{"title":"Effects of Music Therapy on Patients with Hypertensive Disorders of Pregnancy: A Systematic Review and Meta-Analysis.","authors":"Qi Zhuang, Li Chen, You Yang","doi":"10.1089/jicm.2024.0688","DOIUrl":"https://doi.org/10.1089/jicm.2024.0688","url":null,"abstract":"<p><p><b><i>Aim:</i></b> To systematically assess the therapeutic impact of music interventions on hypertensive disorders of pregnancy (HDP). <b><i>Design:</i></b> Systematic review and meta-analysis. <b><i>Methods:</i></b> A comprehensive search of various databases, such as PubMed, Embase, Cochrane Library, Web of Science, Scopus, CINAHL, EBSCO, Chinese National Knowledge Infrastructure, China Biomedical Literature Database, and Foreign Medical Literature Retrieval Service, was conducted to identify randomized controlled trials (RCTs) investigating the impact of music therapy on HDP from their inception through March 2024. Two independent reviewers performed study selection, data extraction, and risk-of-bias assessment using RoB 2. Statistical analyses were conducted in STATA 17, with evidence certainty graded using Grading of Recommendations Assessment, Development, and Evaluation. The protocol followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and was prospectively registered in PROSPERO. <b><i>Results:</i></b> The meta-analysis included 14 RCTs comprising 1,477 participants. Five separate meta-analyses were conducted to compare the efficacy of music therapy versus standard care. Moderate-quality evidence from randomized trials demonstrated significant reductions associated with music therapy in systolic blood pressure (mean difference [MD] <i>= -</i>10.55 mmHg, 95% confidence interval [CI]: -13.86 to -7.24, <i>p</i> < 0.05), diastolic blood pressure (MD <i>= -</i>8.14 mmHg, 95% CI: -10.59 to -5.58, <i>p</i> < 0.05), sleep quality in patients with hypertension (MD <i>= -</i>1.95 points, 95% CI: -2.41 to -1.49, <i>p</i> < 0.05), and depression (MD <i>= -</i>7.80 points, 95% CI: -9.97 to -5.64, <i>p</i> < 0.001). Low-quality evidence suggested a modest improvement in anxiety (MD <i>= -</i>7.24 points, 95% CI: -8.84 to -5.64, <i>p</i> < 0.05). No publication bias was found in the comprehensive analysis results (all <i>p</i> > 0.1). <b><i>Conclusion:</i></b> Our systematic review suggests that adjunctive music therapy provides clinically relevant benefits for controlling systolic and diastolic blood pressure and improving psychological outcomes including anxiety, depression, and sleep quality in patients with HDP when compared with standard care alone.</p>","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144226910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Brian R Anderson, Patricia M Herman, James M Whedon, Ryan Bradley
{"title":"Determinants of Complementary and Integrative Health Approaches: A Cross-Sectional Study Using the All of Us Research Program.","authors":"Brian R Anderson, Patricia M Herman, James M Whedon, Ryan Bradley","doi":"10.1089/jicm.2024.0769","DOIUrl":"10.1089/jicm.2024.0769","url":null,"abstract":"<p><p><b><i>Introduction:</i></b> Complementary and integrative health (CIH) therapies are gaining recognition. However, their utilization within the diverse All of Us (AoU) research program remains unexplored. <b><i>Methods:</i></b> A cross-sectional study of AoU electronic health record and survey data compared characteristics of adult CIH users and nonusers. General linear models estimated factors associated with CIH. <b><i>Results:</i></b> A total of 3171 participants were CIH users (chiropractic or osteopathic manipulation, acupuncture, dietary modification, massage); they were more likely White and less likely Black with higher education versus nonusers. Education, insurance, sex, and race were associated with individual CIH modalities. <b><i>Conclusion:</i></b> Low utilization was observed, and several factors associated with CIH were identified. Further research is needed to address data gaps.</p>","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":"583-587"},"PeriodicalIF":1.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12223372/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jennifer K Carroll, Gabriela Gaona, Daisy Qiang Dong-Cedar, Timothy J Williamson, Lisa W Corbin, Monika Nuffer, Wilson D Pace, Christina Palmer, Joanne Whalen, Meredith Shefferman, Tuyet Thi Nguyen, Carolyn M Valdez, Lauren Grossman, Anh H Tran, Felicia R Greher, Jennifer Hills, Frances Palmer
