Journal of Integrative and Complementary Medicine最新文献

{"title":"Effect of Ayurvedic Interventions on Iron Deficiency Anemia in India: A Systematic Review and Network Meta-Analysis.","authors":"Yadu Damodaran, Kalesh Mappilakudy Karun, Flemin Felix, Chandan Nagendraswamy, Deepthy Melepurakkal Sadanandan, Manish Barvaliya, Subarna Roy","doi":"10.1177/27683605251387011","DOIUrl":"https://doi.org/10.1177/27683605251387011","url":null,"abstract":"<p><p><b><i>Background:</i></b> India bears a heavy burden of iron deficiency anemia (IDA), affecting nearly 50% of the population and contributing to adverse pregnancy outcomes, accounting for 20% of maternal deaths. While IDA continues to be a major health issue in India, there is a lack of comparative data on the efficacy of Ayurvedic treatments. This review aims to fill this evidence gap by systematically evaluating and ranking the efficacy of different Ayurvedic treatments for IDA using network meta-analysis (NMA). <b><i>Methods:</i></b> A systematic search was undertaken on May 1, 2024 using MEDLINE (via PubMed), Scopus, ScienceDirect, AYUSH Research Portal, and Google Scholar to locate randomized controlled trial (RCTs) evaluating interventions and their impact on hemoglobin (Hb) and serum ferritin. We conducted a random-effects NMA using a frequentist framework to estimate the mean difference (MD) and 95% confidence intervals (CIs) for the effects of interventions on outcomes, accounting for heterogeneity (<i>I</i>²). <b><i>Results:</i></b> Nineteen RCTs, comprising 2,121 individuals, assessed 26 different treatments for IDA and met the eligibility criteria. Results from the reference-based forest plots of the sensitivity analysis and corresponding P-scores revealed that both Sarva-Jvara-Hara-Lauha (SJHL) and Pippalyadi Yoga demonstrated statistically significant improvements in Hb levels, with MDs of 1.82 g/dL (95% CI: 0.66-2.98) and 1.45 g/dL (95% CI: 1.21-1.69), respectively. Among the interventions, Bibhitakadi Vatak demonstrated strong effectiveness in raising serum ferritin levels (MD: 3.87 ng/mL; 95% CI: -13.32-21.06). <b><i>Conclusion:</i></b> SJHL and Bibhitakadi Vatak were found to be the most effective strategies for treating IDA. Additional research is needed to substantiate these findings and assess their wider impact on public health. <b><i>Trial Registration:</i></b> PROSPERO registration number CRD42024541803.</p>","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145293799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Whole-Body Cryotherapy in Ankylosing Spondylitis: A Systematic Review with Meta-Analysis.","authors":"Olfa Saidane, Selma Bouden, Siwar Ben Dhia, Leila Rouached, Ines Mahmoud, Rawdha Tekaya, Aicha Ben Tekaya, Chadli Dziri, Leila Abdelmoula","doi":"10.1177/27683605251385396","DOIUrl":"https://doi.org/10.1177/27683605251385396","url":null,"abstract":"<p><p><b><i>Introduction:</i></b> Ankylosing spondylitis (AS) is a chronic inflammatory disease characterized by pain, stiffness, and progressive joint deformities. While pharmacological treatments remain the standard approach, adjunct therapies like whole-body cryotherapy (WBC) have gained attention for their potential benefits in reducing pain and inflammation. However, the effectiveness of WBC in AS remains unclear. <b><i>Methods:</i></b> A systematic search was conducted in PubMed, Scopus, Web of Science, and Embase for studies published up to November 2024. The study followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and was registered in PROSPERO (CRD42024620792). Primary outcomes included disease activity (Bath Ankylosing Spondylitis Disease Activity Index [BASDAI], Ankylosing Spondylitis Disease Activity Score [ASDAS]) and pain intensity (VAS), while secondary outcomes assessed function (Bath Ankylosing Spondylitis Functional Index [BASFI]) and inflammation (C-reactive protein [CRP]). Effect sizes were calculated using Cohen's d, with heterogeneity evaluated through Cochrane's Q-test and Tau² variance. <b><i>Results:</i></b> Five studies involving 310 patients met the inclusion criteria. Tau-squared was estimated as zero, indicating a common effect size across studies with no dispersion of true effects. Intervention protocols varied in temperature (-60°C to -10°C) and session duration (80 sec to 3 min). WBC significantly improved BASDAI (<i>p</i> < 0.001), ASDAS (<i>p</i> = 0.015), BASFI (<i>p</i> = 0.006), and VAS pain scores (<i>p</i> = 0.005), demonstrating a strong therapeutic effect. However, no significant impact was observed on CRP levels (<i>p</i> = 0.684). <b><i>Conclusion:</i></b> WBC significantly improved pain, function, and disease activity in patients with AS. As a promising nonpharmacological adjunct therapy, further research is needed to optimize protocols and evaluate its tolerance and long-term efficacy.