Journal of the American Nutrition Association最新文献

{"title":"Glycemic Index and Appetite Response of Iron-Biofortified Cowpeas (<i>Vigna unguiculata</i> (l.) Walp.) in Healthy Adults and Its Effects on Inflammation and Oxidative Stress in Raw 264.7 Cells.","authors":"Mariana Grancieri, Letícia de Souza Scherrer Medeiros, Cíntia Tomaz Sant'Ana, Livia Maria da Silva, Rita de Cássia Gonçalves Alfenas, Neuza Maria Brunoro Costa","doi":"10.1080/27697061.2025.2502834","DOIUrl":"https://doi.org/10.1080/27697061.2025.2502834","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to determine the glycemic index of conventional and biofortified cowpeas, their effects on healthy individuals' appetite, and their anti-inflammatory and antioxidant effects in RAW 264.7 cells.</p><p><strong>Methods: </strong>Iron biofortified (BRS Aracê, BRS Tumucumaque, and BRS Xiquexique) and conventional (BRS Pajeú) cowpeas were cooked and their chemical composition was analyzed. Eutrophic adults (<i>n</i> = 11) consumed each cowpea and control glucose and post-prandial glucose and appetite responses were obtained over 120 min. <i>In vitro</i>, the study used RAW 264.7 cells stimulated with lipopolysaccharide-LPS (1 µML) and treated with digested cowpea beans (1 mg/mL). Total antioxidant capacity (TAC), nitric oxide, superoxide dismutase (SOD), TNF-α, and IL-10 were analyzed in the cell and culture medium, and NF-κB by immunohistochemistry. The data were analyzed by ANOVA and <i>post-hoc</i> of Tukey (<i>p</i> < 0.05).</p><p><strong>Results: </strong>All cowpeas had a lower incremental area under the glycemic curve (iAUC) than glucose. In appetite responses, Pajeú had the lowest \"hunger sensation\" and higher \"satiety sensation\" (<i>p</i> < 0.05). <i>In vitro</i> analysis showed that Pajeú and Tumucumaque improved TAC and biofortified cowpeas reduced the activation and translocation of NF-κB to nuclei. However, the cowpeas had no effects on SOD activity, nitric oxide, TNF-α, and IL-10 released and production into cells (<i>p</i> > 0.05).</p><p><strong>Conclusions: </strong>Cowpea, biofortified or not, presents benefits in reducing the glycemic index, but has a moderate impact on induced inflammation, being a sustainable option for human intake and health.</p><p><strong>Clinical trial registration: </strong>Brazilian Clinical Trials Registry (ReBEC), number RBR-7ntftdv.</p>","PeriodicalId":29768,"journal":{"name":"Journal of the American Nutrition Association","volume":" ","pages":"1-13"},"PeriodicalIF":6.8,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Updated Insight on the Chemistry, Ethnobotany, and Health Benefits of <i>Asparagus racemosus</i> (Shatavari): With a Special Emphasis on Shatavarin IV.","authors":"Pradipta Banerjee, Arpan Das, Pawan Kumar, Sanjoy Chakraborty, Komal Jalan","doi":"10.1080/27697061.2025.2496945","DOIUrl":"https://doi.org/10.1080/27697061.2025.2496945","url":null,"abstract":"<p><p><i>Asparagus racemosus</i>, more famous as Shatavari, is a popular medicinal plant with a broad species distribution across the Indian subcontinent as well as across the globe. The multidimensional therapeutic potential of this herb has earned it the title of \"Queen of Herbs.\" Shatavari is rich in bioactive constituents including alkaloids, carboxylic acids, polycyclic hydrocarbons, isoflavones, flavonoids, dihydrophenanthrene derivatives, furan derivatives, essential oils, sterols, and steroidal saponin (specifically Shatavarin-I to VI), distributed throughout the rhizome as well as in other parts of the plant. These compounds are frequently used in the treatment of several medical conditions, including dysentery, diabetic retinopathy, hypertension, anxiety disorders, inflammation, tumors, mental disorders, hyperacidity, viral diseases, spasms, chronic fever, and rheumatism. In addition, Shatavari possesses antibacterial, adaptogenic, and antioxidant properties. Shatavarin IV, a sarsapogenin enriched in the roots of Shatavari, is especially beneficial for women's reproductive health and also acts as an effective stressbuster. It is used as a remedy for female infertility by boosting libido, managing sexual organ inflammation, facilitating folliculogenesis and ovulation, preparing the uterus for conception, preventing miscarriages, functioning as a postpartum tonic by enhancing lactation and restoring uterine and hormonal homeostasis. In this regard, a novel Asparagus root formulation, Shevari4T^®, has been developed, with Shatavarin IV content exceeding 7.4%, which promises to deliver the goodness of Shatavari, especially for women. This review provides a comprehensive insight into the holistic health benefits of Shatavari, with particular emphasis on Shatavarin IV.Key teaching pointsAsparagus racemosus (Shatavari) is a perennial climber medicinal plant containing