Journal of Integrative and Complementary Medicine最新文献

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Letter: Supporting Varied and Evolving Integrative Oncology Models in Person-Centered Care. 信:在以人为本的护理中支持多样化和不断发展的综合肿瘤学模式。
IF 1.7 4区 医学
Journal of Integrative and Complementary Medicine Pub Date : 2025-08-01 Epub Date: 2025-05-15 DOI: 10.1089/jicm.2025.0319
Konstantina Stylianou, Nina Fuller-Shavel, Santhosshi Narayanan, Santosh Rao
{"title":"Letter: Supporting Varied and Evolving Integrative Oncology Models in Person-Centered Care.","authors":"Konstantina Stylianou, Nina Fuller-Shavel, Santhosshi Narayanan, Santosh Rao","doi":"10.1089/jicm.2025.0319","DOIUrl":"10.1089/jicm.2025.0319","url":null,"abstract":"","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":"31 8","pages":"760-761"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144822749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Compendium of Health and Wellness Coaching: 2023 Addendum. 健康和保健教练纲要:2023增编。
IF 1.7 4区 医学
Journal of Integrative and Complementary Medicine Pub Date : 2025-08-01 Epub Date: 2025-03-28 DOI: 10.1089/jicm.2024.0672
Abd Moain Abu Dabrh, Jocelyn M Weiss, Bala Munipalli, Miranda P Kaye, Katherine Smith, Eli Shur, Sebastian Harenberg, Rachel Garofalo, Arya B Mohabbat, Arden Robinson, Stefan N Paul, Bettina M Beech, Margaret Moore, Tara J Brigham, Gary A Sforzo
{"title":"Compendium of Health and Wellness Coaching: 2023 Addendum.","authors":"Abd Moain Abu Dabrh, Jocelyn M Weiss, Bala Munipalli, Miranda P Kaye, Katherine Smith, Eli Shur, Sebastian Harenberg, Rachel Garofalo, Arya B Mohabbat, Arden Robinson, Stefan N Paul, Bettina M Beech, Margaret Moore, Tara J Brigham, Gary A Sforzo","doi":"10.1089/jicm.2024.0672","DOIUrl":"10.1089/jicm.2024.0672","url":null,"abstract":"<p><p><b><i>Background:</i></b> Building on the 2017 Compendium of Health and Wellness Coaching (HWC) and its 2019 Addendum, the 2023 Addendum extends the scope of research by incorporating studies published from 2018 to 2022. This latest version continues to serve as a vital resource for practitioners and researchers, offering access to a comprehensive collection of studies spanning established and emerging health domains. <b><i>Methods:</i></b> The 2023 Addendum updates and expands the evidence base to evaluate HWC's effectiveness across various conditions and settings. In this iteration, an expanded range of literature databases was explored to ensure inclusivity, categorizing articles into eight established health conditions-such as diabetes, heart disease, and obesity-while introducing two new categories reflecting research trends in respiratory conditions and chronic pain management. <b><i>Results:</i></b> The addendum includes findings from 212 articles, among which 115 randomized controlled trials (RCTs) demonstrate the effectiveness of HWC in improving patient-centered outcomes such as chronic care management, medication adherence, self-efficacy, and quality of life. Positive impacts were also documented on surrogate biomarkers, particularly in diabetes, hypertension, and cardiovascular care. All articles, including reviews and commentaries, are indexed with detailed methodologies and findings in an accessible spreadsheet format. <b><i>Conclusions:</i></b> Since its first iteration in 2017, the Compendium has grown to encompass over 480 articles, including more than 140 RCTs, illustrating the expanding role of HWC in health care. This evidence base underscores HWC's utility as a key intervention for chronic disease management, preventive care, and whole-person health. Future research should focus on refining coaching methodologies, evaluating long-term outcomes, and exploring cost-effectiveness to enhance HWC's delivery and impact across diverse populations and settings.</p>","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":"726-736"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143731908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reflections on Deciding the Dose of Acupuncture Treatment. 关于确定针灸治疗剂量的思考。
IF 1.7 4区 医学
Journal of Integrative and Complementary Medicine Pub Date : 2025-08-01 Epub Date: 2025-05-19 DOI: 10.1089/jicm.2025.0052
Tae-Hun Kim, Myeong Soo Lee, Stephen Birch, Terje Alraek