</p>","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145287324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness and Safety of Guizhi Fuling Wan (Keishibukuryogan) on Prostate Diseases: A Systematic Review and Meta-Analysis.","authors":"Yunxia Wang, Hongyang Li, Yaxuan Jiang, Hiroyuki Kitano, Nobuyuki Hinata, Keiko Ogawa-Ochiai","doi":"10.1177/27683605251385894","DOIUrl":"https://doi.org/10.1177/27683605251385894","url":null,"abstract":"<p><p><b><i>Objective:</i></b> Aiming at evaluating the effectiveness and safety of Guizhi Fuling Wan or Keishibukuryogan (GZFL) on prostate diseases, to provide available synthesized evidence for clinical application. <b><i>Methods:</i></b> Randomized controlled trials (RCTs) were identified from English, Chinese, Japanese, and Korean electronic databases, the search date ranged from the inception of databases to July 2024. Rev-Man 5.4.1 software was applied in the analysis of extracted data. <b><i>Results:</i></b> 23 studies were included in the meta-analysis, 12 studies on chronic prostatitis(CP) and 11 studies on benign prostatic hyperplasia (BPH). The synthesized results showed that GZFL had a significantly higher effective rate compared to the control group both in BPH (risk difference [RD] = 0.14, 95% confidence interval [CI] [0.10, 0.18], <i>p</i> < 0.00001) and CP (RD = 0.19, 95% CI [0.14, 0.23], <i>p</i> < 0.00001). It reduced the International Prostate Symptom score (mean difference [MD] <i>= -3.19</i>, 95% CI [-5.35, -1.02], <i>p</i> = 0.004) and NIH Chronic Prostatitis Symptom Index score (MD <i>= -4.09</i>, 95% CI [-5.04, -3.15], <i>p</i> < 0.00001), It also had a significant effect on reducing postvoid residual urine (MD <i>= -6.73</i>, 95% CI [-10.12, -3.33], <i>p</i> = 0.0001), prostate volume (MD <i>= -2.59</i>, 95% CI [-4.39, -0.80], <i>p</i> = 0.005), and increasing maximum urinary flow rate (MD = <i>1.61</i>, 95% CI [1.11, 2.10], <i>P</i> < 0.00001). A few studies have also reported its therapeutic effects on prostate cancer. No severe adverse effects were reported. <b><i>Conclusion:</i></b> GZFL is effective and safe for BPH and CP in alleviating symptoms, improving scale scores. Rigorously designed clinical trials are necessary for further clinical application.</p>","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145287369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Effects of Lavender Aromatherapy and Nature Sounds on Anxiety and Pain in Cataract Surgery Patients: A Randomized Controlled Trial.","authors":"Reza Pourmohammad, Ebrahim Nasiri-Formi, Arman Parvizi, Alireza Shouri Bidgol, Soudabeh Haddadi, Hooshang Akbari","doi":"10.1177/27683605251386221","DOIUrl":"https://doi.org/10.1177/27683605251386221","url":null,"abstract":"<p><p><b><i>Introduction:</i></b> Cataract is one of the most common causes of visual impairment globally, often treated with surgery. Patients undergoing cataract surgery frequently experience anxiety and pain, which can adversely affect their physiological and psychological well-being. This randomized controlled trial aimed to compare the effects of lavender aromatherapy and nature sounds on anxiety and pain in patients undergoing cataract surgery with regional anesthesia. <b><i>Methods:</i></b> A total of 120 patients were randomly assigned to three groups: lavender aromatherapy, nature sounds, and control. The experimental groups received their respective interventions for 15 min preoperatively, while the control group received standard care. Anxiety and pain were measured using the Spielberger State-Trait Anxiety Inventory and Visual Analog Scale. Data were analyzed using ANOVA and chi-square tests to compare the groups; statistical significance was set at <i>p</i> < 0.05. <b><i>Results:</i></b> Post-intervention, mean anxiety scores were significantly lower in the lavender (34.85 ± 4.77) and nature sounds (31.95 ± 5.87) groups compared to the control group (49.62 ± 8.70) (<i>P</i> < 0.001). Pain scores following the intervention were reduced in both intervention groups (lavender and nature sounds) compared with the control group. No adverse events were observed in either intervention group. Both lavender aromatherapy (mean difference versus control: -14.8, <i>p</i> < 0.001) and nature sounds (mean difference versus control: -17.7, <i>p</i> < 0.001) significantly reduced anxiety compared to the control group. Results indicated that no adverse events were reported in any group. <b><i>Conclusion:</i></b> Lavender aromatherapy and nature sounds effectively reduced anxiety and pain in cataract surgery patients, suggesting their potential as non-pharmacological complementary therapies.