Journal of the American Nutrition Association最新文献

{"title":"Statement of Retraction: The Major Green Tea Polyphenol, (-)-Epigallocatechin-3-Gallate, Induces Heme Oxygenase in Rat Neurons and Acts as an Effective Neuroprotective Agent Against Oxidative Stress.","authors":"","doi":"10.1080/27697061.2026.2730105","DOIUrl":"10.1080/27697061.2026.2730105","url":null,"abstract":"","PeriodicalId":29768,"journal":{"name":"Journal of the American Nutrition Association","volume":" ","pages":"781"},"PeriodicalIF":3.3,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149018047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tissue-Specific Insulin Resistance Pattern Underlies Heterogeneous Disease Severity and Complications in MASLD.","authors":"Long Teng, Ling Luo, Congxiang Shao, Yanhong Sun, Jiaming Lai, Xiaopei Cao, Zhi Dong, Junzhao Ye, Bihui Zhong","doi":"10.1080/27697061.2026.2742270","DOIUrl":"https://doi.org/10.1080/27697061.2026.2742270","url":null,"abstract":"<p><strong>Background: </strong>Insulin resistance (IR) plays a pathophysiological role in the development of metabolic dysfunction-associated steatotic liver disease (MASLD). However, it remains unclear whether the specific distribution of IR across muscle, adipose tissue, hepatic tissue, and the whole body is associated with the heterogeneous disease severity and its complications.</p><p><strong>Methods: </strong>Consecutive subjects (non-MASLD: 1239, MASLD: 1067) were retrospectively enrolled between June 2014 and June 2024, undergoing comprehensive evaluations that included anthropometric, laboratory, and imaging measurements. Tissue-specific IR indices (muscle IR, adipose IR, hepatic IR) and systemic IR were quantified using parameters derived from an oral glucose tolerance test.</p><p><strong>Results: </strong>Patients with MASLD exhibited lower muscle IR levels but higher adipose IR, hepatic IR, and systemic IR levels compared to those with non-MASLD (all <i>p</i> < 0.001). Multivariate analyses revealed distinct tissue-specific associations: hepatic IR was associated with the odds of moderate-severe steatosis (OR: 15.91, 95%CI 5.92-42.74, <i>p</i> < 0.001), systemic IR with liver injury (OR: 2.75, 95%CI: 1.89-4.00, <i>p</i> < 0.001), adipose IR with significant fibrosis (OR: 5.90, 95%CI: 3.31-10.53, <i>p</i> < 0.001), and muscle IR was inversely associated with CVD (OR: 2.87, 95%CI: 1.70-4.87, <i>p</i> < 0.001). Additionally, MASLD patients with co-occurring adipose-hepatic IR had a higher prevalence of liver injury compared to those with isolated muscle IR (64.0% vs. 28.8%, <i>p</i> < 0.05).</p><p><strong>Conclusions: </strong>Tissue-specific IR profiles may help characterize heterogeneous MASLD manifestations and CVD-associated phenotypes. Further studies are needed to assess whether timely identification of these profiles and initiation of appropriate interventions is beneficial.</p>","PeriodicalId":29768,"journal":{"name":"Journal of the American Nutrition Association","volume":" ","pages":"1-11"},"PeriodicalIF":3.3,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149228931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mediterranean Diet, Physical Activity, and Metabolic Syndrome in Breast Cancer Survivors on Adjuvant Endocrine Therapy: A Cross-Sectional Study From North Africa.","authors":"Ilhem Sarra Manel Mohamedi, Imene Moussaoui","doi":"10.1080/27697061.2026.2731004","DOIUrl":"https://doi.org/10.1080/27697061.2026.2731004","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to determine the prevalence of metabolic syndrome and to examine its association with Mediterranean diet adherence and physical activity among women receiving adjuvant endocrine therapy for hormone receptor-positive breast cancer, in North Africa.