Journal of Integrative and Complementary Medicine最新文献

{"title":"Effect of <i>Matricaria chamomilla</i> on the Quality of Life Among Women with Menopausal Symptoms: A Triple-Blind Randomized Controlled Trial.","authors":"Farideh Mohsenzadeh-Ledari, Mouloud Agajani Delavar, Ali Akbar Moghadamnia, Reza Bekhradi, Sorya Khafri, Fereshteh Behmanesh, Shahla Yazdani","doi":"10.1177/27683605261426288","DOIUrl":"10.1177/27683605261426288","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate whether <i>Matricaria chamomilla</i> (Chamomile) supplementation enhances quality of life (QOL) specifically in vasomotor, psychological, physical, and sexual domains among postmenopausal women in Iran, where research on natural remedies for menopause management is limited.</p><p><strong>Methods: </strong>In this triple-blind randomized controlled trial, 80 postmenopausal women aged 47-62 years were randomly assigned to receive either 400 mg Chamomile capsules daily (standardized to 1.2% apigenin) or placebo for 12 weeks. Randomization was performed using permuted blocks, and the study was triple-blinded (participants, researchers, and data analysts). QOL was assessed using the Menopause-Specific Quality of Life Questionnaire at baseline and 12 weeks. Data were analyzed using analysis of covariance with baseline score adjustments and an intention-to-treat approach for missing data.</p><p><strong>Results: </strong>Chamomile significantly reduced vasomotor symptoms compared to placebo (mean difference = -0.82, 95% confidence interval: -1.25 to -0.39, <i>p</i> ≤ 0.001). No significant improvements were observed in psychological, physical, sexual, or overall QOL scores. Mild side effects (mouth sores, skin spots) caused the withdrawal of two participants from the Chamomile group.</p><p><strong>Conclusions: </strong>Chamomile supplementation demonstrates efficacy in alleviating vasomotor symptoms in postmenopausal women, likely due to its phytoestrogenic properties, but has a limited impact on other QOL domains.</p>","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":"744-751"},"PeriodicalIF":1.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147318542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is It the Sport or the Exercise? Rethinking Sport-Specific Mental Health Interventions.","authors":"Davy Vancampfort, Brendon Stubbs, Tine Van Damme, Simon Rosenbaum","doi":"10.1177/27683605261426296","DOIUrl":"10.1177/27683605261426296","url":null,"abstract":"","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":"709-711"},"PeriodicalIF":1.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147285322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding Primary Care Providers' Decisions to Recommend Complementary and Integrative Health Therapies: A Qualitative Analysis.","authors":"Marlena H Shin, Michael G McGowan, Danna R Kasom, Jessica K Friedman, Lee J S Cross, Diana J Burgess, Juli Olson, Alison M Whitehead, Stephanie L Taylor","doi":"10.1177/27683605261441040","DOIUrl":"10.1177/27683605261441040","url":null,"abstract":"<p><strong>Background: </strong>Evidence-based complementary and integrative health (CIH) therapies are now in clinical practice guidelines for common pain and pain-related conditions. Primary care providers (PCPs) are often the first point of contact for discussing CIH therapies as non-pharmacological health management. Yet, little is known about their decisions to recommend CIH therapies.</p><p><strong>Objective: </strong>To understand: (1) which CIH therapies PCPs recommend and for what health conditions, (2) reasons for their recommendations or lack thereof, and (3) possible solutions to improve appropriateness of recommendations.</p><p><strong>Methods: </strong>Semi-structured qualitative interviews were conducted with 40 PCPs from eight Veterans Health Administration (VA) hospitals offering eight evidence-based CIH therapies (acupuncture, medical massage therapy, yoga, Tai Chi, meditation/mindfulness, biofeedback, clinical hypnosis, guided imagery). A rapid qualitative analysis was performed using a matrix approach.