</p>","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145276068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture-Related Therapies for Primary Dysmenorrhea: A Systematic Review and Network Meta-Analysis.","authors":"HuiYan Zhao, Jung-Hee Jang, Yeon-Hee Ryu, Chang-Hyun Han","doi":"10.1177/27683605251382169","DOIUrl":"https://doi.org/10.1177/27683605251382169","url":null,"abstract":"<p><p><b><i>Background:</i></b> Primary dysmenorrhea (PD) is characterized by a cramping pain in the lower abdomen during menstruation. Acupuncture-related therapy is frequently used to treat patients with PD. We conducted a network meta-analysis to compare the efficacy and safety of acupuncture-related therapies based on Korean and Chinese clinical practice guidelines. <b><i>Methods:</i></b> We searched 10 databases from their inception to November 1, 2024, including the Cochrane Central Register of Controlled Trials, Embase, PubMed, China National Knowledge Infrastructure, Wanfang Database, China Science and Technology Journal Database, SinoMed, KoreaMed, Korean Studies Information Service System, and Oriental Medicine Advanced Search Integrated System. The Cochrane Handbook was used to assess the risk of bias, and analyses were performed using the RevMan and Netmeta packages in R (4.4.2). <b><i>Results:</i></b> A total of 120 studies (9,571 participants with PD) were included, reporting 29 types of acupuncture-related therapies aligned with the Korean and Chinese guidelines. Overall, risk of bias was low. Based on a network meta-analysis, the most effective treatments were acupoint catgut embedding (ACE) + moxibustion, warm acupuncture + acupressure, and warm acupuncture + Western medicine. At 3-month follow-up, the highest visual analog scale (VAS) improvements were observed with ACE + moxibustion, ACE + cupping, and acupressure + manual acupuncture (MA). For prostaglandin E2 (PGE2), the most effective therapies were ACE, MA + western medicine, and MA + moxibustion. For prostaglandin F2α (PGF2α), ACE + Western medicine, MA + moxibustion, and transcutaneous electrical nerve stimulation ranked highest. <b><i>Conclusions:</i></b> Acupuncture-related therapies appear more effective than Western medicine for improving VAS scores during treatment, at 3 months, and for regulating PGE2 and PGF2α levels. Among these, ACE + moxibustion may be the optimal approach for reducing pain intensity, whereas ACE and ACE + Western medicine exhibit the greatest benefits in modulating prostaglandin levels in PD.</p>","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145245671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Reiki on Pain, Anxiety, and Hemodynamic Parameters in Mechanically Ventilated Patients: A Randomized, Single-Blind, and Placebo-Controlled Trial.","authors":"Yasemin Karacan, Ayşe Gül Parlak, Aytül Coşar Ertem","doi":"10.1177/27683605251384808","DOIUrl":"https://doi.org/10.1177/27683605251384808","url":null,"abstract":"<p><p><b><i>Objectives:</i></b> This study aimed to evaluate the effects of Reiki on pain, anxiety, and hemodynamic parameters in patients receiving invasive mechanical ventilation (IMV) in an adult intensive care unit. <b><i>Methods:</i></b> A single-blind, randomized, sham-controlled experimental design was used. Sixty patients undergoing IMV were randomly assigned to either the Reiki group (<i>n</i> = 30) or the sham Reiki group (<i>n</i> = 30). The Reiki group received a 30-min Reiki session, while the sham group received a 30-min simulated session by a noncertified individual with no energy transmission intent. The primary outcome was the change in pain score measured by the Critical Care Pain Observation Tool (CPOT). Secondary outcomes included anxiety level, systolic and diastolic blood pressure, heart rate, and respiratory rate. Data collection tools included the Patient Identification Form, Face Anxiety Scale, CPOT, and a Hemodynamic Parameters Form. <b><i>Results:</i></b> Reiki significantly reduced pain scores (<i>p</i> = 0.009) and anxiety levels (<i>p</i> = 0.04) compared with the sham Reiki group. In terms of hemodynamic parameters, Reiki was more effective in reducing diastolic blood pressure (<i>p</i> = 0.019) and heart rate (<i>p</i> = 0.001). Systolic blood pressure showed a marginal effect (<i>p</i> = 0.052), while respiratory rate demonstrated a significant group effect (<i>p</i> = 0.047) without a time × group interaction. <b><i>Conclusions:</i></b> Reiki demonstrated beneficial effects on pain, anxiety, and certain hemodynamic parameters, particularly diastolic blood pressure and heart rate, with more limited effects on systolic blood pressure and respiratory rate (Trial registration ID: NCT06526949).