Aronia (Chokeberry) Fruit Extract is a Potential Candidate for Managing Metabolic Syndrome in Elderly Patients.

IF 2.6 4区 医学 Q1 NUTRITION & DIETETICS
Pelin Baltacı, Ozan Emre Eyupoglu, Selin Kankaya, Hakan Yavuzer
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Abstract

Objectives: Natural products like Aronia (Aronia melanocarpa) are promising candidates to manage metabolic abnormalities due to their bioactive compounds. This study aimed to evaluate the effects of daily Aronia fruit extract supplementation on the components of Metabolic Syndrome (MetS), cardiovascular health, inflammation, and atherogenic markers in elderly patients.

Methods: Our study is a randomized controlled trial of 44 subjects (12 males and 32 females) diagnosed with MetS. The study groups were the intervention group (n = 22), which received daily 10 g Aronia fruit extract for 8 wk, and the control group, which did not receive the extract (n = 22). Demographics, dietary intake, and food habits were recorded by an extended survey. Baseline and post-intervention measurements of anthropometric data, dietary intake, cardiovascular parameters, blood pressure, blood lipid composition, plasma atherogenic index (PAI), triglyceride (TG), and the triglyceride-glucose index (TyG), and biomarkers of inflammation, including tumor necrosis factor-alpha (TNF-α), Interleukin 6 (IL-6), high-sensitivity C-reactive protein (hs-CRP), and oxidative stress biomarkers, were represented as delta values.

Results: No significant changes were observed in anthropometric measurements within or between groups over the 8 wk. However, several cardiovascular health parameters, including diastolic blood pressure (-10.00 mmHg), PAI index (-0.06), triglycerides (-9.0 mg/dL), and low-density lipoprotein cholesterol (LDL-C) (-6.30 mg/dL) were significantly decreased in the intervention group compared to the control group at the end of 8 wk of use (p < 0.05). Inflammatory markers TNF-α (-7.87 pg/mL) and IL-6 (-0.58 pg/mL), as well as oxidative stress markers, oxidized low-density lipoprotein (ox-LDL) (-132.17 U/L) and small dense low-density lipoprotein (sdLDL) (-0.79 mg/dL), also significantly decreased in the intervention group (p < 0.001).

Conclusion: Our findings suggest that daily supplementation with Aronia fruit extract significantly improves cardiovascular health markers and reduces inflammation and oxidative stress in elderly patients with MetS. Hence, Aronia extract may be an effective dietary supplement for managing MetS in high-risk groups.

苦莓果提取物是治疗老年代谢综合征的潜在候选药物。
目的:由于其生物活性化合物,像野樱草(Aronia melanocarpa)这样的天然产品是管理代谢异常的有希望的候选者。本研究旨在评估每日补充野荆果提取物对老年患者代谢综合征(MetS)成分、心血管健康、炎症和动脉粥样硬化标志物的影响。方法:我们的研究是一项随机对照试验,44名被诊断为MetS的受试者(12名男性和32名女性)。研究分为干预组(n = 22)和对照组(n = 22),干预组每天接受10 g野樱果提取物,持续8周。对照组不接受野樱果提取物。人口统计、饮食摄入和饮食习惯通过一项扩展调查进行记录。基线和干预后测量的人体测量数据、饮食摄入、心血管参数、血压、血脂组成、血浆动脉粥样硬化指数(PAI)、甘油三酯(TG)和甘油三酯-葡萄糖指数(TyG),以及炎症生物标志物,包括肿瘤坏死因子-α (TNF-α)、白细胞介素6 (IL-6)、高敏c反应蛋白(hs-CRP)和氧化应激生物标志物,用δ值表示。结果:8周内或组间人体测量值未见明显变化。然而,与对照组相比,干预组的一些心血管健康参数,包括舒张压(-10.00 mmHg)、PAI指数(-0.06)、甘油三酯(-9.0 mg/dL)和低密度脂蛋白胆固醇(-6.30 mg/dL)在使用8周结束时显著降低(p < p >)。我们的研究结果表明,每日补充野荆果提取物可显著改善老年MetS患者的心血管健康指标,减少炎症和氧化应激。因此,野樱草提取物可能是一种有效的膳食补充剂,用于管理高风险人群的MetS。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
2.50
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