Journal of Integrative and Complementary Medicine最新文献

{"title":"Efficacy and Safety of Phyllanthus Emblica and Tinospora Cordifolia in Postadolescence Acne: A Randomized Double-Blind Placebo-Controlled Trial.","authors":"Achala Liyanage, Nuwan Darshana, Nadeeka Chandraratne, Jennifer Perera","doi":"10.1177/27683605261469317","DOIUrl":"10.1177/27683605261469317","url":null,"abstract":"<p><strong>Introduction: </strong>According to the Ayurveda Pharmacopeia of Sri Lanka, the fruit of <i>Phyllanthus emblica</i> L. (PE) and the stems of <i>Tinospora cordifolia</i> (Willd.) Hook.f. and Thomson (TC) are prescribed for skin diseases such as Kushta (eczema) and Visharpa (spreading inflammatory lesions). Classical Ayurvedic texts, Charaka Samhitha and Sushruta Samhitha, describe PE and TC as \"elixirs of life\" (<i>Rasayana</i>) and widely incorporated them into formulations for dermatological disorders. Their therapeutic effects have been attributed to a range of bioactive phytochemical constituents identified in herbal extracts. Acne leads to poor quality of life (QoL), and available treatment protocols are varied and suboptimal and often lead to adverse events. The aim of the study was to evaluate the efficacy and safety of a herbal formulation comprising PE and TC in patients with mild to moderate acne.</p><p><strong>Methods: </strong>An investigator-initiated, randomized, double-blind, placebo-controlled, dose-ranging clinical trial. Eighty-eight volunteers with postadolescent acne were randomized to receive the standardized oral PE and TC formulation named Link Natural Swastha Amurtha (LNSA) at doses of 300 mg, 400 mg, or 500 mg daily, or a placebo, for 12 weeks. The primary endpoint of the study was the change in total acne lesion counts from baseline to 12 weeks. Secondary endpoints included changes in inflammatory and noninflammatory lesion counts, acne severity, sebum production, and QoL. Safety was assessed through hematological, hepatic, and renal laboratory parameters, along with monitoring of adverse events.</p><p><strong>Results: </strong>A dose-dependent reduction in acne lesion counts was observed in participants receiving LNSA; however, differences between the treatment and placebo groups did not reach statistical significance. All three LNSA dosage groups demonstrated statistically significant improvements in QoL compared with baseline. Laboratory safety parameters remained within normal reference ranges throughout the study, and no serious or treatment-related adverse events were reported.</p><p><strong>Conclusions: </strong>LNSA was found to be safe and well tolerated, with dose-related beneficial effects. The significant improvement in patient-reported QoL is a noteworthy outcome. Further adequately powered studies are warranted to explore the clinical efficacy of LNSA as a standalone or adjunctive therapy in acne management and laboratory studies to determine the mode of action of these plant constituents. (The study was registered in the Clinical Trials Registry in Sri Lanka (International Clinical Trial Registration Platform: SLCTR/2022/025), a member of the Primary Registry of the World Health Organization. https://slctr.lk/trials/slctr-2022-025).</p>","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":"27683605261469317"},"PeriodicalIF":1.9,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148563219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Exploratory CFIR-Informed Process Evaluation Utilizing Data from a Pilot Randomized Controlled Trial of a Yoga-Based Physical Therapy Group Intervention in Inpatient Rehabilitation Following Traumatic Brain Injury.","authors":"Kelly Krese, Mary McNulty, Catherine Justice, Kyla Z Donnelly","doi":"10.1177/27683605261469660","DOIUrl":"https://doi.org/10.1177/27683605261469660","url":null,"abstract":"<p><strong>Objective: </strong>To conduct a Consolidated Framework for Implementation Research (CFIR)-informed process evaluation examining implementation determinants that influenced the delivery of a yoga-based group physical therapy (PT) intervention for individuals with traumatic brain injury (TBI) in an acute inpatient rehabilitation setting, and to describe strategies used to address key implementation barriers encountered.</p><p><strong>Setting: </strong>Inpatient acute rehabilitation TBI unit at a tertiary rehabilitation hospital.</p><p><strong>Intervention: </strong>Patients diagnosed with moderate to severe TBI (<i>n</i> = 11) able to follow 2-step commands who were admitted to the TBI unit and participated in a 60-min yoga-based group PT intervention.