{"title":"Traditional, Complementary, and Integrative Medicine Use Among U.S. Children: National Health Interview Survey 2012 and 2022.","authors":"Amber Je Rhee, Richard L Nahin","doi":"10.1177/27683605261499478","DOIUrl":"https://doi.org/10.1177/27683605261499478","url":null,"abstract":"<p><strong>Background and objectives: </strong>A recent report of traditional, complementary, and integrative medicine (TCIM) utilization by U.S. children found increased usage across 2007, 2012, and 2022 by age, sex, and race/ethnicity. Here, we examine cross-sectional changes between 2012 and 2022 in detail by TCIM approach and sociodemographic and health characteristics, including reports of asthma, depression, diabetes, and pain, in U.S. children aged 4-17 years.</p><p><strong>Methods: </strong>We examined overall TCIM use, use of practitioner-based TCIMs (TCIM directly provided by practitioners) and use of nonpractitioner TCIMs (TCIM not directly provided by practitioners). National Health Interview Survey (NHIS) in 2007, 2012, 2017, and 2022 asked questions on TCIM, but analyses were limited to 2012 and 2022 as they had the most comparable wording. Prevalence and variance estimates were calculated using Proc Survey Procedures in SAS software version 9.4 to account for NHIS's complex sample design.</p><p><strong>Results: </strong>When using the TCIM approaches assessed in this study, we found that utilization among U.S. children increased from 6.4% in 2012 to 17.8% in 2022, largely driven by use of nonpractitioner-based TCIMs, which rose from 3.2% to 14.0%. Among those using practitioner-based TCIM, use specifically for pain management increased from 28.7% to 47.6%. In both years, children who were non-Hispanic, White, Female, from families with at least one college-educated adult, and reporting current depression or asthma were more likely to utilize any TCIM.</p><p><strong>Conclusions: </strong>Based on the TCIM approaches assessed in this study, U.S. children are increasingly utilizing TCIMs, particularly nonpractitioner approaches, mirroring similar increases in TCIM use by U.S. adults. Given the fast pace of TCIM adoption by children in the United States, future research examining the downstream impacts of these changes is warranted.</p>","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":"27683605261499478"},"PeriodicalIF":1.9,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149239711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical and Research Trends in Adult Acupressure Randomized Controlled Trials: A Scoping and Bibliometric Review.","authors":"Angga Wilandika, Diah Nur Indah Sari","doi":"10.1177/27683605261499034","DOIUrl":"https://doi.org/10.1177/27683605261499034","url":null,"abstract":"<p><strong>Introduction: </strong>Acupressure has gained increasing attention as a noninvasive, low-risk, and cost-effective complementary intervention to address persistent symptoms such as pain, anxiety, fatigue, and sleep disturbances among adults. Although the volume of randomized controlled trials (RCTs) evaluating acupressure has grown substantially, an integrated synthesis that combines clinical evidence mapping with bibliometric characterization remains limited. This study aimed to conduct an integrated scoping review and bibliometric analysis of RCTs on acupressure interventions among adults in order to map the scope of clinical evidence and identify publication trends, thematic concentrations, and research collaboration patterns.</p><p><strong>Method: </strong>This integrated scoping review was reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Extension for Scoping Reviews reporting guideline. RCTs published between 2020 and 2025 were retrieved from the Scopus database using Population-Concept-Context (PCC) eligibility criteria. The included studies involved adults aged 18 years or older who received acupressure interventions in clinical or health care settings. Data extraction captured both clinical characteristics and bibliometric indicators. Descriptive synthesis was integrated with bibliometric analyses of annual publication trends, subject areas, geographic distribution, author productivity, collaboration networks, and keyword co-occurrence.</p><p><strong>Results: </strong>A total of 303 RCTs were included. Publication output increased steadily, with a notable surge after 2022. Most studies were indexed within Medicine and Nursing. China, Iran, and the United States were the most productive countries, while international collaboration remained limited. Thematic analysis revealed that pain and musculoskeletal conditions were the dominant focuses, closely linked to quality-of-life outcomes. Psychological symptoms and sleep disturbances formed a strongly interconnected cluster, alongside emerging applications in women's health and chronic disease management.