Yash M Shah, Lara Zador, Sarah Money, Roger Haddad, Nabil Sibai, Carlos E Guerra-Londono, Katherine Nowak, Veronica Zador
{"title":"The Impact of Periprocedural Yoga Therapy on Patients Receiving Interventional Procedures for Chronic Pain.","authors":"Yash M Shah, Lara Zador, Sarah Money, Roger Haddad, Nabil Sibai, Carlos E Guerra-Londono, Katherine Nowak, Veronica Zador","doi":"10.1177/27683605261425598","DOIUrl":"10.1177/27683605261425598","url":null,"abstract":"<p><strong>Introduction: </strong>Chronic pain is a prevalent condition in the United States, and multimodal treatment approaches are the hallmark of management. Yoga therapy is a targeted, systematic approach for treating patients with specific conditions, using focused breathing and relaxation techniques. The purpose of this observational study was to evaluate the impact of yoga therapy on periprocedural pain, anxiety, and satisfaction in patients with chronic pain undergoing interventional procedures.</p><p><strong>Materials and methods: </strong>A total of 36 voluntary subjects participated in this prospective study. Nineteen had a yoga therapist guide them through periprocedural yoga therapy techniques, and 17 underwent the procedure without a yoga therapist. Periprocedural vital signs and pre- and postsurvey responses relating to patient-reported severity of pain, anxiety, and satisfaction were collected and compared between the two groups.</p><p><strong>Results: </strong>The mean difference in Visual Facial Anxiety Scale anxiety rating of patients receiving yoga therapy was 1.12 (95% confidence interval [CI]: -2.11 to -0.12, <i>p</i> = 0.029) points lower than that of patients without therapy. The mean difference in Numeric Rating Scale-10 pain score of patients receiving yoga therapy was 1.93 (95% CI: -3.78 to -0.07, <i>p</i> = 0.042) points lower than that of patients without therapy, controlling for procedural sedation. There were no significant differences in vital signs or overall patient satisfaction (Patient Global Impression of Change-7) following the procedure.</p><p><strong>Discussion: </strong>In patients with chronic pain undergoing interventional procedures, participation in yoga therapy may be associated with a significant reduction in periprocedural anxiety and pain. Further investigation through a randomized controlled trial is necessary to verify these preliminary findings.</p><p><strong>Conclusion: </strong>Yoga therapy may be considered in a multimodal approach to perioperative pain and anxiety management.</p>","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":"677-683"},"PeriodicalIF":1.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147285395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yunhu Chen, Moqing Yin, Fang Yan, Mengqin Xiao, Lihua Fan
{"title":"A Quantitative Chinese Medicine-Derived Dampness Score, Heart Failure Staging, and 12-Month Major Adverse Cardiovascular Events: A Prospective Cohort Study.","authors":"Yunhu Chen, Moqing Yin, Fang Yan, Mengqin Xiao, Lihua Fan","doi":"10.1177/27683605261425593","DOIUrl":"10.1177/27683605261425593","url":null,"abstract":"<p><strong>Introduction: </strong>Chinese medicine (CM) conceptualizes \"dampness\" as a burden of specific symptoms and signs, yet its quantitative relationship with biomedically defined heart failure (HF) stages and prognosis remains unclear. The authors evaluated a CM-derived dampness score in relation to the updated HF stages and 12-month major adverse cardiovascular events (MACEs).</p><p><strong>Methods: </strong>The authors prospectively enrolled adults hospitalized for cardiovascular care between 2023 and 2025. At baseline, clinicians assigned HF Stages A-D as per guidelines. Dampness manifestations were scored with a structured CM scale, and patients were followed for 12 months for MACEs. They compared the dampness burden across stages and used logistic regression and restricted cubic spline models to examine its association with MACEs.</p><p><strong>Results: </strong>Among 797 patients, the prevalence of dampness syndrome increased from 40.4% in Stage A to 88.1% in Stage D, and the mean dampness score increased from 6.2 ± 2.1 to 24.3 ± 5.6 (<i>p</i> < 0.001). During the 12-month follow-up period, 141 of 738 participants (19.1%) experienced MACEs. Each 1-point increase in the dampness score was independently associated with higher odds of MACEs (adjusted odds ratio = 1.17, 95% confidence interval: 1.13-1.20; <i>p</i> < 0.001), and the dose-response curve was approximately linear.