硅氧烷和3-氨基乙烷分子间（3 + 2）环法制备γ-内酰胺

IF 6.2

Precision Chemistry Pub Date : 2025-04-11 DOI:10.1021/prechem.5c00029

Xiang Li, Qiang Feng, Shuxuan Liu, Hai Huang, Zhengyu Han* and Jianwei Sun*,

引用次数: 0

摘要

研究了银催化硅氧烷和3-氨基乙烷分子间（3 + 2）环化反应。该工艺为制备具有高区域选择性和立体选择性的γ-丁内酰胺提供了温和、方便的途径。从机制上讲，分子间C-N键的形成可能先于氧烷环的打开。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Synthesis of γ-Lactams by Intermolecular (3 + 2) Annulation of Siloxy Alkynes and 3-Aminooxetanes

A silver-catalyzed intermolecular (3 + 2) annulation of siloxy alkynes and 3-aminooxetanes has been developed. This process provides mild and convenient access to useful γ-butyrolactams with high regio- and stereoselectivity. Mechanistically, intermolecular C–N bond formation likely precedes oxetane ring opening.

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来源期刊

Precision Chemistry 精密化学技术-

CiteScore

0.80

自引率

0.00%

发文量

期刊介绍： Chemical research focused on precision enables more controllable predictable and accurate outcomes which in turn drive innovation in measurement science sustainable materials information materials personalized medicines energy environmental science and countless other fields requiring chemical insights.Precision Chemistry provides a unique and highly focused publishing venue for fundamental applied and interdisciplinary research aiming to achieve precision calculation design synthesis manipulation measurement and manufacturing. It is committed to bringing together researchers from across the chemical sciences and the related scientific areas to showcase original research and critical reviews of exceptional quality significance and interest to the broad chemistry and scientific community.