</p><p><strong>Methods: </strong>This cross-sectional study recruited 150 women in Oran, Algeria (May 2022-December 2025), receiving either tamoxifen (<i>n</i> = 73) or aromatase inhibitors (<i>n</i> = 77). Metabolic syndrome was defined per International Diabetes Federation 2006 criteria. Mediterranean diet adherence was assessed using a culturally adapted 14-item Mediterranean Diet Adherence Screener (adapted MEDAS). Physical activity level (PAL) was estimated using GENI software and entered as a continuous variable in the primary analysis, with sedentary/non-sedentary categorization (PAL < 1.40) as a secondary analysis. Dietary intake was assessed using a 24-h recall and a three-day food record with photographic verification. Factors independently associated with metabolic syndrome were identified using multivariable logistic regression.</p><p><strong>Results: </strong>Metabolic syndrome was highly prevalent, affecting 68.0% of participants. Although overall prevalence did not differ between treatment groups (aromatase inhibitors: 72.7% <i>vs</i>. tamoxifen: 63.0%; <i>p</i> = 0.202), the two regimens differed in individual metabolic abnormalities: aromatase inhibitor users had lower HDL-cholesterol, higher fasting glucose, and higher blood pressure, while tamoxifen users had higher triglycerides. In multivariable analysis, higher PAL (OR = 0.44 per 0.1-unit increase; 95% CI: 0.28-0.68; <i>p</i> < 0.001) and greater Mediterranean diet adherence (OR = 0.72; 95% CI: 0.60-0.87; <i>p</i> = 0.001) were independently associated with lower odds of metabolic syndrome. The model showed an apparent AUC of 0.832 (5-fold cross-validated AUC: 0.800) and satisfactory calibration (Hosmer-Lemeshow <i>p</i> = 0.400).</p><p><strong>Conclusion: </strong>Metabolic syndrome affects more than two-thirds of breast cancer survivors receiving endocrine therapy, and was independently associated with lower Mediterranean diet adherence and lower physical activity. Given the cross-sectional design, these associations cannot establish causality; nonetheless, these findings support further prospective and interventional research to determine whether modifying these behaviors could reduce this risk.</p>","PeriodicalId":29768,"journal":{"name":"Journal of the American Nutrition Association","volume":" ","pages":"1-13"},"PeriodicalIF":3.3,"publicationDate":"2026-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149115776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chrysin Mitigates Lipopolysaccharide-Induced Jejunal Inflammation and Barrier Dysfunction in Mice.","authors":"Chun-Lung Feng, Shiu-Min Cheng, Cheng-Kuo Chen, Wen-Tzu Wu","doi":"10.1080/27697061.2026.2719472","DOIUrl":"https://doi.org/10.1080/27697061.2026.2719472","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the protective effects of chrysin against lipopolysaccharide (LPS)-induced jejunal injury in mice, focusing on tissue morphology, epithelial apoptosis, inflammation, and the gut microbiota.</p><p><strong>Methods: </strong>Male C57BL/6JNarl mice (<i>n</i> = 24) were randomly divided into three groups. The control (CON) and LPS groups were fed a standard chow diet, whereas the LPS+CHY group received chow supplemented with 1% (w/w) chrysin. After 3 wk of dietary intervention, mice in the LPS and LPS+CHY groups were given an intraperitoneal injection of LPS (10 mg/kg body weight), while the control mice received an equivalent volume of saline. Animals were sacrificed on day 23, and jejunal tissues, cecal contents, and feces were collected.</p><p><strong>Results: </strong>LPS administration induced marked disruption of jejunal morphology,  characterized by reduced villus height, villus area, and goblet cell numbers. Chrysin supplementation significantly attenuated these LPS-induced morphological alterations. Furthermore, the LPS+CHY group exhibited reduced apoptosis and levels of interleukin-6 and tumor necrosis factor-α in jejunal tissues. Chrysin treatment also increased cecal concentrations of propionate, butyrate, and valerate, which were accompanied by beneficial alterations in gut microbiota composition.</p><p><strong>Conclusion: </strong>This study supports the potential of chrysin as a functional dietary compound for maintaining intestinal health under inflammatory stress. Furthermore, it provides evidence suggesting the involvement of microbiota-host metabolic interactions in flavonoid-mediated intestinal protection.