Journal of the American Nutrition Association最新文献

{"title":"Chia Oil (<i>Salvia hispanica</i> L.) Improves the Intestinal Health of <i>Wistar</i> Rats Fed a Hypercaloric Diet.","authors":"Violeta Nunes de Morais, Luiza de Paula Dias Moreira, Mariana Juste Contin Gomes, Mariana Grancieri, Haira Guedes Lucio, Renata Celi Lopes Toledo, Marcella Duarte Villas Mishima, Neuza Maria Brunoro Costa, Bárbara Pereira da Silva, Hércia Stampini Duarte Martino","doi":"10.1080/27697061.2024.2431271","DOIUrl":"10.1080/27697061.2024.2431271","url":null,"abstract":"<p><strong>Background: </strong>A diet rich in fat and sugar is present in society everyday life, leading to the development of metabolic changes, especially in intestinal microbiota. Chia oil is a source of alpha-linolenic acid, which has antioxidant and anti-glycemic effects. Based on this, we hypothesized that chia oil may promote intestinal health.</p><p><strong>Objective: </strong>The study aims to investigate the effects of chia oil on gut microbiota and intestinal health in <i>Wistar</i> rats fed a high-fat and high-fructose diet (HFHF).</p><p><strong>Methods: </strong>The animals were separated into two groups and received the following diets: standard murine diet (AIN-93M) (<i>n</i> = 10) and HFHF (<i>n</i> = 20) to induce metabolic changes (phase I) during eight weeks. After that, the AIN-93M group remained unchanged, while the HFHF group was divided into two groups: HFHF (<i>n</i> = 10) and HFHF with chia oil (HFHF+CO) (<i>n</i> = 10) for ten weeks (phase II, chia oil treatment). We analyzed immunoglobulin A (IgA) levels, cecal pH, short-chain fatty acids (SCFAs), intestinal permeability, intestinal microbiome composition, histomorphometry, and murinometric parameters.</p><p><strong>Results: </strong>Chia oil consumption increased alpha-linolenic acid intake, IgA levels, propionic acid production, cecum weight, goblet cell number, thickness and depth of intestinal crypts, and the thickness of both circular and longitudinal muscle layers of the colon, and decreased cecal pH. No change was observed in the alpha and beta diversity between the HFHF and HFHF+CO groups. The HFHF+CO diet increased the relative abundance of genera <i>Lactobacillus</i> sp., <i>Faecalibacterium</i> sp., and <i>Erysipelatoclostridium</i> sp., compared to the AIN-93M group. No difference was observed in the intestinal permeability among the groups.</p><p><strong>Conclusion: </strong>Chia oil consumption is an alternative for improving the intestinal health of rats fed a HFHF diet.</p>","PeriodicalId":29768,"journal":{"name":"Journal of the American Nutrition Association","volume":" ","pages":"322-331"},"PeriodicalIF":6.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Test Anxiety on Nutritional Habits, Anthropometric Measurements, and Gastrointestinal Symptoms in Adolescents.","authors":"Merve Aytaç, Sinem Bayram","doi":"10.1080/27697061.2024.2431270","DOIUrl":"10.1080/27697061.2024.2431270","url":null,"abstract":"<p><p><b>Objective:</b> Since exam periods are used as a benchmark to determine academic achievement, they may result in increased anxiety, changes in dietary behavior, weight fluctuations and increased gastrointestinal symptoms in students. For this reason, this research was conducted to evaluate the effect of test anxiety on nutritional status and gastrointestinal symptoms in adolescents.</p><p><p><b>Methods:</b> This study was conducted with 104 senior high school students who agreed to participate in the study in a private and public school in Ankara 7 months before the exam and 1 month before the exam to evaluate the effect of exam anxiety on nutritional status and gastrointestinal symptoms of students preparing for the university exam. Health status, nutritional status, anthropometric measurements, information about exam anxiety, International Physical Activity Questionnaire Short Form, Test Anxiety Inventory, Gastrointestinal Symptom Rating Scale, Food Frequency Questionnarie (FFQ) were asked to the students.</p><p><p><b>Results:</b> In both genders, the mean BMI-Z score increased during the second evaluation, indicating a significant difference in various dietary and lifestyle factors such as meal frequency, water intake, and nutrient intake. Most students were classified as minimally active. Additionally, the total score of affective, delusional, and test anxiety inventory increased closer to the exam date. Weak positive correlations were observed between gastrointestinal symptoms and affective, delusional, and test anxiety scores during the first evaluation, while a moderately strong positive correlation emerged during the second evaluation.</p><p><p><b>Conclusion:</b> The results of the current study support that students experience increased gastrointestinal symptoms during the exam period. Nutrition and stress reduction educations should be given in high schools both during and before the exam period in a multidisciplinary team consisted of dietitians and psychologists in order to provide healthy stress management.