multiple bioactive constituents including selected steroidal saponins, namely, Shatavarin I - VI.Shatavarin I and Shatavarin IV are the most potent glycosides found in abundance in the roots of the plant.Shatavarin IV is comprising of two molecules of rhamnose and one glucose molecule, and basically it is a glycoside of sarsasapogenin.Shatavarin IV, a steroidal saponin from Asparagus racemosus, exhibits potent pharmacological effects including antioxidant, anti-cancer, anti-inflammatory, cardioprotective, immunomodulatory, neuroprotective, antibacterial, antidiabetic and antihypertensive properties.It also augments female fertility and reproduction by facilitating folliculogenesis and ovulation, preparing the uterus for conception, preventing miscarriages, functioning as a postpartum tonic by enhancing lactation and restoring uterine and hormonal homeostasis.</p>","PeriodicalId":29768,"journal":{"name":"Journal of the American Nutrition Association","volume":" ","pages":"1-12"},"PeriodicalIF":6.8,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143988982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary Total Antioxidant Capacity of Brazilian Adults and the Elderly: An Analysis Based on the Degree of Food Processing (NOVA Classification).","authors":"Luana Alberti Noronha, Marcela Nogueira Ferrario, Eloá Angélica Koehnlein","doi":"10.1080/27697061.2025.2496489","DOIUrl":"https://doi.org/10.1080/27697061.2025.2496489","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to estimate the dietary total antioxidant capacity (DTAC) of Brazilian adults and elderly and to identify the foods that contributed the most to antioxidant intake and their degree of processing.</p><p><strong>Methods: </strong>Data were collected from the National Dietary Survey of the 2017-2018 Household Budget Survey. DTAC was estimated using a database based on the Ferric-Reducing Ability Power (FRAP) assay, evaluating 1,335 food items consumed by Brazilians, and the degree of processing was identified according to the NOVA Classification.</p><p><strong>Results: </strong>The estimated average DTAC/1000Kcal was 4.27 mmol, and women (4.36mmol), elderly individuals (4.65mmol), black, mixed-race, and indigenous individuals (4.15mmol), residents in rural areas (4.61mmol), and those living in the South region (4.98mmol) had significantly higher DTAC when compared to other groups. DTAC decreased with the increase in income and education levels. Non-alcoholic beverages accounted for 58.84% of DTAC, followed by legumes (16.38%) and fruits (8.17%). Regarding the degree of processing, in natura and minimally processed foods contributed 92% of DTAC (3.93mmol), while ultra-processed foods accounted for 5.5% (0.235mmol).</p><p><strong>Conclusions: </strong>The findings of this study reinforce the importance of consuming in natura and minimally processed foods, in the line with the Dietary Guidelines for the Brazilian Population, particularly with respect to antioxidant intake.</p>","PeriodicalId":29768,"journal":{"name":"Journal of the American Nutrition Association","volume":" ","pages":"1-12"},"PeriodicalIF":6.8,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Effects of Durian and Banana Consumption on Thermic Effect of Food and Metabolic Responses in Healthy Adults.","authors":"Charlotte Yiin Ling, Michelle Ting Yun Yeo, Yan Kang, Shu Min Ng, Xinyan Bi, Christiani Jeyakumar Henry","doi":"10.1080/27697061.2024.2426563","DOIUrl":"10.1080/27697061.2024.2426563","url":null,"abstract":"<p><strong>Objective: </strong>In traditional Chinese philosophy, durian is classified as a \"yang\" food with heaty properties, believed to raise body temperature and blood pressure (BP) after consumption. In contrast, bananas are considered as \"yin,\" possessing cooling effect. However, scientific evidence supporting these concepts is limited. This study aims to compare the metabolic effects in response to durian and banana ingestion.</p><p><strong>Methods: </strong>This randomized cross-over clinical study recruited 16 young, healthy Chinese participants (8 males and 8 females). All participants ingested isocaloric portion (367.5 kcal) of durian and banana with a wash-out period of at least 5 days. 3-h thermic effect of food (TEF) and substrate oxidation were assessed by indirect calorimetry. Postprandial vital signs and metabolic responses were measured over a period of 3 h.</p><p><strong>Results: </strong>Durian induced a higher and longer-lasting TEF than banana in most participants. Additionally, durian significantly lowered BP and increased triglyceride (TG) levels during 3 h after consumption, whereas bananas had no significant effects on these measures. Despite containing much fewer carbohydrates, durian prompted a comparable postprandial rise in blood glucose concentrations to that of banana.