Journal of the American Nutrition Association最新文献

{"title":"The Longitudinal Effect of Sugar-Sweetened Beverage Consumption and Risk of All-Cause and Cause-Specific Mortality in Korean Adults: Results From the Health Examinees Study.","authors":"Hyein Jung, Yoonjoo Choi, Byungmi Kim","doi":"10.1080/27697061.2024.2449024","DOIUrl":"10.1080/27697061.2024.2449024","url":null,"abstract":"<p><strong>Objective: </strong>High consumption of sugar-sweetened beverages (SSBs) is associated with an increased risk of all-cause and cardiovascular disease (CVD) mortality; however, the data and results for Asian populations, particularly in Korea, are limited and unclear. Therefore, this research aimed to investigate the association between types of SSB consumption and risk of all-cause and cause-specific mortality in South Korean adults.</p><p><strong>Methods: </strong>This prospective study included Korean adults aged 40 to 79 who participated in the Health Examinees Study. The baseline survey was conducted from 2004 to 2013, and death data were obtained until December 2022. A food frequency questionnaire was used to assess SSB intake, and all-cause, CVD, and cancer mortality were estimated. The SSB included total SSB, soda, and other drinks (Korean traditional SSB).</p><p><strong>Results: </strong>A total of 126,856 participants were included (mean [standard deviation]: age, 53.1 [8.3] years; 82,311 [64.9%] women). During a mean follow-up of 11.0 years, 5741 all-cause, 936 CVD, and 2662 cancer deaths were recorded. Increased soda consumption was associated with higher all-cause mortality (1-3 servings/wk: hazard ratio [HR], 1.125; 95% confidence interval [CI], 1.003-2.263; ≥3 servings/wk: HR, 1.190, 95% CI, 1.011-1.401), compared with low soda intake (never-<1 serving/wk). However, there was no association between total SSB consumption and other drinks with all-cause and cause-specific mortality. In the dose-response analysis, a trend in which a higher risk of all-cause and CVD cancers was observed with increasing soda intake.</p><p><strong>Conclusion: </strong>In this large prospective study, soda intake of >1 serving/wk was associated with an increased risk of all-cause mortality among Korean adults. However, there was no association between total SSB or other drinks and mortality. As the consumption of SSBs increases in the Korean population, appropriate control strategies are needed to reduce SSB consumption and the disease burden.</p>","PeriodicalId":29768,"journal":{"name":"Journal of the American Nutrition Association","volume":" ","pages":"468-477"},"PeriodicalIF":6.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143013072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnesium Deficiency: The Insidious Executor of the Liver Disease.","authors":"Ziyi Yang, Jia Li, Jie Zhang, Chao Sun","doi":"10.1080/27697061.2024.2443063","DOIUrl":"10.1080/27697061.2024.2443063","url":null,"abstract":"<p><p>Magnesium (Mg), which is predominantly present in cells as a micronutrient, is involved in numerous vital physiological processes, such as DNA repair and energy metabolism. Mg deficiency has been reported to contribute toward the advent and progression of a variety of liver diseases; in particular, these two pathological entities may synergistically act. Given the significant impact and increasing burden of liver diseases on global healthcare resources and economic expenditure, it is tempting to manage Mg insufficiency as novel promising therapeutic strategies. In this review, we comprehensively elaborate on the complicated relationship between Mg deficiency and several contextual liver diseases, with concentrating on the underlying molecular mechanisms.</p>","PeriodicalId":29768,"journal":{"name":"Journal of the American Nutrition Association","volume":" ","pages":"439-453"},"PeriodicalIF":6.