Journal of Integrative and Complementary Medicine最新文献

{"title":"Validated Instruments for Measuring Health Literacy Among Traditional, Complementary, and Integrative Medicine Users: A Critical, Systematic Review.","authors":"Tristan Carter, Hope Foley, Jon Adams, Kim Graham, Amie Steel","doi":"10.1177/27683605261445329","DOIUrl":"10.1177/27683605261445329","url":null,"abstract":"<p><strong>Introduction: </strong>There is a need to better understand traditional, complementary, and integrative medicine (TCIM) and health literacy (HL) as intersecting fields of research, and to identify the impact of HL on TCIM use and practices. This is best achieved through validated instruments that measure TCIM-specific HL.</p><p><strong>Methods: </strong>This critical, systematic review aimed to identify the use and features of validated instruments for measuring HL in the general adult population using TCIM, and the degree to which those elements measure TCIM-specific HL. Evaluation of the methodological rigor of instrument testing and grade determination was undertaken using the Consensus-based Standards for the Selection of Health Measurement Instruments (COSMIN) checklist and an adapted version of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses-COSMIN manual for the systematic review of patient-reported outcome measures.</p><p><strong>Results: </strong>A total of 21 validated HL instruments, identified from 29 studies, were included in the review. Ten instruments were specific or partially specific to TCIM. Most instruments assessed two or more HL domains (<i>n</i> = 14), including five that assessed all four domains of the integrated conceptual model of HL. Approximately one quarter of all instruments received an overall assessment rating of \"very good\" quality (<i>n</i> = 5), with majority of instruments rating as either \"doubtful\" (<i>n</i> = 9) or \"inadequate\" (<i>n</i> = 7) quality.</p><p><strong>Conclusion: </strong>The examination of HL in relation to TCIM use and users will clearly benefit the TCIM research field and the wider health research community. Focused efforts to develop validated TCIM-specific HL instruments will ensure TCIM use and users are not excluded from HL scholarship and advancements.</p>","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":"833-857"},"PeriodicalIF":1.9,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147933979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of Hemorrhoids with Individualized Homeopathic Medicinal Products: A Double-Blind, Randomized, Placebo-Controlled Trial.","authors":"Ankit Saha, Sk Monsur Alam, Rajat Kumar Pal, Subhranil Saha, Munmun Koley, Shubhamoy Ghosh, Sangita Saha, Soumya Bhattacharyya, Sagarika Muduli, Indrani Halder, Mousumi Koley, Amit Gunin, Suhisna Das, Doly Chakraborty, Abdur Rahaman Shaikh, Priyanka Ghosh, Satarupa Sadhukhan, Shyamal Kumar Mukherjee","doi":"10.1177/27683605261435779","DOIUrl":"10.1177/27683605261435779","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Context: &lt;/strong&gt;Anecdotal reports and preliminary clinical observations suggest potential benefits of homeopathic medicines in hemorrhoids, but high-quality evidence remains limited.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To evaluate whether individualized homeopathic medicinal products (IHMPs) are superior to placebo in reducing anorectal symptom severity and improving quality of life over 3 months in adults with hemorrhoids, and to assess their safety and tolerability.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Design: &lt;/strong&gt;Three-month, double-blind, randomized (1:1), placebo-controlled trial.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Setting: &lt;/strong&gt;Surgery, PG3, and research outpatients of a tertiary homeopathic medical college hospital in West Bengal, India.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Patients: &lt;/strong&gt;One hundred and thirty-four adults with grade I-III hemorrhoids.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Intervention: &lt;/strong&gt;IHMPs (verum; &lt;i&gt;n&lt;/i&gt; = 67) or identical-looking placebos (control; &lt;i&gt;n&lt;/i&gt; = 67) both administered alongside standard concomitant care including sitz baths, pelvic floor exercises, and dietary advice.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Main outcome measures: &lt;/strong&gt;The primary outcome was the change in the Anorectal Symptom Severity and Quality-of-Life (ARSSQoL) total score over 3 months. Secondary outcomes included ARSSQoL subscales, numeric rating scales (NRSs), and EQ-5D-5L questionnaire and visual analog scale. Outcomes were assessed monthly for up to 3 months. The primary analysis compared model-based estimates of change over time between groups using repeated measures analysis of variance; the secondary analyses comprised multivariate linear mixed models, Bayesian hierarchical modeling, and sensitivity analyses under intention-to-treat and per-protocol frameworks.