling of PTB biomarkers, and 3D printed valves to control flow through the monoliths. The advantageous iterative design process for arriving at a functional device is documented. The IAE/SPE device performed selective, reproducible extractions of three PTB biomarkers from buffer and depleted maternal blood serum, demonstrating its utility for single-biomarker and multiplexed extractions. After tandem extraction and fluorescent labeling, biomarkers eluted from the SPE monolith in a concentrated plug, facilitating future integration with downstream analysis techniques including microchip electrophoresis. This device effectively combines and automates orthogonal chromatographic extraction methods and constitutes a substantial step toward a complete microfluidic PTB prediction platform.","PeriodicalId":29793,"journal":{"name":"Precision Chemistry","volume":"3 5","pages":"261-271"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12117449/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144183039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Trend of Nonenzymatic Nucleic Acid Amplification: Strategies and Diagnostic Application 非酶核酸扩增的趋势：策略和诊断应用

Precision Chemistry Pub Date : 2025-03-03 DOI: 10.1021/prechem.4c0010010.1021/prechem.4c00100

Junyou Li, Ting Li, Zheng Zou and Hung-Wing Li*,

{"title":"The Trend of Nonenzymatic Nucleic Acid Amplification: Strategies and Diagnostic Application","authors":"Junyou Li, Ting Li, Zheng Zou and Hung-Wing Li*, ","doi":"10.1021/prechem.4c0010010.1021/prechem.4c00100","DOIUrl":"https://doi.org/10.1021/prechem.4c00100https://doi.org/10.1021/prechem.4c00100","url":null,"abstract":"Nonenzymatic nucleic acid amplification reactions, especially nonenzymatic DNA amplification reactions (NDARs), are thermodynamically driven processes that operate without enzymes, relying on toehold-mediated strand displacement (TMSD) and branch migration. With their sensitive and efficient signal amplification capabilities, NDARs have become essential tools for biomarker detection and intracellular imaging. They encompass four primary amplification methods: catalytic hairpin assembly (CHA), hybridization chain reaction (HCR), DNAzyme-based amplification, and entropy-driven circuits (EDC). Based on amplification mechanisms, NDARs can be categorized into three types: stimuli-responsive NDARs, which employ single amplification strategies triggered by specific stimuli like pH, light, or biomolecules; cascade NDARs, which integrate two or more amplification reactions for stepwise signal enhancement; and autocatalytic NDARs, which achieve exponential amplification through self-sustained cycling. These advanced designs progressively improve amplification efficiency, enhance sensitivity, and minimize background noise, enabling precise detection of proteins, viruses, and nucleic acids as well as applications in cancer cell imaging and therapy. Compared with classical NDARs, these approaches significantly reduce signal leakage, offering broader applicability in diagnostics, imaging, and therapeutic contexts. This review summarizes recent advancements, addresses existing challenges, and explores future directions, providing insights into the development and applications of NDARs.","PeriodicalId":29793,"journal":{"name":"Precision Chemistry","volume":"3 4","pages":"187–205 187–205"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/prechem.4c00100","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143878358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0