</p>","PeriodicalId":29768,"journal":{"name":"Journal of the American Nutrition Association","volume":" ","pages":"315-321"},"PeriodicalIF":6.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142772887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Creatine Intake Is Not Associated With Elevated Circulating Cystatin C Levels in Individuals With and Without Kidney Dysfunction in the General Population.","authors":"David Nedeljkovic, Sonja Baltic, Nikola Todorovic, Sergej M Ostojic","doi":"10.1080/27697061.2024.2432484","DOIUrl":"10.1080/27697061.2024.2432484","url":null,"abstract":"<p><strong>Objective: </strong>The potential adverse effects of dietary creatine on kidney health are rarely addressed at the population level, particularly in individuals with preexisting kidney disease. This study aimed to evaluate the association between dietary creatine intake and serum cystatin C levels in participants with and without kidney failure, utilizing data from the 1999-2001 National Health and Nutrition Examination Survey (NHANES) round.</p><p><strong>Method: </strong>A total of 4969 individuals (50.0% female; mean age 51.2 ± 23.9 years) who provided information on dietary creatine intake and had serum cystatin C levels measured were included in the final analysis.</p><p><strong>Results: </strong>Linear regression across the entire sample revealed a significant inverse association between daily creatine intake and cystatin C concentrations (unstandardized <i>B</i> = -0.003; ß = -0.067; <i>p</i> < 0.001), indicating that for each additional milligram of creatine intake, the expected reduction in cystatin C levels was 0.003 mg/dL. In a subsample of respondents with kidney dysfunction, a significant negative association was found between creatine intake and cystatin C levels (unstandardized <i>B</i> = -0.024; ß = -0.165; <i>p</i> = 0.046).</p><p><strong>Conclusions: </strong>Findings suggest that food-derived creatine does not pose a risk of kidney stress, even for individuals with kidney failure, and might be considered a renoprotective nutrient.</p>","PeriodicalId":29768,"journal":{"name":"Journal of the American Nutrition Association","volume":" ","pages":"338-341"},"PeriodicalIF":6.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142956046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining the Efficacy of Mindfulness-Based Interventions in Treating Obesity, Obesity-Related Eating Disorders, and Diabetes Mellitus.","authors":"Antoine Aoun, Cedra Ghoussoub, Cynthia Farsoun, Angy Al Mallah, Faten Ayoub, Nancy Trezia, Sandra Abi Karam","doi":"10.1080/27697061.2024.2428290","DOIUrl":"10.1080/27697061.2024.2428290","url":null,"abstract":"<p><p>Mindfulness is the practice of focusing one's attention and energy on the present moment with an accepting attitude and an open mindset. Its adoption is increasingly utilized in addressing health concerns, particularly in the realm of nutrition. Mindful eating seeks to adjust disordered eating patterns by cultivating intentional awareness of the physical, mental, and emotional aspects of eating. Mindfulness techniques may involve meditation, breathing exercises, and simply being more attentive in daily activities. Integrating mindfulness into a nutrition strategy may improve digestion, foster a healthier relationship with food, and lead to making better choices aligned with overall well-being. This critical review aims to examine recent prevailing studies on the effects of mindfulness-based interventions (MBI) on weight regulation, eating disorders related to obesity, emotional eating, and diabetes management. For the methods section, the study utilized the Google Scholar and PubMed databases, employing the Medical Subject Headings (MeSH) descriptors. The search included articles published up to September 2024, resulting in a total of 122 articles gathered using various keyword combinations. Results show that out of the 122 studies, 28 articles were common, leaving a total of 94 articles. They included 33 randomized controlled trials (RCTs), 17 systematic reviews and meta-analyses, 11 observational studies, 14 reviews, and 19 others. The findings from these studies demonstrate the positive impact of MBI on conditions such as binge eating disorder, weight loss, emotional eating, and diabetes-related issues. In conclusion, the review supports the growing evidence suggesting that the incorporation of mindfulness can play a crucial role in managing obesity, eating disorders, and their associated consequences. However, further research is necessary to establish a definitive understanding of its effectiveness and how to integrate it into healthcare practices.</p>","PeriodicalId":29768,"journal":{"name":"Journal of the American Nutrition Association","volume":" ","pages":"292-305"},"PeriodicalIF":6.