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;After 3 months, IHMPs demonstrated significantly greater improvement than placebo in ARSSQoL total (mean group difference -6.5, 95% confidence interval -8.7, -4.2; &lt;i&gt;p&lt;/i&gt; &lt; 0.001), with large effect sizes. Most ARSSQoL subscales, NRSs, and EQ-5D-5L scores favored IHMPs. Multivariate and Bayesian analyses confirmed consistent intervention-by-time effects, with a high probability of directional superiority for IHMPs in symptom reduction and self-rated health, while sensitivity analyses showed the findings to be robust to protocol deviations. Kent's repertory was the most frequently used in remedy selection. &lt;i&gt;Nitricum acidum&lt;/i&gt; emerged as the most effective remedy. No treatment-related serious adverse events were observed.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;In this randomized, double-blind trial, IHMPs were associated with greater reductions in the ARSSQoL improvements in quality of life compared with placebo over 3 months. Although the magnitude and consistency of effects across multiple analytic approaches suggest potential clinical relevance, the absence of a validated minimal clinically important difference for the ARSSQoL warrants cautious interpretation. Further independent replications and methodological re","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":"874-890"},"PeriodicalIF":1.9,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147610026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness and Safety of Acupuncture for Cancer-Related Cognitive Impairment: A Systematic Review and Meta-Analysis.","authors":"Hao Zhang, Juda Liu, Fang He, Kuojun Ren, Shengying Wang","doi":"10.1177/27683605261436293","DOIUrl":"10.1177/27683605261436293","url":null,"abstract":"<p><strong>Background: </strong>Cancer-related cognitive impairment (CRCI) is a prevalent and clinically significant sequela of cancer and its treatment, markedly reducing quality of life. As a core component of Traditional Chinese Medicine, acupuncture is a potential therapeutic intervention for CRCI; however, conclusive evidence on its efficacy and safety is lacking due to fragmented and methodologically limited studies.</p><p><strong>Objective: </strong>This systematic review and meta-analysis aimed to evaluate the efficacy and safety of acupuncture for CRCI.</p><p><strong>Methods: </strong>We systematically searched eight databases from inception to February 1, 2025, for randomized controlled trials (RCTs) in adults with CRCI comparing acupuncture with control interventions (e.g., conventional care, sham acupuncture, and other active therapies). Risk of bias was assessed using the Cochrane tool (v1). Meta-analyses used RevMan 5.3. Evidence certainty was evaluated with the GRADE framework. Prespecified subgroup analyses explored heterogeneity by acupuncture modality, treatment duration, cancer treatment phase, and cancer type.</p><p><strong>Results: </strong>Forty-four RCTs (<i>n</i> = 3,783) were included. Versus conventional treatment, acupuncture significantly improved Mini-Mental State Examination (MMSE) scores (mean difference [MD] = 2.34, 95% confidence interval [CI] [1.84, 2.85], <i>P</i> < 0.00001), Montreal Cognitive Assessment (MoCA) scores (MD = 1.48, 95% CI: [1.15, 1.82], <i>P</i> < 0.00001), and reduced postoperative cognitive dysfunction (POCD) incidence (risk ratio [RR] = 0.49, 95% CI: [0.41, 0.60], <i>P</i> < 0.00001). Compared with sham acupuncture, acupuncture improved MMSE (MD = 2.48, 95% CI: [1.55, 3.41], <i>P</i> < 0.00001) and MoCA (MD = 1.52, 95% CI: [0.16, 2.88], <i>P</i> = 0.03) scores, though the latter was imprecise. Acupuncture demonstrated no significant benefit for the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 cognitive subscale compared with sham acupuncture (<i>P</i> = 0.11) or other active therapies (<i>P</i> = 0.15). Subgroup analyses identified treatment duration, acupuncture modality, and cancer type as major heterogeneity sources. Safety reporting was often incomplete, yet all documented adverse events were mild and transient. Grading of Recommendations Assessment, Development and Evaluation evidence certainty was low to very low.</p><p><strong>Conclusion: </strong>Acupuncture may improve global cognitive function and reduce POCD incidence in CRCI. However, the safety profile requires further confirmation. Current evidence is limited by methodological weaknesses, substantial heterogeneity, and imprecision, highlighting the need for rigorous, high-quality RCTs with standardized protocols, objective biomarkers, and comprehensive safety monitoring to define acupuncture's role in CRCI management.