Yutaka Suzuki, O. Sakata, S. Imamura, Shuichiro Endo, A. Mizukoshi, Asobu Hattori, M. Morisawa
{"title":"Elemental Research for Quantification of Eustachian Tube Insufflation Method","authors":"Yutaka Suzuki, O. Sakata, S. Imamura, Shuichiro Endo, A. Mizukoshi, Asobu Hattori, M. Morisawa","doi":"10.18178/ijpmbs.5.2.115-120","DOIUrl":"https://doi.org/10.18178/ijpmbs.5.2.115-120","url":null,"abstract":"Commercial equipment is available for conducting Eustachian tube function tests but, generally, the Eustachian tube insufflation method doubles as a treatment and diagnosis. However, with the Eustachian tube insufflation method, the doctor merely performs the auscultation. The Eustachian tube insufflation sounds are not saved as data, and the diagnosis relies on the auditory judgment of the doctor. That is, the technique is not objective. To overcome these disadvantages, we set out to develop a system that would enable the objective evaluation of the Eustachian tube insufflation sounds. We sampled a wide range of Eustachian tube insufflation sounds and tried to identify the acoustic features of specific pathological conditions. However, it was so difficult to find the features of Eustachian tube insufflation sounds and to classify according to observation of spectra completely. Therefore, we proposed a method of inputting the frequency analysis results as feature vectors to a Self-Organizing Map (SOM). Our results confirmed that, when the maximum values of the spectra are normalized using the 0to 5-kHz frequency analysis results, the normal sounds, stenosis, and crepitation could be classified.","PeriodicalId":281523,"journal":{"name":"International Journal of Pharma Medicine and Biological Sciences","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128661258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Agnes Sri Harti, S. D. Sulisetyawati, Atiek Murharyati, Meri Oktariani, Ika Budi Wijayanti
{"title":"The Effectiveness of Snail Slime and Chitosan in Wound Healing","authors":"Agnes Sri Harti, S. D. Sulisetyawati, Atiek Murharyati, Meri Oktariani, Ika Budi Wijayanti","doi":"10.18178/ijpmbs.5.1.76-80","DOIUrl":"https://doi.org/10.18178/ijpmbs.5.1.76-80","url":null,"abstract":"Snail slime (Achatina fulica) has many functions, including wound or scratch and gingivitis healings, and skin care. The essential substances contained in the snail slime involve glycosaminoglycans and proteins. The proteins have important biological functions, including as a bacterial protein (enzyme) binding receptor. Chitosan is a natural polymer containing a hydroxyl group (OH) and amine groups (NH2) which is positively charged in acidic solution. It is antimicrobial and polycationic, so that it can be used as a coagulant agent. The research aims at finding out the effectiveness of snail slime and chitosan in wound healing. The methods employed in the research included isolation of snail slime, the synthesis of chitosan (2%), and in vivo treatment stages using 5 groups of mice as negative controls, snail slime and chitosan (2%). The ratios of snail slime and chitosan examined were 1: 1, 1: 2, and 2: 1. The result shows that snail slime and chitosan (2%) with the ratio of 1: 2 is effective in wound healing. The content of the antiinflammatory factor in snail slime and antimicrobial.","PeriodicalId":281523,"journal":{"name":"International Journal of Pharma Medicine and Biological Sciences","volume":"69 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122610186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
W. Charoensuk, N. Covavisaruch, S. Lerdlum, Y. Likitjaroen
{"title":"Acute Stroke Brain Infarct Segmentation in DWI Images","authors":"W. Charoensuk, N. Covavisaruch, S. Lerdlum, Y. Likitjaroen","doi":"10.18178/ijpmbs.4.2.115-122","DOIUrl":"https://doi.org/10.18178/ijpmbs.4.2.115-122","url":null,"abstract":"Acute ischemic infarct can be quickly identified with Diffusion Weighted Imaging (DWI) method. This research proposes to segment infarct areas in DWI dataset by applying Chan-Vese active contour and localized regionbased active contour algorithms. The knowledge about the infarct intensities of a particular problem dataset is gathered from the result in the first image slice and modified with some priori knowledge about the infarct in DWI images from an expert neurologist. The infarct segment areas from active contour algorithms in the consecutive slices that pass all three conditions: intensity, connectivity and size, are considered as infarct. Using an expert’s manual segment areas as our gold standard, the experiments reveal that our proposed approach should be able to assist human in infarct segmentation in DWI images. The proposed approach achieved good results with 0.8548 ± 0.0384 sensitivity, 0.8787 ± 0.0860 precision