International Journal of Pharma Medicine and Biological Sciences最新文献

Bioinformatics-Based Analysis of Circulating Tumor Cells: A Methodological Overview of Personalized Cancer Treatment 基于生物信息学的循环肿瘤细胞分析:个体化癌症治疗的方法学综述

International Journal of Pharma Medicine and Biological Sciences Pub Date : 2023-01-01 DOI: 10.18178/ijpmbs.12.4.48-53

Volkan Uslan, Ludmilla Thomé Domingos Chinen, Huseyin Seker

{"title":"Bioinformatics-Based Analysis of Circulating Tumor Cells: A Methodological Overview of Personalized Cancer Treatment","authors":"Volkan Uslan, Ludmilla Thomé Domingos Chinen, Huseyin Seker","doi":"10.18178/ijpmbs.12.4.48-53","DOIUrl":"https://doi.org/10.18178/ijpmbs.12.4.48-53","url":null,"abstract":"Circulating Tumor Cells (CTCs) are capable of providing valuable insights throughout the course of a patient’s disease, even during the early stages of cancer. CTCs have recently gained significant interest for their potential for advancing personalized cancer treatment studies. Despite the challenges associated with their detection and analysis, emerging bioinformatics methodologies and technologies have enhanced the understanding of these cells and their role in cancer metastasis. This paper provides a methodological overview of these bioinformatics methodologies, particularly focusing on the computational analysis of CTCs and its implications for personalized cancer treatment strategies. Additionally, the paper highlights the importance of refining current techniques and need for a further development to overcome the limitations of liquid biopsies, such as their limited sensitivity in detecting low-abundance biomolecules. With this overview, we aim to show the transformative potential of CTC analysis combined with bioinformatics, providing valuable insights for future research and clinical applications in cancer immunotherapy and personalized medicine.","PeriodicalId":281523,"journal":{"name":"International Journal of Pharma Medicine and Biological Sciences","volume":"108 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136052990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Computational Identification of Candidate Genes Involved in the Inflammation Pathway of AGE-RAGE Signaling in Lung Cancer Invasiveness 肺癌侵袭性中AGE-RAGE信号炎症通路候选基因的计算鉴定

International Journal of Pharma Medicine and Biological Sciences Pub Date : 2023-01-01 DOI: 10.18178/ijpmbs.12.4.61-69

Grace Wang, Yongsheng Bai

{"title":"Computational Identification of Candidate Genes Involved in the Inflammation Pathway of AGE-RAGE Signaling in Lung Cancer Invasiveness","authors":"Grace Wang, Yongsheng Bai","doi":"10.18178/ijpmbs.12.4.61-69","DOIUrl":"https://doi.org/10.18178/ijpmbs.12.4.61-69","url":null,"abstract":"Due to its high mortality rate, cancer has been at the forefront of biomedical research. Specifically, lung cancer has been an ongoing public health problem as it accounts for the highest number of cancer deaths worldwide. Phenotypic expressions such as the invasiveness of lung cancer can vary among individuals. Studies have shown a strong correlation between lung cancer invasiveness and inflammation pathways, making inflammation an ideal biomarker for lung cancer diagnostics and a target for therapeutics. The AGE-RAGE signaling pathway, which causes inflammation by genes with differential expression, is one such pathway for inflammation. Typical causing factors include but are not limited to reactive oxygen species, miRNA targets, mutational signatures, and other pathological functions. Even though the AGE-RAGE inflammation pathway is influential in cancer, it has not yet been developed in therapeutics for cancer invasiveness and should be further studied. In this study, we evaluated the complexities of the AGE-RAGE pathway expression in cancer. Through a detailed investigation using online genomics databases, bioinformatics data analysis, and literature review, the role of inflammation is systematically explored. We also examined the implications of the upregulation of AGE-RAGE on other pathological functions and diseases.","PeriodicalId":281523,"journal":{"name":"International Journal of Pharma Medicine and Biological Sciences","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136052991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case of Radio Frequency Micro-Needling Combined with Carbon Dioxide Fractional Laser for the Treatment of Severe Post-Acne Scarring 射频微针联合二氧化碳激光治疗重度痤疮后瘢痕1例

International Journal of Pharma Medicine and Biological Sciences Pub Date : 2023-01-01 DOI: 10.18178/ijpmbs.12.4.70-72

