Liana L Guarneiri, Meredith L Wilcox, Chen-Meng Kuan, Kevin C Maki
{"title":"调查苦瓜产品对糖尿病前期成人心脏代谢健康指标的影响","authors":"Liana L Guarneiri, Meredith L Wilcox, Chen-Meng Kuan, Kevin C Maki","doi":"10.1080/27697061.2024.2428301","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>The purpose of this study was to assess the impact of bitter melon extract supplementation on glycemia in individuals with prediabetes.</p><p><strong>Methods: </strong>This was a 12-week randomized, parallel, placebo-controlled study where 75 adults with prediabetes were randomly allocated into the low-dose bitter melon (300 mg/day) (<i>n</i> = 26), high-dose bitter melon (600 mg/day) (<i>n</i> = 24), or control (<i>n</i> = 25) groups.</p><p><strong>Results: </strong>At baseline and weeks 6 and 12, anthropometrics were measured, and fasting blood samples were obtained. The high-dose (1.05% ± 10.2%) and low-dose bitter melon (3.35% ± 13.2%) groups showed smaller increases in blood glucose levels at 12 wk, compared to the control group (11.0% ± 16.3%) (<i>p</i> < 0.05). A subgroup analysis of participants with age ≥ the median demonstrated a greater reduction in glycated hemoglobin at 12 wk in the high-dose bitter melon group (median change: -0.20%; IQRL: -0.20%, -0.05%) vs. the control group (median change: 0.00%; IQRL: -0.10%, 0.20%) (<i>p</i> = 0.017). Compliance with the interventions was >95%, and the study products were tolerated well.</p><p><strong>Conclusion: </strong>The bitter melon extract may help maintain a healthy level of glucose in adults with prediabetes.</p>","PeriodicalId":29768,"journal":{"name":"Journal of the American Nutrition Association","volume":" ","pages":"1-9"},"PeriodicalIF":6.8000,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Investigation of the Influence of a Bitter Melon Product on Indicators of Cardiometabolic Health in Adults with Prediabetes.\",\"authors\":\"Liana L Guarneiri, Meredith L Wilcox, Chen-Meng Kuan, Kevin C Maki\",\"doi\":\"10.1080/27697061.2024.2428301\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>The purpose of this study was to assess the impact of bitter melon extract supplementation on glycemia in individuals with prediabetes.</p><p><strong>Methods: </strong>This was a 12-week randomized, parallel, placebo-controlled study where 75 adults with prediabetes were randomly allocated into the low-dose bitter melon (300 mg/day) (<i>n</i> = 26), high-dose bitter melon (600 mg/day) (<i>n</i> = 24), or control (<i>n</i> = 25) groups.</p><p><strong>Results: </strong>At baseline and weeks 6 and 12, anthropometrics were measured, and fasting blood samples were obtained. The high-dose (1.05% ± 10.2%) and low-dose bitter melon (3.35% ± 13.2%) groups showed smaller increases in blood glucose levels at 12 wk, compared to the control group (11.0% ± 16.3%) (<i>p</i> < 0.05). A subgroup analysis of participants with age ≥ the median demonstrated a greater reduction in glycated hemoglobin at 12 wk in the high-dose bitter melon group (median change: -0.20%; IQRL: -0.20%, -0.05%) vs. the control group (median change: 0.00%; IQRL: -0.10%, 0.20%) (<i>p</i> = 0.017). Compliance with the interventions was >95%, and the study products were tolerated well.</p><p><strong>Conclusion: </strong>The bitter melon extract may help maintain a healthy level of glucose in adults with prediabetes.</p>\",\"PeriodicalId\":29768,\"journal\":{\"name\":\"Journal of the American Nutrition Association\",\"volume\":\" \",\"pages\":\"1-9\"},\"PeriodicalIF\":6.8000,\"publicationDate\":\"2024-11-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of the American Nutrition Association\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1080/27697061.2024.2428301\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"NUTRITION & DIETETICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the American Nutrition Association","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/27697061.2024.2428301","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
Investigation of the Influence of a Bitter Melon Product on Indicators of Cardiometabolic Health in Adults with Prediabetes.
Objective: The purpose of this study was to assess the impact of bitter melon extract supplementation on glycemia in individuals with prediabetes.
Methods: This was a 12-week randomized, parallel, placebo-controlled study where 75 adults with prediabetes were randomly allocated into the low-dose bitter melon (300 mg/day) (n = 26), high-dose bitter melon (600 mg/day) (n = 24), or control (n = 25) groups.
Results: At baseline and weeks 6 and 12, anthropometrics were measured, and fasting blood samples were obtained. The high-dose (1.05% ± 10.2%) and low-dose bitter melon (3.35% ± 13.2%) groups showed smaller increases in blood glucose levels at 12 wk, compared to the control group (11.0% ± 16.3%) (p < 0.05). A subgroup analysis of participants with age ≥ the median demonstrated a greater reduction in glycated hemoglobin at 12 wk in the high-dose bitter melon group (median change: -0.20%; IQRL: -0.20%, -0.05%) vs. the control group (median change: 0.00%; IQRL: -0.10%, 0.20%) (p = 0.017). Compliance with the interventions was >95%, and the study products were tolerated well.
Conclusion: The bitter melon extract may help maintain a healthy level of glucose in adults with prediabetes.
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