Precision Chemistry最新文献_第6页

Precision Chemistry Pub Date : 2025-03-24

Naeem Ahmed*, Wei Luo, Ruijuan Zhao, Qiu Zhang, Di Wu, Xia Zheng, Haorui Wang and Chunhua Cui*,

引用次数: 0

Precision Chemistry Pub Date : 2025-03-24

引用次数: 0

Precision Chemistry Pub Date : 2025-03-24

Ben L. Feringa,

引用次数: 0

Precision Chemistry Pub Date : 2025-03-24

Yan Wang, Yang Zhang, Shuhua Li, Wang Sun, Zhen Zhang, Guofu Zhou, Ben L. Feringa* and Jiawen Chen*,

引用次数: 0

Multiplex Detection of Biomarkers Empowered by Nanomaterials. 纳米材料赋予生物标志物多重检测能力。

Precision Chemistry Pub Date : 2025-03-21 eCollection Date: 2025-06-23 DOI: 10.1021/prechem.4c00096

Zongbo Li, Mingquan Guo, Wenwan Zhong

{"title":"Multiplex Detection of Biomarkers Empowered by Nanomaterials.","authors":"Zongbo Li, Mingquan Guo, Wenwan Zhong","doi":"10.1021/prechem.4c00096","DOIUrl":"10.1021/prechem.4c00096","url":null,"abstract":"Biomarkers, including proteins, nucleic acids, and metabolites, are the molecules that can provide insightful information about biological processes and pathological developments. Identification and quantification of biomarkers are highly beneficial for disease diagnosis, progression monitoring, and treatment supervision. However, disease development often involves the complex interplay of molecular networks that limits the utility of individual biomarkers in reaching reliable diagnostic and therapeutic decisions. Thus, recent developments of bioassays have turned the focus to analysis of a collection of biomarkers simultaneously, aiming to improve precision in diagnosis. To achieve the demanded throughput in multiplex detection while keeping the excellent analytical performance in speed, sensitivity, and selectivity, nanomaterials stand out to be the proper enabling tools, with their unique but highly diversified physical and chemical properties and the much advanced synthesis strategies. Herein, this review highlights the recent (2020-2024) developments in the nanomaterial-enabled, optical multiplex sensing techniques. Four key approaches to achieve multiplexity were discussed: spatial coding, signal coding, biocarriers, and data deconvolution using machine learning. We believe these advancements have driven forward the applications of multiplex detection in clinical settings by improving the throughput of biomarker analysis.","PeriodicalId":29793,"journal":{"name":"Precision Chemistry","volume":"3 6","pages":"297-318"},"PeriodicalIF":0.0,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188404/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiplex Detection of Biomarkers Empowered by Nanomaterials 纳米材料赋予生物标志物多重检测能力

Precision Chemistry Pub Date : 2025-03-21 DOI: 10.1021/prechem.4c0009610.1021/prechem.4c00096

Zongbo Li, Mingquan Guo and Wenwan Zhong*,

{"title":"Multiplex Detection of Biomarkers Empowered by Nanomaterials","authors":"Zongbo Li, Mingquan Guo and Wenwan Zhong*, ","doi":"10.1021/prechem.4c0009610.1021/prechem.4c00096","DOIUrl":"https://doi.org/10.1021/prechem.4c00096https://doi.org/10.1021/prechem.4c00096","url":null,"abstract":"Biomarkers, including proteins, nucleic acids, and metabolites, are the molecules that can provide insightful information about biological processes and pathological developments. Identification and quantification of biomarkers are highly beneficial for disease diagnosis, progression monitoring, and treatment supervision. However, disease development often involves the complex interplay of molecular networks that limits the utility of individual biomarkers in reaching reliable diagnostic and therapeutic decisions. Thus, recent developments of bioassays have turned the focus to analysis of a collection of biomarkers simultaneously, aiming to improve precision in diagnosis. To achieve the demanded throughput in multiplex detection while keeping the excellent analytical performance in speed, sensitivity, and selectivity, nanomaterials stand out to be the proper enabling tools, with their unique but highly diversified physical and chemical properties and the much advanced synthesis strategies. Herein, this review highlights the recent (2020–2024) developments in the nanomaterial-enabled, optical multiplex sensing techniques. Four key approaches to achieve multiplexity were discussed: spatial coding, signal coding, biocarriers, and data deconvolution using machine learning. We believe these advancements have driven forward the applications of multiplex detection in clinical settings by improving the throughput of biomarker analysis.","PeriodicalId":29793,"journal":{"name":"Precision Chemistry","volume":"3 6","pages":"297–318 297–318"},"PeriodicalIF":0.0,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/prechem.4c00096","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144338106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of Active Sites for Reverse Water-Gas Shift Reactions on Pt/TiO₂ Cluster Catalysts. Pt/TiO2簇催化剂上逆水气转换反应活性位点的鉴定