</p><p><strong>Design: </strong>CFIR-informed process evaluation nested within a randomized controlled feasibility trial. Implementation determinants were characterized using meeting minutes from interdisciplinary clinical conferences and research team meetings conducted during intervention development and implementation.</p><p><strong>Main measures: </strong>Primary outcomes were implementation determinants (barriers and facilitators) mapped to CFIR domains. Secondary outcomes included patient-specific physical and cognitive-behavioral participation implementation barriers documented during intervention sessions.</p><p><strong>Results: </strong>Determinants that acted as facilitators included organizational support, interdisciplinary communication, and collaboration, while those that acted as barriers included time demands, cultural factors and professional scope ambiguities.</p><p><strong>Conclusion: </strong>This CFIR-informed process evaluation describes contextual, organizational and professional factors that may influence the implementation of yoga-based PT group intervention in inpatient rehabilitation following TBI. Findings are exploratory and hypothesis-generating, providing preliminary insight to inform future prospective implementation research aimed at optimizing integration and sustainability of yoga-based interventions in early TBI rehabilitation. (ClinicalTrials.Gov Registration#: NCT03701594).</p>","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":"27683605261469660"},"PeriodicalIF":1.9,"publicationDate":"2026-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148550741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Mindfulness-Based Yoga on Psychological Well-Being and Happiness in Individuals with Schizophrenia: A Randomized Controlled Trial.","authors":"Aysel Akbeniz, Funda Kavak Budak","doi":"10.1177/27683605261469654","DOIUrl":"https://doi.org/10.1177/27683605261469654","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effect of a mindfulness-based yoga program on psychological well-being and happiness in individuals diagnosed with schizophrenia.</p><p><strong>Methods: </strong>This randomized controlled trial was conducted between February and August 2024 in two Community Mental Health Centers (CMHCs) located in Malatya, Türkiye. Ninety-six individuals diagnosed with schizophrenia were randomly assigned in a 1:1 ratio to either a mindfulness-based yoga group (<i>n</i> = 48) or a control group (<i>n</i> = 48). The intervention group participated in a 6-week mindfulness-based yoga program consisting of 12 sessions, while the control group received routine CMHC care only. Outcome measures included the Psychological Well-Being Scale (PWB) and the Oxford Happiness Questionnaire Short Form (OHQ-SF). Three participants in the intervention group withdrew consent during follow-up, and two participants in the control group were lost to follow-up. The final analyses included 45 participants in the mindfulness-based yoga group and 46 participants in the control group.</p><p><strong>Results: </strong>No statistically significant differences were observed between the groups at baseline (<i>p</i> > 0.05). Following the intervention, participants in the mindfulness-based yoga group demonstrated significantly higher psychological well-being scores (36.50 ± 4.57 vs. 12.86 ± 3.69, <i>p</i> < 0.001) and happiness scores (21.44 ± 3.55 vs. 10.58 ± 5.64, <i>p</i> < 0.001) compared with the control group. Within-group analyses also showed significant improvements in psychological well-being and happiness in the intervention group (<i>p</i> < 0.001), whereas no significant changes were observed in the control group. No intervention-related adverse events or safety concerns were reported during the study period.</p><p><strong>Conclusions: </strong>Mindfulness-based yoga appears to be a promising complementary intervention for improving psychological well-being and happiness among individuals with schizophrenia. Further multicenter randomized controlled trials with larger samples and longer follow-up periods are needed to confirm these findings.