and 0.8511 ± 0.0475 DSC respectively. ","PeriodicalId":281523,"journal":{"name":"International Journal of Pharma Medicine and Biological Sciences","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126893562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Vitamin D Decreases Adipocyte Size of Pericardial Adipose Tissue in Obese Female Wistar Rat: A Preliminary Study","authors":"Luh Putu Ratna Sundari, I. Arijana, M. Linawati","doi":"10.18178/ijpmbs.9.4.185-189","DOIUrl":"https://doi.org/10.18178/ijpmbs.9.4.185-189","url":null,"abstract":"Abstrac t—Obesity is also associated with the accumulation of fat mass both in subcutaneous and visceral. Pericardial adipose tissue (PAT) is one of the visceral fat tissue that increases when obesity occurs. In previous study, Vitamin D deficiency in obesity was associated with increased thickness of epicardial adipose tissue (EAT). PAT and EAT are associated in anatomical conjunction. This study wants to prove whether the administration of vitamin D can reduce the size of adipocytes in paracardial fat of obese female wistar rat. In this preliminary study, 3 obese female wistar rat (275, 278, 280 grams) were divided into 3 treatments: control, 800 IU of vitamin D, 2400 IU of vitamin D. Vitamin D were administered by oral gavage for 8 weeks. All of rats were sacrificed on week 8 and pericardial fat were extracted for stereology analysis. Our histologis examination showed that the total size of adipocytes pericardial fat were decreased in 2400 IU vit D, in comparison to the 800 IU and control treatment. It showed that vitamin D could decrease the size of adipocyte of pericardial fat in obese female wistar rat.","PeriodicalId":281523,"journal":{"name":"International Journal of Pharma Medicine and Biological Sciences","volume":"215 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134304381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. Yuda, Masaya Kisohara, Y. Yoshida, N. Ueda, J. Hayano
{"title":"Associations between Seasonal Variation of Heart Rate Variability and Healthy Life Expectancy in Japan","authors":"E. Yuda, Masaya Kisohara, Y. Yoshida, N. Ueda, J. Hayano","doi":"10.18178/ijpmbs.9.3.107-110","DOIUrl":"https://doi.org/10.18178/ijpmbs.9.3.107-110","url":null,"abstract":"—Although both summer heat and winter cold increase the risk of health problems, the effects could be modified by living environment and clothes. We investigated the relationship between regional differences in healthy life span (HALE) (HRV) that may reflect biological burden caused by heat and cold weather. Using the Allostatic State Mapping by Ambulatory ECG Repository (ALLSTAR) database, we analyzed the 24-h standard deviation of sinus-rhythm R-R intervals (SDNN) among 86,712 men and 108,771 women across Japan as a measure of HRV. Then, SDNN data were divided into 47 prefectures, averaged over 4 seasons, and associated with the prefectural averages of HALE reported by Japanese government. As the results, in both sexes, prefectural age-adjusted HALE negatively correlated with seasonal variation of prefectural age-adjusted SDNN, while it did not corelated significantly with prefectural age-adjusted SDNN of any seasons. Additionally, there was no significant correlation between prefectural age-adjusted average life expectancy and the seasonal variation of prefectural age-adjusted SDNN. Our observations support the hypothesis that the magnitude of the seasonal variation in biological burden might be a shortening factor for HALE.","PeriodicalId":281523,"journal":{"name":"International Journal of Pharma Medicine and Biological Sciences","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132109624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jinwon Kwon, Subin Yoon, Cheryn Kim, Sang Ryul Kim, Taeseon Yoon
{"title":"Comparison of HTLV and STLV by Using Apriori Algorithm and Decision Tree","authors":"Jinwon Kwon, Subin Yoon, Cheryn Kim, Sang Ryul Kim, Taeseon Yoon","doi":"10.18178/ijpmbs.4.3.163-166","DOIUrl":"https://doi.org/10.18178/ijpmbs.4.3.163-166","url":null,"abstract":"—In this study, Apriori algorithm and Decision tree C5.0 algorithm were employed to compare the sequence patterns of HTLV(Human T-lymphotropic) and STLV(Simian T-lymphotropic) viruses. HTLV and STLV are Deltaretroviruses and are counterparts. However, these viruses have a complex history. One used to be HIV and some were found and named recently. To find the congruity of these viruses, we decided to compare them. Amino acids of the HTLVs showed that pattern of HTLV-1 and 2 could also be applied to HTLV-3, but HTLV-4 has a different pattern. Rules of the sequences tend to follow HTLV-2’s rule, yet it is too subtle to come into consideration. ","PeriodicalId":281523,"journal":{"name":"International Journal of Pharma