</p><p><strong>Conclusions: </strong>In this cohort, CM-defined dampness manifestations increased across HF stages and were linearly associated with the 12-month risk of MACEs. A simple quantitative dampness score may complement conventional risk assessment and provide a pragmatic way to integrate CM evaluation into routine HF management.</p>","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":"668-676"},"PeriodicalIF":1.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147285316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Giorgos Tzigkounakis, Jonathan Brown, Konstantinos Georgiadis
{"title":"Current Umbrella Evidence on Nutraceuticals and Herbal Medicine for Depression in Adults: A Scoping Review.","authors":"Giorgos Tzigkounakis, Jonathan Brown, Konstantinos Georgiadis","doi":"10.1177/27683605261429026","DOIUrl":"10.1177/27683605261429026","url":null,"abstract":"<p><strong>Background: </strong>Depression remains a major global health burden, and conventional antidepressants, although effective, are limited by side effects and withdrawal symptoms.</p><p><strong>Aim: </strong>To map umbrella-level evidence on single-agent nutraceutical and herbal interventions for clinically diagnosed depression in adults.</p><p><strong>Methods: </strong>This scoping review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews and Joanna Briggs Institute guidance. PubMed, PsycINFO, Scopus, and Cochrane Library were searched (2015-2025) for umbrella reviews assessing oral nutraceuticals or herbal medicines for depression.</p><p><strong>Results: </strong>Nine umbrella reviews met inclusion criteria, covering omega-3 fatty acids, vitamin D, probiotics, saffron, St John's wort, zinc, and folate. Umbrella reviews generally reported potential antidepressant benefits and acceptable safety profiles for several interventions, although trial overlap and heterogeneity limited certainty.</p><p><strong>Conclusions: </strong>Evidence indicates promising but inconsistent efficacy across several nutraceutical and herbal agents. Standardized reporting, consideration of baseline nutrient status, and economic evaluation are needed to clarify their role in depression care.</p>","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":"647-658"},"PeriodicalIF":1.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147436090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Association of Habitual Glucosamine Use with Cardiovascular Disease among Individuals with Prediabetes and Diabetes: A Prospective Cohort Study from the UK Biobank.","authors":"Zhixuan Zhang, Yahang Liu, Lulu Pan, Chen Huang, Yongfu Yu, Guoyou Qin","doi":"10.1177/27683605261418094","DOIUrl":"10.1177/27683605261418094","url":null,"abstract":"<p><strong>Background: </strong>Compelling research has indicated that habitual glucosamine use was related to lower risks of cardiovascular disease (CVD) events. However, whether the inverse association is still valid in individuals with diabetes, who take on greater risk of CVD, remains unknown. Therefore, we aimed to examine the association between habitual glucosamine use and CVD in patients with prediabetes and diabetes.</p><p><strong>Methods: </strong>This cohort study included 54,096 participants with glucosamine use information identified from the UK Biobank. Cox regression was used to assess the association of habitual glucosamine use with total CVD events and CVD subtypes in the population with diabetes and prediabetes. We also evaluated the combined impact of C-reactive protein (CRP) level and genetic susceptibility on heart failure, ischemic heart disease (IHD), and stroke.</p><p><strong>Results: </strong>During a median follow-up of 10.56 years, 30,716 cases of overall CVD events were ascertained. We found significant inverse associations between glucosamine use and risk of CVD events among participants with diabetes and prediabetes (overall CVD events: hazard ratio, 0.94 [95%confidence interval: 0.91-0.96]; heart failure: 0.89 [0.81-0.99]; IHD: 0.89 [0.84-0.95], and stroke: 0.86 [0.77-0.97]). The effect of glucosamine on CVD was more pronounced in individuals with low CRP levels (0.85 [0.82-0.89]). Compared with individuals with high genetic risk and not-using glucosamine, glucosamine users with low genetic risk (heart failure: 0.64 [0.52-0.80]; IHD: 0.48 [0.42-0.55]) exhibited the lowest risks of corresponding CVD events.