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142669230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxidative Balance Score Associated with Osteoporosis in Younger Women: A Cross-Sectional Analysis of the National Health and Nutrition Examination Survey 2013-2014 and 2017-2018 Data.","authors":"Teng-di Fan, Di-Kai Bei, Qi Wang","doi":"10.1080/27697061.2024.2436515","DOIUrl":"10.1080/27697061.2024.2436515","url":null,"abstract":"<p><strong>Objective: </strong>To explore the association between oxidative balance score (OBS) and osteoporosis risk, as well as to identify the specific population group.</p><p><strong>Methods: </strong>In this cross-sectional study, we included the data of 5,413 participants using the National Health and Nutrition Examination Survey of 2013-2014 and 2017-2018. Restricted cubic spline (RCS) curves, logistic regression models, trend tests, and stratification analyses were used to evaluate the association between the OBS and osteoporosis risk. Generalized linear models (GLM) were used to identify independent factors related to OBS. Finally, whether OBS played a mediating role in osteoporosis was evaluated using a mediation analysis.</p><p><strong>Results: </strong>Patients with osteoporosis had a lower OBS, and a high OBS score was associated with a decreased risk of osteoporosis (<i>p</i> < 0.05). Further stratification analysis revealed that the relationship between OBS and osteoporosis was robust in the three models in female patients aged < 70 years, which was validated using a trend test (<i>p</i> < 0.05). Age and sex were independent predictors of osteoporosis and the OBS. The OBS was a mediator in the association between sex, but not age, and disease.</p><p><strong>Conclusion: </strong>Our findings indicate a negative relationship between OBS and osteoporosis risk, which was pronounced in younger women and individuals aged < 70 years. Moreover, sex may be related to osteoporosis through the regulation of OBS.</p>","PeriodicalId":29768,"journal":{"name":"Journal of the American Nutrition Association","volume":" ","pages":"366-374"},"PeriodicalIF":6.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143013069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Daily Walnut Consumption on Gastrointestinal Symptoms: A Mixed-Method Study in Healthy Adults.","authors":"Yi-Mei Chen, Shu-Yu Chuang, Chih-Yung Tsai","doi":"10.1080/27697061.2024.2431287","DOIUrl":"10.1080/27697061.2024.2431287","url":null,"abstract":"<p><strong>Background: </strong>Common gastrointestinal (GI) symptoms such as abdominal pain, indigestion, and constipation affect a significant portion of the global population and can substantially impair quality of life. Despite these widespread issues, research specifically investigating the effects of walnuts on gut function and GI symptoms remain limited.</p><p><strong>Objective: </strong>This study investigates the effects of walnuts on gastrointestinal symptoms in healthy adults.</p><p><strong>Design: </strong>An experimental baseline-end study with an equivalent group design was employed.</p><p><strong>Setting: </strong>The experimental group consumed 42 grams of walnuts daily, and their gastrointestinal symptoms were compared with those of a control group that did not consume walnuts over a 3-week period.</p><p><strong>Participants: </strong>Sixty university students were recruited as volunteer subjects, consisting of 30 males and 30 females.</p><p><strong>Intervention(s): </strong>Participants were randomly assigned to either an experimental group or a control group.</p><p><strong>Main outcome measure(s): </strong>The independent variable was walnut consumption, and the dependent variable was gastrointestinal health, assessed using the Gastrointestinal Symptom Rating Scale (GSRS) and a qualitative questionnaire to collect participants' perceived changes in GI symptoms.</p><p><strong>Analysis: </strong>A <i>t</i>-test with a <i>p</i>-value of less than 0.05 and verbatim analysis were utilized.</p><p><strong>Results: </strong>This mixed-methods study provides evidence for the beneficial effects of walnuts in promoting normal digestive function.</p><p><strong>Conclusions and implications: </strong>The study provides alternative evidence for the beneficial effects of walnuts in promoting normal digestive function.</p>","PeriodicalId":29768,"journal":{"name":"Journal of the American Nutrition Association","volume":" ","pages":"332-337"},"PeriodicalIF":6.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142956030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are Nutrition Literacy and Sustainable Dietary Habits Associated with Cardiovascular Disease and Diabetes Developmental Risks?","authors":"Indrani Kalkan, Neda Saleki, İdil Alpat Yavaş, Merve Pehlivan, Nedime Gündüz","doi":"10.1080/27697061.2024.2435039","DOIUrl":"10.1080/27697061.2024.2435039","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to examine the association of nutritional literacy levels and sustainable nutritional behaviors with the risk of developing cardiovascular diseases and diabetes in the Turkish adult population.