{"title":"Health Care Utilization in an Academic Integrative Medicine Center, 2011-2022.","authors":"Jennifer K Carroll, Gabriela Gaona, Daisy Qiang Dong-Cedar, Timothy J Williamson, Lisa W Corbin, Monika Nuffer, Wilson D Pace, Christina Palmer, Joanne Whalen, Meredith Shefferman, Tuyet Thi Nguyen, Carolyn M Valdez, Lauren Grossman, Anh H Tran, Felicia R Greher, Jennifer Hills, Frances Palmer","doi":"10.1089/jicm.2023.0758","DOIUrl":"10.1089/jicm.2023.0758","url":null,"abstract":"<p><p><b><i>Objectives:</i></b> As empirical evidence about the efficacy and therapeutic benefits of integrative medicine grows and insurance coverage of services increases, patient demand for integrative medicine is likely to increase. Relatively few studies have looked at electronic health records (EHRs) data to understand utilization of integrative medicine services within \"real-world\" practice settings. This study's objective is to describe sociodemographic data and health care utilization for adults (age 18 or older) within a large regional health system from 2011 to 2022. <b><i>Methods:</i></b> The study design was a longitudinal cohort analysis using EHRs data for patients seen at an integrative medicine center from 2011 to 2022. <b><i>Setting/Location:</i></b> UCHealth Integrative Medicine Center (\"the Center\") within UCHealth, a not-for-profit health care system with hospitals and clinical facilities throughout Colorado, southern Wyoming, and western Nebraska. <b><i>Participants:</i></b> Adults 18 years or older at the time of care delivery seen at the Center from April 1, 2011, through December 31, 2022. <b><i>Results:</i></b> The Center provided 95,754 visits to 15,157 unique individuals from April 1, 2011, through December 31, 2022. The average number of individuals seen was 1,833 per year (Range 1,405-2,347). The cohort's mean age was 43 years; the majority were female (75%) and white (77.2%) with commercial insurance (87.1%). Medicare (29.6%) and Medicaid (19.7%) insurance were also relatively common. The Social Deprivation Index scores were distributed broadly across the cohort. The top three reasons for visits were chronic pain, mental/behavioral health conditions, and obesity. The most frequent visits were for acupuncture, massage, and physician/physician assistant services. A total of 1,586 health care professionals from 52 different specialties, both within and outside UCHealth, referred to the Center. <b><i>Conclusion:</i></b> This study describes a large cohort of adults seen for integrative medicine services and referral sources within a large regional health care system. Study findings have the potential to shape future integrative health care provision, education, research, and policy.</p>","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":"535-543"},"PeriodicalIF":1.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143558229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jothisha C, Aarti Jagannathan, Hemanth Bhargav, Nishita Jasti, B N Gangadhar
{"title":"Effect of Online Yoga on Child Health During COVID-19 Pandemic: A Qualitative Account from Parents.","authors":"Jothisha C, Aarti Jagannathan, Hemanth Bhargav, Nishita Jasti, B N Gangadhar","doi":"10.1089/jicm.2024.0457","DOIUrl":"10.1089/jicm.2024.0457","url":null,"abstract":"<p><p><b><i>Background and Objectives:</i></b> An individual develops socioemotional and cognitive abilities during childhood and adolescence. The COVID-19 pandemic has had a negative effect on the physical, psychological, social, and cultural health of children. Yoga has been observed to be helpful for children in enhancing their physical and mental health during the COVID-19 pandemic. The current article aims to understand the effect of yoga on children's health during the COVID-19 pandemic. <b><i>Methods:</i></b> The study used a qualitative method and an exploratory design. The data were collected through in-depth interviews using a semistructured interview guide. <b><i>Results:</i></b> Ten themes emerged from the thematic analysis. The major themes included the physical, psychological, and social benefits of yoga on children's health; physical, environmental, and cognitive barriers; and facilitators to practicing yoga. <b><i>Conclusion:</i></b> The parents felt that yoga was beneficial for children in various dimensions. Schools and academic organizations could develop online yoga programs tailored for children and also integrate them into the curriculum, allowing children to practice regularly.</p>","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":"577-582"},"PeriodicalIF":1.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Margaret D Whitley, Nipher Malika, Patricia M Herman, Ian D Coulter, Michele Maiers, Ryan Bradley, Baljit Khamba, Jacob McCarey, Tiffany Keyes