</p><p><strong>Conclusion: </strong>Habitual glucosamine use was associated with lower risks of CVD events in the population with diabetes and prediabetes. The association was more pronounced in individuals with low CRP level and low CVD polygenic risk score level, which helps us to identify the target population more suitable for glucosamine use.</p>","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":"659-667"},"PeriodicalIF":1.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146228991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fei-Fei Lu, Lijuan Chang, Jiayu Shen, Li-Cheng Wang, Yu Su, I-Lin Wang
{"title":"Effects of Acupuncture on Time-Dependent Muscle Endurance in Men with Post-Anterior Cruciate Ligament Injury: A Randomized Controlled Crossover Trial.","authors":"Fei-Fei Lu, Lijuan Chang, Jiayu Shen, Li-Cheng Wang, Yu Su, I-Lin Wang","doi":"10.1177/27683605261422972","DOIUrl":"10.1177/27683605261422972","url":null,"abstract":"<p><strong>Objective: </strong>To investigate whether acupuncture enhances knee joint muscle endurance effectiveness and time-dependent effects after anterior cruciate ligament (ACL) injuries.</p><p><strong>Methods: </strong>This randomized, single-blinded crossover trial included 20 males with ACL injuries. Participants were randomly divided into real acupuncture (RA) group and sham acupuncture (SA) group. RA was stimulated at ST32, ST34, ST36, SP10, and BL57; the SA received acupuncture 1-3 cm near these specific acupoints for 15 min. Both groups underwent RA and SA with a 1-week washout in between. Primary outcomes included kinetic and blood biochemical parameters. Kinetic variables (maximum torque, peak power, maximum average torque, average work, average power, total work, and joint stiffness) were assessed at six time points: pre-intervention and 3, 13, 23, 33, and 43 min postintervention. Blood biochemical markers (glucose, creatine, lactate, ammonia, carnitine, and glutathione) were measured at three time points: pre-exercise, postacupuncture, and postexercise.</p><p><strong>Results: </strong>Significant group × time interaction on isokinetic parameters, joint stiffness, ammonia, lactate, and glutathione (all <i>P</i> < 0.05). <i>Post hoc</i> tests revealed significant increases in isokinetic parameters and stiffness at post1-post3/post4, and ammonia, lactate, and glutathione increased significantly postexercise (all <i>P</i> < 0.05). Compared with the SA, the isokinetic parameters, stiffness, ammonia, lactate, and glutathione were significantly different (all <i>P</i> < 0.05). No significantly difference between groups in glucose and creatine kinase (all <i>P</i> > 0.05), and both increased with time (all <i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>Acupuncture can immediately improve knee joint endurance in ACL injury patients, with time effects lasting 23-33 min after needle removal.</p>","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":"692-702"},"PeriodicalIF":1.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147318548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Defining Traditional Medicine in German-Speaking Countries: A Framework Based on the World Health Organization's Traditional Medicine Strategy.","authors":"Sebastian Wenger","doi":"10.1177/27683605261448755","DOIUrl":"10.1177/27683605261448755","url":null,"abstract":"","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":"633-635"},"PeriodicalIF":1.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147821543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohamed S Zidan, Ahmed M Elfahl, Basant Hamdy Elrefaey, Zizi M Ibrahim, Heba M Elfeky