</p><p><strong>Methods: </strong>Sociodemographic information, disease history, nutritional habits, and physical activity levels of 3146 volunteer individuals (male = 1590, female = 1556) between the ages of 40-75 were collected using a questionnaire form and face-to-face interviews. The sustainable nutritional behaviors of the participants were evaluated using Turkish validated scales for Sustainable and Healthy Eating Behavior (SHE) and nutritional literacy levels with the Evaluation Instrument of Nutrition Literacy on Adults (EINLA). Cardiovascular disease risks of the participants were assessed with the Atherosclerotic Cardiovascular Disease (ASCVD) Risk Estimator program and the Heart Score (SCORE) scale and type-2 diabetes risk with the Finnish Diabetes Risk Score (FINDRISC). Each participant's 24-h food consumption record was obtained using the retrospective recall method.</p><p><strong>Results: </strong>It was determined that ASCVD and SCORE levels were significantly higher in males compared to females. It was observed that individuals with lower cardiovascular and diabetes risk scores had higher educational levels, and the risks increased significantly with age (<i>p</i> < 0.05). Anthropometric measurements such as body mass index, and waist hip circumference were significantly higher in those with higher cardiovascular and diabetes risk scores. Furthermore, in individuals with higher SCORE and FINDRISC levels, SHE and EINLA scores were significantly lower (<i>p</i> < 0.05). It was also observed that SCORE and diabetes risk scores increased with higher energy and macronutrient intakes.</p><p><strong>Conclusion: </strong>The risk of developing cardiovascular disease and diabetes was associated with sustainable nutritional behaviors and nutritional literacy. It may be suggested that increasing nutritional literacy and encouraging sustainable nutritional behaviors may be effective strategies in the management and reduction of the prevalence of certain chronic diseases.KEY TEACHING POINTSCardiovascular diseases and diabetes are two major chronic conditions that can be managed and treated through proper nutrition.Increased nutritional literacy levels and sustainable dietary habits may result in reduced risk of cardiovascular diseases and diabetes.Nutritionists should assess the patients' nutrition literacy levels and implement sustainable, health-focused nutrition education programs to enhance their understanding of nutrition.</p>","PeriodicalId":29768,"journal":{"name":"Journal of the American Nutrition Association","volume":" ","pages":"353-365"},"PeriodicalIF":6.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Dietary Live Microbe Intake and Chronic Diarrhea and Fecal Incontinence: A Cross-Sectional NHANES 2005-2010 Study.","authors":"Liang Ding, Jinnan Duan, Junjie Hou, Tao Yang, Mengping Yuan, A Huo Ma, Yuehua Qin","doi":"10.1080/27697061.2024.2434585","DOIUrl":"10.1080/27697061.2024.2434585","url":null,"abstract":"<p><strong>Objective: </strong>We explored potential relationships between dietary live microbe intake and chronic diarrhea (CD) and fecal incontinence (FI).</p><p><strong>Methods: </strong>We conducted a cross-sectional retrospective study based on the National Health and Nutrition Examination Survey (NHANES) database. Participants were categorized into three groups according to the Sanders classification system (low, medium, and high dietary live microbe groups). CD and FI were defined using a bowel health questionnaire. Logistic regression and restricted cubic spline (RCS) analyses were performed on weighted data to explore potential relationships.</p><p><strong>Results: </strong>In univariate logistic regression analyses, participants in the high dietary live microbe group exhibited a lower CD prevalence when compared to those in the low group (odds ratio (OR) = 0.58, 95% confidence interval (CI): 0.43-0.79). After adjusting for covariates, model 2 (OR = 0.69 95% CI: 0.49-0.96) and model 3 (OR = 0.66 95% CI: 0.45-0.96) data were consistent with model 1 data. No significant association was identified between dietary live microbe intake and FI. Withal, subgroup analyses revealed significant associations between high dietary live microbes and CD in males or participants without abdominal obesity, hypertension, diabetes, and sleep disorder (<i>p</i> < 0.05).</p><p><strong>Conclusions: </strong>In this cross-sectional study, consuming foods rich in live microbes may exert positive effects on CD risk. This finding may facilitate new management strategies for CD.</p>","PeriodicalId":29768,"journal":{"name":"Journal of the American Nutrition Association","volume":" ","pages":"342-352"},"PeriodicalIF":6.