{"title":"Racial and Ethnic Representation Among Complementary and Integrative Health Program Graduates.","authors":"Margaret D Whitley, Nipher Malika, Patricia M Herman, Ian D Coulter, Michele Maiers, Ryan Bradley, Baljit Khamba, Jacob McCarey, Tiffany Keyes","doi":"10.1089/jicm.2024.0745","DOIUrl":"10.1089/jicm.2024.0745","url":null,"abstract":"<p><p><b><i>Background:</i></b> Use of complementary and integrative health care (CIH) varies across racial and ethnic groups in the United States. Lack of racial and ethnic diversity among CIH providers may hinder access to CIH for underrepresented groups. This study aimed to (1) document racial and ethnic representation in licensed CIH professions (chiropractic, acupuncture, traditional East Asian medicine, naturopathic medicine, direct-entry midwifery, and massage therapy), non-licensed CIH professions, and conventional health care; (2) compare diversity in these professions with the U.S. population; and (3) examine changes in CIH diversity in recent years. <b><i>Methods:</i></b> We conducted a repeated cross-sectional study design with the 2011-2022 Integrated Postsecondary Education Data System to examine race and ethnicity among graduates in licensed CIH professions, compared with non-licensed CIH professions and conventional health care. Our sample included 53,393 programs representing 3,524,494 individuals. We examined the proportion of graduates from each racial and ethnic group, compared results with the U.S. population, and graphically explored changes between 2011 and 2022. <b><i>Results:</i></b> Inclusion or exclusion of massage therapy influenced interpretations across all questions. With massage therapy, licensed CIH professions appeared more diverse, with a higher proportion of Latino and Black graduates. Without massage therapy, diversity in licensed CIH professions was similar or slightly reduced compared with non-licensed CIH professions and conventional health care. Notable differences emerged among licensed CIH professions: acupuncture and East Asian medicine had larger proportions of Asian graduates than other CIH programs and the U.S. population. Racial and ethnic diversity in CIH increased modestly between 2011 and 2022. <b><i>Discussion:</i></b> While professions such as massage therapy, acupuncture, and traditional East Asian medicine have greater diversity, a disparity persists between the racial and ethnic composition of licensed CIH professions and the diversity of the overall U.S. population.</p>","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":"544-554"},"PeriodicalIF":1.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12172644/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143473010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gloria Y Yeh, Andrew Ahn, Janet Clark, Michael R Irwin, Jian Kong, Helen Lavretsky, Fuzhong Li, Brad Manor, Wolf Mehling, Byeongsang Oh, Daniel Seitz, Ahmed Tawakol, William W N Tsang, Chenchen Wang, Albert Yeung, Peter M Wayne
{"title":"The Science of Tai Chi and Qigong as Whole Person Health-Part II: Evidence Gaps and Opportunities for Future Research and Implementation.","authors":"Gloria Y Yeh, Andrew Ahn, Janet Clark, Michael R Irwin, Jian Kong, Helen Lavretsky, Fuzhong Li, Brad Manor, Wolf Mehling, Byeongsang Oh, Daniel Seitz, Ahmed Tawakol, William W N Tsang, Chenchen Wang, Albert Yeung, Peter M Wayne","doi":"10.1089/jicm.2024.0958","DOIUrl":"10.1089/jicm.2024.0958","url":null,"abstract":"<p><p><b><i>Background:</i></b> The emerging paradigm of whole person health shares many core principles with traditional complementary and integrative health frameworks, including Tai Chi and Qigong (TCQ). <b><i>Methods:</i></b> In the fall of 2023, the Harvard Medical School Osher Center for Integrative Health hosted the inaugural international conference on <i>The Science of Tai Chi & Qigong for Whole Person Health</i>: <i>Advancing the Integration of Mind-Body