</p>","PeriodicalId":29768,"journal":{"name":"Journal of the American Nutrition Association","volume":" ","pages":"1-10"},"PeriodicalIF":3.3,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148971545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary Patterns and Acne Severity in Middle Eastern Youth: The Negative Correlation Role of Fermented Dairy Products.","authors":"Khaled Seetan, Almu'atasim Khamees, Raghad Yousef Yassin, Amro Mousa Mahmoud Hamad, Bashar Moh'd Kiwan, Dana Mohammad Kasasbeh, Monther Ahmad Ayesh, Irjuwan Muhye Aldeen Abedalaziz, Hamza Samah Almajali, Bashar Salem Al Sarhan","doi":"10.1080/27697061.2026.2725655","DOIUrl":"https://doi.org/10.1080/27697061.2026.2725655","url":null,"abstract":"<p><strong>Objective: </strong>Acne vulgaris is one of the most prevalent skin disorders worldwide, affecting 85-90% of teenagers. Acne can be caused by a variety of factors, but lifestyle decisions like stress levels, sleep patterns, and diet can play a significant part. This research aims to examine how lifestyle factors impact the severity of acne vulgaris.</p><p><strong>Methods: </strong>Patients with acne who visited dermatology clinics at a primary referral hospital in northern Jordan were included. They also used the validated Global Acne Severity Scale to assess acne severity. Structured interviews gathered information on dietary habits, physical activity, sleep quality, smoking behaviors, and psychological stress. The study identified risk factors associated with moderate-to-severe acne through multivariate logistic regression analysis.</p><p><strong>Results: </strong>The study included 423 participants with a mean age of 20.2 years. Frequent consumption of fast food (adjusted odds ratio [aOR] = 1.56, 95% confidence interval [CI]: 1.21-1.81) and sweets (aOR = 1.51, 95% CI: 1.15-1.98); lack of sleep (aOR = 1.19, 95% CI:1.02-1.36); and high psychological stress (aOR = 1.63, 95% CI: 1.28-1.93) were all significant correlates of moderate-to-severe acne. Regular consumption of fruits and vegetables (aOR = 0.66, 95% CI:0.41-0.84) and regular exercise (aOR = 0.76, 95% CI: 0.44-0.89) were inversely associated with acne severity. In the exploratory post hoc dairy-subtype analysis, yogurt (aOR = 0.65, 95% CI: 0.53-0.83) and labneh (aOR = 0.63, 95% CI: 0.51-0.79) were inversely associated with moderate-to-severe acne, whereas non-fermented milk was positively associated (aOR = 1.37, 95% CI: 1.12-1.68).</p><p><strong>Conclusion: </strong>This clinic-based cross-sectional study identified several demographic and lifestyle factors associated with acne severity among Jordanian youth. The exploratory post hoc analysis also identified inverse associations between yogurt and labneh consumption and moderate-to-severe acne, while non-fermented milk showed a positive association. These findings are hypothesis-generating and require confirmation in prospective and interventional studies before specific dietary or lifestyle recommendations can be established.</p>","PeriodicalId":29768,"journal":{"name":"Journal of the American Nutrition Association","volume":" ","pages":"1-11"},"PeriodicalIF":3.3,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148931446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cell Membrane Capacitance and Characteristic Frequency Among Youth and Adults: Reference Data From NHANES 1999-2000.","authors":"Kworweinski Lafontant, Marcus Robinson, Danielle A Sterner, Modesto A Lebron, Brandi Antonio, Jack Livingston, Sofea Smith, Carlo Rossi, Jeffrey R Stout, David H Fukuda","doi":"10.1080/27697061.2026.2665157","DOIUrl":"10.1080/27697061.2026.2665157","url":null,"abstract":"<p><strong>Objective: </strong>Cell membrane capacitance (Cm) and characteristic frequency (fc) are two lesser-studied bioelectrical characteristics that may provide valuable insight into cell membrane integrity, yet reference data on these variables are scant. This study aimed to report normative data for Cm and fc among youth and adult populations. Secondary aims were to compare Cm and fc between subgroups, compare 50 kHz to fc, and explore relationships between fc and fat-free mass (FFM).