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142956044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adherence to a Healthy Plant-Based Diet and Cardiovascular-Kidney-Metabolic Risk Factors in Patients with Moderate to Advanced Chronic Kidney Disease.","authors":"Shang-Li Hung, Ting-Yun Lin, Szu-Chun Hung","doi":"10.1080/27697061.2025.2488366","DOIUrl":"https://doi.org/10.1080/27697061.2025.2488366","url":null,"abstract":"<p><strong>Objective: </strong>The confluence of cardiovascular-kidney-metabolic (CKM) risk factors and chronic kidney disease (CKD) elevates the risk for adverse cardiovascular and kidney outcomes. Mounting evidence has emerged on the benefits of plant-based diets for CKD management. However, whether the benefits are mediated by improved CKM health are unclear. In addition, there remain concerns about the risk of malnutrition and hyperkalemia associated with plant-based diets. The objective of this study was to assess the relationship between adherence to healthy plant-based diets and CKM syndrome, nutritional status, and serum potassium levels in patients with nondialysis CKD stages 3-5.</p><p><strong>Method: </strong>A total of 147 patients (median age 66 years) with CKD (median eGFR 23.1 mL/min/1.73 m²) were included. Responses to a food frequency questionnaire developed for the Asian population with CKD were used to calculate a healthy plant-based diet score (HPDS), which reflects higher consumption of plant foods and reduced intake of animal products and sugar. CKM risk factors included overweight/obesity, central obesity, high blood pressure, high triglycerides, and high blood glucose. Nutritional status was assessed using serum albumin and dietary energy and protein intake.</p><p><strong>Results: </strong>In logistic regression analyses, a higher HPDS was significantly associated with lower odds of all CKM risk factors and malnutrition. After adjusting for age, sex, comorbidities, lifestyle factors, and medications, a higher HPDS remained significantly linked to lower odds of overweight/obesity and central obesity, as well as higher odds of having a normal serum albumin level (≥ 3.8 g/dL), dietary protein intake (≥ 0.6 g/kg/day), and dietary energy intake (≥ 25 g/kg/day). No significant association was observed between HPDS and hyperkalemia.</p><p><strong>Conclusions: </strong>In patients with moderate to advanced CKD, healthy plant-based diets were associated with a lower risk of CKM syndrome. Adherence to a healthy plant-based diet was more likely to achieve a better nutritional status and was not associated with risk of hyperkalemia.</p>","PeriodicalId":29768,"journal":{"name":"Journal of the American Nutrition Association","volume":" ","pages":"1-10"},"PeriodicalIF":6.8,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nonlinear Relationships Between Dietary Selenium Intake and Ischemic Heart Disease Incidence and Mortality: A Cross-Sectional and Longitudinal Ecological Study.","authors":"Saya Nosaka, Tomoko Imai, Keiko Miyamoto, Ayako Sezaki, Fumiya Kawase, Yoshiro Shirai, Chisato Abe, Masayo Sanada, Norie Sugihara, Toshie Honda, Yuta Sumikama, Ayaka Inden, Takayoshi Tsukahara, Hiroshi Shimokata","doi":"10.1080/27697061.2025.2483261","DOIUrl":"https://doi.org/10.1080/27697061.2025.2483261","url":null,"abstract":"<p><strong>Objective: </strong>Selenium, an essential mineral with antioxidant properties, can potentially prevent atherosclerosis and maintain cardiovascular health. However, the association between selenium and ischemic heart disease (IHD) remains unclear. This study aimed to determine the impact of selenium on global IHD incidence (IHDi) and mortality (IHDd) over a 28-year period from 1990 to 2018, using open data for global comparisons.</p><p><strong>Method: </strong>IHDi and IHDd per 100,000 people were obtained from the Global Burden of Disease Study (GBD) 2019 database and estimated selenium intake from the Global Dietary Database. Covariates were obtained from the World Bank and GBD databases. The associations of selenium intake with IHDi and IHDd in the 28 years from 1990 onward were analyzed for 149 countries with populations >1 million, using a Bayesian generalized additive mixed model, controlling for covariates.</p><p><strong>Results: </strong>A nonlinear relationship existed between selenium intake and IHDi and IHDd. The selenium intake levels with the lowest risk for IHDi and IHDd were 93.3 and 78.5 µg/d, respectively. The risk ratios (RRs) for IHDi were 2.30 (95% CI, 1.82-2.84) and 1.40 (95% CI, 1.13-1.73) for selenium intakes of 10.0 µg/d and 200.0 µg/d, respectively. For IHDd, the RRs were 3.40 (95% CI, 2.62-4.40) for intakes of 10.0 µg/d and 1.72 (95% CI, 1.31-2.20) for 200.0 µg/d. The risk was higher for selenium underintake than for overintake.</p><p><strong>Conclusions: </strong>This study revealed a nonlinear relationship between selenium intake and IHDi and IHDd, aiding in establishing a selenium target intake for the primary prevention of IHD and addressing public health problems.</p>","PeriodicalId":29768,"journal":{"name":"Journal of the American Nutrition Association","volume":" ","pages":"1-7"},"PeriodicalIF":6.8,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144041805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}