Inflammatory Response and Malnutrition Based on the Global Leadership Initiative on Malnutrition: Adults and Older People With Oropharyngeal Dysphagia.

IF 2.6 4区 医学 Q1 NUTRITION & DIETETICS
Elisa Lyra, Emilia Addison Machado Moreira, Mariana Machado, Diane de Lima Oliveira, Maiara Brusco de Freitas, Julia Salvan da Rosa, Ana Maria Furkim, Yara Maria Franco Moreno, Tânia Silvia Fröde, Daniela Barbieri Hauschild
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Abstract

Objective: Oropharyngeal dysphagia (OD) exerts an impact on the inflammatory response and malnutrition. We tested the association between the inflammatory response (nitric oxide metabolites, myeloperoxidase, C-reactive protein, interleukin [IL] 1β, IL-6, IL-8 and IL-10) and malnutrition using the criteria of the Global Leadership Initiative on Malnutrition (GLIM) in adults/older people with OD.

Method: A cross-sectional study was conducted involving 51 adults/older people with OD distributed as follows: OD group with malnutrition (n = 15) and OD group without malnutrition (n = 36). A no-dysphagia group (n = 20) was matched to the OD groups for sex/age. Swallowing function was assessed using videofluoroscopy and classified using the Dysphagia Outcome and Severity Scale (DOSS), the Laryngeal Penetration and Aspiration Scale, and the Functional Oral Intake Scale (FOIS). The Functional Independence Measure (FIM) was administered. Unadjusted and adjusted logistic regression analyses were performed.

Results: The prevalence of malnutrition was 29.4% in the OD group. The FIM scale (odds ratio [OR] = 0.97, p = 0.002), Laryngeal Penetration and Aspiration Scale (OR = 1.32, p = 0.024), and FOIS (OR = 0.73, p = 0.026) were significantly associated with malnutrition. Among the inflammatory response markers, only IL-1β (OR = 1.10, p = 0.043) was associated with malnutrition in the adjusted analysis.

Conclusions: IL-1β was associated with malnutrition based on the GLIM criteria after adjustments for excess weight and neurodegenerative diseases. Higher functional dependence and impaired swallowing were associated with malnutrition.

炎症反应和营养不良基于营养不良全球领导倡议:成人和老年人口咽吞咽困难。
目的:口咽吞咽困难(OD)对炎症反应和营养不良有影响。我们测试了炎症反应(一氧化氮代谢物、髓过氧化物酶、c反应蛋白、白细胞介素[IL] 1β、IL-6、IL-8和IL-10)与营养不良之间的关系,使用全球营养不良领导倡议(GLIM)的标准在成年/老年OD患者中进行。方法:采用横断面研究方法,选取51例成年/老年OD患者,分为OD合并营养不良组(n = 15)和OD未合并营养不良组(n = 36)。无吞咽困难组(n = 20)按性别/年龄与OD组相匹配。吞咽功能通过透视检查进行评估,并通过吞咽困难结局和严重程度量表(DOSS)、喉穿透和吸入量表和功能性口服摄入量表(FOIS)进行分类。采用功能独立性测量法(FIM)。进行未调整和调整的逻辑回归分析。结果:OD组营养不良发生率为29.4%。FIM量表(优势比[OR] = 0.97, p = 0.002)、喉穿吸量表(优势比[OR] = 1.32, p = 0.024)和FOIS量表(优势比[OR] = 0.73, p = 0.026)与营养不良显著相关。在炎症反应标志物中,在校正分析中,只有IL-1β (OR = 1.10, p = 0.043)与营养不良相关。结论:根据超重和神经退行性疾病调整后的GLIM标准,IL-1β与营养不良有关。较高的功能依赖和吞咽障碍与营养不良有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
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