</p><p><strong>Method: </strong>A secondary analysis was performed using data from the 1999-2000 U.S. National Health and Nutrition Examination Survey data set, including bioelectrical impedance spectroscopy data from male and female youth (8-17 years) and adults (18-49 years) to report reference data. Mann-Whitney <i>U</i> comparisons between sex and age subgroups and one-sample Wilcoxon rank test comparing fc to the common 50-kHz approximation were also conducted.</p><p><strong>Results: </strong>Cm and fc ranged among youth (Cm = 0.43-4.57 nF; fc = 20.0-95.0 kHz) and adults (Cm = 0.65-4.68 nF; fc = 26.0-89.0 kHz). The youth group had significantly lower Cm (<i>p</i> < .001) and higher fc (<i>p</i> < .001) than the adults, while males had significantly higher Cm (<i>p</i> < .001) and lower fc (<i>p</i> < .001) than females. Compared to 50 kHz, fc was 9.0 kHz higher in youth (<i>p</i> < .001) and 7.0 kHz lower in adults (<i>p</i> < .001), while being 4.0 kHz lower with all ages combined (<i>p</i> < .001).</p><p><strong>Conclusions: </strong>Cm appears to mirror expected FFM differences between youths and adults and between males and females, while fc appears to have a largely inverse relationship with FFM, although the relationship is quadratic with a nadir near 35 to 40 kHz in adulthood. Cm and fc may have potential as noninvasive and clinically practical indicators of cell membrane functionality and maturation, although more research is needed to examine longitudinal validity of these measures alongside direct cellular observation.</p>","PeriodicalId":29768,"journal":{"name":"Journal of the American Nutrition Association","volume":" ","pages":"622-631"},"PeriodicalIF":3.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147989322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interactions Between <i>ADIPOQ</i> rs1501299 Polymorphism, Dietary Macronutrient Composition, and Gastric Cancer Risk: Evidence from a Korean Case-Control Study.","authors":"Vu Anh Trong Dam, Madhawa Gunathilake, Jeonghee Lee, Il Ju Choi, Young-Il Kim, Jeongseon Kim","doi":"10.1080/27697061.2026.2670491","DOIUrl":"10.1080/27697061.2026.2670491","url":null,"abstract":"<p><strong>Objective: </strong>The role of overall macronutrient balance in gastric cancer (GC) risk remains unclear. This study investigated the associations of the Ketogenic Ratio (KR) and Simplified Ketogenic Ratio (sKR), as composite indicators of macronutrient composition, with GC risk, and examined potential modification by the <i>ADIPOQ</i> rs1501299 genotype.</p><p><strong>Methods: </strong>A hospital-based case-control study was conducted among 376 GC cases and 752 controls. Dietary intake was assessed using a validated semi-quantitative food frequency questionnaire. Logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Interactions between KR, sKR, the <i>ADIPOQ</i> rs1501299 polymorphism, and GC risk were evaluated using multiplicative terms in regression models.</p><p><strong>Results: </strong>The <i>ADIPOQ</i> rs1501299 polymorphism alone was not associated with GC risk. Higher KR and sKR were significantly associated with reduced GC risk (KR: OR = 0.64; 95% CI = 0.44-0.93; sKR: OR = 0.59; 95% CI = 0.40-0.86). Notably, a significant gene-diet interaction was observed strictly for sKR, where this association was more pronounced among overweight/obese individuals carrying the <i>ADIPOQ</i> rs1501299 G/T or T/T genotypes (OR = 0.33, 95% CI: 0.16-0.66, <i>P</i> interaction = 0.038). In contrast, no significant interaction was found between KR and the <i>ADIPOQ</i> rs1501299 genotype.</p><p><strong>Conclusion: </strong>Higher KR and sKR are inversely associated with GC risk. The <i>ADIPOQ</i> rs1501299 genotype significantly modifies the association between sKR and GC risk, specifically among overweight/obese individuals. Future studies should focus on developing and validating standard measurements in nutritional epidemiology to elucidate biological pathways from gene-diet interactions.</p>","PeriodicalId":29768,"journal":{"name":"Journal of the American Nutrition Association","volume":" ","pages":"641-652"},"PeriodicalIF":3.