Coordination Chemistry Reviews最新文献

{"title":"Helical self-assemblies of molecule-like coinage metal nanoclusters and their emerging applications","authors":"Subrat Kumar Barik ,&nbsp;M. Sreejit Kumar Rao ,&nbsp;Bigyan Ranjan Jali ,&nbsp;Jean-François Halet ,&nbsp;Himanshu Sekhar Jena","doi":"10.1016/j.ccr.2024.216341","DOIUrl":"10.1016/j.ccr.2024.216341","url":null,"abstract":"<div><div>Ligand protected atomically precise coinage metal (Au, Ag, Cu) nanoclusters (NCs) have attracted considerable interest for their distinctive structural self-assemblies. A recent trend involves exploring the creation of synthetic NCs capable of self-assembling into diverse superstructures with compact helical conformations. These interesting structures are analogous to folded states found in natural proteins. The formation of such supramolecular self-assemblies of NCs is primarily dictated by subtle intra and inter-cluster non-covalent interactions. These include C-H‧‧‧<em>π</em>, <em>π</em>‧‧‧<em>π</em><strong>,</strong> H‧‧‧H, and auro/argento/cupro-philic interactions mediated through surface ligands and metal cores. This review offers a comprehensive insight into the self-assembly mechanisms governing cluster-based helical superstructures. It presents a meticulously designed approach tailored for the construction of atomically precise helical supramolecular materials, specifically focusing on coinage metal NCs. Additionally, it explores the amplification of physicochemical properties triggered by self-assembly and delves into their potential applications in chiral recognition, enantioselective catalysis, molecular sensing and photoluminescence studies. The subject addressed in this review is closely linked to cutting-edge advancements in the precise coinage metal NCs field.</div></div>","PeriodicalId":289,"journal":{"name":"Coordination Chemistry Reviews","volume":"525 ","pages":"Article 216341"},"PeriodicalIF":20.3,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142696522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fundamentals of metal-organic framework-based photocatalysts: The role of chemical diversity and structure engineering","authors":"Qi Ran ,&nbsp;Binbin Tao ,&nbsp;Mohua Li ,&nbsp;Kaidan Zheng ,&nbsp;Yunyong She ,&nbsp;Wenjie Wu ,&nbsp;Zhengtong Li ,&nbsp;Dan Luo ,&nbsp;Xingtao Xu","doi":"10.1016/j.ccr.2024.216324","DOIUrl":"10.1016/j.ccr.2024.216324","url":null,"abstract":"<div><div>The utilization of solar energy in driving chemical reactions through photocatalysis is essential in promoting a sustainable future. However, the development of synthetic materials with photochemical properties continues to pose a significant challenge in the field of materials science. Metal-organic frameworks (MOFs) provide a powerful platform for establishing effective photocatalyst systems due to their atomically precise structures, modifiable chemical environment, and semiconductor-like behavior. This work comprehensively reviews the design and synthesis strategies of MOF-based photocatalysts, with particular emphasis on light absorption, photogenerated carrier separation, catalytic active sites, and reaction selectivity. The objective of these approaches is to identify and rationalize design parameters to generate optimized chemical composition, functional nanostructures, and corresponding performance parameters. In this review, we highlight how the parameters of MOFs can serve as the knobs for maneuvering light harvesting, charge separation and migration, as well as altering subsequent surface chemical reaction. We hope that this will contribute towards further understanding and inspiration for developing photocatalytic reaction based on MOFs materials.