Yiyang Chen , Shuang Liang , Yuxuan Peng , Kongshuo Ma , Kaiqing Yun , Xinbo Ma , Linna Hai , Lin Mei , Lulu Wang , Zhaohui Wang
{"title":"Nanomaterials-enabled mRNA delivery for Cancer immunotherapy","authors":"Yiyang Chen , Shuang Liang , Yuxuan Peng , Kongshuo Ma , Kaiqing Yun , Xinbo Ma , Linna Hai , Lin Mei , Lulu Wang , Zhaohui Wang","doi":"10.1016/j.ccr.2025.216945","DOIUrl":"10.1016/j.ccr.2025.216945","url":null,"abstract":"<div><div>Messenger RNA (mRNA) has emerged as a transformative tool in the prevention and treatment of diseases, particularly malignant tumors. Through various treatment approaches, including vaccines, protein replacement therapy, cell-based therapy and gene editing, mRNA-based antitumor immunity represents a potent therapeutic strategy. However, challenges such as inherent instability and endosomal trapping continue to hinder its full therapeutic potential. Recent advances in nanomaterials have provided unparalleled tools for improving mRNA delivery and enhancing the efficacy of cancer immunotherapy. This review highlights these cutting-edge advancements, focusing on physiological barriers, delivery vectors, routes of administration, and therapeutic modalities. Furthermore, we explore the critical challenges and emerging opportunities in the clinical translation of mRNA-based cancer immunotherapy, offering valuable insights to inspire the development of next-generation therapies.</div></div>","PeriodicalId":289,"journal":{"name":"Coordination Chemistry Reviews","volume":"543 ","pages":"Article 216945"},"PeriodicalIF":20.3,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144571078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Advanced porous platinum group metal nano-structural electrocatalysts for water electrolysis, fuel cells and metal-air batteries","authors":"Ruiwen Zhang, Jialin Sun, Yizhe Chen, Qian Shen, Cheng Ding, Shiming Zhang, Jiujun Zhang","doi":"10.1016/j.ccr.2025.216958","DOIUrl":"10.1016/j.ccr.2025.216958","url":null,"abstract":"<div><div>Platinum-group-metals (PGMs) demonstrate exceptional practical performance in various electrocatalytic reactions, but their widespread application is hindered by challenges such as high cost, scarce resource, and insufficient electrocatalytic activity and stability. Porous PGM-based nanostructure electrocatalysts have emerged as the future choices in view of the effective improvement in surface area increase, active site exposure, precious metal utilization, and mass transfer acceleration. In this review, a comprehensive overview of porous PGM-based nanostructures has been summarized, including the porosity characteristics, the morphology classifications across zero-, one-, two-, and three-dimensional structures, the construction strategies including soft-template, hard-template, self-template, and surface-induction methods, and the electrocatalytic applications in key electrode processes involving oxygen reduction reaction (ORR), oxygen evolution reaction (OER), hydrogen evolution reaction (HER), and alcohol oxidation reaction (AOR). For in-depth atomic-level insights into these porous nanostructures, some significant challenges and potential perspectives are proposed for the advancement of porous PGM-based nanostructure electrocatalysts. This review aims to offer profound viewpoints on porous PGM-based nanostructures, thereby effectively guiding the development of high-performance electrocatalysts and exploring their electrocatalytic applications in diverse electrochemical energy technologies including water electrolysis, fuel cells, and batteries.</div></div>","PeriodicalId":289,"journal":{"name":"Coordination Chemistry Reviews","volume":"543 ","pages":"Article 216958"},"PeriodicalIF":20.3,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mingxing Shi , Huijuan Jia , Jiahui Liu , Ming Gao , Chen Wang , Fengyun Wang , Mingzhu Xia , Wei Jin , Guolin Tong
{"title":"Engineering sustainable porous carbon electrodes for practical-level capacitive deionization desalination","authors":"Mingxing Shi , Huijuan Jia , Jiahui Liu , Ming Gao , Chen Wang , Fengyun Wang , Mingzhu Xia , Wei Jin , Guolin Tong","doi":"10.1016/j.ccr.2025.216949","DOIUrl":"10.1016/j.ccr.2025.216949","url":null,"abstract":"<div><div>Capacitive deionization (CDI) is an emerging desalination technique for eliminating diverse ionic species from water, utilizing porous carbon (PC) to capture ions via electrosorption. Compared with reverse osmosis and distillation, CDI is more energy-efficient and sustainable, posing significant advantages in disposal with low or moderate saline. However, PCs as the CDI core are subject to traditional fabrication processes, suffering from yield-performance imbalance, device corrosion and environmental pollution. Herein, based on the whole production chain, this review first deeply analyzes potential unsustainable problems in the PC preparation process and excavates possible desalting influence mechanisms. The span-new perspective of green inorganic salt- and organic salt-activators, and sustainable manufacturing processes are proposed to dock the PC preparation steps. Crucially, various optimization strategies involving structure, defect, process and prediction engineering are discussed to predict and boost the overall desalting performance. Ultimately, the review appraises scientific barriers and untapped opportunities around the development and application of high-yield-high-performance sustainable PCs, providing viable future outlooks for the expanding research field. Through wide investigation of the CDI field, the review aims to stimulate rapid innovation in sustainable PC-based CDI electrodes.