</p>","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":"27683605261469654"},"PeriodicalIF":1.9,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148521076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Naturopathic Knowledge and Approaches to Managing Hidradenitis Suppurativa: A Cross-Sectional Survey of Australian Naturopaths.","authors":"Norelle Hentschel, Janet Schloss","doi":"10.1177/27683605261469650","DOIUrl":"https://doi.org/10.1177/27683605261469650","url":null,"abstract":"<p><strong>Background: </strong>Hidradenitis suppurativa (HS) is a chronic autoinflammatory skin condition that significantly impacts quality of life and causes comorbidities. Current clinical guidelines focus on antibiotic and biological therapies, which face limitations in efficacy, access, and concerns with antibiotic resistance. This has led patients to seek complementary and alternative medicine (CAM) treatments, often without the guidance of CAM practitioners. Moreover, there is also a significant gap in assessing treatment efficacy of CAM practitioners for HS through validated measures and mental health support in routine care. This is the first Australian survey on the naturopathic treatment of HS.</p><p><strong>Methodology: </strong>A cross-sectional survey was conducted in July 2025 targeting Australian naturopaths. The self-administered, anonymous, 36-item questionnaire investigated the knowledge, treatment strategies, referral practices, and treatment efficacy of naturopaths treating HS.</p><p><strong>Results: </strong>Of 29 respondents, most were female (<i>n</i> = 28,96.6%) and held a bachelor's degree (<i>n</i> = 18, 62.1%). Half had treated HS clinically, primarily via nutritional/dietary modification (<i>n</i> = 12, 92.3%), customized herbal formulations (<i>n</i> = 9, 69.2%), and lifestyle counseling (<i>n</i> = 9, 69.2%). Systemic inflammation (<i>n</i> = 12, 92.3%) and wound healing (<i>n</i> = 10, 76.9%) were the highest priority treatment aims. Interdisciplinary referrals for general practitioners (<i>n</i> = 7, 77.7%) and acupuncturists (<i>n</i> = 5, 55.5%) were frequent, but rarely reciprocal. Treatment efficacy was tracked mainly by patient self-report (<i>n</i> = 12, 92.3%) and clinical observation (<i>n</i> = 7, 53.8%), with no use of validated patient-reported outcome measures (PROMs).</p><p><strong>Conclusions: </strong>A percentage of Australian naturopaths demonstrated substantial awareness and engagement with HS management, emphasizing individualized care through systemic inflammation reduction, wound healing, and targeted nutritional and herbal medicine interventions. Their approaches align with current understanding of HS pathophysiology and patient needs, but notable gaps remain in incorporating validated PROMs and integrating mental health support as a treatment priority. Further research into whole systems naturopathic practices will strengthen the evidence base and enhance multidisciplinary care for patients with HS.</p>","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":"27683605261469650"},"PeriodicalIF":1.9,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148521031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intergenerational Traditional Practices for Primary Dysmenorrhea: A Phenomenological Study.","authors":"Fatma Başaran","doi":"10.1177/27683605261469657","DOIUrl":"https://doi.org/10.1177/27683605261469657","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to explore the intergenerational traditional practices and lived experiences of women regarding primary dysmenorrhea using a phenomenological approach.</p><p><strong>Background: </strong>Exploring safer, more effective, and natural treatment options is the primary way to manage primary dysmenorrhea. With the advancement of globalization, traditional treatment practices based on cultural traditions are increasingly supported and recommended.</p><p><strong>Materials and methods: </strong>In this descriptive phenomenological study, in-depth semi-structured individual interviews were conducted with 24 women with a history of primary dysmenorrhea living in different provinces of Türkiye. The data were analyzed using Colaizzi's seven-stage analysis method. The Consolidated Criteria for Reporting Qualitative Research (COREQ) checklist was used to report the study.</p><p><strong>Results: </strong>The analysis revealed five main categories related to women's experiences and traditional practices for primary dysmenorrhea. Participants commonly reported physical and emotional symptoms during the premenstrual and menstrual periods. Herbal teas, heat-based applications, and perineal practices were frequently used for symptom management. Traditional practices differed across generations; older women reported using a wider variety of culturally transmitted methods, whereas younger women tended to prefer hospital services and pharmacological treatments. Most participants perceived traditional practices as helpful in relieving menstrual discomfort.