</p>","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":"858-873"},"PeriodicalIF":1.9,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147595187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traditional Korean Rehabilitation Medicine and Long-Term Health Outcomes after Lumbar Spine Surgery: A Nationwide Propensity-Matched Cohort Study.","authors":"Boyoung Jeon, Seyune Lee, Yun-Kyung Song","doi":"10.1177/27683605261442059","DOIUrl":"10.1177/27683605261442059","url":null,"abstract":"<p><strong>Introduction: </strong>Unplanned readmission, institutionalization, and early mortality remain common after lumbar spine surgery, especially in older adults. Traditional Korean rehabilitation medicine (TKRM) is widely used in Korea, yet its long-term impact on postoperative outcomes has not been clarified.</p><p><strong>Methods: </strong>In this nationwide, retrospective cohort study, National Health Insurance Service claims data from 2019 to 2021 were used to identify 30,022 adults discharged after lumbar surgery. Propensity-score matching (1:1) produced 11,938 comparable patients who either received TKRM within 6 months of discharge or usual care alone. Cox proportional-hazards models estimated adjusted hazard ratio (aHRs) for readmission, entry into long-term care, and all-cause mortality over 6-24 months; dose-response effects were examined across quartiles of cumulative TKRM visits, and diagnosis-specific subgroup analyses contrasted intervertebral disc disorders with spinal stenosis.</p><p><strong>Results: </strong>Early TKRM use was associated with significantly lower risks of readmission (aHR 0.49; 95% confidence interval 0.32-0.75), entry into long-term care (0.36; 0.21-0.62), and mortality (0.49; 0.32-0.75). A graded inverse relationship was observed: patients in the highest exposure quartile showed the greatest benefit (aHR for readmission: 0.24; long-term care facility: 0.12; mortality: 0.16). Protective effects were most pronounced in intervertebral disc disorders, whereas reductions in readmission did not reach significance for spinal stenosis.</p><p><strong>Conclusions: </strong>Utilization of TKRM within the first six postoperative months is associated with sustained reductions in unplanned readmission, entry into long-term care, and all-cause mortality after lumbar surgery, with a clear dose-response relationship. These findings suggest that early TKRM use may be associated with improved postoperative outcomes following lumbar surgery, although further research is needed to confirm these associations.</p>","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":"891-899"},"PeriodicalIF":1.9,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147646696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and Research Trends in Adult Acupressure Randomized Controlled Trials: A Scoping and Bibliometric Review.","authors":"Angga Wilandika, Diah Nur Indah Sari","doi":"10.1177/27683605261499034","DOIUrl":"https://doi.org/10.1177/27683605261499034","url":null,"abstract":"<p><strong>Introduction: </strong>Acupressure has gained increasing attention as a noninvasive, low-risk, and cost-effective complementary intervention to address persistent symptoms such as pain, anxiety, fatigue, and sleep disturbances among adults. Although the volume of randomized controlled trials (RCTs) evaluating acupressure has grown substantially, an integrated synthesis that combines clinical evidence mapping with bibliometric characterization remains limited. This study aimed to conduct an integrated scoping review and bibliometric analysis of RCTs on acupressure interventions among adults in order to map the scope of clinical evidence and identify publication trends, thematic concentrations, and research collaboration patterns.</p><p><strong>Method: </strong>This integrated scoping review was reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Extension for Scoping Reviews reporting guideline. RCTs published between 2020 and 2025 were retrieved from the Scopus database using Population-Concept-Context (PCC) eligibility criteria. The included studies involved adults aged 18 years or older who received acupressure interventions in clinical or health care settings. Data extraction captured both clinical characteristics and bibliometric indicators. Descriptive synthesis was integrated with bibliometric analyses of annual publication trends, subject areas, geographic distribution, author productivity, collaboration networks, and keyword co-occurrence.</p><p><strong>Results: </strong>A total of 303 RCTs were included. Publication output increased steadily, with a notable surge after 2022. Most studies were indexed within Medicine and Nursing. China, Iran, and the United States were the most productive countries, while international collaboration remained limited. Thematic analysis revealed that pain and musculoskeletal conditions were the dominant focuses, closely linked to quality-of-life outcomes. Psychological symptoms and sleep disturbances formed a strongly interconnected cluster, alongside emerging applications in women's health and chronic disease management.</p><p><strong>Conclusion: </strong>The evidence base for adult acupressure has expanded rapidly and demonstrates increasing thematic coherence. Future research should prioritize broader collaboration, diversified clinical applications, and implementation-oriented studies to enhance the translation of findings into practice.