{"title":"Reflections on Deciding the Dose of Acupuncture Treatment.","authors":"Tae-Hun Kim, Myeong Soo Lee, Stephen Birch, Terje Alraek","doi":"10.1089/jicm.2025.0052","DOIUrl":"10.1089/jicm.2025.0052","url":null,"abstract":"","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":"754-757"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Letter: Bridging Borders and Breaking Down Walls in Integrative Oncology From Patient-Centeredness to Person Centeredness. 信函:从以病人为中心到以人为中心,在综合肿瘤学中跨越边界和打破壁垒。
IF 1.7 4区 医学
Journal of Integrative and Complementary Medicine Pub Date : 2025-08-01 Epub Date: 2025-05-16 DOI: 10.1089/jicm.2025.0167
Nele Van den Cruyce, Koen Hermans
{"title":"<i>Letter:</i> Bridging Borders and Breaking Down Walls in Integrative Oncology From Patient-Centeredness to Person Centeredness.","authors":"Nele Van den Cruyce, Koen Hermans","doi":"10.1089/jicm.2025.0167","DOIUrl":"10.1089/jicm.2025.0167","url":null,"abstract":"","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":"758-759"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effectiveness of Radiofrequency in Primary Dysmenorrhea: A Randomized Controlled Trial. 射频治疗原发性痛经的有效性:一项随机对照试验。
IF 1.7 4区 医学
Journal of Integrative and Complementary Medicine Pub Date : 2025-08-01 DOI: 10.1177/27683605251363182
Beatriz García-García, María José Díaz-Arribas, María Alicia Urraca-Gesto, Juan Antonio Valera-Calero, Rosa María Ortiz-Gutiérrez, Gustavo Plaza-Manzano
{"title":"Effectiveness of Radiofrequency in Primary Dysmenorrhea: A Randomized Controlled Trial.","authors":"Beatriz García-García, María José Díaz-Arribas, María Alicia Urraca-Gesto, Juan Antonio Valera-Calero, Rosa María Ortiz-Gutiérrez, Gustavo Plaza-Manzano","doi":"10.1177/27683605251363182","DOIUrl":"https://doi.org/10.1177/27683605251363182","url":null,"abstract":"<p><p><b><i>Introduction:</i></b> Noninvasive, nonablative capacitive and resistive radiofrequency has emerged as a therapeutic tool for managing pelvic pain. However, research on its efficacy in pelvic floor dysfunctions is limited. This study aimed to evaluate the effectiveness of capacitive and resistive radiofrequency therapy for primary dysmenorrhea. <b><i>Methods:</i></b> A randomized, single-blind, controlled trial was conducted. Forty-five nulliparous women with a medical diagnosis of primary dysmenorrhea were included. Participants were randomly assigned to one of three groups: transabdominal radiofrequency, intracavitary radiofrequency, or control. The intervention groups received nine 20-min sessions, with 3 sessions per week over 3 weeks between menstrual cycles. Pain intensity, menstrual quality of life, general quality of life, and pain pressure thresholds were assessed at baseline, postintervention, and at 1-month follow-up. <b><i>Results:</i></b> Both transabdominal and intracavitary radiofrequency significantly reduced pain intensity compared with the control group (<i>p</i> < 0.001). Intracavitary radiofrequency achieved a greater reduction than transabdominal, although this difference was not statistically significant (<i>p</i> = 0.311). No significant between-group differences were observed in mechanical sensitivity (<i>p</i> > 0.05) across all pressure points. Menstrual quality of life significantly improved in the intracavitary group compared with the control (<i>p</i> = 0.023), whereas the transabdominal group showed no significant improvement (<i>p</i> = 0.176). Changes in general quality of life were not statistically significant in any group (<i>p</i> > 0.05). <b><i>Conclusion:</i></b> Both transabdominal and intracavitary radiofrequency therapies produced short-term reduction in pain intensity in women with primary dysmenorrhea. As the efficacy between modalities did not differ significantly, treatment could be tailored to patient preference and tolerability.</p>","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144785481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Eye Movement Desensitization and Reprocessing for Chronic Pain: A Systematic Review. 慢性疼痛的眼动脱敏和再加工:一项系统综述。
IF 1.7 4区 医学
Journal of Integrative and Complementary Medicine Pub Date : 2025-07-30 DOI: 10.1177/27683605251362035
Abhinav Singla, Pragyat Futela, Komal Arora, Loren Toussaint, Zaain Ahmad, Aleksandra Murawska Baptista, Christopher V Anstine, Ryan T Hurt, Lindsey M Philpot, Arya B Mohabbat