</p><p><strong>Conclusion: </strong>The evidence base for adult acupressure has expanded rapidly and demonstrates increasing thematic coherence. Future research should prioritize broader collaboration, diversified clinical applications, and implementation-oriented studies to enhance the translation of findings into practice.</p>","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":"27683605261499034"},"PeriodicalIF":1.9,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149225119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yosuke Fujita, Tomokazu Kikuchi, Satoru Yamaguchi, Go Horibe, Shintaro Ibata, Takashi Sekiya, Ai Kouchi
{"title":"Risk-Oriented Clinical Management and Observed Safety Outcomes of Acupuncture in Patients at Risk of Metal Allergy: A Single-Center Retrospective Case Series.","authors":"Yosuke Fujita, Tomokazu Kikuchi, Satoru Yamaguchi, Go Horibe, Shintaro Ibata, Takashi Sekiya, Ai Kouchi","doi":"10.1177/27683605261499047","DOIUrl":"https://doi.org/10.1177/27683605261499047","url":null,"abstract":"<p><strong>Background: </strong>Acupuncture is widely used in complementary and integrative medicine. Because acupuncture needles are primarily made of stainless steel, patients at risk of metal allergy require careful management. However, evidence regarding risk-oriented clinical management and observed safety outcomes remains limited. This study aimed to describe risk-oriented clinical management and observed safety outcomes in routine acupuncture practice, including those at risk of metal allergy.</p><p><strong>Methods: </strong>This single-center retrospective case series included consecutive new patients receiving acupuncture over 1 year. Electronic medical records were reviewed for metal allergy risk, clinical management, and adverse events. Patients were classified as at risk of metal allergy based on documented history, self-reported symptoms, or clinical findings. Clinical management was individualized based on risk assessment, clinical judgment, and patient preferences. Safety outcomes included metal contact allergic reactions, systemic metal allergy reactions, and other serious adverse events.</p><p><strong>Results: </strong>Among 230 patients, 23 (10.0%) were classified as at risk of metal allergy. Clinical management included risk assessment, stepwise and minimally invasive approaches, consideration of alternative materials, and post-treatment monitoring. Among 22 patients, 220 treatment sessions were performed. No cases of metal contact allergic reactions, systemic metal allergy reactions, or other serious adverse events were observed. Likewise, no such adverse events were observed in the overall study population.</p><p><strong>Conclusion: </strong>This study provides a practice-based description of risk-oriented clinical management and observed safety outcomes in patients receiving acupuncture, including those at risk of metal allergy. The findings illustrate how patients at risk of metal allergy were assessed and managed in routine acupuncture practice, while the absence of observed adverse events should be interpreted cautiously given the limited sample size and observational study design.</p>","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":"27683605261499047"},"PeriodicalIF":1.9,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149224892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Michele J Maiers, Patricia M Herman, Heather Zwickey, Tiffany Keyes, Margaret Whitley, Nipher Malika, Ryan Bradley, Margaret A Chesney, Ian D Coulter
{"title":"Creating Research Capacity in Complementary and Integrative Institutions: Design of the RAND Research Across Complementary and Integrative Health Institutions (REACH) Center.","authors":"Michele J Maiers, Patricia M Herman, Heather Zwickey, Tiffany Keyes, Margaret Whitley, Nipher Malika, Ryan Bradley, Margaret A Chesney, Ian D Coulter","doi":"10.1177/27683605261499028","DOIUrl":"https://doi.org/10.1177/27683605261499028","url":null,"abstract":"<p><strong>Purpose: </strong>Complementary and integrative health (CIH) professions educate a distinctive and growing segment of the U.S. health care workforce, including acupuncturists, doctors of chiropractic, and naturopathic physicians. Historically their small, largely private, non-profit educational institutions have faced structural barriers to building sustainable, competitive research programs. Limited access to research infrastructure such as biostatistical and informatics support, grants administration, and experienced mentorship has constrained the ability of CIH academic institutions to successfully compete for research grants and federal funding. This inhibits the ability of those trained in CIH professions to contribute robust evidence relevant to their professional practice and to such current research endeavors as whole person health and health policy. Furthermore, CIH academic institutions are largely tuition dependent. Without grants, research and scholarship are often funded indirectly by student fees. These challenges may also be faced by other family medicine professions trained in small academic centers.