</p>","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":"27683605261499034"},"PeriodicalIF":1.9,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149225119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk-Oriented Clinical Management and Observed Safety Outcomes of Acupuncture in Patients at Risk of Metal Allergy: A Single-Center Retrospective Case Series.","authors":"Yosuke Fujita, Tomokazu Kikuchi, Satoru Yamaguchi, Go Horibe, Shintaro Ibata, Takashi Sekiya, Ai Kouchi","doi":"10.1177/27683605261499047","DOIUrl":"https://doi.org/10.1177/27683605261499047","url":null,"abstract":"<p><strong>Background: </strong>Acupuncture is widely used in complementary and integrative medicine. Because acupuncture needles are primarily made of stainless steel, patients at risk of metal allergy require careful management. However, evidence regarding risk-oriented clinical management and observed safety outcomes remains limited. This study aimed to describe risk-oriented clinical management and observed safety outcomes in routine acupuncture practice, including those at risk of metal allergy.</p><p><strong>Methods: </strong>This single-center retrospective case series included consecutive new patients receiving acupuncture over 1 year. Electronic medical records were reviewed for metal allergy risk, clinical management, and adverse events. Patients were classified as at risk of metal allergy based on documented history, self-reported symptoms, or clinical findings. Clinical management was individualized based on risk assessment, clinical judgment, and patient preferences. Safety outcomes included metal contact allergic reactions, systemic metal allergy reactions, and other serious adverse events.</p><p><strong>Results: </strong>Among 230 patients, 23 (10.0%) were classified as at risk of metal allergy. Clinical management included risk assessment, stepwise and minimally invasive approaches, consideration of alternative materials, and post-treatment monitoring. Among 22 patients, 220 treatment sessions were performed. No cases of metal contact allergic reactions, systemic metal allergy reactions, or other serious adverse events were observed. Likewise, no such adverse events were observed in the overall study population.</p><p><strong>Conclusion: </strong>This study provides a practice-based description of risk-oriented clinical management and observed safety outcomes in patients receiving acupuncture, including those at risk of metal allergy. The findings illustrate how patients at risk of metal allergy were assessed and managed in routine acupuncture practice, while the absence of observed adverse events should be interpreted cautiously given the limited sample size and observational study design.</p>","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":"27683605261499047"},"PeriodicalIF":1.9,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149224892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Creating Research Capacity in Complementary and Integrative Institutions: Design of the RAND Research Across Complementary and Integrative Health Institutions (REACH) Center.","authors":"Michele J Maiers, Patricia M Herman, Heather Zwickey, Tiffany Keyes, Margaret Whitley, Nipher Malika, Ryan Bradley, Margaret A Chesney, Ian D Coulter","doi":"10.1177/27683605261499028","DOIUrl":"https://doi.org/10.1177/27683605261499028","url":null,"abstract":"<p><strong>Purpose: </strong>Complementary and integrative health (CIH) professions educate a distinctive and growing segment of the U.S. health care workforce, including acupuncturists, doctors of chiropractic, and naturopathic physicians. Historically their small, largely private, non-profit educational institutions have faced structural barriers to building sustainable, competitive research programs. Limited access to research infrastructure such as biostatistical and informatics support, grants administration, and experienced mentorship has constrained the ability of CIH academic institutions to successfully compete for research grants and federal funding. This inhibits the ability of those trained in CIH professions to contribute robust evidence relevant to their professional practice and to such current research endeavors as whole person health and health policy. Furthermore, CIH academic institutions are largely tuition dependent. Without grants, research and scholarship are often funded indirectly by student fees. These challenges may also be faced by other family medicine professions trained in small academic centers.