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147949785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Educational Gaps and Communication Priorities for the Healthfulness of Carbohydrate Foods.","authors":"Josh Erndt-Marino, Alyssa Ghirardelli","doi":"10.1080/27697061.2026.2687436","DOIUrl":"10.1080/27697061.2026.2687436","url":null,"abstract":"<p><strong>Background: </strong>Although shared understanding between consumers and experts, and within experts themselves, is essential for healthier food choices, no existing method systematically prioritizes foods based on the magnitude of health education gaps.</p><p><strong>Objective: </strong>To develop and apply a quantitative belief-mapping methodology to identify commonly consumed foods that warrant prioritization for research and nutrition communication.</p><p><strong>Methods: </strong>Based on survey data and a meta-nutrition profiling system that represents transparent and harmonized expert healthfulness ratings, consumer misalignment and misperception relative to experts, as well as expert-only uncertainty, were quantified across 20 commonly consumed carbohydrate-rich foods. Foods were then ranked by jointly considering misalignment, expert uncertainty, and national consumption prevalence.</p><p><strong>Results: </strong>Among the 20 foods evaluated, 85% received a consumer-to-expert Alignment Grade of C or D, and 75% received an Uncertain expert-only healthfulness classification. Among consumers, the most negatively misperceived foods-those rated less healthy by consumers than by experts-included all surveyed potato based foods (French fries, chips, and baked potatoes) and unbuttered, air-popped popcorn. In contrast, honey was the most positively misperceived food, being rated as healthier by consumers than by experts. Most foods (70%) exhibited a mixture of negative and positive misperception (≥15/85%). When misalignment, expert uncertainty, and high U.S. consumption were considered jointly, white rice, white bread, corn tortilla, and fruit juice with vitamin C emerged as priority foods for future research and nutrition education.</p><p><strong>Conclusions: </strong>Substantial consumer-expert misalignment and expert uncertainty were observed across commonly consumed carbohydrate-containing foods. This scalable belief-mapping methodology prioritizes foods for future nutrition research, communication efforts, and policy.</p>","PeriodicalId":29768,"journal":{"name":"Journal of the American Nutrition Association","volume":" ","pages":"663-671"},"PeriodicalIF":3.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148253532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Fermented Papaya Preparation Intake on Fatigue Recovery, Useful Field of View and Oxidative Stress: A Pilot Interventional Study in Professional Bus and Motor Racing Drivers.","authors":"Maki Osato, Okezie I Aruoma, Keiko Nishida, Keiko Kondou, Akio Hirano, Masahiro Saito, Hirofumi Aoki, Yuki Hayashi","doi":"10.1080/27697061.2026.2677194","DOIUrl":"10.1080/27697061.2026.2677194","url":null,"abstract":"<p><strong>Objectives: </strong>Fermented Papaya Preparation (FPP) is a supplement with antioxidant, anti-inflammatory, and immune-modulatory effects. This study investigated the effects of one-month continuous FPP intake on health parameters related to driving performance, the useful field of view (UFOV) and post-work fatigue recovery in active bus drivers and the effect of FPP on elite performance motor racing drivers and elite motor racing drivers.</p><p><strong>Method: </strong>This study examined the effects of one-month continuous intake of FPP on health outcomes, oxidative stress markers and useful field of view (UFOV) in active bus drivers and elite motor racing drivers.</p><p><strong>Result: </strong>Significant reductions were observed in oxidative stress markers (urinary 8-hydroxy-2'-deoxyguanosine [8-OHdG]) and reaction times within the UFOV. Subjective health measures related to driving performance-including concentration, vitality, fatigue, and sleep quality-also showed significant improvements. Participants with improved UFOV demonstrated concurrent reductions in urinary 8-OHdG. In the health-related quality of life assessment using the short form health survey SF-12^®, significant improvements were detected in \"general health perception\" (<i>p</i> < 0.01), \"vitality\" (<i>p</i> < 0.05), and \"mental health\" (<i>p</i> < 0.01) after intervention. In the performance of elite drivers' assessment, the malondialdehyde (MDA) values in elite motor sport drivers were similar at the beginning of the race and at the 12 hr period, there were notable differences in the values at 24 hr following the endurance motor racing. The non-supplemented drivers had the highest level of MDA, and protein carbonyls with values of 1.26 µM and 0.411 µmoles/g protein respectively. The corresponding values for the FPP-supplemented drivers were 0.714 µM and 0.115 µmoles/g protein respectively.