</p><p><strong>Interventions: </strong>One response to these challenges was the founding of the RAND Center for Collaborative Research in CIH (the RAND Center), which was launched in 2020. This center later received support to become the NIH-funded RAND Research Across Complementary and Integrative Health Institutions (REACH) Center. This article describes the historical context motivating the creation of a multi-institutional, virtual research center; the collaborative process through which it was developed; its organizational structure and guiding principles; and the ways in which it adapts and extends established clinical and translational research infrastructure models to meet the needs of CIH institutions.</p><p><strong>Conclusion: </strong>The RAND REACH Center represents a novel, scalable approach to strengthening research capacity, fostering cross-institutional collaboration, and developing the next generation of CIH clinician-scientists.</p>","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":"27683605261499028"},"PeriodicalIF":1.9,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149220751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Associations of Traditional Chinese Medicine Therapy with Risks of Lower-Limb Amputation, Cardiovascular Mortality and All-Cause Mortality in Patients with Peripheral Arterial Occlusive Disease-A Retrospective Cohort Study.","authors":"Wei-Syun Hu, Cheng-Li Lin","doi":"10.1177/27683605261499015","DOIUrl":"https://doi.org/10.1177/27683605261499015","url":null,"abstract":"<p><strong>Objective: </strong>This is a retrospective cohort study assessing the association between the use of Traditional Chinese Medicine (TCM) and the risk of lower-limb amputation, cardiovascular (CV) mortality, and all-cause mortality among people with peripheral arterial occlusive disease (PAOD).</p><p><strong>Methods: </strong>The study utilized data from the National Health Insurance Research Database of the Ministry of Health and Welfare of Taiwan. A 1:1 propensity score matching ratio based on gender, age (5-year interval), comorbidities, medications, and year of index date.The risk of outcomes among PAOD patients with and without TCM use was estimated by a Cox proportional hazards model.</p><p><strong>Results: </strong>The study findings showed that TCM treatment was associated with a significant decreased risk of lower-limb loss (adjusted hazard ratio [aHR] = 0.55, 95% confidence interval [CI] = 0.50-0.61), CV death (aHR = 0.33, 95% CI = 0.31-0.34), and all-cause mortality (aHR = 0.34, 95% CI = 0.34-0.35) among people with PAOD, especially for CV death and all-cause death.</p><p><strong>Conclusion: </strong>We found that patients with PAOD treated with TCM have a decreased risk of endpoints, especially for CV death and all-cause death.</p>","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":"27683605261499015"},"PeriodicalIF":1.9,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149220747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Elhameh Nikkhah, Alireza Ostadrahimi, Sara Rahimi, Nima Radkhah, Soghra Aliasgharzadeh, Arash Khorrami, Samira Pourmoradian
{"title":"The Effectiveness and Safety of <i>Coleus forskohlii</i> Extract as an Anti-Obesity Agent: A Systematic Review.","authors":"Elhameh Nikkhah, Alireza Ostadrahimi, Sara Rahimi, Nima Radkhah, Soghra Aliasgharzadeh, Arash Khorrami, Samira Pourmoradian","doi":"10.1177/27683605261492576","DOIUrl":"https://doi.org/10.1177/27683605261492576","url":null,"abstract":"<p><strong>Background: </strong>Natural products, including medicinal plants, have been explored for obesity management. <i>Coleus forskohlii</i> contains the bioactive compound forskolin, which may influence body composition and weight regulation. This systematic review assessed the effectiveness and safety of <i>C. forskohlii</i> extract as an anti-obesity agent.