</p><p><strong>Interventions: </strong>One response to these challenges was the founding of the RAND Center for Collaborative Research in CIH (the RAND Center), which was launched in 2020. This center later received support to become the NIH-funded RAND Research Across Complementary and Integrative Health Institutions (REACH) Center. This article describes the historical context motivating the creation of a multi-institutional, virtual research center; the collaborative process through which it was developed; its organizational structure and guiding principles; and the ways in which it adapts and extends established clinical and translational research infrastructure models to meet the needs of CIH institutions.</p><p><strong>Conclusion: </strong>The RAND REACH Center represents a novel, scalable approach to strengthening research capacity, fostering cross-institutional collaboration, and developing the next generation of CIH clinician-scientists.</p>","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":"27683605261499028"},"PeriodicalIF":1.9,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149220751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of Traditional Chinese Medicine Therapy with Risks of Lower-Limb Amputation, Cardiovascular Mortality and All-Cause Mortality in Patients with Peripheral Arterial Occlusive Disease-A Retrospective Cohort Study.","authors":"Wei-Syun Hu, Cheng-Li Lin","doi":"10.1177/27683605261499015","DOIUrl":"https://doi.org/10.1177/27683605261499015","url":null,"abstract":"<p><strong>Objective: </strong>This is a retrospective cohort study assessing the association between the use of Traditional Chinese Medicine (TCM) and the risk of lower-limb amputation, cardiovascular (CV) mortality, and all-cause mortality among people with peripheral arterial occlusive disease (PAOD).</p><p><strong>Methods: </strong>The study utilized data from the National Health Insurance Research Database of the Ministry of Health and Welfare of Taiwan. A 1:1 propensity score matching ratio based on gender, age (5-year interval), comorbidities, medications, and year of index date.The risk of outcomes among PAOD patients with and without TCM use was estimated by a Cox proportional hazards model.</p><p><strong>Results: </strong>The study findings showed that TCM treatment was associated with a significant decreased risk of lower-limb loss (adjusted hazard ratio [aHR] = 0.55, 95% confidence interval [CI] = 0.50-0.61), CV death (aHR = 0.33, 95% CI = 0.31-0.34), and all-cause mortality (aHR = 0.34, 95% CI = 0.34-0.35) among people with PAOD, especially for CV death and all-cause death.</p><p><strong>Conclusion: </strong>We found that patients with PAOD treated with TCM have a decreased risk of endpoints, especially for CV death and all-cause death.</p>","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":"27683605261499015"},"PeriodicalIF":1.9,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149220747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effectiveness and Safety of <i>Coleus forskohlii</i> Extract as an Anti-Obesity Agent: A Systematic Review.","authors":"Elhameh Nikkhah, Alireza Ostadrahimi, Sara Rahimi, Nima Radkhah, Soghra Aliasgharzadeh, Arash Khorrami, Samira Pourmoradian","doi":"10.1177/27683605261492576","DOIUrl":"https://doi.org/10.1177/27683605261492576","url":null,"abstract":"<p><strong>Background: </strong>Natural products, including medicinal plants, have been explored for obesity management. <i>Coleus forskohlii</i> contains the bioactive compound forskolin, which may influence body composition and weight regulation. This systematic review assessed the effectiveness and safety of <i>C. forskohlii</i> extract as an anti-obesity agent.</p><p><strong>Methods: </strong>PubMed, Scopus, Web of Science, Cochrane Central Register of Controlled Trials, and Google Scholar were systematically searched from January 1990 to May 2023. Study selection and data extraction were performed independently by two reviewers. Risk of bias was evaluated using the Cochrane Risk of Bias 1 tool.</p><p><strong>Results: </strong>Four randomized controlled trials met inclusion criteria. Evidence suggests that <i>C. forskohlii</i> extract may reduce fat mass and body fat percentage; however, findings regarding weight loss and overall body composition have been inconsistent. Adverse effects were generally mild and infrequent.</p><p><strong>Conclusions: </strong>Current evidence suggests that <i>C. forskohlii</i> extract may serve as a complementary therapy for obesity. High-quality, long-term, double-blind, randomized, placebo-controlled trials are required to confirm its efficacy and safety.</p>","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":"27683605261492576"},"PeriodicalIF":1.9,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149138457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The World Cup Is Won Between Matches: What Elite Sport Can Teach Us About Integrative Health.","authors":"Holger Cramer","doi":"10.1177/27683605261495327","DOIUrl":"https://doi.org/10.1177/27683605261495327","url":null,"abstract":"","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":"27683605261495327"},"PeriodicalIF":1.9,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149138550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}