</div></div>","PeriodicalId":289,"journal":{"name":"Coordination Chemistry Reviews","volume":"543 ","pages":"Article 216949"},"PeriodicalIF":20.3,"publicationDate":"2025-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144562925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Biomimetic theranostic nano-agents based on NIR organic small molecules","authors":"Lizhen Xu, Qian Zhang, Xin Wang, Weiying Lin","doi":"10.1016/j.ccr.2025.216910","DOIUrl":"10.1016/j.ccr.2025.216910","url":null,"abstract":"<div><div>Leveraging advanced fluorescence imaging (FLI), photoacoustic imaging (PAI), photothermal imaging (PTI), and phototherapeutic capabilities (photothermal therapy, PTT; photodynamic therapy, PDT), Near-Infrared (NIR) organic small molecules (including BODIPY derivatives, Xanthene analogs, Cyanines, and Benzothiazole-based compounds, etc.) have shown considerable promise in disease diagnosis and treatment. Nevertheless, the biomedical applications (as the theranostic agents for disease) of these NIR organic small molecules encounter significant challenges including immune system recognition, rapid blood clearance, unsatisfactory targeting efficiency and limited tumor accumulation. Notably, biomimetic nano-agents constructed from biomaterials-including macrophage membranes, tumor cell components, erythrocyte derivatives, extracellular vesicles, hybrid membranes, bacteriophages, and algal constituents-have emerged as promising strategies to address these challenges. Therefore, substantial research efforts have been dedicated to developing such biomimetic nano-agents-based delivery systems for the precision transportation of NIR organic small molecule. Furthermore, biomimetic theranostic nano-agents that combine NIR organic small molecules with biomimetic biomaterials have demonstrated enhanced organ-specific and pathological tissue targeting capabilities alongside superior diagnostic and therapeutic performance. However, a systematic summary of current advancements in biomimetic theranostic nano-agents based on NIR organic small molecules remains conspicuously vacant. Therefore, this review aims to systematically summarize cutting-edge developments in biomimetic theranostic nano-agents based on NIR organic small molecules, as well as their biomedical applications (diagnosis and treatment of diseases). Additionally, we provide an in-depth discussion of current technical bottlenecks and potential solutions for optimizing the clinical translation of biomimetic theranostic nano-agents based on NIR organic small molecule.</div></div>","PeriodicalId":289,"journal":{"name":"Coordination Chemistry Reviews","volume":"543 ","pages":"Article 216910"},"PeriodicalIF":20.3,"publicationDate":"2025-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144562927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shiyu Wang , Hongjun Song , Caixia Yin , Fangjun Huo
{"title":"Advances in probe crossing the blood–brain barrier strategies and fluorescent imaging for brain dynamics","authors":"Shiyu Wang , Hongjun Song , Caixia Yin , Fangjun Huo","doi":"10.1016/j.ccr.2025.216940","DOIUrl":"10.1016/j.ccr.2025.216940","url":null,"abstract":"<div><div>The blood–brain barrier (BBB) is a selectively permeable barrier that plays a crucial role in protecting the brain. However, the dual nature of its protective mechanisms presents significant challenges for the development of real-time imaging tools targeting active substances within the brain. With the emergence of novel diseases and the worsening of pre-existing brain disorders such as epilepsy, Alzheimer's disease (AD), and glioblastoma, there is an urgent need to expand the repertoire of chemical tools to refine diagnostic and therapeutic strategies for these conditions. In this context, fluorescent probes have shown remarkable potential for the development and optimization of novel diagnostic tools capable of crossing the BBB. Their advantages include adjustable molecular weight, controllable lipid water partition coefficients, and the capability for real-time imaging in living organisms. In this review, we discuss the evaluation methods and physicochemical parameters of fluorescent probes designed to cross the BBB. We also summarize recent studies on fluorescent probes for detecting active substances in the brain, including reactive nitrogen species (RNS), reactive oxygen species (ROS), reactive sulfur species (RSS), proteins, and neurotransmitters. These studies highlight the methodologies and practicalities of developing efficient fluorescent probes for BBB penetration. Furthermore, this paper briefly addresses the challenges associated with fluorescent probes crossing the BBB and proposes potential strategies for future technological advancements. These insights provide valuable references for the development of new optical probes for in situ brain imaging.</div></div>","PeriodicalId":289,"journal":{"name":"Coordination Chemistry Reviews","volume":"543 ","pages":"Article 216940"},"PeriodicalIF":20.3,"publicationDate":"2025-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144562928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yawen Yang , Hexi Li , Dandan Liu , Wei Hu , Ruixue Wang , Zhihao Yi , Anna Zhu
