蜗牛黏液与壳聚糖在伤口愈合中的作用

Agnes Sri Harti, S. D. Sulisetyawati, Atiek Murharyati, Meri Oktariani, Ika Budi Wijayanti
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引用次数: 29

摘要

蜗牛粘液(Achatina fulica)有许多功能,包括伤口或刮伤和牙龈炎愈合,以及皮肤护理。蜗牛黏液中所含的基本物质包括糖胺聚糖和蛋白质。这些蛋白具有重要的生物学功能,包括作为细菌蛋白(酶)结合受体。壳聚糖是一种含羟基(OH)和氨基(NH2)的天然聚合物,在酸性溶液中带正电。它具有抗菌性和多阳离子性,因此可以用作混凝剂。本研究旨在探讨蜗牛黏液和壳聚糖在伤口愈合中的作用。研究方法包括分离蜗牛黏液、合成壳聚糖(2%)和以5组小鼠为阴性对照、蜗牛黏液和壳聚糖(2%)为体内处理阶段。蜗牛黏液与壳聚糖的比例分别为1:1、1:1和2:1。结果表明,蜗牛黏液与壳聚糖(2%)的比例为1:2,具有较好的伤口愈合效果。蜗牛黏液中抗炎因子的含量及抗菌作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Effectiveness of Snail Slime and Chitosan in Wound Healing
Snail slime (Achatina fulica) has many functions, including wound or scratch and gingivitis healings, and skin care. The essential substances contained in the snail slime involve glycosaminoglycans and proteins. The proteins have important biological functions, including as a bacterial protein (enzyme) binding receptor. Chitosan is a natural polymer containing a hydroxyl group (OH) and amine groups (NH2) which is positively charged in acidic solution. It is antimicrobial and polycationic, so that it can be used as a coagulant agent. The research aims at finding out the effectiveness of snail slime and chitosan in wound healing. The methods employed in the research included isolation of snail slime, the synthesis of chitosan (2%), and in vivo treatment stages using 5 groups of mice as negative controls, snail slime and chitosan (2%). The ratios of snail slime and chitosan examined were 1: 1, 1: 2, and 2: 1. The result shows that snail slime and chitosan (2%) with the ratio of 1: 2 is effective in wound healing. The content of the antiinflammatory factor in snail slime and antimicrobial.
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