</p>","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145239916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Continuum Model of Determinants Across Socioecologically Nested Health Care Partners: Patient, Clinician, and Administrator Perspectives on Complementary and Integrative Health Care for Nonpharmacological Pain Management.","authors":"Tegan J Reeves, Arti Prasad, Miamoua Vang, Sophie Kurschner, Jeffery A Dusek, Richard Printon","doi":"10.1177/27683605251384812","DOIUrl":"https://doi.org/10.1177/27683605251384812","url":null,"abstract":"<p><p><b><i>Purpose:</i></b> This work explores perceptions across a state with both rural and urban populations in an ecologically informed mapping of health care partners to gain a panoramic view of potential barriers and facilitators to using complementary and integrative healthcare (CIH) for nonpharmacological pain management (NPM). <b><i>Materials and methods:</i></b> Semi-structured interviews (<i>N</i> = 48) were conducted with a regionally representative recruitment in six stakeholder groups: chronic pain patients (<i>n</i> = 15), CIH providers (<i>n</i> = 12), clinicians (primary/specialty care providers, nurse practitioners, <i>n</i> = 8), health care administrators (<i>n</i> = 6), and health insurance representatives (<i>n</i> = 7). A six-phase approach using collaborative and iterative thematic analysis was employed. <b><i>Results:</i></b> Findings suggest that themes of determinants exist on a continuum from barrier to facilitator, rather than in isolation. Continuums emerged in four categories of themes: Financial, Logistic, Relational, and Experiential. Major barriers were access, insurance, biases, and education, and major facilitators were partnership, education, and awareness. Ecological nesting of stakeholder major themes showed that perceptions by patients emphasized Financial and Experiential categories; providers emphasized Financial, Logistical, and Relational; administrators emphasized Relational and Experiential; and insurance representatives emphasized Relational. <b><i>Conclusion:</i></b> The continuum model enables use of person-centered scaling of barriers to facilitators in four categories to communicate their own personal context. Socioecological mapping reveals potential differences in perceptions of health care partners. Future work includes systematic review of the literature within the categories and development of a tool to identify person-centered barriers, needs, and facilitators to utilization of CIH for NPM.</p>","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145239832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Xinmailong Injection for Chronic Heart Failure: A Systematic Review and Meta-Analysis for Randomized Clinical Trials.","authors":"Shu-Wen Zhang, Jia-Ping Chen, Hui-Qi Zong, Xiang Li, Hong-Xu Liu","doi":"10.1089/jicm.2025.0031","DOIUrl":"10.1089/jicm.2025.0031","url":null,"abstract":"<p><p><b><i>Introduction:</i></b> Xinmailong injection (XMLI) is a common Traditional Chinese Medicine for treating chronic heart failure (CHF) in China. However, strong evidence-based medical evidence for XMLI is lacking. <b><i>Purpose:</i></b> To evaluate the efficacy and safety of XMLI in patients with CHF. <b><i>Methods:</i></b> PubMed, the Cochrane Library, Web of Science, Embase, China National Knowledge Infrastructure, Wanfang Database, VIP Database for Chinese Technical Periodicals, and Chinese Biomedical Literature Database were searched to identify randomized controlled trials (RCTs) of XMLI for CHF from the inception of the databases to November 2, 2024. The Cochrane risk of bias tool for randomized trials (RoB 2) was used to evaluate the quality of studies, and STATA 17.0 software was used to perform a meta-analysis of left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEDD), brain natriuretic peptide (BNP), N-terminal pro-brain natriuretic peptide (NT-proBNP), 6-min walking distance (6-MWD), and adverse reactions. The quality of evidence was rated using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. <b><i>Results:</i></b> Twenty-three RCTs comprising 2643 patients were included. Meta-analysis showed that compared with those under conventional Western drug treatment (CWT), combined