Practices into Contemporary Healthcare</i> at Harvard Medical School. A two-part white paper was written to summarize key conference topics, findings, and issues. <b><i>Results and Discussion:</i></b> Part II presented here summarizes evidence gaps and future research opportunities, including: understudied clinical conditions and populations, impact of long-term TCQ training, understanding the impact of specific TCQ styles, training regimens, dosage, and contextual effects; implementation, cost-effectiveness, and medical utilization research; individual data meta-analysis, and teaching competencies, credentialing, and licensure. Part I of this white paper discusses the rationale for the conference, synthesizes the state of evidence for TCQ as rehabilitative and preventive tools for a range of clinical conditions, and summarizes the translational research informing therapeutic mechanisms associated with TCQ training.</p>","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":"521-534"},"PeriodicalIF":1.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12172645/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Spraker-Perlman Holly, R Elyse Heidelberg, Rachel P Wright, Amy G Ly, Maggi Meyer, Chris Vukadinovich, Justin N Baker, Deena R Levine
{"title":"Pediatric Hematology-Oncology Provider Attitudes and Beliefs About the Use of Integrative Modalities for Their Patients: A Cross-Sectional Survey.","authors":"Spraker-Perlman Holly, R Elyse Heidelberg, Rachel P Wright, Amy G Ly, Maggi Meyer, Chris Vukadinovich, Justin N Baker, Deena R Levine","doi":"10.1089/jicm.2024.0623","DOIUrl":"10.1089/jicm.2024.0623","url":null,"abstract":"<p><p><b><i>Purpose:</i></b> Children with cancer suffer from physical and psychological symptoms. Integrative medicine modalities (IMMs) for symptom management are increasingly popular, but whether these are acceptable to pediatric hematology-oncology (PHO) providers remains unknown. To address this knowledge gap and guide integrative medicine (IM) program development, a needs assessment was conducted to understand PHO provider knowledge, attitudes, and beliefs regarding IMMs for symptom management in children with hematologic or oncologic disorders. <b><i>Methods:</i></b> A detailed survey instrument was crafted using primary literature and expert opinion, iteratively reviewed for validity, and piloted tested by health care providers (HCPs). The survey was distributed electronically to patient-facing staff and stratified by clinical role. Survey response data from physicians and advanced practice providers (APPs) underwent descriptive analysis using SAS v.9.4 (Cary, NC). <b><i>Results:</i></b> A total of 78 PHO physicians and APPs completed this survey (response rate 29.5%). While most PHO physicians and APPs do not feel confident discussing incorporation of IMMs into the care of PHO patients, they are willing to (1) receive additional education in IM and (2) refer to a trusted IM provider. Providers do not believe that families typically disclose use of IMM to HCPs, and many worry about the use of entities such as high-dose vitamins and chiropractic care. <b><i>Conclusions:</i></b> PHO providers are concerned about the use of specific IMMs in their patients' care but support massage and mindfulness almost universally. Most PHO clinicians are willing to engage trained IM providers and support strategies that may contribute to improved quality of life for their patients and families.</p>","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":"555-564"},"PeriodicalIF":1.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Peter M Wayne, Andrew Ahn, Janet Clark, Michael R Irwin, Jian Kong, Helen Lavretsky, Fuzhong Li, Brad Manor, Wolf Mehling, Byeongsang Oh, Daniel Seitz, Ahmed Tawakol, William W N Tsang, Chenchen Wang, Albert Yeung, Gloria Y Yeh