Li Tang, Lan Ge, Yan Xiao, Yaoying Li

引用次数: 0

Study on FSHD2 Myotube Nucleus Disease Based on Mononuclear RNA-seq Identification 基于单核RNA-seq鉴定的FSHD2肌管核病研究

International Journal of Pharma Medicine and Biological Sciences Pub Date : 2023-01-01 DOI: 10.18178/ijpmbs.12.4.54-60

Zihan Liao, Virgia Wang

引用次数: 0

Dynamic Changes in Routine Laboratory Parameters with COVID-19: In-depth Analysis of 17 Patients Requiring Critical Care 新冠肺炎患者常规实验室参数的动态变化:17例重症监护患者的深入分析

International Journal of Pharma Medicine and Biological Sciences Pub Date : 2022-07-01 DOI: 10.18178/ijpmbs.11.3.65-69

K. Khalid, Amira Aishah Che Ani, Azhar Abdul Orani, Nur Najmi Abdul Halim, Azman Hamid

{"title":"Dynamic Changes in Routine Laboratory Parameters with COVID-19: In-depth Analysis of 17 Patients Requiring Critical Care","authors":"K. Khalid, Amira Aishah Che Ani, Azhar Abdul Orani, Nur Najmi Abdul Halim, Azman Hamid","doi":"10.18178/ijpmbs.11.3.65-69","DOIUrl":"https://doi.org/10.18178/ijpmbs.11.3.65-69","url":null,"abstract":"—Dynamic changes in routine blood parameters in COVID-19 patients might be helpful to prognosticate deterioration in COVID-19 patients and evaluate treatment effect. Our study aimed to evaluate the temporal changes in red blood cell indices (MCV, MCH, MCHC, RDW) in COVID-19 patients and the association of other relevant clinical parameters. We analysed 17 medical records of COVID-19 patients in retrospect who required critical care from 1 January 2020 until 28 February 2021 in Hospital Tuanku Fauziah, Perlis, Malaysia. Data extracted include details with regards to escalation and de-escalation of oxygen therapy, clinical and laboratory parameters. There were three time points of interest in our study: (i) admission (Adm), (ii) highest mode of oxygen therapy (HighM), and (iii) weaned off oxygen therapy (WeanOxy). The result showed that the mean duration to clinical deterioration requiring the highest mode of oxygen delivery was 2.3 ±1.85 days and the highest escalation device for oxygen delivery was high flow nasal cannula (n=7, 41.2%). There was no statistically significant difference in RDW, MCV, MCH, and MCHC at different clinical time points, p>0.05. However, there was a statistically significant increment in TWBC trend between Adm-HighM-WeanOxy, χ2(2)=7.023, p=0.030. Our study did not find evidence of structural RBC changes reflected in RBC indices. However, recovery from COVID-19 was reflected in the rise of TWBC and ANC, similar to that observed with other viral illnesses.","PeriodicalId":281523,"journal":{"name":"International Journal of Pharma Medicine and Biological Sciences","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116247481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Using Artificial Neural Networks to Perform Feature Selection on Microarray Data 利用人工神经网络对微阵列数据进行特征选择

International Journal of Pharma Medicine and Biological Sciences Pub Date : 2022-07-01 DOI: 10.18178/ijpmbs.11.3.54-58

G. Armano, Osvaldo Marullo

引用次数: 0

Bacterial Colonies on Agar Plate Counting Using Image Processing 利用图像处理对琼脂平板细菌菌落计数

International Journal of Pharma Medicine and Biological Sciences Pub Date : 2022-07-01 DOI: 10.18178/ijpmbs.11.3.48-53

Manao Bunkum, S. Visitsattapongse

引用次数: 1

Phytochemical Screening and Evaluation of Antioxidant, Antibacterial Activities of Ethanol Extract from Combretum quadrangulare Collected in Vietnam 越南产四棱草乙醇提取物的植物化学筛选及抗氧化、抗菌活性评价

International Journal of Pharma Medicine and Biological Sciences Pub Date : 2022-07-01 DOI: 10.18178/ijpmbs.11.3.59-64