</p><p><strong>Methods: </strong>PubMed, Scopus, Web of Science, Cochrane Central Register of Controlled Trials, and Google Scholar were systematically searched from January 1990 to May 2023. Study selection and data extraction were performed independently by two reviewers. Risk of bias was evaluated using the Cochrane Risk of Bias 1 tool.</p><p><strong>Results: </strong>Four randomized controlled trials met inclusion criteria. Evidence suggests that <i>C. forskohlii</i> extract may reduce fat mass and body fat percentage; however, findings regarding weight loss and overall body composition have been inconsistent. Adverse effects were generally mild and infrequent.</p><p><strong>Conclusions: </strong>Current evidence suggests that <i>C. forskohlii</i> extract may serve as a complementary therapy for obesity. High-quality, long-term, double-blind, randomized, placebo-controlled trials are required to confirm its efficacy and safety.</p>","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":"27683605261492576"},"PeriodicalIF":1.9,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149138457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The World Cup Is Won Between Matches: What Elite Sport Can Teach Us About Integrative Health.","authors":"Holger Cramer","doi":"10.1177/27683605261495327","DOIUrl":"https://doi.org/10.1177/27683605261495327","url":null,"abstract":"","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":"27683605261495327"},"PeriodicalIF":1.9,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149138550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prioritizing Barriers and Facilitators of Traditional, Complementary, and Integrative Medicine Service Use: A Delphi and Analytical Hierarchy Process Study in Iran.","authors":"Seyede Maryam Najibi, Faride Sadat Jalali, Yaser Sarikhani, Mahdie Hajimonfarednejad, Seyed Hosein Seyedi, Mohammad Hashem Hashempur","doi":"10.1177/27683605261435775","DOIUrl":"10.1177/27683605261435775","url":null,"abstract":"<p><strong>Introduction: </strong>Recognizing and prioritizing the factors that influence the selection of treatment options is essential for effective health service planning and an appropriate health care delivery system. This study aimed to identify and prioritize the barriers and facilitators to the use of Traditional, Complementary, and Integrative Medicine (TCIM) in Iran.</p><p><strong>Materials and methods: </strong>A two-phase, mixed-methods study was conducted. First, a two-round Delphi survey was conducted with a panel of 32 experts, including specialists in Persian medicine (PM) and health policymakers, to acheive consensus on a list of barriers and facilitators within the Iranian context. Subsequently, the Analytical Hierarchy Process (AHP) was applied with a 12-expert panel to determine the relative weight and priority of the agreed-upon criteria.</p><p><strong>Results: </strong>The Delphi process yielded consensus on 18 facilitators and nine barriers. The facilitators were categorized into two main dimensions (Cultural and social facilitators, and Systemic facilitators) and six sub-dimensions. In comparison, the barriers formed four main dimensions (service delivery barriers, policy challenges, financial barriers, and knowledge and attitudinal barriers). Quantitative AHP results revealed that among facilitators, \"effects of health professionals\" (Final Weight: 0.29) was the most critical dimension, with \"Recommendation and referral by conventional physicians (CPs)\" (Final Weight: 0.18) as its top factor. Conversely, among barriers, \"Policy Challenges\" (Final Weight: 0.50) was the most significant dimension, substantially outweighing others.</p><p><strong>Conclusion: </strong>The findings highlight that the recommendation of TCIM by CPs are the strongest facilitator; yet, overarching policy challenges critically hamper its implementation. Addressing this disconnect requires integrated policy reforms and interdisciplinary collaboration to leverage TCIM within Iran's health care system effectively.</p>","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":"797-807"},"PeriodicalIF":1.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147783054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Christa K Raak, David D Martin, Katja Boehm, Daniela Hacke, Sebastian Unger, Thomas Ostermann