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142883098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Standardized <i>Boswellia serrata</i> Extract Improves Knee Joint Function and Cartilage Morphology in Human Volunteers with Mild to Moderate Osteoarthritis in a Randomized Placebo-Controlled Study.","authors":"Brijesh Kumar, Abhijeet Balbhim Ghaytidak, Abhinav Kumar Pandey, Raghu Ram Somepalli, Praveen Sarda, Siba Prasad Raychaudhuri, Meher Prasanna Rokkam","doi":"10.1080/27697061.2024.2438894","DOIUrl":"10.1080/27697061.2024.2438894","url":null,"abstract":"<p><strong>Background and objective: </strong><i>Boswellia serrata</i> Roxb. ex Colebr. (Family: Burseraceae; Genus: Boswellia) gum resin (Salai guggul) has profound therapeutic value in Ayurvedic and Unani medicines in alleviating several chronic inflammatory illnesses, including arthritis, asthma, skin and blood diseases, fever, etc. SN13108F (Aflapin^®) is a proprietary, standardized <i>Boswellia serrata</i> gum resin extract. This 180-day randomized, placebo-controlled clinical study aimed to evaluate cartilage morphology using magnetic resonance imaging (MRI), pain and joint function and long-term safety in the SN13108F-supplemented volunteers with knee osteoarthritis (KOA).</p><p><strong>Materials and methods: </strong>Eighty adult male and female subjects with the Kellgren-Lawrence grade II - III KOA were supplemented with SN13108F (100 mg/day) or a matched placebo for 180 consecutive days.</p><p><strong>Results: </strong>SN13108F reduced (<i>p</i> < 0.001; vs. baseline and placebo) Western Ontario and McMaster Universities Osteoarthritis Index, Visual Analogue Scale, Lequesne's Functional Index scores, improved six-minute walk test, and stair climb test. Post-trial MRI assessments of the tibiofemoral joints revealed that the cartilage volume, thickness, and joint space width were increased (<i>p</i> < 0.001; vs. placebo), and levels of high-sensitivity C-reactive protein, matrix metalloproteinase-3, Fibulin-3, type II collagen degradation peptide in serum, and cross-linked C-terminal telopeptide of type II collagen in urine were significantly reduced (<i>p</i> < 0.001; vs. baseline and placebo) in the SN13108F-supplemented subjects. Hematology, complete serum biochemistry, urine analysis, and the participants' vital signs did not alter between the groups.</p><p><strong>Conclusion: </strong>SN13108F supplementation is safe, and it mitigates joint pain and improves musculoskeletal function and cartilage morphology in KOA.</p>","PeriodicalId":29768,"journal":{"name":"Journal of the American Nutrition Association","volume":" ","pages":"375-386"},"PeriodicalIF":6.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142865595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of Glycemic Index and Glycemic Load of Indigenous Cereal Products of Pakistan.","authors":"Muniba Khaliq, Sanaullah Iqbal, Farhan Saeed, Gaurav Sanghvi, Faiyaz Ahmed, Ayesha Amjad, Amina Chughtai, Muhammad Nawaz, Naveed Akbar, Rajashree Panigrahi, Amara Rasheed, Muhammad Afzaal, Fakhar Islam","doi":"10.1080/27697061.2025.2523600","DOIUrl":"https://doi.org/10.1080/27697061.2025.2523600","url":null,"abstract":"<p><strong>Background: </strong>Glycemic index (GI) and glycemic load (GL) are important dietary gears for managing diabetes and reducing chronic disease risk.</p><p><strong>Objective: </strong>The objective of study was to prepare glycemic index (GI) and glycemic load (GL) table, for the first time, of 50 indigenous cereal-based products of Pakistan.</p><p><strong>Methodology: </strong>Test foods were categorized into 6 categories: bread, rice, porridges, biscuits, snacks, and desserts. Every food product, 50 g of available carbohydrates, was tested on at least 10 healthy participants and blood glucose level was determined at set intervals through the finger-prick method. Glucose and white bread were used as reference foods. The GI and GL values were calculated from the incremental area under the curve (IAUC) of each test food as a percentage of every participant's average IAUC for the reference food. GL was calculated as the product of the test food's GI and the amount of available carbohydrate in a reference serving size.</p><p><strong>Results: </strong>Results indicated that only seven test foods had low GI (55 or less), sixteen were classified as medium (56-69) and twenty-seven showed high GI values (>70).