{"title":"Eye Movement Desensitization and Reprocessing for Chronic Pain: A Systematic Review.","authors":"Abhinav Singla, Pragyat Futela, Komal Arora, Loren Toussaint, Zaain Ahmad, Aleksandra Murawska Baptista, Christopher V Anstine, Ryan T Hurt, Lindsey M Philpot, Arya B Mohabbat","doi":"10.1177/27683605251362035","DOIUrl":"https://doi.org/10.1177/27683605251362035","url":null,"abstract":"<p><p><b><i>Background:</i></b> Nonpharmacologic interventions have known benefits for managing chronic pain, particularly for conditions such as fibromyalgia, and are included in clinical guidelines. However, eye movement desensitization and reprocessing (EMDR) has not been established as a routine clinical practice for pain management. <b><i>Objective:</i></b> To systematically review the efficacy of EMDR for managing chronic pain. <b><i>Methods:</i></b> A search was conducted to identify randomized clinical trials (RCTs) and observational studies by using the keywords \"EMDR\" and \"chronic pain.\" Information was collected on the study population, EMDR protocol, methods for pain assessment, and outcomes. Risk of bias was evaluated, and intervention effect sizes were determined by calculating Hedges <i>g</i> values for long-term follow-up data in RCTs. <b><i>Results:</i></b> A total of nine studies, including seven RCTs, were reviewed. The studies used various diverse pain measurement tools and EMDR protocols. All reported significant improvements in pain symptoms with EMDR. Most of the studies reported statistically significant improvements in associated mental health issues, notably in psychological distress (four out of four studies), anxiety (three out of three studies), and depression (three out of four studies). Effect sizes varied among the studies, with three RCTs reporting large effects, two RCTs reporting moderate effects, and one RCT reporting small or nonsignificant effects. <b><i>Conclusion:</i></b> EMDR shows promise for managing chronic pain and addressing associated mental health symptoms. Despite study differences and limitations, the findings of this systematic review support the potential use of EMDR for chronic pain management.</p>","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144745343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy and Safety of Acupuncture for Obesity: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. 针灸治疗肥胖的疗效和安全性:随机对照试验的系统回顾和荟萃分析。
IF 1.7 4区 医学
Journal of Integrative and Complementary Medicine Pub Date : 2025-07-30 DOI: 10.1177/27683605251363181
Liang Ding, Yan Xiao
{"title":"Efficacy and Safety of Acupuncture for Obesity: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.","authors":"Liang Ding, Yan Xiao","doi":"10.1177/27683605251363181","DOIUrl":"https://doi.org/10.1177/27683605251363181","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;&lt;i&gt;Introduction:&lt;/i&gt;&lt;/b&gt; Obesity poses an important public health concern globally, requiring effective and safe interventions. Acupuncture, a traditional Chinese medicine therapy, is increasingly used to address various health conditions, including obesity. Previous systematic reviews have examined acupuncture for obesity, but none have comprehensively synthesized evidence from both English and non-English-language databases with rigorous methodological assessment. This review addresses this gap by providing an updated synthesis of randomized controlled trials (RCTs) evaluating acupuncture's effectiveness and safety for obesity management. &lt;b&gt;&lt;i&gt;Aim and Objectives:&lt;/i&gt;&lt;/b&gt; The primary goal of this research was to evaluate the effectiveness of various acupuncture treatments; it includes acupressure, auricular acupuncture, auricular acupressure, and more treatments for obesity. Specifically, we aimed to determine whether these acupuncture therapies are as effective as placebos or traditional treatments for weight loss. Additionally, we aimed to systematically assess the safety profile of acupuncture by examining the types and frequency of adverse events reported across trials. &lt;b&gt;&lt;i&gt;Method:&lt;/i&gt;&lt;/b&gt; We conducted a systematic review following Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) 2020 guidelines. We searched PubMed, Google Scholar, ISI Web of Science, China National Knowledge Infrastructure, Wanfang Database, and VIP Database from inception to September 2024 without language restrictions. Two independent reviewers screened titles, abstracts, and full texts. We included RCTs comparing acupuncture interventions (manual acupuncture, electroacupuncture, laser acupuncture, auricular acupuncture, or acupressure) with placebo, sham treatments, lifestyle interventions, or medications in adults