{"title":"Osteopathic Visceral Manipulation on Functional Constipation in Obese Adults: A Randomized Controlled Clinical Trial.","authors":"Mohamed S Zidan, Ahmed M Elfahl, Basant Hamdy Elrefaey, Zizi M Ibrahim, Heba M Elfeky","doi":"10.1177/27683605261427696","DOIUrl":"10.1177/27683605261427696","url":null,"abstract":"<p><strong>Background and objectives: </strong>Functional constipation is a common gastrointestinal disorder, particularly among obese individuals, due to factors such as reduced physical activity, altered gut motility, and increased intra-abdominal pressure. Visceral manipulation (VM), a manual therapy targeting internal organs, has emerged as a potential non-pharmacological intervention. This randomized controlled trial aimed to evaluate the efficacy of osteopathic VM in improving symptoms of functional constipation in obese adults.</p><p><strong>Material and methods: </strong>A total of 102 obese adults (Body Mass Index ≥ 30 kg/m<sup>2</sup>), diagnosed with functional constipation based on the Rome IV criteria, were randomly assigned to either an intervention group receiving VM alongside standard care (<i>n</i> = 51) or a control group receiving standard care alone (<i>n</i> = 51). The intervention group underwent 20 VM sessions over four weeks. Primary outcomes included stool consistency (assessed by the Bristol Stool Scale) and defecation pain (measured by the Visual Analogue Scale). Secondary outcomes included defecation frequency and oral laxative usage. Data were analyzed using mixed-design Multivariate Analysis of Variance (MANOVA).</p><p><strong>Results: </strong>Compared with the control group, the VM group showed significant improvements in stool consistency (<i>p</i> = 0.001), increased defecation frequency (<i>p</i> = 0.001), reduced defecation pain (<i>p</i> = 0.001), and lower oral laxative intake (<i>p</i> < 0.01). No adverse events were reported, and the treatment was well-tolerated.</p><p><strong>Conclusion: </strong>Visceral Manipulation appears to be an effective adjunctive therapy for managing functional constipation in obese adults. It offers a safe, noninvasive approach that improves gastrointestinal function and may reduce the need for pharmacological treatment. Further long-term studies are warranted to confirm these findings and assess sustained outcomes.</p>","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":"684-691"},"PeriodicalIF":1.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147646718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Saul Berkovitz, Nicole Collaço, Klara Dolakova, John Hughes
{"title":"A Systematic Review of Turmeric/Curcumin for Prevention and Treatment of Oral Mucositis Due to Radiotherapy and/or Chemotherapy for Head and Neck Cancer.","authors":"Saul Berkovitz, Nicole Collaço, Klara Dolakova, John Hughes","doi":"10.1177/27683605261426992","DOIUrl":"10.1177/27683605261426992","url":null,"abstract":"<p><strong>Introduction: </strong>Oral mucositis (OM) is oral mucosal damage caused by cancer treatment, including radiotherapy and chemotherapy. It is a common and debilitating adverse effect with significant impact on the quality of life. Current guidelines recommend various treatments, but the evidence base remains limited, highlighting the need for novel therapeutic approaches. Phytotherapy, including turmeric (<i>Curcuma longa</i>), offers potential due to its antioxidant, anti-inflammatory, antimicrobial, and wound-healing properties, which have shown promise in addressing inflammatory conditions. This systematic review aims to identify and appraise the quality of studies of turmeric/curcumin (T/C) for OM and evaluate its potential effectiveness and safety to inform future research.</p><p><strong>Methods: </strong>A systematic search of Medline and CINAHL databases was conducted on October 20, 2025. The Cochrane Risk of Bias v2 and GRADE tools were used to assess the risk of bias and certainty of evidence. All peer-reviewed, primary randomized controlled trials were included, which examined the effectiveness, acceptability, and/or safety of T/C for OM in head and neck cancer participants receiving radiotherapy. We included studies written in any language, published at any time, and conference abstracts if we could not retrieve the full texts but not unpublished articles. Studies were included if they evaluated products containing only turmeric or curcumin (except for flavorings). Studies that evaluated turmeric or curcumin in combination with other herbs or substances were excluded.