XMLI and CWT effectively increased LVEF (mean difference [MD] = 6.66, 95% confidence interval [CI] [5.23, 8.09], <i>Z</i> = 9.12, <i>p</i> < 0.001) and 6-MWD (MD = 44.01, 95% CI [28.63,59.38], <i>Z</i> = 5.61, <i>p</i> < 0.001) and reduced LVEDD (MD = -4.19, 95% CI [-5.55, -2.83], <i>Z</i> = -6.05, <i>p</i> < 0.001), BNP (MD = -178.84, 95% CI [-230.29, -127.40], <i>Z</i> = -6.81, <i>p</i> < 0.001), and NT-proBNP (MD = -490.95, 95% CI [-729.40, -252.50], <i>Z</i> = -4.04, <i>p</i> < 0.001). There were no statistically significant differences between the two adverse reactions (risk ratio [RR] = 1.47, 95% CI [0.73,2.99], <i>Z</i> = 1.08, <i>p</i> = 0.28). The GRADE assessment rated adverse reactions as moderate-quality evidence, while LVEDD, BNP, NT-proBNP, and 6-MWD were classified as low-quality evidence, and LVEF was categorized as very low-quality evidence. <b><i>Conclusions:</i></b> This systematic review demonstrates that combining XMLI with CWT is effective and safe for managing CHF and offers an evidence-based adjunctive therapeutic strategy. Further high-quality clinical trials are required to investigate the prognostic implications and long-term outcomes.</p>","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":"876-888"},"PeriodicalIF":1.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144249927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nursing in Integrative Oncology: Perspectives from the Society for Integrative Oncology Nursing SIG.","authors":"Noël M Arring, Jason M Kiernan, Dawn L Langley-Brady, Margaret C Keller, Sara E Reynolds, Laura Pole, Lynda G Balneaves","doi":"10.1177/27683605251379350","DOIUrl":"10.1177/27683605251379350","url":null,"abstract":"","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":"857-859"},"PeriodicalIF":1.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145065796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Acupressure in Managing the Pain-Fatigue-Sleep Disturbance-Depression Symptom Cluster in Patients with Cancer: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.","authors":"Li-Hua Yang, Si-Yu Li, Ya Yang, Sheng-Nan Yang, Hai-Li Guo, Ming-Ming Hu, Pei-Bei Duan, Chao Xia","doi":"10.1089/jicm.2024.0914","DOIUrl":"10.1089/jicm.2024.0914","url":null,"abstract":"<p><p><b><i>Objective:</i></b> To assess the effectiveness of acupressure in addressing the symptom cluster of pain, fatigue, sleep disturbances, and depression (P-F-S-D) in patients with cancer through a systematic review. <b><i>Methods:</i></b> A comprehensive search was conducted across three English-language medical databases (PubMed, Embase, and the Cochrane Library) and two Chinese databases (China National Knowledge Infrastructure and Wanfang). Only randomized controlled trials (RCTs) examining the impact of acupressure on the P-F-S-D symptom cluster were included. Two reviewers independently screened studies, evaluated the risk of bias, and extracted relevant data in parallel. The risk of bias in eligible RCTs was appraised using the revised Cochrane Risk of Bias tool (RoB 2.0). Meta-analysis was performed using Stata software. <b><i>Results:</i></b> A total of 20 studies (reported in 21 articles) met the inclusion criteria and were classified as either having a low risk of bias or some concerns regarding bias. Meta-analysis revealed that acupressure achieved large-effect reductions in the P-F-S-D symptom cluster compared to both sham acupoint (endpoint standardized mean difference [SMD] = -0.84 [-1.05, -0.63], 4-week follow-up SMD = -0.87 [-1.35, -0.39]) and usual care groups (endpoint SMD = -0.68 [-0.83, -0.53], 4-week follow-up SMD = -0.60 [-0.87, -0.33]) (all <i>p</i> = 0.000). Initial high heterogeneity (<i>I</i>² = 65.6%-67.1%) resolved after sensitivity analysis (<i>I</i>² = 19.7%-35.2%), confirming result robustness. Subgroup analysis further revealed that acupressure significantly benefited various symptom combinations, including P-F-S-D, P-F-S, F-S-D, F-S, P-S, and P-F. No serious adverse events were reported. <b><i>Conclusions:</i></b> The findings of this study suggest that acupressure should be considered for patients with cancer experiencing the P-F-S-D symptom cluster. However, given the considerable heterogeneity, potential bias, and lack of systematic adverse event reporting in the included studies, further large-scale, multicenter, high-quality RCTs are necessary to better evaluate the effectiveness and safety of acupressure for multisymptom relief.</p>","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":"860-875"},"PeriodicalIF":1.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}