</p><p><strong>Conclusion: </strong>While durian offers nutritional benefits and a BP-lowering effect, moderation is recommended due to its high sugar and fat content, which can elevate blood glucose and lipid levels, and its \"heatiness\" may cause digestive discomforts and a sore throat according to anecdotal experiences.</p>","PeriodicalId":29768,"journal":{"name":"Journal of the American Nutrition Association","volume":" ","pages":"283-291"},"PeriodicalIF":6.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142627903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the Influence of a Bitter Melon Product on Indicators of Cardiometabolic Health in Adults with Prediabetes.","authors":"Liana L Guarneiri, Meredith L Wilcox, Chen-Meng Kuan, Kevin C Maki","doi":"10.1080/27697061.2024.2428301","DOIUrl":"10.1080/27697061.2024.2428301","url":null,"abstract":"<p><strong>Objective: </strong>The purpose of this study was to assess the impact of bitter melon extract supplementation on glycemia in individuals with prediabetes.</p><p><strong>Methods: </strong>This was a 12-week randomized, parallel, placebo-controlled study where 75 adults with prediabetes were randomly allocated into the low-dose bitter melon (300 mg/day) (<i>n</i> = 26), high-dose bitter melon (600 mg/day) (<i>n</i> = 24), or control (<i>n</i> = 25) groups.</p><p><strong>Results: </strong>At baseline and weeks 6 and 12, anthropometrics were measured, and fasting blood samples were obtained. The high-dose (1.05% ± 10.2%) and low-dose bitter melon (3.35% ± 13.2%) groups showed smaller increases in blood glucose levels at 12 wk, compared to the control group (11.0% ± 16.3%) (<i>p</i> < 0.05). A subgroup analysis of participants with age ≥ the median demonstrated a greater reduction in glycated hemoglobin at 12 wk in the high-dose bitter melon group (median change: -0.20%; IQRL: -0.20%, -0.05%) vs. the control group (median change: 0.00%; IQRL: -0.10%, 0.20%) (<i>p</i> = 0.017). Compliance with the interventions was >95%, and the study products were tolerated well.</p><p><strong>Conclusion: </strong>The bitter melon extract may help maintain a healthy level of glucose in adults with prediabetes.</p>","PeriodicalId":29768,"journal":{"name":"Journal of the American Nutrition Association","volume":" ","pages":"306-314"},"PeriodicalIF":6.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142627926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chia Oil (<i>Salvia hispanica</i> L.) Improves the Intestinal Health of <i>Wistar</i> Rats Fed a Hypercaloric Diet.","authors":"Violeta Nunes de Morais, Luiza de Paula Dias Moreira, Mariana Juste Contin Gomes, Mariana Grancieri, Haira Guedes Lucio, Renata Celi Lopes Toledo, Marcella Duarte Villas Mishima, Neuza Maria Brunoro Costa, Bárbara Pereira da Silva, Hércia Stampini Duarte Martino","doi":"10.1080/27697061.2024.2431271","DOIUrl":"10.1080/27697061.2024.2431271","url":null,"abstract":"<p><strong>Background: </strong>A diet rich in fat and sugar is present in society everyday life, leading to the development of metabolic changes, especially in intestinal microbiota. Chia oil is a source of alpha-linolenic acid, which has antioxidant and anti-glycemic effects. Based on this, we hypothesized that chia oil may promote intestinal health.</p><p><strong>Objective: </strong>The study aims to investigate the effects of chia oil on gut microbiota and intestinal health in <i>Wistar</i> rats fed a high-fat and high-fructose diet (HFHF).</p><p><strong>Methods: </strong>The animals were separated into two groups and received the following diets: standard murine diet (AIN-93M) (<i>n</i> = 10) and HFHF (<i>n</i> = 20) to induce metabolic changes (phase I) during eight weeks. After that, the AIN-93M group remained unchanged, while the HFHF group was divided into two groups: HFHF (<i>n</i> = 10) and HFHF with chia oil (HFHF+CO) (<i>n</i> = 10) for ten weeks (phase II, chia oil treatment). We analyzed immunoglobulin A (IgA) levels, cecal pH, short-chain fatty acids (SCFAs), intestinal permeability, intestinal microbiome composition, histomorphometry, and murinometric parameters.</p><p><strong>Results: </strong>Chia oil consumption increased alpha-linolenic acid intake, IgA levels, propionic acid production, cecum weight, goblet cell number, thickness and depth of intestinal crypts, and the thickness of both circular and longitudinal muscle layers of the colon, and decreased cecal pH. No change was observed in the alpha and beta diversity between the HFHF and HFHF+CO groups. The HFHF+CO diet increased the relative abundance of genera <i>Lactobacillus</i> sp., <i>Faecalibacterium</i> sp., and <i>Erysipelatoclostridium</i> sp., compared to the AIN-93M group. No difference was observed in the intestinal permeability among the groups.