{"title":"Published Database Resources for Traditional, Complementary, and Integrative Medicine: Update of a Systematic Review.","authors":"Christa K Raak, David D Martin, Katja Boehm, Daniela Hacke, Sebastian Unger, Thomas Ostermann","doi":"10.1177/27683605261441386","DOIUrl":"10.1177/27683605261441386","url":null,"abstract":"<p><strong>Background: </strong>Traditional, Complementary, and Integrative Medicine (TCIM) has been established in the academic context of universities. In recent years, strategies have been developed worldwide to strengthen the role of TCIM in supporting the health of the population. Online databases are a common way for obtaining evidence-based information. This article is an update of a former systematic review from 2010 on published databases resources for TCIM.</p><p><strong>Methods: </strong>The databases CINAHL, CAMbase, Web of Science, MEDLINE/PubMed, and Google Scholar search engine were searched for databases related to TCIM published in peer-reviewed journals between 2010 and November 2024. All included databases were visited online, and information on the origin, content, and scope of the database was extracted.</p><p><strong>Results: </strong>A total of 6579 articles were identified through the literature search. After exclusion of irrelevant articles, full-text screening of 127 articles yielded 37 new databases. Together with 16 still available old databases, these mainly contained information on herbal therapies (<i>n</i> = 15) and Traditional Chinese Medicine (<i>n</i> = 11) from 18 different countries. Newly identified medicinal plant databases offer various scientific resources such as crude drugs, indigenous plants, and structures for natural and phytochemical components with molecular biological content.</p><p><strong>Conclusions: </strong>This literature review illustrates the dynamic development in the database landscape over the last 15 years. While the number of bibliographic databases is shrinking, databases in the field of medical plants/herbal therapy content are on the rise, which might be due to advances in plant genomics and molecular biology.</p>","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":"785-796"},"PeriodicalIF":1.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147699924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anjaneya Venkata Vara Prasad Mungara, Nawazish Rabbani Shaik, Chandra Kiran M, Varun P Sureja
{"title":"CL16019, A Combination of <i>Cissus quadrangularis</i> and <i>Boswellia serrata</i> Extracts Promotes the Healing of Distal Radius Fractures: A Multicentric, Randomized, Open-Label Study.","authors":"Anjaneya Venkata Vara Prasad Mungara, Nawazish Rabbani Shaik, Chandra Kiran M, Varun P Sureja","doi":"10.1177/27683605261435781","DOIUrl":"10.1177/27683605261435781","url":null,"abstract":"<p><strong>Objective: </strong>Distal radius fracture (DRF) is the most frequent injury to the upper limb. Complications include nonunion, wrist stiffness and instability, local discomfort, and tendon irritation. The purpose of the current open-label clinical study was to evaluate the safety, efficacy, and tolerability of CL16019, an herbal formulation of <i>Cissus quadrangularis</i> and <i>Boswellia serrata</i> extract, in accelerating fracture healing in volunteers with DRFs.</p><p><strong>Methods: </strong>Fifty participants (both male and female; age: 30-50 years) with type I, IIA, or IIB DRFs (as per Lidstrom classification) were equally randomized and treated with standard treatment (ST) or ST + CL16019 for 60 days. The primary efficacy outcome was the radiographical bone fracture healing rate as scored by the Radius Union Scoring System (RUSS). Pain, swelling, and tenderness were among the clinical characteristics evaluated using the visual analog scale (VAS). Wrist function improvements were assessed using the Patient-Rated Wrist Evaluation Questionnaire (PRWEQ). The intergroup and intragroup results were analyzed using a paired <i>t-</i>test and an analysis of covariance model, respectively.</p><p><strong>Results: </strong>The RUSS scores for the ST and ST + CL16019 groups at the end of the trial were 5.54 ± 1.77 and 7.96 ± 0.20, respectively, with a <i>p</i>-value <0.0001. In addition, the CL16019 volunteers showed substantial (<i>p</i> < 0.05) declines in their VAS and PRWEQ scores. The ST + CL16019 group demonstrated higher Physician Global Assessment and Subject Global Assessment scores.</p><p><strong>Conclusions: </strong>Supplementation of CL16019 along with standard therapy was found to enhance the bone fracture healing rate, possibly by accelerating the callus formation rate and enhancing cortical bridging. These findings imply that CL16019 might be a good adjunctive in addition to ST for the faster healing of DRFs. The trial was registered with the Clinical Trial Registry of India (CTRI) with the registration number CTRI/2021/12/039006, on December 29, 2021.</p>","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":"808-820"},"PeriodicalIF":1.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147533353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}