</p><p><strong>Conclusion: </strong>The study concludes that majority of cereal based traditional foods/recipes have medium to high GI and GL.</p>","PeriodicalId":29768,"journal":{"name":"Journal of the American Nutrition Association","volume":" ","pages":"1-8"},"PeriodicalIF":6.8,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144529955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Vitamin D and IBD Nexus: Immune Links and Therapeutic Prospects.","authors":"Yukta Garg, Nandini Sharma, Raj Kumar Narang, Amandeep Singh","doi":"10.1080/27697061.2025.2518117","DOIUrl":"https://doi.org/10.1080/27697061.2025.2518117","url":null,"abstract":"","PeriodicalId":29768,"journal":{"name":"Journal of the American Nutrition Association","volume":" ","pages":"1-5"},"PeriodicalIF":6.8,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144477017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Effects of Durian and Banana Consumption on Thermic Effect of Food and Metabolic Responses in Healthy Adults.","authors":"Charlotte Yiin Ling, Michelle Ting Yun Yeo, Yan Kang, Shu Min Ng, Xinyan Bi, Christiani Jeyakumar Henry","doi":"10.1080/27697061.2024.2426563","DOIUrl":"10.1080/27697061.2024.2426563","url":null,"abstract":"<p><strong>Objective: </strong>In traditional Chinese philosophy, durian is classified as a \"yang\" food with heaty properties, believed to raise body temperature and blood pressure (BP) after consumption. In contrast, bananas are considered as \"yin,\" possessing cooling effect. However, scientific evidence supporting these concepts is limited. This study aims to compare the metabolic effects in response to durian and banana ingestion.</p><p><strong>Methods: </strong>This randomized cross-over clinical study recruited 16 young, healthy Chinese participants (8 males and 8 females). All participants ingested isocaloric portion (367.5 kcal) of durian and banana with a wash-out period of at least 5 days. 3-h thermic effect of food (TEF) and substrate oxidation were assessed by indirect calorimetry. Postprandial vital signs and metabolic responses were measured over a period of 3 h.</p><p><strong>Results: </strong>Durian induced a higher and longer-lasting TEF than banana in most participants. Additionally, durian significantly lowered BP and increased triglyceride (TG) levels during 3 h after consumption, whereas bananas had no significant effects on these measures. Despite containing much fewer carbohydrates, durian prompted a comparable postprandial rise in blood glucose concentrations to that of banana.</p><p><strong>Conclusion: </strong>While durian offers nutritional benefits and a BP-lowering effect, moderation is recommended due to its high sugar and fat content, which can elevate blood glucose and lipid levels, and its \"heatiness\" may cause digestive discomforts and a sore throat according to anecdotal experiences.</p>","PeriodicalId":29768,"journal":{"name":"Journal of the American Nutrition Association","volume":" ","pages":"283-291"},"PeriodicalIF":6.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142627903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chia Oil (<i>Salvia hispanica</i> L.) Improves the Intestinal Health of <i>Wistar</i> Rats Fed a Hypercaloric Diet.","authors":"Violeta Nunes de Morais, Luiza de Paula Dias Moreira, Mariana Juste Contin Gomes, Mariana Grancieri, Haira Guedes Lucio, Renata Celi Lopes Toledo, Marcella Duarte Villas Mishima, Neuza Maria Brunoro Costa, Bárbara Pereira da Silva, Hércia Stampini Duarte Martino","doi":"10.1080/27697061.2024.2431271","DOIUrl":"10.1080/27697061.2024.2431271","url":null,"abstract":"<p><strong>Background: </strong>A diet rich in fat and sugar is present in society everyday life, leading to the development of metabolic changes, especially in intestinal microbiota. Chia oil is a source of alpha-linolenic acid, which has antioxidant and anti-glycemic effects. Based on this, we hypothesized that chia oil may promote intestinal health.</p><p><strong>Objective: </strong>The study aims to investigate the effects of chia oil on gut microbiota and intestinal health in <i>Wistar</i> rats fed a high-fat and high-fructose diet (HFHF).