</p><p><strong>Conclusion: </strong>In conclusion, women described traditional practices as helpful in managing primary dysmenorrhea symptoms, and these practices were shaped through intergenerational cultural transmission.</p>","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":"27683605261469657"},"PeriodicalIF":1.9,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148521080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bridging Policy and Practice: Strengthening Complementary and Integrative Medicine Through the Lens of the Delhi Declaration.","authors":"Rinky Thakur, Avishek Mishra, Mahesh K Vyas","doi":"10.1177/27683605261469679","DOIUrl":"https://doi.org/10.1177/27683605261469679","url":null,"abstract":"<p><strong>Introduction: </strong>Complementary and Integrative Health (CIH) is recognized for its potential to contribute to universal health coverage (UHC), holistic well-being, and patient-centered care. It encompasses traditional, complementary, and integrative medicine, such as Ayurveda, Yoga, Naturopathy, and Traditional Chinese Medicine. The Second World Health Organization (WHO) Global Summit on Traditional Medicine, held in New Delhi from December 17 to 19, 2025, concluded with the adoption of the Delhi Declaration.</p><p><strong>Methods: </strong>Each commitment of the Delhi Declaration is explained with supporting scientific evidence, emphasizing traditional medicine's (TM's) role in addressing global health challenges. Key policy priorities are outlined, and the conceptual framework is presented for consideration of implications.</p><p><strong>Results: </strong>This article outlines a conceptual framework to advance evidence-based TM for UHC, equity in health care systems, and sustainable development. In the declarations, participating countries committed to prioritizing key policies to strengthen the TM through the generation of evidence, regulation, and safety, as well as integrating CIH into national health systems (particularly primary health care) and optimizing cross-sectoral value through data generation, collaboration, and empowering communities. Each commitment is explained with supporting scientific evidence from peer-reviewed literature, emphasizing TM's role in addressing global health challenges. These priorities align with the WHO Global Traditional Medicine Strategy 2025-2034. The Declaration aims to establish TM as a biocultural heritage, fostering innovation while safeguarding biodiversity and Indigenous rights.</p><p><strong>Conclusion: </strong>Policy implications, research, and practice are discussed to fulfill the decade-long strategy of WHO and the role of the Delhi Declaration in bringing TM into the main health care systems rather than as a complementary health care. Also, making a policy framework for increased funding, standardized data systems, and multistakeholder partnerships to achieve the Sustainable Development Goals (SDGs), particularly SDG 3.</p>","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":"27683605261469679"},"PeriodicalIF":1.9,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148449640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implications for Access to Chiropractic Services in the Workers' Compensation System: A State-by-State Coverage Policy Comparison.","authors":"Morgan Young","doi":"10.1177/27683605261469674","DOIUrl":"https://doi.org/10.1177/27683605261469674","url":null,"abstract":"<p><strong>Background: </strong>Chiropractic services are well-aligned with the goals of workers' compensation (WC) coverage in returning patients to work timely, safely, and cost-effectively. Coverage policies in WC dictate the extent of utilization and participation in chiropractic and define patient access.</p><p><strong>Methods: </strong>This article accessed online-available U.S. WC chiropractic coverage policies through artificial intelligence tools and search engines. The article compares state-by-state chiropractic coverage policies while also examining general trends, significant divergences, and common models across WC chiropractic coverage plans.</p><p><strong>Results: </strong>Utilization of chiropractic between states is highly variable, despite many similarities in coverage. Most states include chiropractic, but with a variety of stipulations and limits which are described.