</p><p><strong>Results: </strong>PCPs recommended patients use acupuncture, medical massage therapy, yoga, Tai Chi, and meditation/mindfulness the most and biofeedback, clinical hypnosis, and guided imagery the least. Pain was the main condition for referrals to all CIH therapies except clinical hypnosis and guided imagery, which were most recommended for smoking cessation and mental health, respectively. Decisions to recommend were largely driven by PCP's knowledge of CIH therapies' effectiveness for particular health conditions. Other factors were PCP's own beliefs about CIH therapies, their perceptions about patients' beliefs, patients' positive experiences, and organizational factors (e.g., understanding what therapies are covered for which conditions and the local referral process). PCPs wanted brief educational information containing many types of content, ranging from therapy descriptions to clinical practice guidelines and information on institutional policies on CIH therapy provision.</p><p><strong>Conclusions: </strong>Although some PCPs are appropriately recommending evidence-based CIH therapies, lack of knowledge is a critical barrier for many others. This could be addressed with the educational information tailored to the content and format that PCPs specifically requested.</p>","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":"752-760"},"PeriodicalIF":1.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147639991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Letter:</i> The Tamil Nadu Government Yoga and Naturopathy Network: A Functioning Model of the Delhi Declaration Integration Pathway.","authors":"Maheshkumar Kuppusamy, Venugopal Vijayakumar, Manavalan Narayanaswamy, Deenadayalan Boopalan","doi":"10.1177/27683605261483938","DOIUrl":"https://doi.org/10.1177/27683605261483938","url":null,"abstract":"","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":"27683605261483938"},"PeriodicalIF":1.9,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148841328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Response to the Letter:</i> Concerns regarding Cervical Arterial Pathology.","authors":"Robert J Trager, Clinton J Daniels, Cheryl Hawk, David N Taylor, Sheryl A Walters, Morgan R Price, Kristian R Anderson, Louis S Crivelli, Scott A Mooring, Carina A Staab, Christopher B Oakley","doi":"10.1177/27683605261483906","DOIUrl":"https://doi.org/10.1177/27683605261483906","url":null,"abstract":"","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":"27683605261483906"},"PeriodicalIF":1.9,"publicationDate":"2026-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148809177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Letter:</i> Concerns Regarding Cervical Arterial Pathology in the Trager et al. Clinical Practice Guideline.","authors":"Steven Brown","doi":"10.1177/27683605261483894","DOIUrl":"https://doi.org/10.1177/27683605261483894","url":null,"abstract":"","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":"27683605261483894"},"PeriodicalIF":1.9,"publicationDate":"2026-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148809122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Classical Hand Massage on Pain in Patients Undergoing Coronary Artery Bypass Graft Surgery: Randomized Controlled Trial.","authors":"Öykü Kara, Seher Deniz Öztekin, Nihan Yapıcı","doi":"10.1177/27683605261475452","DOIUrl":"https://doi.org/10.1177/27683605261475452","url":null,"abstract":"<p><strong>Introduction: </strong>Coronary artery bypass grafting (CABG) is one of the most common major surgical procedures, and patients often experience severe postoperative pain. Effective, safe, and nonpharmacological strategies are needed to support pain management and physiological stability after CABG. This study aimed to evaluate the effect of classical hand massage on postoperative pain and physiological parameters in patients undergoing CABG surgery.</p><p><strong>Methods: </strong>This single-blind randomized controlled trial study was conducted with 80 patients in the cardiovascular surgery intensive care unit. The intervention group received 30 min of classic hand massage (15 min per hand) in addition to routine care, while the control group received routine care alone. The primary outcome was postoperative pain intensity measured using the Visual Analog Scale (VAS). Secondary outcomes included systolic blood pressure, diastolic blood pressure, pulse rate, respiratory rate, and oxygen saturation. These outcomes were assessed before the intervention (T₀) and at 5, 30, 60, 90, and 120 min thereafter (T₁-T₅), and between-group differences were evaluated at a significance level of <i>p</i> < 0.05.