</p><p><strong>Methods: </strong>The animals were separated into two groups and received the following diets: standard murine diet (AIN-93M) (<i>n</i> = 10) and HFHF (<i>n</i> = 20) to induce metabolic changes (phase I) during eight weeks. After that, the AIN-93M group remained unchanged, while the HFHF group was divided into two groups: HFHF (<i>n</i> = 10) and HFHF with chia oil (HFHF+CO) (<i>n</i> = 10) for ten weeks (phase II, chia oil treatment). We analyzed immunoglobulin A (IgA) levels, cecal pH, short-chain fatty acids (SCFAs), intestinal permeability, intestinal microbiome composition, histomorphometry, and murinometric parameters.</p><p><strong>Results: </strong>Chia oil consumption increased alpha-linolenic acid intake, IgA levels, propionic acid production, cecum weight, goblet cell number, thickness and depth of intestinal crypts, and the thickness of both circular and longitudinal muscle layers of the colon, and decreased cecal pH. No change was observed in the alpha and beta diversity between the HFHF and HFHF+CO groups. The HFHF+CO diet increased the relative abundance of genera <i>Lactobacillus</i> sp., <i>Faecalibacterium</i> sp., and <i>Erysipelatoclostridium</i> sp., compared to the AIN-93M group. No difference was observed in the intestinal permeability among the groups.</p><p><strong>Conclusion: </strong>Chia oil consumption is an alternative for improving the intestinal health of rats fed a HFHF diet.</p>","PeriodicalId":29768,"journal":{"name":"Journal of the American Nutrition Association","volume":" ","pages":"322-331"},"PeriodicalIF":6.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the Influence of a Bitter Melon Product on Indicators of Cardiometabolic Health in Adults with Prediabetes.","authors":"Liana L Guarneiri, Meredith L Wilcox, Chen-Meng Kuan, Kevin C Maki","doi":"10.1080/27697061.2024.2428301","DOIUrl":"10.1080/27697061.2024.2428301","url":null,"abstract":"<p><strong>Objective: </strong>The purpose of this study was to assess the impact of bitter melon extract supplementation on glycemia in individuals with prediabetes.</p><p><strong>Methods: </strong>This was a 12-week randomized, parallel, placebo-controlled study where 75 adults with prediabetes were randomly allocated into the low-dose bitter melon (300 mg/day) (<i>n</i> = 26), high-dose bitter melon (600 mg/day) (<i>n</i> = 24), or control (<i>n</i> = 25) groups.</p><p><strong>Results: </strong>At baseline and weeks 6 and 12, anthropometrics were measured, and fasting blood samples were obtained. The high-dose (1.05% ± 10.2%) and low-dose bitter melon (3.35% ± 13.2%) groups showed smaller increases in blood glucose levels at 12 wk, compared to the control group (11.0% ± 16.3%) (<i>p</i> < 0.05). A subgroup analysis of participants with age ≥ the median demonstrated a greater reduction in glycated hemoglobin at 12 wk in the high-dose bitter melon group (median change: -0.20%; IQRL: -0.20%, -0.05%) vs. the control group (median change: 0.00%; IQRL: -0.10%, 0.20%) (<i>p</i> = 0.017). Compliance with the interventions was >95%, and the study products were tolerated well.</p><p><strong>Conclusion: </strong>The bitter melon extract may help maintain a healthy level of glucose in adults with prediabetes.</p>","PeriodicalId":29768,"journal":{"name":"Journal of the American Nutrition Association","volume":" ","pages":"306-314"},"PeriodicalIF":6.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142627926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Test Anxiety on Nutritional Habits, Anthropometric Measurements, and Gastrointestinal Symptoms in Adolescents.","authors":"Merve Aytaç, Sinem Bayram","doi":"10.1080/27697061.2024.2431270","DOIUrl":"10.1080/27697061.2024.2431270","url":null,"abstract":"<p><p><b>Objective:</b> Since exam periods are used as a benchmark to determine academic achievement, they may result in increased anxiety, changes in dietary behavior, weight fluctuations and increased gastrointestinal symptoms in students. For this reason, this research was conducted to evaluate the effect of test anxiety on nutritional status and gastrointestinal symptoms in adolescents.