{"title":"A critical review on integrated fabric-based functionalized composites for protection and decontamination of chemical and biological warfare agents","authors":"Yawen Yang , Hexi Li , Dandan Liu , Wei Hu , Ruixue Wang , Zhihao Yi , Anna Zhu","doi":"10.1016/j.ccr.2025.216905","DOIUrl":"10.1016/j.ccr.2025.216905","url":null,"abstract":"<div><div>Chemical and biological warfare agents (CWAs/BWAs) pose severe global security threats due to their unpredictable performance and extreme lethality, driving urgent demands for advanced protective technologies. As critical components in personal protective equipment, fabric-based materials have emerged as promising candidates for CWA/BWA countermeasures owing to their unique combination of lightweight fexibility, physiological comfort, and adaptable barrier properties. Recent breakthroughs in functional composites have enabled the development of smart fabrics integrating multidimensional protection mechanisms through strategic incorporation of advanced materials including metal-organic frameworks (MOFs), carbon nanomaterials, inorganic nanoparticles, and functional polymers. These engineered fabrics demonstrate synergistic capabilities combining protection and decontamination properties. Despite remarkable progress, this field currently lacks comprehensive understanding of material design principles, structure-property relationships, and technology implementation challenges.</div><div>This review initiates with a systematic analysis on fabric substrates and advanced manufacturing techniques for functional composites, focusing on the intrinsic properties of various fabric architectures and their corresponding functionalization strategies. And then, we comprehensively examine the implementation mechanisms of fabric-based composites in protecting against CWA/BWAs, organized by material classification. Each category undergoes rigorous assessments across three critical dimensions: protective efficacy, operational mechanisms, and current technological constraints, accompanied by targeted improvement methodologies. The discussion subsequently addresses cutting-edge multifunctional platforms that unify threat detection, prevention, and post-exposure decontamination. This work ultimately seeks to establish a structure-property-application framework to guide the rational design of next-generation protective fabrics, while identifying key challenges in scalability and field deploy ability to bridge laboratory innovation and practical defense applications.</div></div>","PeriodicalId":289,"journal":{"name":"Coordination Chemistry Reviews","volume":"543 ","pages":"Article 216905"},"PeriodicalIF":20.3,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144556650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Muhammad Suhail , Alamgir , Abdul Wahab , Tatiana Eggers , Zahoor Ahmad , Khurram Shehzad , M. Zubair Iqbal
{"title":"Magnetically responsive hydrogel systems: Fundamental features, emerging applications, and future horizons","authors":"Muhammad Suhail , Alamgir , Abdul Wahab , Tatiana Eggers , Zahoor Ahmad , Khurram Shehzad , M. Zubair Iqbal","doi":"10.1016/j.ccr.2025.216916","DOIUrl":"10.1016/j.ccr.2025.216916","url":null,"abstract":"<div><div>Smart hydrogels have garnered significant attention due to their responsiveness to external stimuli. Magnetic-responsive hydrogels, in particular, are engineered by integrating magnetic nanomaterials into the hydrogel matrix. Their distinctive properties, including rapid magnetic responsiveness, precise spatial control, and the ability to exert non-invasive, remote forces, have expanded their potential in biomedical applications. Magnetic hydrogels exhibit various responses such as propulsion, deformation, and thermogenesis under an external magnetic field, offering deep tissue penetration for therapeutic purposes. This review aims to provide a comprehensive summary of recent advancements in the biomedical applications of magnetic hydrogels. It primarily explores the unique characteristics and fabrication techniques of these materials, as well as their various classifications and applications within the biomedical field. The challenges and future directions for preparing magnetic hydrogels are also discussed.</div></div>","PeriodicalId":289,"journal":{"name":"Coordination Chemistry Reviews","volume":"543 ","pages":"Article 216916"},"PeriodicalIF":20.3,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144549980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Morphological variation of metal-organic frameworks and its impacts on their functional properties","authors":"Chayanika Pathak , Subhradeep Mistry , Saona Seth","doi":"10.1016/j.ccr.2025.216928","DOIUrl":"10.1016/j.ccr.2025.216928","url":null,"abstract":"<div><div>Morphology plays an important role on the functional properties of solid-state materials. Metal-organic frameworks (MOFs), a subclass of crystalline solids, are observed to show interesting morphological variations including different shapes and sizes of crystals, polymorphism, nanoparticles, hollow structures, etc., based on the reaction conditions employed for synthesis. Different hierarchical structures, as well as phase transformations, are also observed for many MOFs that are often associated with distinct morphological features. In general, the morphological diversity of MOFs is achieved by preferential growth in certain crystallographic directions that can be modulated by the use of various additives. In some cases, it is observed that crystal