</p><p><strong>Conclusion: </strong>Chia oil consumption is an alternative for improving the intestinal health of rats fed a HFHF diet.</p>","PeriodicalId":29768,"journal":{"name":"Journal of the American Nutrition Association","volume":" ","pages":"322-331"},"PeriodicalIF":6.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Test Anxiety on Nutritional Habits, Anthropometric Measurements, and Gastrointestinal Symptoms in Adolescents.","authors":"Merve Aytaç, Sinem Bayram","doi":"10.1080/27697061.2024.2431270","DOIUrl":"10.1080/27697061.2024.2431270","url":null,"abstract":"<p><p><b>Objective:</b> Since exam periods are used as a benchmark to determine academic achievement, they may result in increased anxiety, changes in dietary behavior, weight fluctuations and increased gastrointestinal symptoms in students. For this reason, this research was conducted to evaluate the effect of test anxiety on nutritional status and gastrointestinal symptoms in adolescents.</p><p><p><b>Methods:</b> This study was conducted with 104 senior high school students who agreed to participate in the study in a private and public school in Ankara 7 months before the exam and 1 month before the exam to evaluate the effect of exam anxiety on nutritional status and gastrointestinal symptoms of students preparing for the university exam. Health status, nutritional status, anthropometric measurements, information about exam anxiety, International Physical Activity Questionnaire Short Form, Test Anxiety Inventory, Gastrointestinal Symptom Rating Scale, Food Frequency Questionnarie (FFQ) were asked to the students.</p><p><p><b>Results:</b> In both genders, the mean BMI-Z score increased during the second evaluation, indicating a significant difference in various dietary and lifestyle factors such as meal frequency, water intake, and nutrient intake. Most students were classified as minimally active. Additionally, the total score of affective, delusional, and test anxiety inventory increased closer to the exam date. Weak positive correlations were observed between gastrointestinal symptoms and affective, delusional, and test anxiety scores during the first evaluation, while a moderately strong positive correlation emerged during the second evaluation.</p><p><p><b>Conclusion:</b> The results of the current study support that students experience increased gastrointestinal symptoms during the exam period. Nutrition and stress reduction educations should be given in high schools both during and before the exam period in a multidisciplinary team consisted of dietitians and psychologists in order to provide healthy stress management.</p>","PeriodicalId":29768,"journal":{"name":"Journal of the American Nutrition Association","volume":" ","pages":"315-321"},"PeriodicalIF":6.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142772887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Creatine Intake Is Not Associated With Elevated Circulating Cystatin C Levels in Individuals With and Without Kidney Dysfunction in the General Population.","authors":"David Nedeljkovic, Sonja Baltic, Nikola Todorovic, Sergej M Ostojic","doi":"10.1080/27697061.2024.2432484","DOIUrl":"10.1080/27697061.2024.2432484","url":null,"abstract":"<p><strong>Objective: </strong>The potential adverse effects of dietary creatine on kidney health are rarely addressed at the population level, particularly in individuals with preexisting kidney disease. This study aimed to evaluate the association between dietary creatine intake and serum cystatin C levels in participants with and without kidney failure, utilizing data from the 1999-2001 National Health and Nutrition Examination Survey (NHANES) round.</p><p><strong>Method: </strong>A total of 4969 individuals (50.0% female; mean age 51.2 ± 23.9 years) who provided information on dietary creatine intake and had serum cystatin C levels measured were included in the final analysis.</p><p><strong>Results: </strong>Linear regression across the entire sample revealed a significant inverse association between daily creatine intake and cystatin C concentrations (unstandardized <i>B</i> = -0.003; ß = -0.067; <i>p</i> < 0.001), indicating that for each additional milligram of creatine intake, the expected reduction in cystatin C levels was 0.003 mg/dL. In a subsample of respondents with kidney dysfunction, a significant negative association was found between creatine intake and cystatin C levels (unstandardized <i>B</i> = -0.024; ß = -0.165; <i>p</i> = 0.046).</p><p><strong>Conclusions: </strong>Findings suggest that food-derived creatine does not pose a risk of kidney stress, even for individuals with kidney failure, and might be considered a renoprotective nutrient.</p>","PeriodicalId":29768,"journal":{"name":"Journal of the American Nutrition Association","volume":" ","pages":"338-341"},"PeriodicalIF":6.