</div></div>","PeriodicalId":289,"journal":{"name":"Coordination Chemistry Reviews","volume":"525 ","pages":"Article 216324"},"PeriodicalIF":20.3,"publicationDate":"2024-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142694386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coupled binuclear copper sites in biology: An experimentally-calibrated computational perspective","authors":"Agnieszka Stańczak ,&nbsp;Ioannis Kipouros ,&nbsp;Petr Eminger ,&nbsp;Eleanor M. Dunietz ,&nbsp;Edward I. Solomon ,&nbsp;Lubomír Rulíšek","doi":"10.1016/j.ccr.2024.216301","DOIUrl":"10.1016/j.ccr.2024.216301","url":null,"abstract":"<div><div>The broad class of O₂-activating coupled-binuclear copper (CBC) metalloenzymes contain a unique [Cu₂O₂] catalytic core. This core is responsible for catalyzing challenging biochemical transformations, particularly the regioselective monooxygenations/oxidations of substituted phenols. Despite almost four decades of intense experimental and theoretical research, the factors governing the diverse reactivity of CBC enzymes had remained only partially understood. In this review, we highlight the recent synergy between spectroscopy, kinetic experiments, and state-of-the-art computations (including hybrid quantum and molecular mechanical, QM/MM, and advanced wave function theory, WFT, methods) that provided a conclusive mechanistic picture of the initial stages of the <em>ortho-</em>hydroxylation of phenolic substrates catalyzed by the CBC enzyme tyrosinase (Ty). We emphasize the power of calibrated theoretical calculations, supported by experimental spectroscopic and kinetic data on intermediates, in providing definitive insight into the catalytic reaction coordinate. We provide a critical review of previous efforts towards elucidating structure-function correlations over the four CBC protein classes (hemocyanins, catechol oxidases, tyrosinases, <em>o</em>-aminophenol oxygenases). We outline how a systematic mechanistic understanding across the different CBC enzyme classes could uncover their elusive structure-function correlations, opening new possibilities for utilizing the [Cu₂O₂] catalytic core outside its native biological context for applications in materials and biocatalysis.</div></div>","PeriodicalId":289,"journal":{"name":"Coordination Chemistry Reviews","volume":"525 ","pages":"Article 216301"},"PeriodicalIF":20.3,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142691065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in porous adsorbents for perfluorocarbon greenhouse gas sorption and separation","authors":"Shao-Min Wang,&nbsp;Peigao Duan,&nbsp;Qing-Yuan Yang","doi":"10.1016/j.ccr.2024.216339","DOIUrl":"10.1016/j.ccr.2024.216339","url":null,"abstract":"<div><div>Perfluorocarbons (PFCs) such as CF₄, C₂F_6, and C₃F₈, are extensively used in the microelectronics and semiconductor industries, yet their global warming potentials—thousands of times greater than that of CO₂—underscore the urgent need for effective mitigation strategies. While converting PFCs into non-PFCs offers a method for their destruction, a more sustainable approach lies in the recovery and recycling of these compounds using advanced adsorbents. This review explores the potential of cutting-edge porous materials, including metal-organic frameworks (MOFs), covalent-organic frameworks (COFs), and porous organic cages (POCs), for the adsorption and separation of PFCs. By precisely tuning pore sizes and chemical environments through modifications of metal ions and ligands, these porous adsorbents can be tailored to exhibit specific adsorption and separation capabilities. The review focuses on the selective separation of PFCs from nitrogen and other fluorinated gases, with particular emphasis on the latest advancements in adsorbents designed to differentiate between PFCs and other fluorinated compounds in the presence of nitrogen.</div></div>","PeriodicalId":289,"journal":{"name":"Coordination Chemistry Reviews","volume":"525 ","pages":"Article 216339"},"PeriodicalIF":20.3,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142690621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances in Rh(III)-based anticancer complexes","authors":"Souvik Saha ,&nbsp;Rajesh Kushwaha ,&nbsp;Apurba Mandal ,&nbsp;Nidhi Singh ,&nbsp;Samya Banerjee","doi":"10.1016/j.ccr.2024.216306","DOIUrl":"10.1016/j.ccr.2024.216306","url":null,"abstract":"<div><div>Since the serendipitous discovery of cisplatin's anticancer activity, transition metal complexes have caught enormous attention in medicinal inorganic chemistry, especially in cancer drug development research. Recently, the drug resistance and side effect problems of market-available cancer drugs have accelerated the screening of novel transition metal complexes in cancer therapy. Over the past few years, Rh(III)-based complexes have received significant attention from inorganic chemists as possible alternatives to Pt(II) anticancer drugs. Numerous Rh(III) complexes are reported to be more cytotoxic and effective than cisplatin against various cancer types. Interestingly, several Rh(III) complexes have shown remarkable anticancer efficacy even against cisplatin-resistant cancer cells, making them potential solutions for drug resistance problems. The anticancer efficacy of such Rh(III) complexes was super-tuned by the rational selection of ligands and overall charge. Moreover, these anticancer active complexes also exhibited different novel anticancer mechanisms by targeting specific biomolecules/organelles to overcome drug resistance.