IF 6.2

Precision Chemistry Pub Date : 2025-03-21 eCollection Date: 2025-07-28 DOI: 10.1021/prechem.5c00010

Li Feng, Jin-Xun Liu

{"title":"Identification of Active Sites for Reverse Water-Gas Shift Reactions on Pt/TiO2 Cluster Catalysts.","authors":"Li Feng, Jin-Xun Liu","doi":"10.1021/prechem.5c00010","DOIUrl":"https://doi.org/10.1021/prechem.5c00010","url":null,"abstract":"The reverse water-gas shift (RWGS) reaction is a key process for CO2 conversion and sustainable fuel production, yet the nature of the active sites on Pt/TiO2 cluster catalysts remains elusive. Using first-principles microkinetic simulations, we systematically investigated the catalytic behavior of Pt clusters on TiO2 under operational reaction conditions. We studied three distinct catalytic sitesPt cluster surfaces, oxygen vacancies (OV) on TiO2, and Pt-OV-Ti interfacesand revealed that the Pt-OV-Ti interface exhibited the highest RWGS activity via a redox mechanism. This synergy enhances CO2 activation and facilitates oxygen reduction more effectively than the isolated OV on TiO2, which show 4-fold lower activity. In contrast, CO-covered Pt clusters show minimal CO2 activation but serve as H2 dissociation sites, enabling hydrogen spillover to adjacent OV on TiO2, thereby sustaining the RWGS process. Kinetic analysis revealed OH reduction to H2O as the rate-determining step on both interfacial Pt-OV-Ti and at the OV on the TiO2-X support. These findings highlight the pivotal role of the Pt-OV-Ti interface in driving the RWGS and offer a design strategy for optimizing high-temperature CO2 hydrogenation catalysts by maximizing the number of interfacial active sites.","PeriodicalId":29793,"journal":{"name":"Precision Chemistry","volume":"3 7","pages":"380-388"},"PeriodicalIF":6.2,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12308596/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144761594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced Hydrogen Adsorption on In₂O₃(111) via Oxygen Vacancy Engineering. 氧空位工程增强In2O3（111）对氢的吸附

Precision Chemistry Pub Date : 2025-03-20 eCollection Date: 2025-06-23 DOI: 10.1021/prechem.5c00005

Yishui Ding, Jie Chen, Haihong Zheng, Yalong Jiang, Linbo Li, Xiangrui Geng, Xu Lian, Lu Yang, Ziqi Zhang, Kelvin Hongliang Zhang, Hexing Li, JianQiang Zhong, Wei Chen

{"title":"Enhanced Hydrogen Adsorption on In2O3(111) via Oxygen Vacancy Engineering.","authors":"Yishui Ding, Jie Chen, Haihong Zheng, Yalong Jiang, Linbo Li, Xiangrui Geng, Xu Lian, Lu Yang, Ziqi Zhang, Kelvin Hongliang Zhang, Hexing Li, JianQiang Zhong, Wei Chen","doi":"10.1021/prechem.5c00005","DOIUrl":"10.1021/prechem.5c00005","url":null,"abstract":"The emergence of In2O3 as an efficient catalyst for selective hydrogenation has attracted significant attention. However, the mechanism of hydrogen (H2) dissociation on In2O3 remains experimentally elusive. In this work, we show that the interaction of H2 with In2O3 is strongly influenced by the presence of oxygen vacancies. Using a combination of in situ near-ambient-pressure X-ray photoelectron spectroscopy (NAP-XPS), ultraviolet photoelectron spectroscopy (UPS), infrared reflection absorption spectroscopy (IRRAS), and density functional theory (DFT) calculations, we systematically investigated the interaction of H2 on well-defined oxidized In2O3(111) and partially reduced In2O3-x (111) surfaces. Our results reveal that H2 dissociates and adsorbs as hydroxyl groups (OH), which are exclusively stabilized on the In2O3-x (111) surface. The adsorbed hydrogen species act as electron donors, contributing to interfacial electron accumulation near the surface and inducing downward band bending. DFT calculations further indicate that oxygen vacancies in In2O3-x (111) are critical for facilitating the heterolytic dissociation of H2, leading to the stabilization of In-H and OH species. These findings provide valuable implications for the catalytic behavior of indium oxide in hydrogenation and hydrogen-involved redox reactions.","PeriodicalId":29793,"journal":{"name":"Precision Chemistry","volume":"3 6","pages":"337-347"},"PeriodicalIF":0.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188397/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced Hydrogen Adsorption on In2O3(111) via Oxygen Vacancy Engineering 氧空位工程增强In2O3（111）对氢的吸附