</p><p><p><b>Methods:</b> This study was conducted with 104 senior high school students who agreed to participate in the study in a private and public school in Ankara 7 months before the exam and 1 month before the exam to evaluate the effect of exam anxiety on nutritional status and gastrointestinal symptoms of students preparing for the university exam. Health status, nutritional status, anthropometric measurements, information about exam anxiety, International Physical Activity Questionnaire Short Form, Test Anxiety Inventory, Gastrointestinal Symptom Rating Scale, Food Frequency Questionnarie (FFQ) were asked to the students.</p><p><p><b>Results:</b> In both genders, the mean BMI-Z score increased during the second evaluation, indicating a significant difference in various dietary and lifestyle factors such as meal frequency, water intake, and nutrient intake. Most students were classified as minimally active. Additionally, the total score of affective, delusional, and test anxiety inventory increased closer to the exam date. Weak positive correlations were observed between gastrointestinal symptoms and affective, delusional, and test anxiety scores during the first evaluation, while a moderately strong positive correlation emerged during the second evaluation.</p><p><p><b>Conclusion:</b> The results of the current study support that students experience increased gastrointestinal symptoms during the exam period. Nutrition and stress reduction educations should be given in high schools both during and before the exam period in a multidisciplinary team consisted of dietitians and psychologists in order to provide healthy stress management.</p>","PeriodicalId":29768,"journal":{"name":"Journal of the American Nutrition Association","volume":" ","pages":"315-321"},"PeriodicalIF":6.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142772887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Creatine Intake Is Not Associated With Elevated Circulating Cystatin C Levels in Individuals With and Without Kidney Dysfunction in the General Population.","authors":"David Nedeljkovic, Sonja Baltic, Nikola Todorovic, Sergej M Ostojic","doi":"10.1080/27697061.2024.2432484","DOIUrl":"10.1080/27697061.2024.2432484","url":null,"abstract":"<p><strong>Objective: </strong>The potential adverse effects of dietary creatine on kidney health are rarely addressed at the population level, particularly in individuals with preexisting kidney disease. This study aimed to evaluate the association between dietary creatine intake and serum cystatin C levels in participants with and without kidney failure, utilizing data from the 1999-2001 National Health and Nutrition Examination Survey (NHANES) round.</p><p><strong>Method: </strong>A total of 4969 individuals (50.0% female; mean age 51.2 ± 23.9 years) who provided information on dietary creatine intake and had serum cystatin C levels measured were included in the final analysis.</p><p><strong>Results: </strong>Linear regression across the entire sample revealed a significant inverse association between daily creatine intake and cystatin C concentrations (unstandardized <i>B</i> = -0.003; ß = -0.067; <i>p</i> < 0.001), indicating that for each additional milligram of creatine intake, the expected reduction in cystatin C levels was 0.003 mg/dL. In a subsample of respondents with kidney dysfunction, a significant negative association was found between creatine intake and cystatin C levels (unstandardized <i>B</i> = -0.024; ß = -0.165; <i>p</i> = 0.046).</p><p><strong>Conclusions: </strong>Findings suggest that food-derived creatine does not pose a risk of kidney stress, even for individuals with kidney failure, and might be considered a renoprotective nutrient.</p>","PeriodicalId":29768,"journal":{"name":"Journal of the American Nutrition Association","volume":" ","pages":"338-341"},"PeriodicalIF":6.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142956046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}