{"title":"The Science of Tai Chi and <i>Qigong</i> as Whole Person Health-Part I: Rationale and State of the Science.","authors":"Peter M Wayne, Andrew Ahn, Janet Clark, Michael R Irwin, Jian Kong, Helen Lavretsky, Fuzhong Li, Brad Manor, Wolf Mehling, Byeongsang Oh, Daniel Seitz, Ahmed Tawakol, William W N Tsang, Chenchen Wang, Albert Yeung, Gloria Y Yeh","doi":"10.1089/jicm.2024.0957","DOIUrl":"10.1089/jicm.2024.0957","url":null,"abstract":"<p><p><i><b>Background:</b></i> The emerging paradigm of whole person health shares many core principles with traditional complementary and integrative health frameworks, including Tai Chi and Qigong (TCQ). <i><b>Methods:</b></i> In the Fall of 2023, the Harvard Medical School Osher Center for Integrative Health hosted the inaugural international conference on <i>The Science of Tai Chi & Qigong</i> as <i>Whole Person Health</i>: <i>Advancing the Integration of Mind-Body Practices into Contemporary Healthcare</i> held at Harvard Medical School. A two-part white paper was written to summarize key conference topics, findings, and issues. <i><b>Results and Discussion:</b></i> Part I presented here summarizes the rationale for the conference and synthesizes the state of evidence for TCQ as rehabilitative and preventive tools for a range of clinical conditions, including falls and balance, cognition, mental health, sleep, cardiorespiratory health, musculoskeletal health, cancer, as well as translational evidence related to the neurophysiology, brain and immune function, and biomarkers of inflammation. The state of science of TCQ, viewed through the lens of traditional East Asian health constructs, is also discussed. Part II of this white paper outlines evidence gaps and opportunities and discusses strategies to address challenges in TCQ research, dissemination, and implementation.</p>","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":"499-520"},"PeriodicalIF":1.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12172646/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Beyond Neutrality: Why Conflicts of Interest Are Human-and Transparency Is a Must.","authors":"Holger Cramer","doi":"10.1089/jicm.2025.0338","DOIUrl":"10.1089/jicm.2025.0338","url":null,"abstract":"","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":"497-498"},"PeriodicalIF":1.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Homeopathic Treatment of Chronic Low-Back Pain: A Double-Blind, Randomized, Placebo-Controlled Trial.","authors":"Sagarika Muduli, Sanjib Sarkar, Rajat Kumar Pal, Shubhamoy Ghosh, Sk Monsur Alam, Subhranil Saha, Satyajit Naskar, Suhasish Roy, Ankit Saha, Indrani Halder, Priyanka Ghosh, Abdur Rahaman Shaikh, Munmun Koley, Shyamal Kumar Mukherjee","doi":"10.1089/jicm.2024.0564","DOIUrl":"10.1089/jicm.2024.0564","url":null,"abstract":"<p><p><b><i>Objectives:</i></b> To detect differences between individualized homeopathic medicinal products (IHMPs) and placebo after 4 months of intervention in patients with chronic low-back pain (LBP). <b><i>Design:</i></b> Four-month, double-blind, randomized (1:1), placebo-controlled, two parallel arms trial. <b><i>Setting:</i></b> PG3 and research outpatient department of D. N. De Homoeopathic Medical College & Hospital. <b><i>Subjects:</i></b> Sixty participants with chronic LBP. <b><i>Interventions:</i></b> Verum (<i>n</i> = 30; IHMPs plus concomitant care) versus control (<i>n</i> = 30; placebos plus concomitant care). <b><i>Outcome Measures:</i></b> Primary-Oswestry LBP Disability Questionnaire (ODQ); Secondary-Roland Morris Pain and Disability Questionnaire (RMPDQ); McGill Pain Questionnaire-Short Form (SF-MPQ); measured at baseline, and every month, up to 4 months. <b><i>Results:</i></b> Group differences achieved significance or near significance in all the specified outcomes-ODQ score (<i>F</i><sub>1, 58</sub> = 4.331, <i>p</i> = 0.042), RMPDQ score (<i>F</i><sub>1, 58</sub> = 2.939, <i>p</i> = 0.092), and SF-MPQ total score (<i>F</i><sub>1, 58</sub> = 6.666, <i>p</i> = 0.012). <i>Rhus toxicodendron</i> (<i>n</i> = 13), <i>Bryonia alba</i> (<i>n</i> = 8), <i>Hypericum perforatum,</i> and <i>Nux vomica</i> (<i>n</i> = 5 each) were the most frequently prescribed medicines. Different repertories were used as per the need of the cases-Kent, Synthesis, Murphy, Pulford, Boericke, Boger Boenninghausen's Characteristics and Repertory, and Complete. Minor adverse events were reported from either group. <b><i>Conclusions:</i></b> Thus, homeopathic medicines worked significantly better than placebos in reducing chronic LBP. Independent replications are warranted to substantiate the findings. <b><i>Clinical Trial Registration Number:</i></b> CTRI/2022/04/041878.</p>","PeriodicalId":29734,"journal":{"name":"Journal of Integrative and Complementary Medicine","volume":" ","pages":"565-576"},"PeriodicalIF":1.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143417003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}