with obesity (body mass index ≥30 or ≥25 kg/m&lt;sup&gt;2&lt;/sup&gt; for Asian populations). We excluded studies combining acupuncture with other therapies except diet, as diet modification is standard care for obesity. Study quality was assessed using the Cochrane Risk of Bias tool 2.0. Meta-analyses were conducted using random-effects models in RevMan 5.4. Heterogeneity was assessed using &lt;i&gt;I&lt;/i&gt;&lt;sup&gt;2&lt;/sup&gt; statistics. The certainty of evidence was evaluated using Grading of Recommendations, Assessment, Development and Evaluations (GRADE) methodology. &lt;b&gt;&lt;i&gt;Results:&lt;/i&gt;&lt;/b&gt; Of 202 identified records, 20 RCTs (&lt;i&gt;n&lt;/i&gt; = 2261 participants) met inclusion criteria. Fifteen RCTs with complete data were included in meta-analyses. Compared with lifestyle interventions, acupuncture resulted in additional weight loss of 1.72 kg (95% confidence interval [CI]: 0.50-2.93, &lt;i&gt;I&lt;/i&gt;&lt;sup&gt;2&lt;/sup&gt; = 20%, five studies, &lt;i&gt;n&lt;/i&gt; = 237). Compared with placebo/sham treatments, acupuncture achieved greater weight reduction of 1.56 kg (95% CI: 0.78-2.34, &lt;i&gt;I&lt;/i&gt;&lt;sup&gt;2&lt;/sup&gt; = 0%, eight studies, &lt;i&gt;n&lt;/i&gt; = 412). When compared with medications, acupun","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tai Chi Easy for Opioid Use Disorder: Pilot Feasibility Outcomes and Lessons Learned. 太极易于阿片类药物使用障碍:试点可行性结果和经验教训。
IF 1.3 4区 医学
Journal of Integrative and Complementary Medicine Pub Date : 2025-07-18 DOI: 10.1177/27683605251360930
Zhanette Coffee, Terry A Badger, Ruth Taylor-Piliae, Todd W Vanderah, Chong Ho Yu, Judith S Gordon
{"title":"Tai Chi Easy for Opioid Use Disorder: Pilot Feasibility Outcomes and Lessons Learned.","authors":"Zhanette Coffee, Terry A Badger, Ruth Taylor-Piliae, Todd W Vanderah, Chong Ho Yu, Judith S Gordon","doi":"10.1177/27683605251360930","DOIUrl":"https://doi.org/10.1177/27683605251360930","url":null,"abstract":"<p><p><b><i>Background:</i></b> Opioid use disorder (OUD) remains a global crisis, with chronic pain (CP), anxiety, and opioid cravings contributing to treatment discontinuation and return to opioid use. Despite the effectiveness of medications for OUD (MOUD) such as buprenorphine and methadone, they are underutilized, with nearly 50% of individuals discontinuing prematurely or returning to opioid use. Mind-body therapies (e.g., mindfulness, acupuncture, Tai Chi) have shown promise in reducing stress, drug cravings, and pain while improving well-being. However, Tai Chi has not been systematically tested for individuals with OUD and co-occurring CP and anxiety. The authors aimed to evaluate the feasibility of a virtual Tai Chi Easy (vTCE) intervention as an adjunct therapy for adults with OUD and co-occurring CP, and/or anxiety. <b><i>Methods:</i></b> A theory-driven, pre-post, single-group quasi-experimental design was used to evaluate intervention feasibility benchmarks and conduct baseline comparisons between inpatient and outpatient participants. The 8-week vTCE intervention consisted of gentle movements, breathing exercises, self-massage, and mindfulness practices, integrating these components into a holistic mind-body approach. <b><i>Results:</i></b> Of 32 screened individuals, 19 enrolled and 15 participated. Recruitment goals were partially met after expanding to outpatient settings (65% of the target). Retention was low, with only 3 participants (15.8%) completing the final assessment. Presurvey completion was high (95%), but postsurvey completion was limited (15.7%). Adherence was low, with only 20% attending more than one session. Acceptability and appropriateness averaged 3.5/5, and feasibility reached 4/5. No injuries were reported, supporting intervention safety. <b><i>Conclusion:</i></b> The vTCE intervention was not feasible in the inpatient setting. Outpatient settings showed greater feasibility, with notable differences in baseline characteristics, including self-reported opioid cravings. Lessons learned from this pilot study highlight the need to tailor recruitment, retention, and intervention strategies for future research testing vTCE as an adjunct therapy for individuals with OUD and co-occurring symptoms receiving outpatient MOUD. <b><i>Trial Registration:</i></b> ClinicalTrials.gov (Identifier: NCT05850533). Registered: 04/25/2023.</p>","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144668670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expanding the Role of Physiotherapists in Delivering Body-Mind Interventions for Mental Health in Low-Income Countries. 扩大物理治疗师在低收入国家为心理健康提供身心干预方面的作用。