</div><div>In this review, we discussed smartly designed Rh(III) complexes that presented efficient antiproliferative activity via different mechanisms of action (MoA) from conventional chemotherapeutics (such as cisplatin). Herein we have focused on their MoA such as targeting specific organelle (mitochondria) and mismatched DNA base pair, selective inhibition of protein or enzyme (thioredoxin reductase), delivery of bioactive ligands (curcumin) at the tumor site by cytotoxic Rh(III) complexes. Apart from this, we have also discussed the in-solution behavior of Rh(III) complexes, their stability in a different medium, and their ability to provide live cell or organelle imaging used to track the cellular co-localization of drugs.</div></div>","PeriodicalId":289,"journal":{"name":"Coordination Chemistry Reviews","volume":"525 ","pages":"Article 216306"},"PeriodicalIF":20.3,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142684821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photocatalytic oxidation of various organic substrates using multinuclear Ru(II)-polypyridyl complexes","authors":"Amit Chauhan ,&nbsp;Satyam Singh ,&nbsp;Atresh Kumar Singh ,&nbsp;Alok Kumar Singh ,&nbsp;Sushil Kumar ,&nbsp;Rajesh K. Yadav ,&nbsp;Atul P. Singh ,&nbsp;Umesh N. Tripathi ,&nbsp;Manoj Kumar","doi":"10.1016/j.ccr.2024.216344","DOIUrl":"10.1016/j.ccr.2024.216344","url":null,"abstract":"<div><div>Over the past few years, an extensive usage of transition metal complexes as photoactive SET (single electron transfer) agents in the synthetic organic chemistry has opened new doors to reinvent the already known organic transformations as well as to create different paths for previously unattainable reaction products. Especially, Ru(II)-polypyridyl complexes have acted as a pillar owing to an inherent advantage of their triplet excited-state involved in various photoactivities. Though the photophysics of Ru(II) complexes has been well documented within inorganic community, they are less exploited for the problems of interest to the synthetic organic chemists. Recent development in this field suggests that a connection between organic synthesis and photoactive metal complexes might lead to successful outcomes in both the research areas. Notably, in contrast to the rigorous employment of mononuclear Ru(II)-polypyridyl complexes, the multinuclear species have been less well-studied and their fundamental optoelectronic properties and applications are relatively under explored. However, the multinuclear Ru(II) species offer more promising photophysical features compared to the mononuclear analogues <em>via</em> fine-tuning of the bridging ligands and/or the individual metal centres. Recently, such species have enabled essential breakthroughs in the research fields of photocatalysis, light-emitting devices (LEDs), photodynamic therapy (PDT), smart materials, optical sensors and so on. In this study, we offer an overview of the photophysics of multinuclear Ru(II)-polypyridyl complexes with an aim to explain their ground- and excited-state features, along with related light-driven electron/energy transfer processes for potential catalytic oxidation of various organic substrates such as alcohols, sulfides, alkenes, <em>etc.