T. Men, Huynh Kim Yen, Huỳnh Thị Cẩm Lan, Nguyen Hoang Son, D. Khang, Nguyen Trong Tuan

{"title":"Phytochemical Screening and Evaluation of Antioxidant, Antibacterial Activities of Ethanol Extract from Combretum quadrangulare Collected in Vietnam","authors":"T. Men, Huynh Kim Yen, Huỳnh Thị Cẩm Lan, Nguyen Hoang Son, D. Khang, Nguyen Trong Tuan","doi":"10.18178/ijpmbs.11.3.59-64","DOIUrl":"https://doi.org/10.18178/ijpmbs.11.3.59-64","url":null,"abstract":"— Combretum quadrangulare Kurz has long been considered a precious herb, which is very useful in treating various kinds of diseases on humans and aquatic animals. The study was conducted to evaluate the antioxidant and antibacterial effects of ethanol extracts from Combretum quadrangulare Kurz fruit collected in Kien Giang province, Vietnam. Research results showed that ethanol extract from Combretum quadrangulare Kurz fruit contained bioactive compounds such as alkaloids, flavonoids, steroids and triterpenoids, tannins, and phenolics. In the ethanol extract of Combretum quadrangulare Kurz fruit, the content of total phenolics and total flavonoids were recorded at 230.89 ± 2.36 mg GAE/g extract and 165.35 ± 5.80 mg QE/g extract, respectively. The survey results of in vitro antioxidant capacity through four methods of DPPH, ABTS ●+ , RP and TAC indicated that the extracts of Combretum quadrangulare Kurz fruit showed its good activity with EC 50 values of 103.90 ± 0.40 µg/mL, 24.18 ± 0.06 µg/mL, 128.58 ± 0.20 µg/mL and 79.30 ± 1.40 µg/mL, respectively. The investigation results of in vivo antioxidant activity on fruit fly Drosophila melanogaster model showed that the fruit flies raised in the medium supplemented with 1 mg/mL extract of Combretum quadrangulare Kurz fruit had in vivo antioxidant effect under the conditions of oxidative stress induced by Paraquat and H 2 O 2 . In addition, the extract from Combretum quadrangulare Kurz fruit also had the ability to against the bacteria causing diseases in aquatic animals such as Edwardsiella ictaluri, Aeromonas hydrophila and Streptococcus agalactiae .","PeriodicalId":281523,"journal":{"name":"International Journal of Pharma Medicine and Biological Sciences","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130424620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Species Recognition of Aspergillus Conidia Using Convolutional Neural Networks in Scanning Electron Microscopy Imagery 扫描电镜图像中基于卷积神经网络的分生曲霉物种识别

International Journal of Pharma Medicine and Biological Sciences Pub Date : 2022-01-01 DOI: 10.18178/ijpmbs.11.1.8-13

Huaizhong Zhang, Marta Filipa Simões

{"title":"Species Recognition of Aspergillus Conidia Using Convolutional Neural Networks in Scanning Electron Microscopy Imagery","authors":"Huaizhong Zhang, Marta Filipa Simões","doi":"10.18178/ijpmbs.11.1.8-13","DOIUrl":"https://doi.org/10.18178/ijpmbs.11.1.8-13","url":null,"abstract":"— This paper presents a practical recognition method based on deep learning techniques, for fungal species, through Scanning Electron Microscopy (SEM) images. A small number of images was acquired. To circumvent the issue of not having many samples, a method of generating the training set is proposed to increase target signatures and optimize the baseline quality of inputs for object recognition. To tackle the challenge of detecting varied scale targets, a sophisticated and powerful Convolutional Neural Network (CNN) based on faster region R-CNN, with the prepared training dataset, was trained. In this study, the datasets for five different species of Aspergillus were previously collected via SEM. The proposed method is applied to identify the spore structures – conidia – in the images so as to recognize the species respectively. The initial experimental results show that the developed method can qualitatively and quantitatively identify the relevant species effectively, being of major importance for the development of easier diagnostic and identification tools in mycology.","PeriodicalId":281523,"journal":{"name":"International Journal of Pharma Medicine and Biological Sciences","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130910387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dissociative Identity Disorder: Understanding of DID, Symptoms and Causes 解离性身份障碍:对DID、症状和原因的理解

International Journal of Pharma Medicine and Biological Sciences Pub Date : 2022-01-01 DOI: 10.18178/ijpmbs.11.1.26-29

Peng Liu

引用次数: 0