</p><p><strong>Conclusions: </strong>Opportunities are available for chiropractors in WC, where coverage is often broader than many other national coverage plans. Employers and jurisdictions may find enhanced chiropractic utilization and participation beneficial for patient satisfaction, safety, and cost-effective care for musculoskeletal conditions.</p>","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":"27683605261469674"},"PeriodicalIF":1.9,"publicationDate":"2026-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148438112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Operation Whole Health: An Operation Warp Speed Directed at Noncommunicable Diseases.","authors":"Ryan R Burdick, Michele J Maiers, Andrea K Albertson, Charles E Sawyer","doi":"10.1177/27683605261461166","DOIUrl":"https://doi.org/10.1177/27683605261461166","url":null,"abstract":"<p><p>Noncommunicable diseases (NCDs) account for the majority of morbidity, mortality, and health expenditures, yet progress toward international reduction targets remains limited. Although evidence-based strategies for prevention and long-term management are well-established, health systems predominantly remain biomedical and fragmented across clinical, public health, and community sectors. This structural misalignment constrains the ability to scale prevention and deliver coordinated chronic disease management. This paper proposes \"Operation Whole Health\" as a framework for a paradigm shift in the health care system. Drawing on lessons from the coordinated mobilization observed in the United States during the COVID-19 response, the framework emphasizes the importance of mission clarity, cross-sector workforce integration, and sustained financing to achieve significant and scalable change. Whole health models-person-centered, interprofessional, and prevention-oriented-offer a mechanism for aligning clinical care with behavioral, social, and community determinants of health. Expanding prevention capacity includes systematic integration of traditional, complementary, and integrative medicine professionals, whose competencies align with chronic disease prevention but remain underutilized within publicly financed systems. Because effective whole health interventions for NCDs are known, a key constraint in widespread implementation may be policy prioritization rather than scientific uncertainty. A structural redesign of health care anchored in the whole health paradigm may be needed to alter NCD trajectories and stabilize long-term health expenditures.</p>","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":"27683605261461166"},"PeriodicalIF":1.9,"publicationDate":"2026-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148424823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Music Intervention for Anxiety and Pain During Breast Biopsy Procedures: A Comprehensive Systematic Review and Meta-Analysis of Randomized Controlled Trials.","authors":"Yao Chen, Hafiza Qurat Ul Ain, Inshal Jawed, Abu Huraira Bin Gulzar, Muhammad Umair, Hermann Yokolo, Danaish Kumar","doi":"10.1177/27683605261461167","DOIUrl":"https://doi.org/10.1177/27683605261461167","url":null,"abstract":"<p><strong>Introduction: </strong>Breast biopsies often cause anxiety and pain that influence patients' experience and procedure outcomes. Music interventions offer a practical alternative to pharmacological methods for reducing these effects.</p><p><strong>Methods: </strong>We conducted a PRISMA-compliant systematic review and meta-analysis to evaluate the efficacy of music during breast biopsies. We searched PubMed, Cochrane CENTRAL Library, EMBASE, and ClinicalTrials.gov up to May 2025. We included randomized controlled trials (RCTs) comparing music interventions with routine care without music intervention. The primary outcomes were anxiety and pain scores; secondary outcomes assessed changes in these scores before and after the procedure. We calculated standardized mean differences (SMDs) with 95% confidence intervals (CIs) using a random-effects model.</p><p><strong>Results: </strong>Seven RCTs with 606 participants met the inclusion criteria. The mean age of participants was 50.8 years. Anxiety scores were significantly lower in the music group compared with controls (SMD = -0.22, 95% CI: -0.38 to -0.06, <i>p</i> < 0.05, <i>I</i>² = 0%). Anxiety reduction from pre- to postprocedure was also greater with music (SMD = 0.25, 95% CI: 0.07-0.44, <i>p</i> < 0.05, <i>I</i>² = 0%). However, pain scores did not differ significantly (SMD = -0.33, 95% CI: -0.83 to 0.17, <i>p</i> > 0.05, <i>I</i>² = 82%).