</p><p><strong>Results: </strong>Classic hand massage significantly reduced sternotomy pain at all follow-up times (2.30-3.50 vs. 5.37-6.20; <i>p</i> < 0.001). Drain pain was also lower at 5 min (2.07 ± 0.64 vs. 3.94 ± 1.25) and 30 min (2.07 ± 0.64 vs. 4.11 ± 1.32) (<i>p</i> < 0.001). Back and leg-incision pain showed no between-group differences (<i>p</i> > 0.05). Systolic blood pressure was lower at 30 and 60 min (<i>p</i> = 0.012; <i>p</i> = 0.037), and diastolic blood pressure at 5 and 30 min (<i>p</i> = 0.015; <i>p</i> = 0.018). Respiratory rate decreased and oxygen saturation increased at all times (<i>p</i> < 0.001). Pulse rate did not differ (<i>p</i> > 0.05). No patient requested analgesics. No adverse events or intervention-related harms were observed during the study period.</p><p><strong>Conclusion: </strong>Hand massage was associated with lower pain scores and favorable physiological responses in patients undergoing CABG surgery. Nevertheless, further multicenter studies with larger sample sizes are needed to strengthen the evidence base and support the generalizability of these findings.</p>","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":"27683605261475452"},"PeriodicalIF":1.9,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148798701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Evidence Map of Tai Chi and Qigong, 2014-2024: A Systematic Review.","authors":"Selene S Mak, Jennifer E Allen, Meron M Begashaw, Jessica M Beroes-Severin, Isomi M Miake-Lye, Paul G Shekelle","doi":"10.1177/27683605261476938","DOIUrl":"https://doi.org/10.1177/27683605261476938","url":null,"abstract":"<p><strong>Introduction: </strong>The objective of this evidence map of systematic reviews was to identify and map systematic reviews published from 2014 to 2024 that evaluated Tai Chi or <i>qigong</i> for adult health conditions, summarize review conclusions, and abstract the reported certainty, quality, or strength of evidence.</p><p><strong>Methods: </strong>We searched Allied and Complementary Medicine Database, CINAHL, Cochrane Database of Systematic Reviews, Ovid MEDLINE, PsycINFO, and Scopus from January 2014 to March 2024. Eligible publications were systematic reviews of Tai Chi or <i>qigong</i> for adult health conditions that used a formal approach to assess certainty, quality, or strength of evidence and reported those ratings for the effect of Tai Chi or <i>qigong</i>. Four reviewers screened titles and abstracts in duplicate. Data on review characteristics, conclusions, and reported certainty assessments were extracted by one reviewer and verified by a second reviewer.</p><p><strong>Results: </strong>We included 26 systematic reviews. Two reviews reported high-certainty evidence for improved postmenopausal bone mineral density and reduced blood pressure in hypertension. Sixteen reviews reported at least one moderate-certainty conclusion. Eighteen of the 26 reviews reported adverse events data; among those 18 reviews, no serious adverse events were reported.</p><p><strong>Discussion: </strong>Among the included reviews, high-certainty evidence of benefit was reported for hypertension and postmenopausal bone mineral density. Several additional conditions had moderate-certainty conclusions, but much of the literature remained low or very low certainty. Safety interpretation was limited by inconsistent reporting of harms in the included reviews.</p>","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":"27683605261476938"},"PeriodicalIF":1.9,"publicationDate":"2026-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148762325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sanshimao Formula Improves Recurrence-Free Survival in Early and Intermediate Hepatocellular Carcinoma Patients with Cirrhosis: A Randomized Controlled Trial.","authors":"Wei Xie, Xiangyu Zhang, Jiawei Zhao, Yongbin Meng, Xia Li, Juan Du","doi":"10.1177/27683605261477729","DOIUrl":"https://doi.org/10.1177/27683605261477729","url":null,"abstract":"<p><strong>Background: </strong>This study was designed to assess the safety and preliminary efficacy of Sanshimao (SSM) formula in early and intermediate hepatocellular carcinoma (HCC) patients with cirrhosis.