Medicine and Biological Sciences","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124438899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Analysis of Relationships between Combinations of Biological Signals and Subjective Interest","authors":"Masaki Omata, Shogo Tanabe","doi":"10.18178/ijpmbs.4.3.158-162","DOIUrl":"https://doi.org/10.18178/ijpmbs.4.3.158-162","url":null,"abstract":"—Interest greatly affects human behavior. Interest is often measured by a questionnaire or observational methods and is used for marketing or advertising purposes. However, there are some problems in the reliability of results of such conventional methods. We propose that using biological signals can help address these issues because such signals are associated with biological reactions to interest. This study describes an experiment and multiple linear regression analyses of the relationships between a viewer’s interest in an infomercial and the viewer’s biological signals such as electroencephalogram, hemoencephalography, blood volume pulse, skin conductance, and respiration. The subjective interests of viewers were measured by a questionnaire. A comprehensive index of interest based on the answer values was extracted by principal component analysis. We then constructed an individual regression equation to estimate the degree of interest from different combinations of biological signals. ","PeriodicalId":281523,"journal":{"name":"International Journal of Pharma Medicine and Biological Sciences","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117151311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Therapeutic Tool to Diagnose ASD in Children","authors":"Johsual Thiveniya Sathiyamoorthy, Gayashini Shyanka Ratnayake","doi":"10.18178/ijpmbs.11.4.96-101","DOIUrl":"https://doi.org/10.18178/ijpmbs.11.4.96-101","url":null,"abstract":"—Today the autism rate in Sri Lanka is increasing and 1.07% that is 1 in every 93 children is affected by autism. Among south Asian countries Sri Lanka has been reported with highest prevalence Many factors affect the behavior of an autistic child, and an interaction is needed for the improvement of their behavioral patterns. It is identified that music therapy could play an important role as an intervention method to increase the social, interactive, and communicative skills of the affected children as well as to manage the challenges faced by them. The aim of this research is to identify and analyze the problems faced by the autistic children and their guardians when looking after them and identifying how diagnosis can be done with emotion API and ASSQ questionnaire and how the challenges such as stress, anxiety, depression can be controlled and improved using music.","PeriodicalId":281523,"journal":{"name":"International Journal of Pharma Medicine and Biological Sciences","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115236441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Novel Approach for Detecting Driver Mutated Pathways in Glioblastoma Multiform","authors":"Yassine El Kati, Shu Lin Wang, Fouad Kharroubi","doi":"10.18178/IJPMBS.8.1.17-21","DOIUrl":"https://doi.org/10.18178/IJPMBS.8.1.17-21","url":null,"abstract":"","PeriodicalId":281523,"journal":{"name":"International Journal of Pharma Medicine and Biological Sciences","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125422690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cellular Thermal Measurement and Characteristic Analysis of Yeast Cells by Dielectrophoresis","authors":"R. Kido, K. Taguchi","doi":"10.18178/ijpmbs.4.4.213-217","DOIUrl":"https://doi.org/10.18178/ijpmbs.4.4.213-217","url":null,"abstract":"In this paper we measured the cellular thermal changes by dielectrophoresis when we used yeast cell for the target cell. First, we conformed about heat damage evaluation of the yeast cells in the suspension. This is because to check the effectiveness of our proposed experimental systems and our electrodes. As a result, it was found that cells activity could be checked from shunt voltage changes. Second, we conformed about cellular thermal measurement using yeast cell. As the results, yeast cell was trapped between the electrodes by the DEP force and shunt voltage changes were measured as the impedance changes between the electrodes. Shunt voltage increased with the temperature rise, and decreased with the temperature drop. In addition, this phenomenon was confirmed only when the cells have been trapped. Also, when the number of trapped cell increased, voltage changes became larger. ","PeriodicalId":281523,"journal":{"name":"International Journal of Pharma Medicine and Biological Sciences","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125541574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}