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142956046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining the Efficacy of Mindfulness-Based Interventions in Treating Obesity, Obesity-Related Eating Disorders, and Diabetes Mellitus.","authors":"Antoine Aoun, Cedra Ghoussoub, Cynthia Farsoun, Angy Al Mallah, Faten Ayoub, Nancy Trezia, Sandra Abi Karam","doi":"10.1080/27697061.2024.2428290","DOIUrl":"10.1080/27697061.2024.2428290","url":null,"abstract":"<p><p>Mindfulness is the practice of focusing one's attention and energy on the present moment with an accepting attitude and an open mindset. Its adoption is increasingly utilized in addressing health concerns, particularly in the realm of nutrition. Mindful eating seeks to adjust disordered eating patterns by cultivating intentional awareness of the physical, mental, and emotional aspects of eating. Mindfulness techniques may involve meditation, breathing exercises, and simply being more attentive in daily activities. Integrating mindfulness into a nutrition strategy may improve digestion, foster a healthier relationship with food, and lead to making better choices aligned with overall well-being. This critical review aims to examine recent prevailing studies on the effects of mindfulness-based interventions (MBI) on weight regulation, eating disorders related to obesity, emotional eating, and diabetes management. For the methods section, the study utilized the Google Scholar and PubMed databases, employing the Medical Subject Headings (MeSH) descriptors. The search included articles published up to September 2024, resulting in a total of 122 articles gathered using various keyword combinations. Results show that out of the 122 studies, 28 articles were common, leaving a total of 94 articles. They included 33 randomized controlled trials (RCTs), 17 systematic reviews and meta-analyses, 11 observational studies, 14 reviews, and 19 others. The findings from these studies demonstrate the positive impact of MBI on conditions such as binge eating disorder, weight loss, emotional eating, and diabetes-related issues. In conclusion, the review supports the growing evidence suggesting that the incorporation of mindfulness can play a crucial role in managing obesity, eating disorders, and their associated consequences. However, further research is necessary to establish a definitive understanding of its effectiveness and how to integrate it into healthcare practices.</p>","PeriodicalId":29768,"journal":{"name":"Journal of the American Nutrition Association","volume":" ","pages":"292-305"},"PeriodicalIF":6.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142669230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxidative Balance Score Associated with Osteoporosis in Younger Women: A Cross-Sectional Analysis of the National Health and Nutrition Examination Survey 2013-2014 and 2017-2018 Data.","authors":"Teng-di Fan, Di-Kai Bei, Qi Wang","doi":"10.1080/27697061.2024.2436515","DOIUrl":"10.1080/27697061.2024.2436515","url":null,"abstract":"<p><strong>Objective: </strong>To explore the association between oxidative balance score (OBS) and osteoporosis risk, as well as to identify the specific population group.</p><p><strong>Methods: </strong>In this cross-sectional study, we included the data of 5,413 participants using the National Health and Nutrition Examination Survey of 2013-2014 and 2017-2018. Restricted cubic spline (RCS) curves, logistic regression models, trend tests, and stratification analyses were used to evaluate the association between the OBS and osteoporosis risk. Generalized linear models (GLM) were used to identify independent factors related to OBS. Finally, whether OBS played a mediating role in osteoporosis was evaluated using a mediation analysis.</p><p><strong>Results: </strong>Patients with osteoporosis had a lower OBS, and a high OBS score was associated with a decreased risk of osteoporosis (<i>p</i> < 0.05). Further stratification analysis revealed that the relationship between OBS and osteoporosis was robust in the three models in female patients aged < 70 years, which was validated using a trend test (<i>p</i> < 0.05). Age and sex were independent predictors of osteoporosis and the OBS. The OBS was a mediator in the association between sex, but not age, and disease.</p><p><strong>Conclusion: </strong>Our findings indicate a negative relationship between OBS and osteoporosis risk, which was pronounced in younger women and individuals aged < 70 years. Moreover, sex may be related to osteoporosis through the regulation of OBS.</p>","PeriodicalId":29768,"journal":{"name":"Journal of the American Nutrition Association","volume":" ","pages":"366-374"},"PeriodicalIF":6.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143013069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}