</p><p><strong>Conclusion: </strong>Music interventions were associated with a small but statistically significant reduction in anxiety during breast biopsy procedures, but no significant reduction in pain. These findings support music as a safe, nonpharmacological option to improve patient experience, particularly with respect to procedural anxiety.</p>","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":"27683605261461167"},"PeriodicalIF":1.9,"publicationDate":"2026-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148399560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Emotional Disorders on the Efficacy of Acupuncture in Refractory Diarrhea-Predominant Irritable Bowel Syndrome: A Secondary Analysis of a Randomized Controlled Trial.","authors":"Jun Zhao, Xia Li, Jian-Xia Dong, Jia-Yi Yang, Zhi-Gang Li, Lin Zhu","doi":"10.1177/27683605261461176","DOIUrl":"https://doi.org/10.1177/27683605261461176","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Acupuncture is an effective method for alleviating abdominal pain and diarrhea in patients, but the impact of emotional disorders (anxiety or depression) on the efficacy of acupuncture for refractory diarrhea-predominant irritable bowel syndrome (RIBS-D) remains unknown.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;One hundred seventy patients with RIBS were randomly equally divided into acupuncture and sham acupuncture groups. The primary outcome was the response rate, measured by the change in the IBS-Symptom Severity Score (IBS-SSS) from baseline at week 4. The secondary outcomes included stool frequency, stool consistency, work and social adaptability, and quality of life (QOL).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Eighty-five patients with RIBS (80 with RIBS-D) received 4 weeks of acupuncture therapy. According to the psychological state assessment, 27 of the 80 patients were anxiety patients, 53 were nonanxiety patients, 21 were depressive patients, and 59 were nondepressive patients. The IBS-SSS response rate at week 4 was 92.6% in anxiety patients and 88.7% in nonanxiety patients (&lt;i&gt;p&lt;/i&gt; = 0.581). In terms of secondary outcomes, there was no significant intergroup difference in stool frequency or stool consistency between the anxiety group and the nonanxiety group (&lt;i&gt;p&lt;/i&gt; = 0.730, &lt;i&gt;p&lt;/i&gt; = 0.418). After adjusting for baseline covariates, no statistically significant differences were detected between the anxiety and nonanxiety groups in the Work and Social Adjustment Scale (WSAS) scores and IBS-QOL scores at week 4 (&lt;i&gt;p&lt;/i&gt; = 0.398, &lt;i&gt;p&lt;/i&gt; = 0.207). Similarly, no significant difference was noted in the IBS-SSS response rate at week 4 between depressive and nondepressive patients (&lt;i&gt;p&lt;/i&gt; = 0.932). However, regardless of baseline covariate correction, there was no significant intergroup difference between the depression group and the nondepressive group in terms of stool frequency, stool consistency, WSAS score, or IBS-QOL score at the fourth week (&lt;i&gt;p&lt;/i&gt; = 0.054, &lt;i&gt;p&lt;/i&gt; = 0.491, &lt;i&gt;p&lt;/i&gt; = 0.873, &lt;i&gt;p&lt;/i&gt; = 0.940). In addition, correlation analysis revealed that depression scores at week 4 were positively correlated with the IBS-SSS subscale scores for frequency of abdominal pain and disruption of QOL (&lt;i&gt;β&lt;/i&gt; = 0.254, &lt;i&gt;p&lt;/i&gt; = 0.012; &lt;i&gt;β&lt;/i&gt; = 0.231, &lt;i&gt;p&lt;/i&gt; = 0.028), whereas there was no significant relationship between anxiety and depression and the severity of abdominal pain, bloating, or bowel satisfaction score.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;No statistically significant differences were detected between patients with and without emotional disorders in terms of IBS-SSS response rate, stool frequency, stool consistency, and work and social adaptability following acupuncture treatment. However, depression had a negative effect on the IBS-related abdominal pain frequency scores and IBS-related QOL, suggesting that acupuncture might be an effective nonpharmacological therapy for IBS with comorbid dep","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":"27683605261461176"},"PeriodicalIF":1.9,"publicationDate":"2026-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148377270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}