defects can be a significant player for certain morphological features and also can induce phase and morphological transitions of MOFs. Morphological variation is found to impact the internal and external surface areas of the MOF crystals for interactions with guests and thereby, significantly influences guest diffusion kinetics. Similarly, other physical properties, such as mechanical strength, optical appearance, hydrophobicity etc., are also found to be impacted by the morphology of MOFs. In turn, such variation in properties is reflected in their performances in different applications, such as gas uptake, chemical separation, catalysis and energy storage applications. In this review article, we discuss different morphological aspects of MOFs, different routes to achieving morphological variations, role of morphology in tailoring their properties and functional behaviors and future scope for achieving better morphological control.</div></div>","PeriodicalId":289,"journal":{"name":"Coordination Chemistry Reviews","volume":"543 ","pages":"Article 216928"},"PeriodicalIF":20.3,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144556648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xiao-Le Chang , Ting Yan , Wei-Guo Pan , Li-Wei Wang
{"title":"Designing and screening metal-organic frameworks for enhancing CO2 capture and separation performance","authors":"Xiao-Le Chang , Ting Yan , Wei-Guo Pan , Li-Wei Wang","doi":"10.1016/j.ccr.2025.216929","DOIUrl":"10.1016/j.ccr.2025.216929","url":null,"abstract":"<div><div>CO<sub>2</sub> emission by the burning of fossil fuels is the main cause of the greenhouse effect. The remission of this chief greenhouse gas has allured the extensive concern thanks to the threat of global climate warming from CO<sub>2</sub> emission. Therefore, the development of efficient and environmentally friendly carbon capture and storage technology under the background of sustainable low-carbon economy plays a crucial role in mitigating global climate change. Metal-organic frameworks (MOFs) have significant application potential for selective capture and separation of CO<sub>2</sub>, attributed to their high specific surface area, adjustable pore structure and abundant active sites. Based on the physical and chemical adsorption principles, this study first clarifies the mechanism of CO<sub>2</sub> capture and separation by MOFs. Then, the selecting indicators of MOFs with outstanding comprehensive adsorption and separation performance have been put forward, including the stability, adsorption capacity, selective adsorption performance against the coexistence of multiple components, regeneration performance, recycling performance and the economy. Meanwhile, the evaluation criteria of the adsorbents have been systematically summarized and established. Subsequently, from the perspective of pore structure regulation, metal center and organic ligand modification, MOF-based composite construction and high temperature carbonization, many promising measures to improve the CO<sub>2</sub> adsorption performance have been proposed. In addition, the technical and economic feasibility of MOFs-based adsorbents in the field of CO<sub>2</sub> capture and separation have been analyzed. In the end, the prospects of developing MOFs for selective CO<sub>2</sub> adsorption and separation are discussed. This work provides lots of critical comments and outlooks on the CO<sub>2</sub> capture and separation of MOF adsorbents. It is expected that this review enables scholars to grasp timely the recent progress in MOFs materials for selective CO<sub>2</sub> capture and separation and hence render some valuable insights into the future investigations to accomplish the better improvements.</div></div>","PeriodicalId":289,"journal":{"name":"Coordination Chemistry Reviews","volume":"543 ","pages":"Article 216929"},"PeriodicalIF":20.3,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144549978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"When coordination chemistry meets soft matter: From hybrid nanoparticles to assemblies","authors":"Fabienne Gauffre , Yannick Coppel , Jean-Daniel Marty , Christophe Mingotaud , Myrtil L. Kahn","doi":"10.1016/j.ccr.2025.216893","DOIUrl":"10.1016/j.ccr.2025.216893","url":null,"abstract":"<div><div>In coordination chemistry, a molecule interacting with a metal is described as a ligand coordinating to the metal center. When such a molecule contains both a polar group and an apolar part (such as an alkyl tail), this ligand is also referred to as a surfactant in the field of soft matter science. This dual role suggests that coordination chemistry and soft matter are two overlapping scientific fields. In this review, we will highlight that this overlap occurs not only at the molecular level, where the ligand could be considered as a surfactant, but also at larger scales, when the molecular complex is used as a precursor to synthesize nanoparticles. Finally, the ligand can drive nanoparticles assembly. Thus, the concepts of coordination chemistry and soft matter enrich each other, leading to original combined properties as well as a better understanding of systems developed at the intersection of these two sciences.</div></div>","PeriodicalId":289,"journal":{"name":"Coordination Chemistry Reviews","volume":"543 ","pages":"Article 216893"},"PeriodicalIF":20.3,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144563881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}