</p><p><strong>Conclusion: </strong>These findings suggest that FPP can be safely consumed by professional drivers and may serve as a complementary self-care strategy targeting fatigue recovery, thereby mitigating risk factors associated with driving accidents such as age-related decline in driving useful field of view, sleep quality, cognitive function, and accumulation. FPP may be applied as a \"Driver Support Tool\" contributing to fatigue reduction, health maintenance, and accident risk reduction in both professional and elderly drivers. FPP may hold significance in improving recovery and cognition in elite motor sports drivers and general auto drivers.</p>","PeriodicalId":29768,"journal":{"name":"Journal of the American Nutrition Association","volume":" ","pages":"603-614"},"PeriodicalIF":3.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148151571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infant Formula With Added Alpha-Lactalbumin Improves Nighttime Feeding Patterns With Implications for Sleep Quality.","authors":"Diana Orenstein, Devon Kuehn, Andrea Knezevic, Margaret Carney, Saige Camara, Chris Peltier","doi":"10.1080/27697061.2026.2659830","DOIUrl":"10.1080/27697061.2026.2659830","url":null,"abstract":"<p><strong>Objective: </strong>Sleep is crucial during infancy and supports health and development. Tryptophan is influential in the sleep/wake cycle, and studies have shown that increasing tryptophan intake can improve sleep outcomes. Consumption of alpha-lactalbumin increases ratios of tryptophan to large neutral amino acids (LNAA), an indicator of brain concentrations associated with sleep latency. The objective was to evaluate whether an infant formula with added alpha-lactalbumin improves sleep quality, indicated by nighttime feeding patterns.</p><p><strong>Method: </strong>Healthy infants born at full term were randomized to study formula (SF) with added alpha-lactalbumin or a formula with identical protein content without added alpha-lactalbumin (CF). Feeding patterns were assessed over 24 weeks and serum amino acids were measured at week 16. Groups were compared using repeated-measures mixed models and Wilcoxon rank-sum test, and the relationship between feeding and amino acid concentrations was assessed with correlation analysis.</p><p><strong>Results: </strong>In 128 infants, mean time between nighttime feeds differed between the groups over time on study (<i>p</i> = 0.03) At 16 weeks, mean time between nighttime feeds was greater (+32 min; 95% confidence interval [CI], 5-60; <i>p</i> = 0.02), and mean number of nighttime feeds was lower (-0.3; 95% CI: -0.6 to 0.0; <i>p</i> = 0.04) in the SF group. Tryptophan concentrations (96 ± 15 μmol/L vs 86 ± 17 μmol/L, <i>p</i> = 0.019) and the ratio of tryptophan to LNAA (0.146 ± 0.026 vs 0.130 ± 0.018; <i>p</i> = 0.007) were higher in the SF subgroup.</p><p><strong>Conclusions: </strong>Clinically relevant longer duration between nighttime feeds was observed in infants in the SF group throughout most of the study, with an average of 32 additional minutes at 16 weeks. Concurrently, infants in the SF group had a higher tryptophan:LNAA ratio, supporting the hypothesis that the addition of alpha-lactalbumin may have positively impacted outcomes associated with sleep quality.</p><p><strong>Trial registration: </strong>www.clinicaltrials.gov (NCT04218929 and NCT04389606 January 6, 2020, and May 15, 2020, respectively).</p>","PeriodicalId":29768,"journal":{"name":"Journal of the American Nutrition Association","volume":" ","pages":"615-621"},"PeriodicalIF":3.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}