Precision Chemistry Pub Date : 2025-03-19 DOI: 10.1021/prechem.5c0000510.1021/prechem.5c00005

Yishui Ding, Jie Chen, Haihong Zheng, Yalong Jiang, Linbo Li, Xiangrui Geng, Xu Lian, Lu Yang, Ziqi Zhang, Kelvin Hongliang Zhang, Hexing Li, JianQiang Zhong* and Wei Chen*,

{"title":"Enhanced Hydrogen Adsorption on In2O3(111) via Oxygen Vacancy Engineering","authors":"Yishui Ding, Jie Chen, Haihong Zheng, Yalong Jiang, Linbo Li, Xiangrui Geng, Xu Lian, Lu Yang, Ziqi Zhang, Kelvin Hongliang Zhang, Hexing Li, JianQiang Zhong* and Wei Chen*, ","doi":"10.1021/prechem.5c0000510.1021/prechem.5c00005","DOIUrl":"https://doi.org/10.1021/prechem.5c00005https://doi.org/10.1021/prechem.5c00005","url":null,"abstract":"The emergence of In2O3 as an efficient catalyst for selective hydrogenation has attracted significant attention. However, the mechanism of hydrogen (H2) dissociation on In2O3 remains experimentally elusive. In this work, we show that the interaction of H2 with In2O3 is strongly influenced by the presence of oxygen vacancies. Using a combination of in situ near-ambient-pressure X-ray photoelectron spectroscopy (NAP-XPS), ultraviolet photoelectron spectroscopy (UPS), infrared reflection absorption spectroscopy (IRRAS), and density functional theory (DFT) calculations, we systematically investigated the interaction of H2 on well-defined oxidized In2O3(111) and partially reduced In2O3–x(111) surfaces. Our results reveal that H2 dissociates and adsorbs as hydroxyl groups (OH), which are exclusively stabilized on the In2O3–x(111) surface. The adsorbed hydrogen species act as electron donors, contributing to interfacial electron accumulation near the surface and inducing downward band bending. DFT calculations further indicate that oxygen vacancies in In2O3–x(111) are critical for facilitating the heterolytic dissociation of H2, leading to the stabilization of In–H and OH species. These findings provide valuable implications for the catalytic behavior of indium oxide in hydrogenation and hydrogen-involved redox reactions.","PeriodicalId":29793,"journal":{"name":"Precision Chemistry","volume":"3 6","pages":"337–347 337–347"},"PeriodicalIF":0.0,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/prechem.5c00005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144338105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improving the Cold-Start Performance of Proton Exchange Membrane Fuel Cells via Precision Engineering of Key Materials. 关键材料精细化工程提高质子交换膜燃料电池冷启动性能。

Precision Chemistry Pub Date : 2025-03-14 eCollection Date: 2025-04-28 DOI: 10.1021/prechem.4c00079

Zhiyuan Ge, Shuying Xu, Xiaoyang Fu, Zipeng Zhao

{"title":"Improving the Cold-Start Performance of Proton Exchange Membrane Fuel Cells via Precision Engineering of Key Materials.","authors":"Zhiyuan Ge, Shuying Xu, Xiaoyang Fu, Zipeng Zhao","doi":"10.1021/prechem.4c00079","DOIUrl":"https://doi.org/10.1021/prechem.4c00079","url":null,"abstract":"Proton exchange membrane fuel cells (PEMFCs) have emerged as important zero-emission power sources due to their efficiency and eco-friendly characteristics. A critical feature required for their widespread adoption is the performance of low-temperature cold start. However, at subzero degrees Celsius, the freezing of the produced water can hinder or even lead to failure of the fuel cell start-up process. To successfully achieve a cold start under such conditions, the PEMFC must rapidly and reliably transition from a fully cooled state to a stable operating condition. Various improvements have been focused on the system engineering aspect to address this challenge, yet many of these methods come with their drawbacks. This paper reviews the recent progress of the PEMFC cold start from the perspective of key materials engineering. It provides a detailed summary of how the proton exchange membrane (PEM), catalyst layer, microporous layer (MPL), and gas diffusion layer (GDL) affect the cold-start performance. Further analysis reveals that the fundamental mechanisms of improving cold-start performance can be summarized into three aspects: increasing the ratio of water bound in the ionomer, hindering the transformation process from supercooled water to ice, improving the removal of supercooled water, or ensuring it is transported to the outside of the membrane electrode assembly (MEA) before it gets frozen. By precisely regulating these key components, it is possible to develop a simple and energy-efficient solution for improving the cold start performance of the PEMFC.","PeriodicalId":29793,"journal":{"name":"Precision Chemistry","volume":"3 4","pages":"172-186"},"PeriodicalIF":0.0,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12042135/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0