</p><p><strong>Results: </strong>Nine randomized controlled trials were included, involving 503 participants. Three studies involved radiotherapy alone, and six used radio-chemotherapy. Turmeric/curcumin was administered orally (<i>n</i> = 3), or as mouthwashes/gels (<i>n</i> = 6). All studies reported superiority of turmeric/curcumin in outcomes such as severity and the onset of OM, pain, dysphagia, weight loss, hospitalization for OM, and requirement for nasogastric feeding. Adverse event reporting was generally poor, though no severe AEs were documented. Risk of bias was rated as low in five studies, with two studies rated as \"some concerns\" and two as \"high risk.\" The GRADE assessment indicated low certainty evidence for two key outcomes: severity of OM and weight loss.</p><p><strong>Conclusion: </strong>Turmeric/curcumin for OM management appears to show some potential. High-quality, well-designed studies are needed to assess its clinical efficacy, effectiveness, safety, acceptability, and cost-effectiveness, and the optimal route of delivery and formulation.</p>","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":"636-646"},"PeriodicalIF":1.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147391349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"<i>Corrigendum to:</i> \"Effect of Reiki on Pain, Anxiety, and Hemodynamic Parameters in Mechanically Ventilated Patients: A Randomized, Single-Blind, and Placebo-Controlled Trial\".","authors":"","doi":"10.1177/27683605261422726","DOIUrl":"10.1177/27683605261422726","url":null,"abstract":"","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":"703"},"PeriodicalIF":1.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147318611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pedro Iván Arias-Vázquez, Rosa Giannina Castillo-Avila, Mauro Nicolás Guzzardo, Adalberto Loyola-Sánchez, Duilio Román Guzzardo, Russell Arcila-Novelo, Héctor Ricardo Quezada-González, Carlos Alfonso Tovilla-Zárate
{"title":"Short-Term Efficacy of Periarticular-Perineural Dextrose Injections for Pain and Function in Knee Osteoarthritis: A Systematic Review.","authors":"Pedro Iván Arias-Vázquez, Rosa Giannina Castillo-Avila, Mauro Nicolás Guzzardo, Adalberto Loyola-Sánchez, Duilio Román Guzzardo, Russell Arcila-Novelo, Héctor Ricardo Quezada-González, Carlos Alfonso Tovilla-Zárate","doi":"10.1177/27683605261469666","DOIUrl":"https://doi.org/10.1177/27683605261469666","url":null,"abstract":"<p><strong>Introduction: </strong>Periarticular dextrose injections have been proposed as a therapeutic strategy for individuals with knee osteoarthritis (KOA). While they have been suggested to be effective for reducing pain and improving function, their safety and efficacy have not been widely evaluated.</p><p><strong>Objective: </strong>This systematic review aims to evaluate the safety and efficacy of periarticular-perineural dextrose injections (PPDI) in individuals with KOA and to determine their clinical potential as a therapeutic modality.</p><p><strong>Methods: </strong>A systematic search was conducted in PubMed, Embase, Web of Science, and the Cochrane Central Register of Controlled Trials. Studies that compared PPDI against other therapeutic strategies for treating KOA were included.</p><p><strong>Results: </strong>Eight studies (<i>n</i> = 599 participants) were included. Within-group analysis showed all studies reported a statistically significant reduction in pain and improvement in functional limitations with PPDI. Between-group analysis found these injections to be equally or more effective than noninvasive treatments for pain reduction and functional limitations improvement in the short and medium term. A majority of studies reported that these injections were equally or more effective than intra-articular injections for pain and function in the short term; however, in the medium term, most studies reported intra-articular injections to be equally or more effective. No major adverse reactions or side effects were reported.</p><p><strong>Conclusion: </strong>The results suggest that PPDI could be a potential therapeutic intervention for individuals with KOA. However, due to the low methodological quality of the included studies, definitive conclusions cannot be drawn. Further high-quality clinical trials are needed to confirm these findings.</p>","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":"27683605261469666"},"PeriodicalIF":1.9,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148580306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}