</em></div></div>","PeriodicalId":289,"journal":{"name":"Coordination Chemistry Reviews","volume":"525 ","pages":"Article 216344"},"PeriodicalIF":20.3,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142684757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iron group elements (Fe, Co, Ni) in Electrocatalytic applications: Evaluation, characterization and prospects","authors":"Jiwen Wu ,&nbsp;Naiyan Liu ,&nbsp;Fengshi Li ,&nbsp;Binbin Jia ,&nbsp;Jinlong Zheng","doi":"10.1016/j.ccr.2024.216343","DOIUrl":"10.1016/j.ccr.2024.216343","url":null,"abstract":"<div><div>Electrocatalysis represents a promising approach for addressing energy shortages and environmental concerns. The quest for electrocatalysts characterized by high activity, low cost, and excellent stability is pivotal to advancing the field of electrocatalysis. Notably, the extraordinary electronic structure of iron group elements (Fe, Co, Ni) has garnered significant attention. This work introduces the evaluation indexes of electrocatalytic reactions, and also analyzes in-suit/operando characterization techniques commonly used in the study of electrocatalytic processes. The review encompasses the application of iron group electrocatalysts in various reactions including hydrogen evolution reaction (HER), oxygen evolution reaction (OER), overall water splitting (OWS), oxygen reduction reaction (ORR), nitrogen reduction reaction (NRR) and carbon dioxide reduction reaction (CO₂RR). Furthermore, the paper presents a summary of the reaction mechanisms underlying each electrocatalytic process. It also delves into the research progress of iron group elements in diverse electrocatalytic reactions, aimed at advancing the advancement of electrocatalysts which are more available and stable. Lastly, the paper examines the situation status, challenges, and future prospects of iron group electrocatalysts, offering insights into the evolving landscape of iron group materials and the design of commercially viable electrocatalysts.</div></div>","PeriodicalId":289,"journal":{"name":"Coordination Chemistry Reviews","volume":"525 ","pages":"Article 216343"},"PeriodicalIF":20.3,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142684764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances of Schiff base metal complexes as potential anticancer agents","authors":"Lin Lv,&nbsp;Tianpeng Zheng,&nbsp;Lu Tang,&nbsp;Zhaoran Wang,&nbsp;Wukun Liu","doi":"10.1016/j.ccr.2024.216327","DOIUrl":"10.1016/j.ccr.2024.216327","url":null,"abstract":"<div><div>The successful clinical application of Pt-based drugs in anticancer therapy has stimulated interest in the development of metallodrugs. Numerous metal complexes with significant anticancer activity and fewer side effects have been reported. However, lack of stability is one of the problems restricting the development of metallodrugs. Schiff bases attract a lot of interest because of their excellent properties. They can stabilize various oxidation states of metals and be synthesized easily. Therefore, Schiff bases are known as “privileged ligands” for transition metals. Schiff base metal complexes have a wide range of activities, among which anticancer activity is remarkable and has a large potential for development. In this review, various Schiff base metal complexes with anticancer activities from 2015 to the present are summarized. Their structures, biological activities, targets, and mechanisms of action are discussed in depth. These complexes display a diverse array of structures and have been shown to possess significant anticancer activity. Notably, Schiff base metal complexes demonstrated anticancer activity through various mechanisms, including deoxyribonucleic acid (DNA) damage, reactive oxygen species (ROS) generation, mitochondrial pathway, endoplasmic reticulum stress (ERS), inhibition of epidermal growth factor receptor (EGFR), activation of immunogenic cell death (ICD), and the induction of apoptosis. This review may provide guidance to the development and mechanistic investigations of future anticancer metallodrugs.</div></div>","PeriodicalId":289,"journal":{"name":"Coordination Chemistry Reviews","volume":"525 ","pages":"Article 216327"},"PeriodicalIF":20.3,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142678784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of theranostic nanoplatforms based on gadolinium-layered double hydroxides for magnetic resonance imaging-guided stimuli-enhanced chemotherapy","authors":"Leila Khalili ,&nbsp;Gholamreza Dehghan ,&nbsp;Hamed Hamishehkar ,&nbsp;Leonid G. Voskressensky ,&nbsp;Alireza Khataee","doi":"10.1016/j.ccr.2024.216316","DOIUrl":"10.1016/j.ccr.2024.216316","url":null,"abstract":"<div><div>The requirements for non-invasive visualization and precise treatment of cancers are