IF 1.3 4区 医学
Journal of Integrative and Complementary Medicine Pub Date : 2025-07-15 DOI: 10.1177/27683605251360928
Davy Vancampfort, James Mugisha
{"title":"Expanding the Role of Physiotherapists in Delivering Body-Mind Interventions for Mental Health in Low-Income Countries.","authors":"Davy Vancampfort, James Mugisha","doi":"10.1177/27683605251360928","DOIUrl":"https://doi.org/10.1177/27683605251360928","url":null,"abstract":"","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144638293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of LIV-52 for the Treatment of Hepatic Disorders: A Systematic Review and Meta-Analysis. LIV-52治疗肝脏疾病的效果:一项系统综述和荟萃分析。
IF 1.3 4区 医学
Journal of Integrative and Complementary Medicine Pub Date : 2025-07-02 DOI: 10.1089/jicm.2024.0703
Anshu Priya, Munmun Kumari, Anjani Kumar, Kusum Kumari, Amit Kumar, Jyoti Ranjan, Lakhan Majhee
{"title":"Effect of LIV-52 for the Treatment of Hepatic Disorders: A Systematic Review and Meta-Analysis.","authors":"Anshu Priya, Munmun Kumari, Anjani Kumar, Kusum Kumari, Amit Kumar, Jyoti Ranjan, Lakhan Majhee","doi":"10.1089/jicm.2024.0703","DOIUrl":"https://doi.org/10.1089/jicm.2024.0703","url":null,"abstract":"<p><p><b><i>Background:</i></b> Chronic liver diseases (CLDs) are major contributors to hepatic disorder-related morbidity and mortality worldwide. LIV-52, a herbo-mineral product, has demonstrated anti-inflammatory and immunomodulatory properties. <b><i>Objective:</i></b> Several randomized controlled trials (RCTs) have been conducted to verify its hepatoprotective effects across diverse patient groups with CLDs. This study aims to perform a meta-analysis to evaluate the therapeutic efficacy of LIV-52 in liver diseases. <b><i>Data Sources:</i></b> PubMed, the Cochrane Library, EMBASE, and Web of Science were searched to identify eligible RCTs published through March 10, 2025, where the efficacy of LIV-52 was compared with usual treatments for liver diseases. Meta-analysis was performed using RevMan and GRADEPro software. <b><i>Eligibility Criteria:</i></b> RCTs comparing LIV-52 with or without standard care in patients with CLDs. <b><i>Data Collection and Analysis:</i></b> Data were extracted independently by two reviewers. Meta-analysis was performed using a random-effects model. <b><i>Results:</i></b> From the 10 RCTs involving 758 patients, the hepatoprotective effects of LIV-52 treatment were examined. Benefits were noted in the areas of appetite loss (odds ratio = 0.25, confidence interval [CI] = 0.06 to 1.00, <i>p</i>-value = 0.05), renormalization of the liver enzyme serum-glutamic-pyruvic transaminase (SGPT; mean difference [MD] = -16.37, CI = -30.87 to -1.88, <i>p</i>-value <0.03), and improvement in fat metabolism in patients with liver cirrhosis (zinc sulfate [ZnS] turbidity [MD = 6.76, CI = 2.4 to 11.12, <i>p</i>-value <0.002] and fecal fat secretion [MD = -1.66, CI = -2.53 to -0.75, <i>p</i>-value <0.0001]). However, no significant effects of LIV-52 were observed for liver enzymes such as serum-glutamic-oxaloacetic transaminase, alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), bilirubin, and the hematological parameters. The overall quality of evidence (QoE) as assessed using GRADEPro ranged from very low to moderate, with the majority of comparisons supported by low or very low due to small sample sizes and high bias risks, while the findings for some outcomes, hemoglobin and prothrombin time outcomes, supported moderate-quality evidence. Adverse events (AEs) were assessed in three RCTs; no intervention-related AEs were reported. <b><i>Conclusion:</i></b> The findings of this meta-analysis suggest that LIV-52 offers certain hepatoprotective benefits, particularly in improving appetite, normalizing SGPT levels, and enhancing fat metabolism in patients with liver diseases. The broader efficacy of LIV-52 is limited, and the low QoE warrants cautious interpretation. Further high-quality, large-scale studies are needed to enhance the certainty of evidence and confirm the LIV-52 efficacy and safety across all outcomes.</p>","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144555151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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