</p><p><strong>Methods: </strong>We conducted a prospective randomized, open-label, controlled trial, assigning early and intermediate HCC patients with cirrhosis in a 1:1 ratio to either the control group or the SSM group. Patients were followed for a 16-month treatment period. Patients in the SSM group received additional SSM formula in addition to their conventional management compared with control. Primary analysis was performed in the intention-to-treat (ITT) population, and a sensitivity analysis was conducted in the per-protocol (PP) population. The primary endpoint was recurrence-free survival (RFS). Liver stiffness measurement (LSM), laminin-5 (LN-5), collagen type IV (COL IV), hyaluronic acid (HA), and procollagen type III (HPC III) were exploratory secondary endpoints.</p><p><strong>Results: </strong>A total of 106 patients were randomized (53 per group), and 90 patients who completed the study were included in the PP analysis. In the ITT population, the SSM group showed significantly improved RFS compared with control (hazard ratio [HR] = 0.47, 95% confidence interval [CI]: 0.27-0.81, <i>p</i> = 0.007). The PP sensitivity analysis yielded consistent findings (HR = 0.28, 95% CI: 0.15-0.52, <i>p</i> < 0.001). At the end of the 16-month treatment period, LSM levels in the SSM group were significantly lower than those in the control group (mean difference: -3.17 kPa, 95% CI: -5.45 to -0.89, <i>p</i> = 0.0018). Serum LN-5, COL IV, HA, and HPC III decreased significantly in the SSM group (all <i>p</i> < 0.05), whereas no significant changes were observed in the control group. No deaths or serious adverse events were reported in either group, and all reported adverse events were Grade 1 in severity.</p><p><strong>Conclusion: </strong>Adjuvant SSM formula significantly improved the RFS in early and intermediate HCC patients with cirrhosis after curative hepatectomy or locoregional therapy. Alongside the observed RFS benefits, reductions in liver stiffness and extracellular matrix biomarkers were also noted. However, a causal relationship between these outcomes remains unconfirmed.</p>","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":"27683605261477729"},"PeriodicalIF":1.9,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148707810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Study on the Diagnostic Value of Commonly Used Clinical Nutritional Quantitative Indicators for the Diagnosis of Qi and Blood Deficiency Syndrome in Elderly Patients.","authors":"Jingran Cao, Yanjie Han, Qingsheng Luo, Wei Liu","doi":"10.1177/27683605261475455","DOIUrl":"https://doi.org/10.1177/27683605261475455","url":null,"abstract":"<p><strong>Objective: </strong>To diagnose qi and blood deficiency syndromes using common nutritional quantitative indicators.</p><p><strong>Methods: </strong>A cross-sectional study was conducted on 1049 hospitalized elderly patients (mean age 71 years). On admission, TCM syndrome differentiation and nutritional assessment were performed; TCM syndrome types, BMI, hemoglobin (Hb), LY, and ALB were recorded. Differences in nutritional indicators between the qi and blood deficiency and nondeficiency groups were compared (<i>P</i> < 0.05 for significance). Logistic regression analyzed the impact of nutritional indicators (independent variables) on the syndrome (dependent variable), with OR as the effect value. Receiver operating characteristic curves were drawn to assess diagnostic value via AUC.</p><p><strong>Results: </strong>The prevalence of qi and blood deficiency syndrome was 13.06%. BMI, Hb, LY, and ALB in the deficiency group were lower (<i>P</i> < 0.05). Higher levels of these indicators were protective factors (OR: 0.848, 0.980, 0.446, 0.950; all <i>P</i> < 0.05). BMI (AUC = 0.312), Hb (AUC = 0.390), and LY (AUC = 0.362) had diagnostic value (all <i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>Low BMI, Hb, and LY have potential diagnostic value for the syndrome of qi and blood deficiency, and can serve as objective reference criteria for TCM pattern differentiation.</p>","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":"27683605261475455"},"PeriodicalIF":1.9,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148674198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}