ongoing, demanding continuous efforts to enhance the development of potent theranostic modalities. Notably, groundbreaking advancements in nanotechnology have positioned layered double hydroxides (LDHs) at the forefront of biomedical research. LDH carriers are highly valued in medicinal applications due to their ability to integrate the benefits of multiple modalities, thus paving a promising path to clinical use. Recent breakthroughs in the rational design of theranostics have underscored the potential of gadolinium (Gd)-doped LDHs, which are particularly well-suited for the diagnosis of diseases. This review focuses on providing a comprehensive overview of the latest significant advances in Gd-LDH assemblies in cancer theranostics, with an emphasis on a bottom-up intercalation strategy, influential factors, and formulation methodologies. These aspects are crucial for researchers developing innovative intercalation processes and novel multi-component materials. Additionally, we address the kinetic inertness and colloidal stability of Gd-intercalated LDHs, which are essential for advanced theranostic applications. Finally, we present a forward-looking discussion on the challenges and future opportunities related to Gd-LDH complexes, aiming to identify the obstacles researchers encounter in advancing the clinical application of Gd-LDHs and to offer potential insights for further research.</div></div>","PeriodicalId":289,"journal":{"name":"Coordination Chemistry Reviews","volume":"525 ","pages":"Article 216316"},"PeriodicalIF":20.3,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142678786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding the working principle of sustainable catalytic materials for selective hydrogenation of carbonyls bond in α, β-unsaturated aldehydes","authors":"Muhammad Zahid ,&nbsp;Ahmed Ismail ,&nbsp;Muhammad Farooq Khan ,&nbsp;Nauman Ali ,&nbsp;Syedul Hasnain Bakhtiar ,&nbsp;Atef El Jery ,&nbsp;Basem Al Alwan ,&nbsp;Rizwan Ullah ,&nbsp;Fazal Raziq ,&nbsp;Weidong He ,&nbsp;K.H.L. Zhang ,&nbsp;Jiabao Yi ,&nbsp;Xiaoqiang Wu ,&nbsp;Sharafat Ali ,&nbsp;Liang Qiao","doi":"10.1016/j.ccr.2024.216295","DOIUrl":"10.1016/j.ccr.2024.216295","url":null,"abstract":"<div><div>The superior hydrogenation of carbonyl (C=O) bonds in α, β-unsaturated aldehydes (UAL) has attracted considerable attention from economic and industrial perspectives. Several efforts have been made because hydrogenation of the olefin (C<img>C) bond is kinetically and thermodynamically preferred over C<img>O bond hydrogenation. Hence, to achieve superior hydrogenation of the targeted C<img>O bond, highly active and durable catalysts are required. Herein, functional hydrogenation catalytic materials and their working principles are thoroughly discussed and apprehended. The active role of noble, non-noble mono/bi-metal catalysts and support materials along with the key factors arising from the structure of catalysts that promotes the C<img>O bond selectivity were thoroughly disclosed. Essential techniques and strategies, such as tuning the surface electronic properties and generating electro-nucleophilic sites via synergistic effects, geometric effects, and applying a confinement or steric effect for improved C<img>O bond hydrogenation, are briefly apprehended. The aggregate analysis suggested two crucial approaches for the engineering of a vastly selective and stable hydrogenation catalytic material: (1) tuning the electronic number of an active noble metal and (2) stabilizing the active noble metal by selecting distinctive support materials, especially metal-organic frameworks (MOFs) owing to its special physiochemical features, to construct robust metal-support interactions. In the end, various crucial key factors and additional active sites that are also encountered to attain the desired selectivity of the C<img>O bond are concisely reviewed. Regardless of the numerous successes, significant development is still essential to expand our understanding of the preferential hydrogenation of challenging C<img>O bonds in UAL.</div></div>","PeriodicalId":289,"journal":{"name":"Coordination Chemistry Reviews","volume":"525 ","pages":"Article 216295"},"PeriodicalIF":20.3,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142673495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}